Review
Plant Sciences
Yucheng Ming, Libo Jiang, Dongchao Ji
Summary: This review discusses the recent advances in epigenetic regulation of tomato fruit ripening, including DNA methylation, N6-Methyladenosine mRNA modification, histone demethylation/deacetylation, and non-coding RNA. This research contributes to a better understanding of the regulatory mechanisms governing tomato fruit ripening and provides new insights for precise modulation of these mechanisms.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Plant Sciences
Zhiya Liu, Xuetong Wu, Huwei Liu, Meiling Zhang, Weibiao Liao
Summary: Fruit ripening is regulated by transcription factors, plant hormone ethylene, and DNA methylation. DNA methylation affects fruit ripening by transferring methyl groups. Tomato fruit ripening is dynamically regulated by DNA methylation and demethylation, but the specific molecular mechanism is still unclear.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Cell Biology
Lauren Winkler, Maria Jimenez, Joshua T. Zimmer, Adam Williams, Matthew D. Simon, Nadya Dimitrova
Summary: The study shows that the full transcription, splicing, and accumulation of lincRNA-p21 are not crucial for gene regulation, but the production of lincRNA-p21 through specific exon regions can promote cis-activation of the gene.
Article
Biochemistry & Molecular Biology
Lei Deng, Tianxia Yang, Qian Li, Zeqian Chang, Chuanlong Sun, Hongling Jiang, Xianwen Meng, Tingting Huang, Chang-Bao Li, Silin Zhong, Chuanyou Li
Summary: MED25 plays a crucial role in fruit ripening by interacting with master transcription factors of the EIN3/EIL family and forming a transcriptional module with EIL1. It controls ethylene-induced gene transcription by facilitating pre-initiation complex formation and regulates the expression of ripening-related regulatory and structural genes through promoter binding. The EIL1-MED25 module, along with its downstream regulators, orchestrates both positive and negative feedback transcriptional circuits to fine-tune ethylene homeostasis during fruit ripening.
Article
Agronomy
Ziyan Liu, Tanglu Hu, Chunxin Yu, Weiming Tan, Yuanyue Shen, Liusheng Duan
Summary: This study designed and synthesized a class of structurally simple AVG analogues, and molecular docking analysis revealed that compounds 2i, 2k, and 2n exhibited higher binding activity. Experimental results showed that 2i, 2k, and 2n could reduce ethylene production and delay postharvest ripening of tomatoes, with 2n being the most effective AVG analogue. This research provides a new approach for controlling ethylene action and extending the shelf life of fruits, and has significant implications for structure-activity relationship studies and the development of more functional AVG analogues.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Plant Sciences
Susu Guo, Yanyan Zheng, Demei Meng, Xiaoyan Zhao, Zhaoze Sang, Jinjuan Tan, Zhiping Deng, Zhaobo Lang, Bo Zhang, Qing Wang, Mondher Bouzayen, Jinhua Zuo
Summary: This study identified mRNAs with increasing m5C levels involved in fruit ripening, as well as genes associated with response to biotic and abiotic stresses and cell wall metabolism. Differential expression of genes encoding transcription factors and key enzymes related to ethylene biosynthesis and signal transduction was also observed. These findings provide important insights into the mechanisms of fruit ripening and post-harvest behavior.
Review
Biochemistry & Molecular Biology
Connor Barrett, Anuj Budhiraja, Vijay Parashar, Mona Batish
Summary: Ewing's sarcoma is a pediatric sarcoma caused by a chromosomal translocation, with stable genomes in patients. Noncoding RNAs, especially microRNAs and long noncoding RNAs, have been shown to play crucial roles in ES, although further exploration is needed to fully understand their functions in this type of cancer.
Article
Biochemistry & Molecular Biology
Changan Zhu, Shaofang Wu, Ting Sun, Zhiwen Zhou, Zhangjian Hu, Jingquan Yu
Summary: Rosmarinic acid (RA) treatment in postharvest significantly delayed ripening, reduced ethylene production, inhibited color change, promoted amino acid accumulation, and enhanced antioxidant activity in tomato fruits. These findings indicate a novel function of RA in fruit ripening, offering an attractive strategy to manage and improve the quality of tomato fruits.
