Article
Developmental Biology
Brenden Osborne, Sonia R. Dancey, Erika Mery, Irina Oltean, Vid Bijelic, Joseph de Nanassy, Sarah L. Lawrence, Felipe Moretti, Dina El Demellawy
Summary: This study aimed to investigate the relationship between the severity and distribution of villitis of unknown etiology (VUE) and adverse neonatal outcomes. The results showed a significant association between the severity and distribution of VUE and the need for newborn resuscitation, but no significant association with other neonatal outcomes of interest. Further studies with larger sample sizes are needed to confirm these associations for obstetric and neonatal case management.
Article
Developmental Biology
Brenden Osborne, Irina Oltean, Ewa Sucha, Nicholas Mitsakakis, Nick Barrowman, Shannon Bainbridge, Dina El Demellawy
Summary: The study found no statistical associations between distinct VUE features and FGR diagnosis, but the location of villitis may be associated with worse neonatal outcomes. Adjusting for prematurity < 37 weeks, there were lower odds of NICU admission in basal vs non-basal cases, indicating potential differences in neonatal outcomes based on VUE location.
Article
Obstetrics & Gynecology
Hadas Ganer Herman, Alexander Volodarsky-Perel, Tuyet Nhung Ton Nu, Alexandre Machado-Gedeon, Yiming Cui, Jonathan Shaul, Michael H. Dahan
Summary: The study investigates if obstetric outcomes and placental findings differ according to embryo quality in pregnancies conceived with IVF. The results suggest that pregnancies following the transfer of lower-quality embryos are associated with a higher rate of low-lying placentas and several adverse placental lesions.
HUMAN REPRODUCTION
(2023)
Article
Developmental Biology
Linda M. Ernst, Crystal Bockoven, Alexa Freedman, Vivien Wang, Matthew Pellerite, Todd N. Wylie, Kristine M. Wylie
Summary: Viruses, particularly herpesviruses, were more frequently detected in cases compared with controls. Antiviral pathways were upregulated in cases. VUE may have multiple inflammatory gene expression profiles.
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Biochemistry & Molecular Biology
Kayo Tanaka, Hiroaki Tanaka, Ryota Tachibana, Kento Yoshikawa, Takuya Kawamura, Sho Takakura, Hiroki Takeuchi, Tomoaki Ikeda
Summary: This study aimed to investigate the effects of tadalafil as an intrauterine treatment for fetal growth restriction (FGR). The results showed that tadalafil improved placental mTOR signaling and facilitated fetal growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Joao Figueira Scarini, Natalia de Magalhaes Rodrigues, Wellington Lima Sabino, Ciro Soares, Thayna Melo de Lima Morais, Reydson Alcides de Lima-Souza, Livia Ramalho Crescencio, Rogerio de Oliveira Gondak, Fernanda Viviane Mariano, Albina Altemani, Erika Said Abu Egal
Summary: The study identified the predominance of M1 macrophages in inflamed areas of villitis of unknown etiology (VUE), indicating their influence in the pathogenesis of VUE. The higher presence of M2 in both inflamed villi and normal areas suggests a potential immunoregulatory mechanism in the inflammatory process of VUE.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Cell Biology
Miguel A. Ortega, Oscar Fraile-Martinez, Cielo Garcia-Montero, Miguel A. Saez, Miguel Angel alvarez-Mon, Diego Torres-Carranza, Melchor alvarez-Mon, Julia Bujan, Natalio Garcia-Honduvilla, Coral Bravo, Luis G. Guijarro, Juan A. De Leon-Luis
Summary: The placenta is a crucial organ in pregnancy, with various functions. Understanding its development and role is essential for comprehending pregnancy and related diseases.
