Article
Biochemistry & Molecular Biology
Enrique Alfaro, Elena Diaz-Garcia, Sara Garcia-Tovar, Ester Zamarron, Alberto Mangas, Raul Galera, Eduardo Lopez-Collazo, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: This study suggests that hypoxia may induce the overexpression of proteasome genes in COVID-19 patients, which is associated with lymphocyte count reduction, increased inflammatory markers, and clinical complications.
Article
Clinical Neurology
Francois Lersy, Thibault Willaume, Jean-Christophe Brisset, Olivier Collange, Julie Helms, Francis Schneider, Agathe Chammas, Alexandre Willaume, Nicolas Meyer, Mathieu Anheim, Francois Cotton, Stephane Kremer
Summary: During the COVID-19 outbreak, extensive white matter microhemorrhages were detected in patients with severe infections. The main mechanisms leading to this complication seem to be blood-brain barrier dysfunction secondary to hypoxemia and high concentration of uremic toxins.
JOURNAL OF NEUROLOGY
(2021)
Article
Urology & Nephrology
Priscila Preciado, Leticia M. Tapia Silva, Xiaoling Ye, Hanjie Zhang, Yuedong Wang, Peter Waguespack, Jeroen P. Kooman, Peter Kotanko
Summary: Maintenance hemodialysis patients are at high risk for COVID-19, and may experience hypoxemia prior to clinical symptoms. The use of SaO(2) measurements during dialysis can help identify COVID-19 patients early. Oxygen supplementation during dialysis may be necessary post-diagnosis to improve patient outcomes.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Computer Science, Interdisciplinary Applications
Qingsong Yao, Li Xiao, Peihang Liu, S. Kevin Zhou
Summary: The study introduces a label-free approach for segmenting COVID-19 lesions in CT via voxel-level anomaly modeling, reducing the burden of data annotation. By learning patterns of normal tissues, a network capable of distinguishing normal tissues from COVID-19 lesions was established.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Critical Care Medicine
Christopher S. King, Hannah Mannem, Jasleen Kukreja, Shambhu Aryal, Daniel Tang, Jonathan P. Singer, Ankit Bharat, Juergen Behr, Steven D. Nathan
Summary: The COVID-19 pandemic has caused acute lung injury in millions of individuals worldwide, some of whom may require lung transplantation for severe lung injury or post-COVID fibrosis. Lung transplantation after COVID-19 infection presents unique challenges, including difficulties in evaluation and education, deconditioning, and infectious concerns. Transplant physicians must carefully consider the risks and benefits of lung transplantation in post-COVID fibrosis patients compared to other lung diseases.
Article
Critical Care Medicine
Thomas Langer, Matteo Brioni, Amedeo Guzzardella, Eleonora Carlesso, Luca Cabrini, Gianpaolo Castelli, Francesca Dalla Corte, Edoardo De Robertis, Martina Favarato, Andrea Forastieri, Clarissa Forlini, Massimo Girardis, Domenico Luca Grieco, Lucia Mirabella, Valentina Noseda, Paola Previtali, Alessandro Protti, Roberto Rona, Francesca Tardini, Tommaso Tonetti, Fabio Zannoni, Massimo Antonelli, Giuseppe Foti, Marco Ranieri, Antonio Pesenti, Roberto Fumagalli, Giacomo Grasselli
Summary: Limited data are available on the use of prone position in intubated, invasively ventilated patients with COVID-19. This study investigated the use and effects of prone position during the first wave of the 2020 pandemic. The majority of patients improved oxygenation during prone position, likely due to better ventilation perfusion matching.
Article
Medicine, General & Internal
Baoni Sun, Hai Wang, Junhua Lv, Honghong Pei, Zhenghai Bai
Summary: Patients with COVID-19 who experience hypotension and hypoxemia have a worse prognosis, with age, temperature, troponin, and blood glucose levels being associated with mortality. The prediction model developed using these factors shows high predictive value for forecasting the outcomes of these individuals.