Article
Cell Biology
Wentao Ma, Weihong Zhang, Bing Cui, Jing Gao, Qiuhong Liu, Mengying Yao, Hanbing Ning, Lihua Xing
Summary: This study reveals that EPCs derived EVs transmit TUG1 to alleviate sepsis by promoting macrophage M2 polarization. Additionally, TUG1 can competitively bind to miR-9-5p to upregulate SIRT1 expression, leading to the inhibition of miR-9-5p-mediated SIRT1 inhibition, which contributes to a more comprehensive understanding of the pathogenesis of sepsis.
CELL DEATH & DISEASE
(2021)
Article
Plant Sciences
Yusuke Kamiyoshihara, Yuki Achiha, Shin Ishikawa, Shinji Mizuno, Hitoshi Mori, Akira Tateishi, Donald J. Huber, Harry J. Klee
Summary: Ethylene receptors function in heteromeric complexes across subfamilies in tomato fruit, providing insights into the regulation of ethylene signaling during tomato fruit ripening. Tomato receptor members form heteromeric complexes to fine-tune signal output to the downstream pathway, similar to the Arabidopsis system but with some differences.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Agriculture, Multidisciplinary
Ying Yang, Laifeng Lu, Dandan Sun, Jinghao Wang, Nifei Wang, Liping Qiao, Qingbin Guo, Changlu Wang
Summary: The study showed that OGs generated by fungal PG could delay tomato fruit softening and maintain fruit firmness; RNA sequencing data confirmed the involvement of pathways like ethylene and jasmonic acid signals; Suppressing the expression of ethylene response factor SlERF6 could attenuate the softening process restrained by OG.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Qianyu Yue, Xinyue Yang, Pengda Cheng, Jieqiang He, Wenyun Shen, Yixuan Li, Fengwang Ma, Chundong Niu, Qingmei Guan
Summary: MdKING1, a subunit of SnRKs, promotes fruit ripening through ethylene pathway.
Article
Plant Sciences
Bin Liang, Yufei Sun, Juan Wang, Yu Zheng, Wenbo Zhang, Yandan Xu, Qian Li, Ping Leng
Summary: The study revealed the crucial role of tomato ABA co-receptor type 2C phosphatase SlPP2C3 in regulating fruit ripening and fruit glossiness. SlPP2C3 interacts selectively with ABA receptors and kinase, negatively regulates ABA signaling, and affects the onset of fruit ripening.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Plant Sciences
Guoxiang Jiang, Zhiwei Li, Xiaochun Ding, Yijie Zhou, Hongmei Lai, Yueming Jiang, Xuewu Duan
Summary: A WUSCHEL-related homeobox transcription factor (TF), SlWOX13, regulates tomato fruit ripening via ethylene synthesis and signaling, as well as transcriptional regulation of key ripening-related TFs.
Review
Agriculture, Multidisciplinary
John Momo, Abdul Rawoof, Ajay Kumar, Khushbu Islam, Ilyas Ahmad, Nirala Ramchiary
Summary: Tomato crops have gained significance due to their rich nutrition, pharmaceutical benefits, and flavor, leading to increased consumption worldwide. Traditional breeding and functional research have made progress in overcoming biotic and abiotic stresses. Proteomic investigations have contributed to advancing functional genomics and transcriptomic research. However, further research in proteomics is needed to understand the regulation of tomato growth and development comprehensively. This comprehensive review of proteomic studies on tomatoes will benefit future breeders and researchers aiming to improve tomato crops.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Neuroimaging
Dapeng Sun, Baixue Jia, Xu Tong, Peter Kan, Xiaochuan Huo, Anxin Wang, Raynald, Gaoting Ma, Ning Ma, Feng Gao, Dapeng Mo, Ligang Song, Xuan Sun, Lian Liu, Yiming Deng, Xiaoqing Li, Bo Wang, Gang Luo, Yongjun Wang, Zeguang Ren, Zhongrong Miao
Summary: This study investigated the incidence, predictors, and clinical impact of parenchymal hemorrhage (PH) after endovascular treatment (EVT) in Chinese patients with acute ischemic stroke (AIS) caused by anterior circulation large vessel occlusion (LVO). The findings showed that low admission ASPECTS, high serum glucose, and elevated neutrophil-to-lymphocyte ratio (NLR) were independent predictors of PH, while underlying intracranial atherosclerotic stenosis (ICAS) and intracranial angioplasty/stenting were associated with a lower risk of PH. Additionally, patients with PH had worse functional outcomes.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Obstetrics & Gynecology
Xiang-Lan Liu, Li Ding, Xiao Lu, Yan-Jiao Hu, Xiao-Li Zhou, Dong-Liang Lin
Summary: A cervical yolk sac tumor in a 44-yr-old woman shares similarities with adenocarcinomas with enteroblastic differentiation (AEBDs) in the digestive system. The tumor exhibits a glandular-predominant growth pattern and is positive for p16, glypican-3 (GPC3), spalt-like transcription factor 4 (SALL4), CDX-2, and p53. TP53 mutation and HPV 35 infection were detected. This aggressive tumor should be recognized for its enteroblastic component in pathology reports.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2023)
Article
Nutrition & Dietetics
Qi Cui, Yang Xia, Yashu Liu, Yifei Sun, Kang Ye, Wenjie Li, Qijun Wu, Qing Chang, Yuhong Zhao
Summary: This study evaluated the reproducibility and validity of the Food Frequency Questionnaire (FFQ) for residents in northeast China. The findings demonstrated that the FFQ is reliable and valid for assessing the intake of most foods and nutrients.