Review
Immunology
Mekinian Arsene, Kamila Kolanska, Meryam Cheloufi, Aurore Coulomb, Jonathan Cohen, Noemie Abisror, Marie Bornes, Gilles Kayem, Jaume Alijotas-Reig, Olivier Fain
Summary: Villitis of unknown etiology (VUE) is characterized by lympho-histiocytic infiltrates in the villous stroma, which can have adverse effects on fetal growth and pregnancy outcomes. However, data on the management and treatment of VUE are extremely limited, with a need for prospective and well-designed studies to determine the real prevalence of adverse pregnancy events associated with VUE.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dayuan Shi, Xinyao Zhou, Luyao Cai, Xing Wei, Luye Zhang, Qianqian Sun, Fenhe Zhou, Luming Sun
Summary: Changes in placental DNA methylation patterns in sFGR may have functional implications for differentially methylated genes and regulatory regions. The study validates the presence of abnormally methylated CYP11A1 gene in the placenta of sFGR.
Article
Peripheral Vascular Disease
Francesca Gaccioli, Ulla Sovio, Sungsam Gong, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: This study aimed to investigate the relationship between protein levels of sFLT1 and PlGF in maternal serum and placental tissue lysates. The findings showed that the sFLT1:PlGF ratio is increased in both preeclampsia and FGR, but in preeclampsia, it is primarily driven by increased placental sFLT1 levels, while in FGR, it is primarily driven by decreased placental PlGF levels.
Article
Pharmacology & Pharmacy
Lewis J. Renshall, Frances Beards, Angelos Evangelinos, Susan L. Greenwood, Paul Brownbill, Adam Stevens, Colin P. Sibley, John D. Aplin, Edward D. Johnstone, Tambet Teesalu, Lynda K. Harris
Summary: This study demonstrates the potential of using EGF-loaded, peptide-decorated liposomes to improve placental function. GPS-decorated liposomes containing EGF significantly increased amino acid transporter activity in healthy placental tissues, but were ineffective in those from pregnancies with FGR. Targeted liposomes represent a safe and useful tool for developing new therapies for placental dysfunction.
Article
Environmental Sciences
Guangquan Chen, Shiyi Xiong, Qiao Jing, Cornelis A. M. van Gestel, Nico M. van Straalen, Dick Roelofs, Luming Sun, Hao Qiu
Summary: This study investigated the effects of polystyrene nanoplastics (PS-NPs) on fetal development and cholesterol metabolism in mice. The exposure to PS-NPs led to a decline in fetal weights and abnormal cell morphologies in the placenta and fetus. Transcriptomic and metabolomic analyses revealed disturbances in cholesterol metabolism and other pathways, offering new insights into the mechanisms underlying the detrimental effects of PS-NPs on placenta and fetus.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Obstetrics & Gynecology
Hannah M. Scott, Ramila Mehta, Megan E. Branda, Jennifer Hughes, Sunanda V. Kane, Sylvie Girard, Andrew P. Norgan, Regan N. Theiler, Elizabeth Ann L. Enninga
Summary: This study investigated the effects of anti-TNF-alpha treatment in pregnant women with autoimmune diseases. The results showed that anti-TNF-alpha therapy did not significantly affect the occurrence of chronic villitis of unknown etiology or other obstetric complications. Therefore, this study supports the safety profile of biologic use in pregnancy.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, General & Internal
Daniel Boron, Jakub Kornacki, Ewa Wender-Ozegowska
