Article
Medicine, Research & Experimental
Harun Un, Rustem Anil Ugan, Muhammet Ali Gurbuz, Yasin Bayir, Aysenur Kahramanlar, Gokce Kaya, Elif Cadirci, Zekai Halici
Summary: The study demonstrated that Phloretin (PH) and Phloridzin (PZ) had protective effects against cisplatin-induced nephrotoxicity by regulating oxidative stress and inflammatory response, improving renal function enzyme levels. Additionally, PH and PZ normalized SOD and GSH levels, suppressed MDA levels, reduced the expressions of inflammatory factors and nuclear factors, and decreased HSP70 expression.
Article
Multidisciplinary Sciences
Shalini Dixit, Shiv Vardan Singh, Shilpa Mohanty, Dnyaneshwar U. Bawankule, Anirban Pal, Karuna Shanker, M. M. Gupta, Tahmeena Khan, Nora Abdullah AlFaris, Jozaa Zaidan Altamimi, Tahany Saleh Aldayel
Summary: This study evaluated the neuroprotective, antioxidant, and antiplasmodial properties of polyphenols from Malus Sikkimensis. The results showed that phloretin displayed better antioxidant potential and significant antiplasmodial activity. Phloridzin and phloretin suppressed the release of pro-inflammatory cytokines in a dose-dependent manner and had potential anti-neuroinflammatory effects.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yuka Takahashi, Katsuya Narumi, Takanobu Nadai, Hinata Ueda, Taiki Yamamura, Ayako Furugen, Masaki Kobayashi
Summary: Apple polyphenols such as phloretin and phloridzin inhibit the transport of substrate drugs mediated by OATP2B1 in vitro. Specifically, phloretin can decrease the uptake of rosuvastatin in rats, suggesting a potential role in altering drug absorption. However, the systemic exposure of rosuvastatin was not significantly affected by phloretin in rats.
Article
Chemistry, Applied
Michal Majkut, Joanna Kwiecinska-Pirog, Elzbieta Wszelaczynska, Jaroslaw Poberezny, Eugenia Gospodarek-Komkowska, Kajetan Wojtacki, Tadeusz Barczak
Summary: The study found that for most samples, there was a significant reduction in antimicrobial properties (MBC >= 50%) at 82 degrees Celsius and 62 degrees Celsius after exposure for 15 minutes and 120 minutes. Short exposure time reduced vitamin C content (<= 50%) but increased total polyphenols content (>= 27%) and FRAP value (>= 106%).
Review
Biochemistry & Molecular Biology
Yong-Kang Wang, Si-Yi Hu, Feng-Yi Xiao, Zhan-Bo Dong, Jian-Hui Ye, Xin-Qiang Zheng, Yue-Rong Liang, Jian-Liang Lu
Summary: Sweet tea, a popular herbal drink in southwest China, is rich in dihydrochalcones, which are mainly found in tender leaves of certain plants and have significant neuroprotective effects by regulating multiple pathological processes.
Article
Immunology
Rahel L. Birru, Kiflai Bein, Natalya Bondarchuk, Heather Wells, Qiao Lin, Y. Peter Di, George D. Leikauf
Summary: Phloretin, a polyphenol found in apples, exhibits antibacterial and anti-inflammatory properties, showing potential in reducing bacterial-induced injury in COPD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Plant Sciences
Diana Ionela Stegarus, Ecaterina Lengyel, George Florian Apostolescu, Oana Romina Botoran, Corneliu Tanase
Summary: This study investigated three species of the Stachys genus in terms of aromatic profile, total polyphenol content, antibacterial activity, and antioxidant capacity. Gas chromatography coupled with flame ionization detection was used to explore the herbal alcoholic extracts. The results showed differences in polyphenol content and antioxidant activity among the three Stachys species, with distinctive volatile compounds identified in each. The microbiological results demonstrated antimicrobial capacity, particularly on Gram-positive bacteria, and highlighted the potential to differentiate between Stachys species using plant tissue VOC profiles.