BRITISH JOURNAL OF NUTRITION
(2023)
Correction
Obstetrics & Gynecology
Sadaf Pervaz, Amin Ullah, Enoch Appiah Adu-Gyamfi, Jones Lamptey, Sanjay Kumar Sah, Mei-Jiao Wang, Ying-Xiong Wang
REPRODUCTIVE SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Qing Chang, Qijun Wu, Yang Xia, Hehua Zhang, Shanyan Gao, Yixiao Zhang, Yuan Yuan, Jing Jiang, Hongbin Qiu, Jing Li, Chunming Lu, Chao Ji, Xin Xu, Donghui Huang, Huixu Dai, Zhiying Zhao, Hang Li, Xiaoying Li, Xiaosong Qin, Caigang Liu, Xiaoyu Ma, Xinrui Xu, Da Yao, Yuhong Zhao
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Engineering, Ocean
Zhuangcai Tian, Hanlu Liu, Shaotong Zhang, Jinran Wu, Jiahao Tian
Summary: This paper proposes a method for predicting the shear stress induced by shoaling internal solitary waves (ISWs) based on machine learning. The developed approach has been proven to be effective and accurate in predicting the shear stress and can be used to evaluate the safety and stability of ocean engineering. This method is of great significance in promoting the development of deep-water ocean engineering.
MARINE GEORESOURCES & GEOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jing Liu, Ji Lv, Zheyi Liu, Zheng Fang, Can Lai, Shan Zhao, Mingliang Ye, Fangjun Wang
Summary: In this study, it was discovered that interfacial hydrophobic hydration significantly enhances H-bond networks at the interface between a glycan-modified adsorbent and a methanol-water-acetonitrile ternary solution. This enhancement promotes the adsorbent-solution heterogeneous glycan-glycan recognition and interaction, leading to improved glycopeptide enrichment. Compared with the commonly used hydrophilic-interaction enrichment strategy, more intact N- and O-glycopeptides are identified and the enrichment recoveries are significantly increased. This study also provides in-depth profiling of N- and O-glycosylation on SARS-CoV-2 S1 and hACE2 proteins.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Psychology, Multidisciplinary
Yefeng Chen, Yiwen Pan, Haohan Cui, Xiaolan Yang
Summary: This article proposes a possible mechanism that people may have underconfidence bias in information updating due to motivated reasoning, which generates the asymmetric pattern in contagion, different from the overconfident bias observed in the literature. The study designs an experiment to relate unethical behavior to social learning, where subjects decide whether to conduct unethical behavior publicly based on private information about penalty. The results confirm that people rely more on others' decisions than their own signal, suggesting the bias facilitates the contagion.
