期刊
TRENDS IN IMMUNOLOGY
卷 41, 期 5, 页码 436-452出版社
CELL PRESS
DOI: 10.1016/j.it.2020.03.002
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资金
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (TILC) [694502]
- Agence Nationale de la Recherche
- Equipe Labellisee `La Ligue,' Ligue Nationale contre le Cancer
- MSDAvenir
- Innate Pharma
- INSERM
- CNRS
- Aix Marseille Univ
- Marseille Immunopole
The innate lymphoid cell (ILC) family consists of natural killer (NK) cells, helper-like lymphoid cells (ILC1s, ILC2s, and ILC3s), and lymphoid tissue inducer (LTi) cells. Helper-like ILCs are considered the innate counterpart of T-helper cells because of similarities in their cytokine output and expression of key transcription factors. ILCs provide and regulate innate immune functions before the development of adaptive immunity. They are involved in host defense against pathogens, inflammation, tissue repair, and metabolic homeostasis. However, they can also be involved in inflammatory disorders and carcinogenesis. In this review, we summarize the latest research on ILC development and plasticity in humans and mice, focusing on the pathogenic role of helper-like ILCs in inflammatory disorders, such as asthma, Crohn's disease (CD), and rheumatoid arthritis (RA).
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