Article
Chemistry, Multidisciplinary
Javier Bonet-Aleta, Jose I. Garcia-Peiro, Silvia Irusta, Jose L. Hueso
Summary: Nanozymes are nanomaterials that mimic the catalytic activity of natural enzymes and are widely used in the development of biosensing analytical tools. In this study, a gold-platinum nanoparticle with core-shell configuration was synthesized and exhibited remarkable oxidase-like activity towards specific substrates. By exploiting the loss of activity, an analytical method was developed to detect and quantify glutathione levels.
Article
Chemistry, Analytical
Ying Liu, Jianghong Yan, Zhiheng Sun, Yu Huang, Xuwen Li, Yongri Jin
Summary: In this study, a 3D hierarchical flower-like nanozyme named MnO2/PS was successfully prepared for the first time. The MnO2/PS nanozyme demonstrated favorable oxidase activity and catalytic ability for TMB in a near-neutral environment. The method proposed showed good selectivity and high sensitivity for the detection of reduced GSH.
Article
Engineering, Chemical
Yue Wu, Wanru Wang, Siya Ye, Kanwal Iqbal, Li Liu, Guoyu Qiu, Weichun Ye
Summary: In this study, Pt-loaded NiCo2O4 nanoparticles were successfully synthesized by controlling the treatment of complexes, achieving high-sensitivity colorimetric detection of acetaminophen. The colorimetric sensor demonstrated good selectivity for acetaminophen in natural water.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Chemistry, Applied
Shao-Bin He, Liu Yang, Yu Yang, Hamada A. A. Noreldeen, Gang-Wei Wu, Hua-Ping Peng, Hao-Hua Deng, Wei Chen
Summary: Chitosan modification, especially carboxylated chitosan (CC), has been explored for the preparation of PtNPs. CC-PtNPs exhibit improved colloidal stability and ascorbate oxidase-like activity compared to chitosan-modified Pt nanozyme. Based on CC-PtNPs, a fluorometric acid phosphatase sensor with excellent sensitivity and selectivity has been successfully developed.
CARBOHYDRATE POLYMERS
(2022)
Article
Biophysics
Mengli Zhang, Yongqi Wang, Na Li, Dangqiang Zhu, Feng Li
Summary: Nanozyme-based colorimetric assays have been developed for the specific detection of the agricultural fungicide thiophanate-methyl (TM) by exploiting its inhibitory effect on nanozyme activity. The Cu-doped carbon nanozyme, with excellent oxidase-like properties, was designed and the chromogenic substrate's oxidation process was promoted by Cu-induced generation of reactive oxygen species. This method exhibits a specific response to TM in the range of 0.2-15 μg/mL with a low limit of detection of 0.04 μg/mL (S/N = 3), and a smartphone-assisted rapid detection was achieved by identifying the RGB value of the chromogenic system.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Yiming Jiang, Jiawei Zhu, Li Li, Yahui Gao, Juncai Leng, Jiai Yan, Shuoming Liu, Feng Zhang, Han Liu, Chenlu Zhu, Lichun Guo, Haijiao Xie, Wei Zhao
Summary: Researchers have designed and fabricated a novel peroxidase mimic catalyst based on Pd@PtxRu4-x (1 <= x <= 3). The catalyst exhibits higher catalytic activity and kinetics compared to classical PtRu nanozyme and horseradish peroxidase. Density functional theory calculations suggest that the superior catalytic performance is due to the modulation of the adsorption behavior of key reaction intermediates on the surface. The catalyst also shows potential for sensing glucose and glutathione molecules in human serum.
