Host nutrient milieu drives an essential role for aspartate biosynthesis during invasive Staphylococcus aureus infection

MicroLESA: Integrating Autofluorescence Microscopy, In Situ Micro-Digestions, and Liquid Extraction Surface Analysis for High Spatial Resolution Targeted Proteomic Studies

(2019) Daniel J. Ryan et al.   ANALYTICAL CHEMISTRY

MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis

(2019) Nicole E. Putnam et al.   PLoS Pathogens

Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection

(2019) Sarah E. Rowe et al.   Nature Microbiology

Aspartate deficiency limits peptidoglycan synthesis and sensitizes cells to antibiotics targeting cell wall synthesis in Bacillus subtilis

(2018) Heng Zhao et al.   MOLECULAR MICROBIOLOGY

Staphylococcus aureustargets the purine salvage pathway to kill phagocytes

(2018) Volker Winstel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions

(2018) James E. Cassat et al.   Science Translational Medicine

Genetic requirements for Staphylococcus aureus nitric oxide resistance and virulence

(2018) