Article
Chemistry, Multidisciplinary
Li Lu, Xin Zhang, Yu Kang, Zhuang Xiong, Kun Zhang, Xuetao Xu, Liping Bai, Hongguang Li
Summary: A series of thirty coumarin derivatives were synthesized and evaluated for their anti-tyrosinase activity. Compound 5l showed excellent anti-tyrosinase activity and inhibited melanin content and cellular tyrosinase activity without toxicity. It has the potential to relieve tyrosinase-related hyperpigmentation.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Marina Mingoia, Carmela Conte, Annalisa Di Rienzo, Marilisa Pia Dimmito, Lorella Marinucci, Gloria Magi, Hasan Turkez, Maria Concetta Cufaro, Piero Del Boccio, Antonio Di Stefano, Ivana Cacciatore
Summary: This study reports the synthesis of novel cinnamic acid-based antimicrobials (DM1-11) and their potential as antibacterial drugs for the treatment of ESKAPE-related skin infections. DM2 shows significant antibacterial activity and wound healing properties, making it a potentially safe topical agent for wound treatment.
Article
Biochemistry & Molecular Biology
Panpan Wu, Borong Tu, Jinfeng Liang, Shengzhu Guo, Nana Cao, Silin Chen, Zhujun Luo, Jiahao Li, Wende Zheng, Xiaowen Tang, Dongli Li, Xuetao Xu, Wenfeng Liu, Xi Zheng, Zhaojun Sheng, Adam P. Roberts, Kun Zhang, Weiqian David Hong
Summary: A series of triterpenoid derivatives, including ursolic acid (UA), oleanolic acid (OA), and 18β-glycyrrhetinic acid (GA), were synthesized with various substituted aromatic side chains at the C-2 position. Among them, the GA derivative with aromatic side chains showed potent antibacterial activity against drug sensitive and resistant S. aureus, indicating potential for development of a new type of triterpenoid antibacterial agent.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Yao-Yao Jiang, Shaochun Wu, Yan-Wei Wu, Yang Gao, Daochen Chong, Changning Sun, Mei-Yan Wei, Yu-Cheng Gu, Chang-Lun Shao, Yuchao Gu
Summary: This study designed and synthesized a series of BFA-cinnamic acid ester derivatives, and evaluated their in vitro cytotoxic activities on different cancer cell lines. The most potent derivative 33 showed improved aqueous solubility and strong cytotoxic activity against HepG2 and BEL-7402 cell lines, while exhibiting low toxicity on normal liver cell line L02. Mechanistic studies revealed that 33 achieved its anti-tumor effects by blocking the cell cycle and inducing apoptosis, and displayed favorable pharmacokinetic properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qiuping Zhang, Yanni Wang, Zongyuan Wang, Eyad Abdulwhab Hamoud Mohammed, Quanyi Zhao, Dian He, Zhen Wang
Summary: A series of glycyrrhetinic acid derivatives containing disulfide bond were synthesized and compounds 3 and 4 were found to have the potential to be promising candidates for treating inflammation and lung fibrosis.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Chenglong Cheng, Gudong Li, Guojun Zheng, Changyuan Yu
Summary: A series of novel cinnamic acid triptolide ester derivatives were synthesized and evaluated for their growth inhibitory effects on human hepatoma HepG2 cells. One specific derivative, CL20, showed the best cytotoxicity and outperformed natural triptolide, indicating its potential as a lead compound for further pharmacological research.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Somayeh Mojtabavi, Mohammad Reza Khoshayand, Mohammad Reza Fazeli, Mohammad Ali Faramarzi, Nasrin Samadi
Summary: The in-vitro study using a combination of laccase and cinnamic acid showed significant inhibition of pathogenic microorganisms growth and biofilm formation, as well as teeth whitening effects. The combination also successfully removed teeth discoloration caused by coffee without causing surface damage. The study further demonstrated the redox potential values of phenolic monomers/oligomers are related to their biological activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Jianping Li, Xiaofeng Min, Xi Zheng, Shaohua Wang, Xuetao Xu, Jinbao Peng
Summary: Tyrosinase inhibitors, including cinnamic acid-eugenol esters, especially c27, showed definite inhibitory activity against tyrosinase, which is crucial in melanin production. Compound c27 exhibited the strongest tyrosinase inhibitory activity and could potentially be used as a lead compound in finding tyrosinase inhibitors.
Article
Biochemistry & Molecular Biology
De-Feng Xu, Pei-Wen Su, Chao Wang, Lei Miao, Jun-Sheng Zhang, Hua Zhang
Summary: Thirteen cinnamic acid derivatives, including six newly reported hybrids, were isolated and identified from Tinospora sagittata. These compounds exhibited potential pharmacological activities, such as antioxidant, antibacterial, and anti-diabetic effects, in various bioassays.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Medicinal
Andrey Markov, Anna A. Ilyina, Oksana Salomatina, Aleksandra Sen'kova, Alina A. Okhina, Artem D. Rogachev, Nariman F. Salakhutdinov, Marina A. Zenkova
Summary: The modification of natural or semisynthetic triterpenoids with amines shows promise in improving their pharmacological properties. In this study, 11 novel amide derivatives of soloxolone methyl (SM) were designed and synthesized. The research revealed one of the derivatives, compound 12, had high anti-glioblastoma potential and the ability to cross the blood-brain barrier. Further investigations found that compound 12 induced apoptosis, inhibited clonogenicity and motility of glioblastoma cells, and effectively blocked tumor growth in a mouse model.
Article
Chemistry, Medicinal
Ke Liu, Yingda Zang, Cangjie Shen, Chuangjun Li, Jie Ma, Jingzhi Yang, Xingyan Sun, Xinyi Chen, Nan Wang, Dongming Zhang
Summary: A series of pyrano[3,2-a]carbazole alkaloid derivatives were designed and synthesized, and their anticancer activities were studied against 10 cancer cell lines. Compounds with N-methyl piperazine showed significant anticancer activity, especially against MCF-7 cell lines. In addition, cell morphology changes, cell cycle arrest, apoptosis induction, and interactions with tubulin were investigated, providing insights for further optimization of these alkaloids as potential anticancer lead compounds.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Shuobin Liang, Xinyuan Ma, Man Li, Yanliang Yi, Qianqian Gao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao
Summary: In this study, a series of heptavalent glycyrrhetinic acid derivatives based on beta-cyclodextrin scaffold were designed and synthesized using click chemistry. The synthesized compounds showed promising inhibitory activity against influenza virus infection, making them potential candidates for influenza entry inhibitors.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Mingju Wen, Jianbo Sun, Miao Yang, Xueling Zhang, Yue Wang, Wen Zhou, Yuning Shi, Yujing Huang, Na Li, Li Chen
Summary: Twelve new hybrid compounds of Esculetin with nitric oxide (NO) donors and/or mitochondrial targeting groups were designed, synthesized, and evaluated for their anti-tumor activity and mechanism in vitro and in vivo. The most potent compound A11 exhibited nanomolar antiproliferative activity on triple-negative breast cancer (TNBC) MDA-MB-231 cells, with a selective inhibitory effect. The mechanism involved mitochondrial targeting, releasing a high concentration of NO, increasing the expression of CypD, and triggering cancer cell apoptosis through increased ROS production, along with cell cycle arrest at the G2/M phase. Moreover, A11 demonstrated superior TNBC inhibition rate and reduced toxicity compared to doxorubicin (DOX) in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Shihan Wang, Li Ji, Dongxue Zhang, Hongye Guo, Yongsheng Wang, Wei Li
Summary: In this study, 1-methylhydantoin cinnamic imides were synthesized and their anti-inflammatory activity was evaluated. In vitro experiments showed that certain compounds effectively inhibited the production of inflammatory molecules and had some cytotoxicity. In vivo experiments demonstrated that these compounds could alleviate ear edema in mice, with compound 5 showing the most significant effect.
Article
Biochemistry & Molecular Biology
Marina Marinovic, Hrvoje Rimac, Lais Pessanha de Carvalho, C. Rola, S. Santana, Kristina Pavic, Jana Held, Miguel Prudencio, Zrinka Rajic
Summary: By building a quantitative structure-activity relationship model, researchers designed and synthesized a series of new antimalarial drugs. One of the new drugs, UT harmicine, exhibited high antiplasmodial activity and good selectivity towards Plasmodium.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Jianfei Dong, Haoxin Deng, Zhuangzhuang Xu, Mengmeng Yan, Shengnan Wei, Fahui Wang, Xiaoping Wen, Guoyan Chen, Anchao Zhang
Summary: Under the condition of constant gas composition equivalence ratio, the behavior and shape change of premixed gas flames with different hydrogen doping ratios in the flaring rate pipe were studied. The experimental results showed that the premixed gas flames exhibited complex shape changes, including the appearance of tulip flames, which were accompanied by deceleration of the flame front and an increase in overpressure in the combustion chamber.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Environmental Sciences
Mengmeng Yan
Summary: This study found disparities in mortality rates of ischemic heart diseases related to ambient PM2.5 among states in the United States, with higher rates for males than for females, but the disparities have decreased in recent years. Additionally, some states showed an increasing trend in mortality rates of ischemic heart diseases related to ambient PM2.5.