Summary: Intima-media thickness (IMT) measurement is a non-invasive method to assess arterial wall, and it is associated with atherosclerosis and endothelial dysfunction. Pre-existing conditions like diabetes, chronic hypertension, and obesity may impair the adaptation to pregnancy and influence fetal IMT. Increased fetal abdominal aorta IMT (aIMT) has been correlated with placental dysfunctions, which may lead to gestational hypertension, preeclampsia, and fetal growth restriction. Understanding the underlying pathomechanism is crucial for developing targeted therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Yossi Mizrachi, Ann Dekalo, Ohad Gluck, Hadas Miremberg, Lotem Dafna, Ohad Feldstein, Eran Weiner, Jacob Bar, Ron Sagiv
HUMAN REPRODUCTION
(2017)
Article
Obstetrics & Gynecology
Eran Weiner, Ohad Feldstein, Letizia Schreiber, Ehud Grinstein, Elad Barber, Ann Dekalo, Jacob Bar, Michal Kovo
FETAL DIAGNOSIS AND THERAPY
(2018)
Article
Obstetrics & Gynecology
Eran Weiner, Elad Barber, Ohad Feldstein, Ann Dekalo, Letizia Schreiber, Jacob Bar, Michal Kovo
REPRODUCTIVE SCIENCES
(2018)
Article
Developmental Biology
Eran Weiner, Elad Barber, Ohad Feldstein, Letizia Schreiber, Ann Dekalo, Yossi Mizrachi, Jacob Bar, Michal Kovo
Article
Obstetrics & Gynecology
Eran Weiner, Ohad Feldstein, Liliya Tamayev, Ehud Grinstein, Elad Barber, Jacob Bar, Letizia Schreiber, Michal Kovo
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2018)
Article
Obstetrics & Gynecology
Elad Barber, Eran Weiner, Ohad Feldstein, Ann Dekalo, Yossi Mizrachi, Damla Celen Gonullu, Jacob Bar, Letizia Schreiber, Michal Kovo
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2018)
Article
Behavioral Sciences
Edwa Friedlander, Nurit Yirmiya, Efrat Laiba, Ayelet Harel-Gadassi, Maya Yaari, Ohad Feldstein, David Mankuta, Salomon Israel
Article
Obstetrics & Gynecology
Ohad Feldstein, Michal Kovo, Ori Tal, Michal Braunstein, Ehud Grinstein, Letizia Schreiber, Jacob Bar, Eran Weiner
HYPERTENSION IN PREGNANCY
(2019)
Article
Obstetrics & Gynecology
Mor Bustan-Nahumson, Sandy Bornstein, Ohad Feldstein, Michal Levy, Letizia Schreiber, Jacob Bar, Michal Kovo, Eran Weiner
REPRODUCTIVE SCIENCES
(2020)
Article
Developmental Biology
Michal Levy, Michal Kovo, Ohad Feldstein, Ann Dekalo, Letizia Schreiber, Omer Levanon, Jacob Bar, Eran Weiner
Summary: Pregnancies complicated by FGR with concomitant HC were associated with higher rates of adverse neonatal outcomes, including lower Apgar scores, increased neonatal death, and higher rates of composite adverse and severe adverse neonatal outcomes.
Article
Multidisciplinary Sciences
Ohad Gluck, Elad Barber, Ohad Feldstein, Ori Tal, Ram Kerner, Ran Keidar, Inna Wolfson, Shimon Ginath, Jacob Bar, Ron Sagiv
Summary: The study aimed to evaluate the efficacy of subcutaneous trocar site and/or intraperitoneal analgesia in reducing pain after gynecologic operative laparoscopy. However, the results showed that there was no significant difference in postoperative pain levels between the groups, indicating that the application of subcutaneous and/or intraperitoneal analgesia is not effective in reducing pain in this context.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Ohad Feldstein, Hadar Gali-Zamir, Eduardo Schejter, Tali Feinberg, Einav Yehuda-Shnaidman, Jacob Bornstein, Tally Levy
Summary: In women aged 25-30, primary hrHPV screening is more effective in detecting high-grade cervical intraepithelial lesions compared to cytology screening. However, hrHPV screening in this age group may result in a higher rate of false-positive results, leading to more colposcopies and unnecessary treatments.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Eran Weiner, Ohad Feldstein, Letizia Schreiber, Ehud Grinstein, Elad Barber, Ann Dekalo, Yossi Mizrachi, Jacob Bar, Michal Kovo
REPRODUCTIVE SCIENCES
(2020)
Letter
Obstetrics & Gynecology
E. Friedlander, M. Yaari, N. Yirmiya, A. Harel-Gadassi, O. Feldstein, D. Mankuta, R. P. Ebstein
EARLY HUMAN DEVELOPMENT
(2017)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)