Article
Plant Sciences
Corneliu Tanase, Alexandru Nicolescu, Adrian Nisca, Ruxandra Stefanescu, Mihai Babota, Anca Delia Mare, Cristina Nicoleta Ciurea, Adrian Man
Summary: This study evaluated the biological potential of red oak bark extracts, finding that they were rich in phenols and tannins, and exhibited antioxidant, anti-glucosidase, and anti-tyrosinase activity, as well as antimicrobial effects against certain bacteria and Candida species.
Article
Chemistry, Applied
Maria Emilia Lorenzo, Carina Noelia Casero, Patricia Elizabeth Gomez, Adrian Federico Segovia, Lara Carolina Figueroa, Alejandro Quiroga, Maria Laura Werning, Daniel Alberto Wunderlin, Maria Veronica Baroni
Summary: This study investigated the antioxidant and antibacterial activity of several woody plants, and found that Larrea cuneifolia leaf extracts exhibited the highest antioxidant activity, while Sarcomphalus mistol wood extracts showed the highest antibacterial activity. Fifty-nine polyphenols were identified in the leaves and wood of Larrea and S. mistol species.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Adrian Nisca, Ruxandra Stefanescu, Diana Ionela Stegarus, Anca Delia Mare, Lenard Farczadi, Corneliu Tanase
Summary: The study evaluated and compared the chemical composition and biological activities of two different pine species (Pinus nigra and Pinus sylvestris) bark extracts, finding that extracts from Pinus sylvestris had higher antioxidant activity and better antibacterial effects, while Pinus nigra extracts contained higher levels of volatile compounds.
Article
Pharmacology & Pharmacy
Radni D. Deshpande, Devanshi S. Shah, Sharda Gurram, Durgesh K. Jha, Paramita Batabyal, Purnima D. Amin, Sadhana Sathaye
Summary: This study successfully developed formulated oral PHL granules with good stability, favorable pharmacokinetic properties, and retained antioxidant properties of PHL.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Food Science & Technology
Qili Zhang, Li Wang, Yanfang Zhao
Summary: Lithocarpus polystachyus is a versatile pharmacological agent with a wide range of activities, including antioxidation, anti-inflammation, anti-diabetes, anti-tumor, anti-hypertension, anti-obesity, hepatoprotection, and neuroprotection. Its major active ingredients, dihydrochalcones, have various biological properties. This review summarizes the latest research on L. polystachyus, providing a scientific basis for understanding its health benefits and potential novel applications.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Yuan Xie, Guiguang Cheng, Zhoushan Wu, Shang Shi, Jinghao Zhao, Lin Jiang, Dengbang Jiang, Mingwei Yuan, Yudan Wang, Minglong Yuan
Summary: In order to ensure food safety and extend shelf-life, a new type of antioxidant-active packaging film was prepared by using a poly(lactic acid) film containing phloridzin adsorbed on an MCM-41 mesoporous molecular sieve. The film showed good antioxidant and antibacterial properties and significantly delayed lipid oxidation in strawberry packaging.
Article
Biochemistry & Molecular Biology
Opeyemi Joshua Olatunji, Oladipupo Odunayo Olatunde, Titilope John Jayeoye, Sudarshan Singh, Sirinporn Nalinbenjapun, Sasikarn Sripetthong, Warangkana Chunglok, Chitchamai Ovatlarnporn
Summary: This study investigated the antioxidant, antimicrobial, anticancer, and phytochemical profiling of extracts from the leaves and stem/root of Acanthus ebracteatus. The results showed that the extracts contained various bioactive compounds and exhibited high antioxidant and anticancer activities.
Article
Biochemistry & Molecular Biology
Mostafa El Khomsi, Hamada Imtara, Mohammed Kara, Anouar Hmamou, Amine Assouguem, Brahim Bourkhiss, Mahmoud Tarayrah, Mashail N. AlZain, Nurah M. Alzamel, Omar Noman, Driss Hmouni
Summary: The extracts from the roots and leaves of Anchusa italica Retz exhibit significant antioxidant and antibacterial activities, possibly due to the high content of flavonoids and polyphenols.