期刊
CHEMISTRY LETTERS
卷 45, 期 7, 页码 743-745出版社
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.160177
关键词
Chalcone hybrid; Radical scavenging; Antioxidant mechanism
资金
- National Nature Science Foundation of China [81273896, 81573558]
- High Level Universities Construction Special Foundation of Guangdong [2050205]
- Outstanding Young Teachers in Higher Education Institutions of Guangdong Province [Yq2013045]
As antioxidants and potential beneficial agents in cell transplantation, natural chalcone-tannin hybrids can protect mesenchymal stem cells against ROS-mediated damage. In their antioxidant abilities, galloyl moiety, 4-OH, and 2'-OH present antioxidant indexes of 0.58:0.13:0.29. The galloyl moiety enhances antioxidant levels of chalcone-tannin hybrids. Their antioxidant mechanisms may include Fe2+-chelating and direct radical scavenging, which comprises at least one electron transfer (ET). The Fe2+-chelating and ET may mainly occur in the galloyl moiety, while 4-OH without H-bonding interference prefers to donate H atom.
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