Article
Chemistry, Physical
Tiantian Feng, Qing Hao, Bing Sun, Dong Wang
Summary: Metal-covalent organic frameworks (MCOFs) with regular structures, adjustable pore channels, designable structures, and abundant tunable metal-catalytic active sites are promising candidates for advanced single-atom enzymes.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Rui Shi, Jin Yang, Shiqi Cheng, Shangying Qin, Li Huang, Yilin Wang, Yuanjin Xu
Summary: AuNPs@MoS2 NSs with high peroxidase-like activity were synthesized and used for colorimetric determination of biothiols. Under optimized experimental conditions, this method showed good linear response to three biothiols and was successfully applied for Hcy determination in human serum samples, indicating its potential application in real samples.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Namitha K. K. Preman, Supriya Jain, Anila Antony, Dhanya M. M. Shetty, Nasrin Fathima, K. Sudhakara Prasad, Renjith P. P. Johnson
Summary: This study developed a colorimetric sensor using gold nanoparticles as a catalyst for ultra-trace detection of mercury ions in water. The colorimetric detection method can be used to determine mercury contamination in various water and biological samples.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biophysics
Zhiqiang Wang, Xiaoqian Zhou, Wei Wang
Summary: Designing nanozymes with excellent catalytic activity through valence state engineering and defect engineering is a widely applicable strategy. In this work, a simple calcination method was used to regulate the valence of manganese and crystalline states in manganese oxide nanozymes. The oxidase-like activity of the nanozymes benefited from a mixed valence state dominated by Mn (III), and the amorphous structure with more active defect sites significantly enhanced the catalytic efficiency. Moreover, amorphous mixed-valent Mn-containing (amvMn) nanozymes with unique cocklebur-like biomimetic morphology achieved specific binding to cancer cells through the Velcro effects. The nanozymes mediated TMB coloration through their oxidase-like activity, enabling the colorimetric detection of cancer cells. This work not only provides guidance for optimizing nanozyme performance, but also inspires the development of equipment-free visual detection methods for cancer cells.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Materials Science, Multidisciplinary
Lumin Wang, Jialu Xue, Jin Chang, Chenyang Yu, Henghan Dai, Zhenjie Yao, Jinyuan Zhou, Gengzhi Sun, Wei Huang
Summary: Fe,N-doped carbon material Fe,N-C-800 exhibits excellent peroxidase-like performance, with outstanding substrate affinity and catalytic velocity, showing potential for ultrasensitive detection of H2O2 in disposable paper bioassays.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Hui Huang, Donghui Song, Wenjing Zhang, Shuaizhen Fang, Qianxi Zhou, Haoyu Zhang, Zheng Liang, Yongxin Li
Summary: A sensor strategy based on a metal-organic framework is developed for one-step cascade detection of choline. This method exhibits excellent catalytic activity and stability, allowing for efficient detection of choline across a wide concentration range.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ruihong Yao, Zhijian Li, Jin Li, Kai Tuo, Daobing Zhang, Congbin Fan, Gang Liu, Yonghui Deng, Shouzhi Pu
Summary: A novel and light-responsive nanozyme with enzyme-like characteristics was synthesized based on core-shell MOF@COF hybrid materials. The core-shell Cu-MOF@Py-Tt hybrid materials exhibited extremely high oxidase-like enzymatic catalytic activity with visible light irradiation. A light-control, sensitive and rapid colorimetric method for determination of glutathione (GSH) was designed based on the core-shell Cu-MOF@Py-Tt with excellent nanozyme activity.
MICROCHEMICAL JOURNAL
(2023)
Article
Biophysics
Jiajia Zhang, Yongfei Li, Xue Gong, Yi Wang, Wensheng Fu
Summary: In this study, a smartphone-based colorimetric reader using cobalt oxyhydroxide (CoOOH) nanorings was successfully applied to detect antioxidants in green tea. The developed nanosensor offers a portable and visual detection method for antioxidants and has the potential to be extended to the visual detection of various diseases.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Analytical
Phan Ba Khanh Chau, Thinh Viet Dang, Moon Il Kim
Summary: We synthesized crystalline MnOOH nanowires (MNWs) via a simple solvothermal treatment of KMnO4, which exhibited excellent oxidase-like activity due to the presence of pure Mn3+ sites. MNWs catalyzed the rapid oxidation of dopamine into aminochromes, resulting in a vivid brown color. Based on the catalytic features of MNWs, we developed a paper dipstick for the one-step colorimetric detection of dopamine.