Article
Physics, Applied
Zhi-Yu Xie, Xuanxuan Xing, Lianzheng Yu, Yu-Xin Chang, Ya-Xia Yin, Li Xu, Mengmeng Yan, Sailong Xu
Summary: This article introduces a cathode material for sodium ion batteries that is co-doped with transition metals. The material shows high capacity, good cycling stability, and high energy density in sodium ion batteries. The study suggests that co-doping can improve structural transformation and ion conductivity, thereby enhancing performance.
APPLIED PHYSICS LETTERS
(2022)
Article
Chemistry, Physical
Zhuangzhuang Xu, Haoxin Deng, Shengnan Wei, Mengmeng Yan, Xiaoping Wen, Fahui Wang, Guoyan Chen
Summary: The effects of initial temperature (T = 300-500 K) and hydrogen volume fractions (5%-20%) on the combustion characteristics of premixed syngas/air flames in rectangular tubes were experimentally investigated. High-speed camera and pressure sensor were used to analyze flame propagation and overpressure dynamics. Simulation using the CHEMKIN-PRO model and GRI Mech 3.0 mechanism was also conducted. The results revealed that flame propagation speed increased with initial temperature until the flame touched the wall. Afterward, the opposite trend was observed. Higher initial temperature resulted in increased overpressure rise rate but reduced peak overpressure. Laminar burning velocity and adiabatic flame temperature also increased with initial temperature.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Chemistry, Physical
Yu Pan, Jin Zheng, Yangyang Xu, Xiaogang Chen, Mengmeng Yan, Jinlei Li, Xu Zhao, Yanlai Feng, Yuhan Ma, Mengyuan Ding, Rongwu Wang, Jianxin He
Summary: In this study, a polyimide aerogel with excellent mechanical strength and thermal properties was synthesized using a combination of electrospinning, freeze-drying, and in situ thermal crosslinking. The resulting aerogels exhibited low density, high porosity, high tensile strength, good compressive fatigue resistance, and excellent thermal insulation, making them excellent candidates for thermal insulation materials in high and low-temperature environments.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Environmental
Mengmeng Yan, Changxiong Zhu, Binxu Li, Shiming Su, Hongna Li
Summary: This study investigated the synergistic effects of electrokinetic remediation (EKR) on antibiotic resistance and arsenic (As) contamination in paddy soils. The study found that EKR treatments with pig manure amendment showed better remediation efficiency, reducing the content of available As and the abundance of antibiotic-resistant bacteria. The electric field played a significant role in antibiotic degradation and certain types of antibiotic resistance genes were easier to remove. Brevundimonas was found to be the most significantly different species during remediation, and Bacillus and Clostridium_ sensu_stricto_1 were potential host bacteria for antibiotic resistance genes in the electric field. Membrane transport was identified as an effective strategy for microorganisms to respond to the stress of electric field and co-contamination.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Junyun Cheng, Gaole Lin, Tianhao Wang, Yunzhu Wang, Wenbo Guo, Jie Liao, Penghui Yang, Jie Chen, Xin Shao, Xiaoyan Lu, Ling Zhu, Yi Wang, Xiaohui Fan
Summary: CRISPR-based genetic screening is a powerful approach for unbiased functional genomics research. Single-cell CRISPR screening techniques allow the analysis of regulatory networks in complex biological systems at unprecedented resolution. These methods involve perturbing cells en masse using a pooled CRISPR library and high-content phenotyping.