BEHAVIORAL SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Mengfei Li, QianQian Yang, Lili Fan, Xiaojie Dai, Zixi Kang, Rongming Wang, Daofeng Sun
Summary: Researchers have developed alternative electrocatalysts with high stability for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The electrocatalyst, composed of hollow CoOx nanoparticles embedded in carbon nanofibers, showed excellent long-term stability and promising performance in reversible Zn-air batteries. The remarkable electrocatalytic performance is attributed to the optimized adsorption of *OOH intermediate and reduced free energy of the potential-limiting step.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Letter
Biochemistry & Molecular Biology
Qiao-ling Ruan, Zhi-chao Wang, Cheng-jiang Wei, Wei Wang, Qing-luan Yang, Jing Wu, Yan-min Wan, Ling-ling Ge, Wen-hong Zhang, Qing-feng Li
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Physiology
Xinwei Wang, Jiulong Song, Peng Xia, Qiang Lin, Anliang Chen, Kai Cheng, Fane Kong, Yi Shi, Xueping Li
Summary: High-intensity interval training (HIIT) is a physical therapy that can alleviate osteoarthritis (OA)-associated hyperalgesia. Cacna2d1, a subunit protein of calcium channel, plays a crucial role in nerve cell activity. However, the effect of HIIT on OA hyperalgesia and the involvement of Cacna2d1 remains unclear. In this study, OA rat models were established using monosodium iodoacetate (MIA) injection, and different groups were compared. Pain threshold, cartilage analysis, Cacna2d1 expression, and pain neurotransmitters were measured. The results demonstrated that HIIT could attenuate OA-associated hyperalgesia, possibly through the down-regulation of Cacna2d1 expression.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Ying Hu, Yan Liu, Siqi Zhang, Ting Zhang, Bin Dai, Bo Peng, Hongbo Yang, Yakang Dai
Summary: This study proposes a cross-space convolutional neural network (CS-CNN) for the classification of four-class motor imagery-electroencephalogram (MI-EEG), aiming to improve classification accuracy and robustness. The algorithm utilizes modified customized band common spatial patterns (CBCSP) and duplex mean-shift clustering (DMSClustering) to express specific rhythms and source distribution information in cross-space, and extracts multi-view features from time, frequency, and space domains to fuse the characteristics from two spaces and classify them using CNN. Experimental results show that the proposed algorithm achieves a classification accuracy of 96.05% (with real MRI information) and 94.79% (without MRI) in the private dataset. Moreover, in the BCI competition IV-2a, CS-CNN outperforms state-of-the-art algorithms with an accuracy improvement of 1.98% and a standard deviation reduction of 5.15%.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Immunology
Zhishuo Wang, Chenghua Yan, Qizhen Du, Yuying Huang, Xuezhen Li, Dan Zeng, Ruizhi Mao, Rama Krishna Gurram, Shipeng Cheng, Wangpeng Gu, Lin Zhu, Weiguo Fan, Liyan Ma, Zhiyang Ling, Ju Qiu, Dangsheng Li, Enmei Liu, Yaguang Zhang, Yiru Fang, Jinfang Zhu, Bing Sun
Summary: This study found a negative correlation between the neurotransmitter serotonin and the cytokines IL-5 and IL-13 produced by ILC2s, which are related to depression. Serotonin can alleviate lung inflammation by suppressing ILC2 activation. The serotonin receptor HTR2A is highly expressed on ILC2s and can be targeted with an agonist called DOI to inhibit ILC2 activation and reduce type 2 immune response. Targeting HTR2A on ST2(+) ILC2s could be a potential treatment strategy for type 2 lung inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xi Lin, Lixing Dai, Qinqin Yang, Qizhi Yang, Hongjian He, Lingceng Ma, Jingjing Liu, Jingliang Cheng, Congbo Cai, Jianfeng Bao, Zhong Chen, Shuhui Cai, Jianhui Zhong
Summary: This study developed a real-time abdominal T-2 mapping method that does not require breath-holding or respiratory-gating. The single-shot multiple overlapping-echo detachment (MOLED) pulse sequence was used for free-breathing T-2 mapping of the abdomen. Deep learning was utilized to untangle the non-linear relationship between the MOLED signal and T-2 mapping. A synthetic data generation flow based on Bloch simulation, modality synthesis, and randomization was proposed to overcome the inadequacy of real-world training set.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Physical
Tengda Wang, Shaoying Dai, Jie Wang, Bin Liu, Meiwen Cao, Bo Guan, Yuchun Han, Yilin Wang
Summary: The large-scale use of detergents for oil-fouling removal in industry generates a significant amount of wastewater, leading to economic and environmental problems. This study presents a recyclable, efficient, and eco-friendly approach to remove oil-fouling by constructing a dynamic imine-based surfactant.