Article
Chemistry, Analytical
Zhongnan Huang, Sunxing Yu, Meili Jian, Zhimin Weng, Haohua Deng, Huaping Peng, Wei Chen
Summary: This study presents an electrochemiluminescence (ECL) platform based on gold nanoclusters for ultrasensitive detection of glutathione (GSH) and adenosine triphosphate (ATP). The platform exhibits high sensitivity, wide dynamic range, and strong anti-interference properties, showing great potential in the detection of GSH-related substances.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Haohua Deng, Kaiyuan Huang, Lingfang Xiu, Weiming Sun, Qiaofeng Yao, Xiangyu Fang, Xin Huang, Hamada A. A. Noreldeen, Huaping Peng, Jianping Xie, Wei Chen
Summary: Researchers have increased the photoluminescence quantum yield of water-soluble gold clusters at the single-cluster level by forming bis-Schiff base linkages, providing important insights for enhancing the luminescence efficiency of gold clusters.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Guolin Hong, Canping Su, Mingchun Lai, Zhongnan Huang, Zhimin Weng, Yaling Chen, Haohua Deng, Wei Chen, Huaping Peng
Summary: In this study, a novel co-reactant-mediated high-performance low-potential Au nano-cluster (AuNC)-based ECL system was successfully developed for the detection of SARS-CoV-2 N protein. The ECL system exhibited higher energy efficiency and quantum yield, with a wide linear range and low detection limit. It showed good reproducibility and stability, making it suitable for the detection of actual serum samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Kai -Yuan Huang, Ling -Fang Xiu, Xiang-Yu Fang, Ming-Rui Yang, Hamada A. A. Noreldeen, Wei Chen, Hao-Hua Deng
Summary: This research discovers a proton binding-induced enhanced intramolecular charge transfer state in gold nanoclusters. By combining this newfound intramolecular charge transfer mechanism and a restriction of intramolecular motion strategy, a red shift in emission maxima and increased fluorescence quantum efficiency are achieved.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Correction
Chemistry, Analytical
Zhimin Weng, Zhenglian Li, Yixuan Zhang, Mingying Zhang, Zhongnan Huang, Wei Chen, Huaping Peng
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhimin Weng, Zhenglian Li, Yixuan Zhang, Mingying Zhang, Zhongnan Huang, Wei Chen, Huaping Peng
Summary: This study proposes a novel AuNC-based ECL sensing platform and explores the regulation mechanism of electron transfer on ECL. By investigating the ECL quenching effect of OM-AuNCs under the influence of Cu2+, it is found that the ECL intensity of OM-AuNCs is affected by the electron transfer process, enabling sensitive detection of Cu2+ in a low concentration range without the need for amplification techniques. This study enriches the application of ET-mediated ECL and promotes a more rational design of ECL sensors.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Qile Li, Ke Xu, Haipeng Zhang, Zengguang Huang, Chao Xu, Zhen Zhou, Huaping Peng, Linxing Shi
Summary: In this study, a novel Ru(bpy)(3)(2+)-Au-WS2 nanocomposite ECL probe was developed for the detection of carcinoembryonic antigen (CEA). The probe showed high sensitivity and selectivity due to the synergistic effect and biocompatibility of Au nanoparticles (Au NPs) and WS2 nanosheet. The ECL platform exhibited excellent anodic ECL performance, good reproducibility, stability, and anti-interference performance.
