Article
Chemistry, Analytical
Hessamaddin Sohrabi, Mir Reza Majidi, Karim Asadpour-Zeynali, Alireza Khataee, Ahad Mokhtarzadeh
Summary: This research demonstrates a label-free electrochemical-based genosensing assay for the sensitive detection of the L-fuculokinase genome related to Haemophilus influenzae (H. influenzae). Multiple electrochemical modifier-tagged agents were effectively used to enhance the electrochemical responses. The designed genosensing bio-platform achieved low detection and quantification limits (LOD and LOQ) of 6.14 fM and 11 fM, respectively, and demonstrated a wide linear range of 0.1 to 1000 pM. The assay showed high selectivity, good performance, and reliable repeatability and reproducibility, making it a promising method for rapidly and quantitatively detecting H. influenzae.
Article
Biochemistry & Molecular Biology
Zheng Wei, Xiaoping Cai, Weifeng Cui, Junping Zhang
Summary: A CA19-9 electrochemical immunosensor was developed using a self-assembled membrane modified with a gold electrode. It demonstrated good specificity, strong anti-interference ability, and high precision and accuracy. The results showed its potential application value.
Article
Chemistry, Analytical
Giulia Moro, Cedrix J. Dongmo Foumthuim, Marco Spinaci, Ettore Martini, Dafne Cimino, Eleonora Balliana, Peter Lieberzeit, Flavio Romano, Achille Giacometti, Rui Campos, Karolien De Wael, Ligia Maria Moretto
Summary: There is an urgent need for sensing strategies to screen perfluoroalkyl substances (PFAS) in aqueous matrices. Changes in fluorinated self-assembled monolayers (SAM) with different architectures were studied upon exposure to both long and short-chain PFAS. The applicability of fluorinated SAM in PFAS sensing was evaluated using electrochemical impedance spectroscopy and voltam-metric techniques, supported by molecular dynamics simulations. Pinhole/defect-free fluorinated SAM were found to be applicable to long-chain PFAS screening using a switch-on sensing strategy, while a switch-off sensing strategy was reported for screening of both short/long-chain PFAS.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Angelo Tricase, Anna Imbriano, Nicoletta Ditaranto, Eleonora Macchia, Rosaria Anna Picca, Davide Blasi, Luisa Torsi, Paolo Bollella
Summary: This study combines electrochemical and XPS experiments to investigate the conformational rearrangement of self-assembled monolayers (SAMs) on an electrode surface due to the application of an electrical field. It was found that activation and deactivation processes play a crucial role in reaction yields and conformational rearrangement, ultimately impacting the performance of bioelectronic devices.
Article
Chemistry, Physical
Yurong Zhao, Xuzhi Hu, Limin Zhang, Dong Wang, Stephen M. King, Sarah E. Rogers, Jiqian Wang, Jian R. Lu, Hai Xu
Summary: Controlling the dimension of nanostructures self-assembled from short peptides remains a challenge, with peptide bolaamphiphiles forming nanotubes due to the interplay between side chain structure and hydrophobicity; changes in amino acid side chain structure can significantly impact nanostructure formation, with the introduction of hydroxyl groups alleviating steric hindrance.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Analytical
Lili Zhang, Na Li, Zhuangzhuang Chen, Xia Li, Aihua Fan, Huibo Shao
Summary: This study investigated the substitution of intermolecular hydrogen bonds on the surface of simulated biofilm at molecular level using SECM. The results showed that acetic acid could replace the hydrogen bonds between ferrocenemethanol and MPA SAM, and the substitution effect became more significant with increasing concentration of acetic acid.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Baolin Zhao, Bastian Gothe, Arthur Groh, Thomas Schmaltz, Johannes Will, Hans-Georg Steinrueck, Tobias Unruh, Stefan Mecking, Marcus Halik
Summary: This study demonstrates the use of phosphonic acid oligomers in self-assembled monolayer field-effect transistors, showing increased mobility in devices by controlling the thiophene unit counts. X-ray techniques reveal the molecular-scale packing and order of SAMs with different chain lengths.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Judita Anthi, Eva Vaneckova, Monika Spasovova, Milan Houska, Marketa Vrabcova, Eva Vogelova, Barbora Holubova, Hana Vaisocherova-Lisalova, Viliam Kolivoska
Summary: Ultrathin surface-tethered polymer brushes, particularly the zwitterionic poly(carboxybetaine) (pCB) brushes, show great potentials in sensing applications. Experimental studies were conducted to investigate the influence of the alkanethiolate self-assembled monolayers (SAMs) chain length on the properties of the antifouling poly(carboxybetaine methacrylamide) (pCBMAA) brushes. The results showed that the SAM length has a significant impact on the characteristics of the brushes, with longer-chain SAMs exhibiting better biofouling resistance.