Article
Chemistry, Multidisciplinary
Zhuangzhuang Xu, Haoxin Deng, Xiaoping Wen, Fahui Wang, Guoyan Chen, Mengmeng Yan, Shengnan Wei
Summary: The combustion characteristics of premixed methane-air flames in a half-open tube with a two-sided 45 degrees branch structure at different ignition positions were studied using experiments and large eddy simulations. The results showed high consistency between the simulation and experiment, providing insight into the effects of branch tube structure and ignition position on flame dynamics. The maximum overpressures obtained in the experiment were 10.1 and 10.7 kPa at ignition positions IP0 and IP900, respectively, while in the simulation, they were 9.2 and 10.4 kPa. The Karlovitz number at IP0, representing the interaction intensity between the flame surface and turbulence, ranged from a maximum of 9.2 to a minimum of 0.04. The premixed flame exhibited folded and corrugated small flames, as well as a thin reaction zone.
Article
Materials Science, Composites
Mengmeng Yan, Xiaogang Chen, Yangyang Xu, Yu Pan, Jinlei Li, Junli Li, Ting Wu, Huanli Zheng, Xiaoxiao Chen, Jianxin He
Summary: Thermal management materials with high thermal conductivities, heat resistances, and excellent mechanical properties are needed for modern electronic power systems. This study synthesized para-aramid nanofibers using a greener method and combined them with water-dispersible reduced graphene oxide to create a highly thermally conductive composite membrane. The composite membrane showed high thermal conductivity and tensile strength, making it suitable for high-temperature applications. Additionally, it demonstrated excellent thermal management performance in reducing surface temperature of LED lamps.
COMPOSITES COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yu Fu, Weidong Wang
Summary: This study examines the association between sunshine duration and mortality rates at the provincial level in China. The results suggest that increased sunshine duration is associated with increased mortality rates.
Article
Multidisciplinary Sciences
Maria M. Romeiras, Anyse P. Essoh, Silvia Catarino, Joceline Silva, Katelene Lima, Eromise Varela, Monica Moura, Isildo Gomes, Maria Cristina Duarte, Maria Paula Duarte
Summary: Plants play a crucial role in medical practice in West African countries, including the Cabo Verde archipelago. This study assessed the medicinal uses of native species in Santiago, the largest island of the archipelago, and evaluated the antioxidant, antimicrobial, and antidiabetic activities of two native tree species. The results revealed 24 native plants used in traditional medicine on Santiago Island and highlighted the importance of sustainable use and conservation of medicinal plants in Cabo Verde.
Article
Endocrinology & Metabolism
Mengmeng Yan, Yingying Liu
Summary: This study aimed to compare the prevalence of BMI categories between individuals living alone (LA) and those not living alone (NLA). The results showed that LA had lower prevalence of obesity compared to NLA, especially in the 45-64 age group. Additionally, LA had lower prevalence of overweight, particularly in the 18-34 and >64 age groups.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Review
Biochemistry & Molecular Biology
Wenbo Guo, Yining Hu, Jingyang Qian, Lidan Zhu, Junyun Cheng, Jie Liao, Xiaohui Fan
Summary: Spatial omics technologies provide valuable insights into cells and tissues within a complex context, enhancing our understanding of complex biological systems. Laser capture microdissection (LCM) is an advanced method that quickly collects regions of interest (ROIs) from heterogeneous tissues, and is widely used for studying the cellular and molecular mechanisms of diseases.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yunpeng Wang, Mengmeng Yan, Kang Xu, Yu-Xin Chang, Jin Guo, Qinghua Wang, Bin Wang, Duan Wang, Ya-Xia Yin, Sailong Xu
Summary: This study presents an improvement strategy for P2-type Fe, Mn-based layered oxides as cathode materials for sodium-ion batteries (SIBs) by Li/Ni co-doping and the resulting biphasic structure. The co-doping suppresses the high-voltage phase transition, leading to enhanced rate capability and cyclic stability of the cathode.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Analytical
Min Li, Hao Wang, Xiaodi Yu, Xindi Jia, Chao Zhu, Jiahui Liu, Fan Zhang, Zilei Chen, Mengmeng Yan, Qinzheng Yang
Summary: The enzyme-linked apta-sorbent assay (ELASA) is widely used for small-molecule compound detection, but enzyme labels still have drawbacks. To overcome these drawbacks, a nanozyme-linked apta-sorbent assay (NLASA) coupled with surface-enhanced Raman scattering (SERS)-colorimetric dual-mode detection was reported. The NLASA method provides rapid and sensitive detection for ochratoxin A (OTA) and can be expanded to other small molecules.