Article
Biophysics
Quan-Quan Zhuang, Jia-Lin Yang, Hui-Na Qiu, Kai-Yuan Huang, Yu Yang, Hua-Ping Peng, Hao-Hua Deng, Hui-Qiong Jiang, Wei Chen
Summary: This study presented a novel class of luminogen called 6-Aza-2-thiothymine-decorated gold nanoclusters (ATT-AuNCs) with aggregation-induced emission property, which demonstrated potent antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). By generating reactive oxygen species (ROS) and altering the expression of multiple target proteins in MRSA cells, ATT-AuNCs effectively eliminated MRSA. Additionally, ATT-AuNCs could serve as a wound-healing agent. Therefore, ATT-AuNCs are considered robust antimicrobial aggregation-induced emission luminogens (AIEgens) capable of targeting multiple pathways to eliminate drug-resistant bacteria.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Spectroscopy
Chen -Ting Zhu, Kai -Yuan Huang, Qing-Lin Zhou, Xiang -Ping Zhang, Gang-Wei Wu, Hua-Ping Peng, Hao-Hua Deng, Wei Chen, Hamada A. A. Noreldeen
Summary: Sulfonamides are widely used but their accumulation in the human body can cause serious diseases. Therefore, a convenient, effective, and sensitive method to detect them is needed. In this study, a sensor array using BSA-AuNCs was constructed to detect five Sulfonamides, and the changes in fluorescence intensity at different excitation wavelengths were used for identification. This method shows great potential in the fields of food and drug monitoring.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Huaping Peng, Mingchun Lai, Huijing Wang, Zhimin Weng, Yu Yang, Zhongnan Huang, Weiming Sun, Juewen Liu, Wei Chen
Summary: In this study, an energy level engineering strategy was proposed to regulate the electrochemiluminescence (ECL) performance using ligand-protected gold nanoclusters (AuNCs) as luminophores and N,N-diisopropylethylamine (DIPEA) as a coreactant. The energy level matching between the AuNCs and DIPEA effectively promoted electron transfer reactions, improving excitation efficiency and reducing trigger potential. The narrow bandgap of the AuNCs further enhanced emission efficiency. The developed theory was successfully applied to design a highly stable near-infrared ECL system with low trigger potential.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Zhongnan Huang, Zhenglian Li, Zhimin Weng, Paramasivam Balasubramanian, Mingchun Lai, Wei Chen, Juewen Liu, Huaping Peng
Summary: In this study, a model system was developed to evaluate the effect of electrocatalysis (EC) on electrochemiluminescence (ECL) through kinetic analysis of electrocatalytic reactions. The results demonstrated a dual EC-mediated ECL enhancement and identified the catalytically active sites. With a better understanding of the EC mechanism, the researchers successfully used EC to regulate ECL and developed a biosensor with a record low limit of detection.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Ruiting Chen, Hejing Chen, Huaping Peng, Yanjie Zheng, Zhen Lin, Xinhua Lin
Summary: A DNA biosensor based on a multi-walled carbon nanotube array modified electrode was developed for the detection of the MDR1 gene, which is crucial in cancer clinical therapy.
Review
Materials Science, Biomaterials
Shao-Bin He, Li-Yong Shi, Qiong-Hua Zheng, Yin Zhang, Wei Chen, Yi-Ming Zeng
Summary: Respiratory diseases, a significant public health concern, require feasible treatment and prevention strategies. Nanotechnology, specifically nanozymes and nanomaterials, has shown promise in the field of respiratory disease research. This article reviews the progress of nanozymes in diagnosing, treating, and preventing respiratory diseases, aiming to inspire new ideas for their beneficial applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Inorganic & Nuclear
Luyao Xu, Yu Yang, Weihua Wu, Chaoguo Wei, Guanying Luo, Zhongnan Huang, Wei Chen, Huaping Peng
Summary: A facile aqueous synthesis method was developed for ligand-free cesium lead halide perovskite nanoplatelets, showing good environmental stability and excellent photoresponse.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Yu Yang, Chaoguo Wei, Wenjun Wang, Hamada A. A. Noreldeen, Zhongnan Huang, Haohua Deng, Huaping Peng, Xinghua Xia, Wei Chen
Summary: Research has shown that using 6-aza-2-thio-thymine-AuNCs (ATT-AuNCs) as a photoactive material can achieve high performance in photoelectrochemical properties, with characteristics such as higher cathodic photocurrent density and carrier density compared to other AuNCs.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).