ANALYTICA CHIMICA ACTA
(2023)
Article
Nanoscience & Nanotechnology
Julian M. Dlugosch, Henning Seim, Achyut Bora, Takuya Kamiyama, Itai Lieberman, Falk May, Florian Mueller-Plathe, Alexei Nefedov, Saurav Prasad, Sebastian Resch, Kai Saller, Christian Seim, Maximilian Speckbacher, Frank Voges, Marc Tornow, Peer Kirsch
Summary: This article presents a prototype of a ferroelectric tunnel junction (FTJ) based on a self-assembled monolayer (SAM) of small, functional molecules. The SAM is highly uniform and thin, and exhibits reversible conductance switching. Compared to inorganic material-based FTJs, this approach using SAMs of small organic molecules allows for a higher level of functional complexity while maintaining a robust and simple fabrication process. The technology is expected to find applications in information storage and processing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Optics
Zhengkun Wang, Haiyang Sha, Ke Yang, Yong Zhu, Jie Zhang
Summary: In this study, the plasmonic response of self-assembled monolayer silver nanoparticles was comprehensively investigated using various computational and experimental techniques. The Fano resonance and SERS application were studied, and it was found that the higher-energy antibonding mode is not only from the antibonding dipole-dipole mode, but also from the antibonding quadrupole-quadrupole mode and hybridized magnetic mode. The effects of dimer gap and size were discussed in detail, and a two coupled oscillators model was used to illustrate the mechanism of the Fano resonance.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Chemistry, Physical
Jianfeng Li, Wei Cao, Jinjin Li, Ming Ma
Summary: The study revealed that fluorination of perfluorocarbon SAM enhances superlubricity performance, achieving significantly lower friction coefficient and greater load-bearing capacity between graphite in water.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Joan Atcher, Pedro Mateus, Brice Kauffmann, Frederic Rosu, Victor Maurizot, Ivan Huc
Summary: The study demonstrates the orchestration of ever larger conformational changes through the development of increasingly complex foldamers, including the rare motif of aromatic sheets in synthetic foldamer structures. Experimental results confirm the formation of compact dimers through self-assembly of intercalated aromatic strands, and X-ray crystallography and molecular dynamics simulation validate the stability of the two distinct conformational dimeric states and their interconversion possibilities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Jie Xiao, Muyu Cong, Minmin Li, Xin Zhang, Yahui Zhang, Xinjia Zhao, Wenqi Lu, Zhimou Guo, Xinmiao Liang, Guangyan Qing
Summary: This study reports the development of a heterogeneous subnanochannel membrane formed by coating a functionalized self-assembled metal-organic framework (MOF) monolayer (SAMM) film on a porous anodic aluminum oxide membrane. The membrane exhibits excellent capacity for anion-selective transport and has the potential for significant advancement in osmotic power.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shakil N. N. Afraj, Chun-Hsiao Kuan, Jian-Sing Lin, Jen-Shyang Ni, Arulmozhi Velusamy, Ming-Chou Chen, Eric Wei-Guang Diau
Summary: Four X-shaped quinoxaline-based organic dyes, PQx (1), TQx, (2), PQxD (3), and TQxD (4), are developed as p-type self-assemble monolayer (SAM) for tin perovskite solar cells (TPSC). The thermal, optical, and electrochemical properties of these SAMs are thoroughly investigated. Tin perovskite layers are successfully deposited on these SAM surfaces using a two-step approach, and the achieved device performance follows the order of TQxD (8.3%) > TQx (8.0%) > PQxD (7.1%) > PQx (6.1%). Among them, TQxD (4), with a thiophene pi-extended conjugation unit in the SAM structure, exhibits the highest hole extraction rates, greatest hole mobilities, and slowest charge recombination, leading to the best reported efficiency of 8.3% for SAM-based TPSC. Moreover, all devices except PQx show good enduring stability, retaining approximately 90% of their original values after 1600 hours of shelf storage.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Yiwen Wang, Wenlin Jiang, Shi-Chun Liu, Chieh-Ting Lin, Baobing Fan, Yanxun Li, Huanhuan Gao, Ming Liu, Francis R. Lin, Alex K. -Y. Jen
Summary: The operational stability of organic photovoltaics (OPVs) remains a major challenge for commercialization. By replacing the conventional hole-transporting layer with self-assembled monolayers of specific phosphonic acids, the lifetime and efficiency of OPV devices can be significantly improved. The improved performance is attributed to the stabilized vertical distribution of donor and acceptor components, reducing energetic disorder and non-radiative recombination losses. The application of these phosphonic acids in ternary devices demonstrates even higher efficiency and longer lifetime.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).