FRONTIERS IN MEDICINE
(2021)
Article
Emergency Medicine
Ishak San, Cagdas Yildirim, Burak Bekgoz, Emin Gemcioglu
Summary: The study showed that transport in the prone position can effectively increase arterial blood gas oxygen levels in hypoxemic and awake probable COVID-19 pneumonia patients. Patients transported for more than 15 minutes demonstrated significant improvements in partial oxygen and arterial oxygen saturation values, while those transported for 15 minutes or less did not show significant changes in these parameters.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Carlos Roberto Ribeiro Carvalho, Rodrigo Caruso Chate, Marcio Valente Yamada Sawamura, Michelle Louvaes Garcia, Celina Almeida Lamas, Diego Armando Cardona Cardenas, Daniel Mario Lima, Paula Gobi Scudeller, Joao Marcos Salge, Cesar Higa Nomura, Marco Antonio Gutierrez
Summary: A predictive clinical model based on CXR, mMRC, oximetry, and spirometry data has been proposed to accurately screen patients with lung lesions after SARS-CoV-2 infection. The model is simple, accessible, and low-cost, making it suitable for early detection of COVID-19 sequelae.
Article
Infectious Diseases
S. Ruiz, D. Concordet, T. Lanot, B. Georges, P. Goudy, S. Baklouti, C. Mane, E. Losha, H. Vinour, D. Rousset, M. Lavit, V Minville, J-M Conil, P. Gandia
Summary: The study evaluated hydroxychloroquine concentrations in the lung epithelial lining fluid in critically ill COVID-19 patients. Results showed that lung exposure may be higher than plasma concentrations, indicating that low plasma concentrations should not lead to increased drug dosage.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Review
Respiratory System
Kai E. Swenson, Stephen J. Ruoss, Erik R. Swenson
Summary: The unique presentation of COVID-19 lung injury has sparked speculation about underlying differences in lung compliance, pulmonary vascular responses, and nervous system sensing. However, there is currently no compelling evidence to support a distinct pathophysiological approach for these patients compared to traditional ARDS care.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Pediatrics
Carmina Guitart, Ricardo Suarez, Monica Girona, Sara Bobillo-Perez, Lluisa Hernandez, Monica Balaguer, Francisco Jose Cambra, Iolanda Jordan
Summary: The study aimed to describe lung ultrasound findings in children with COVID-19 infection. Children with respiratory symptoms mostly showed a S.score of 2 and 3 with subpleural consolidations on lung ultrasound, while even COVID-19 patients with non-respiratory symptoms had visible lung alterations on ultrasound. This suggests that lung ultrasound can be a useful tool for diagnosing and monitoring COVID-19 patients in both respiratory and non-respiratory cases.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Bryan S. Blette, Anders Granholm, Fan Li, Manu Shankar-Hari, Theis Lange, Marie Warrer Munch, Morten Hylander Moller, Anders Perner, Michael O. Harhay
Summary: The recommended dose of dexamethasone for severe or critical COVID-19 patients is currently 6 mg per day. However, personalized dosing may be more optimal due to the heterogeneity of these patients. A study comparing 6 mg/d to 12 mg/d of dexamethasone found that the higher dose was associated with better long-term outcomes, particularly in certain patient subgroups. This suggests that using 12 mg/d of dexamethasone could be beneficial for most patients and further research is needed to optimize dosing.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Paolo Bima, Emanuele Pivetta, Denise Baricocchi, Jacopo Davide Giamello, Francesca Risi, Matteo Vesan, Michela Chiarlo, Giuliano De Stefano, Enrico Ferreri, Giuseppe Lauria, Stefano Podio, Peiman Nazerian, Franco Apra, Enrico Lupia, Fulvio Morello
Summary: This study assessed the utility of lung ultrasound (LUS) in the Emergency Department (ED) for prognostic stratification of COVID-19 patients. The findings showed that LUS had good performance in predicting hospitalization or death as the primary outcome. The integration of LUS with a clinical score further improved sensitivity. LUS can improve prognostic stratification and support standardized disposition decisions for unvaccinated COVID-19 patients in the ED.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Onur Turan, Burcu Arpinar Yigitbas, Pakize Ayse Turan, Arzu Mirici
Summary: This study investigated the characteristics and prognosis of COPD patients among COVID-19 population in Turkey. It found that although COPD patients had some poor prognostic features, there was no statistical difference in overall survival rates between COPD and non-COPD COVID-19 patients. Age, oxygenation status, serum D-dimer level, lymphocyte count, and pneumonia were significantly associated with mortality in COVID-19 patients.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)