期刊
REGENERATIVE MEDICINE
卷 15, 期 2, 页码 1329-1344出版社
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2019-0065
关键词
bisperoxovanadium; evidence-based medicine; eye; lung; muscle; muscle; nervous system; PTEN inhibitors; signaling pathways; wound healing
资金
- NIH -NIGMS [R01GM120056]
Although the human body can heal, it takes time, and slow healing and chronic wounds often occur. Thus, identifying novel therapies to aid regeneration is needed. Here, we conducted a systematic review following the Preferred Reporting Items for Systematic Reviews guidelines and assessed preclinical studies on phosphatase and tensin homolog (PTEN) inhibitors and their effects on tissue repair and regeneration. In conditions associated with neurodegeneration, tissue injury and ischemia, the PTEN-regulated PI3K/AKT signaling pathway is activated. The use of PTEN inhibitors resulted in better tissue response by reducing the healing time and lesion sizes or inducing neuronal regeneration. Notably, all studies included in this systematic review indicated that pharmacological inhibition of PTEN enhanced the repair process of the eye, lung, muscle and nervous system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据