期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 23, 页码 7716-7720出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201600962
关键词
cellular imaging; gadolinium; magnetic resonance imaging; redox-responsive; silica microspheres
资金
- MIUR [PRIN 2010B5B2NL, PRIN 2012K7ASN]
- MAECI [PGR 00222]
- Compagnia di San Paolo (THERASIL Project) [CSP-2014]
The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.
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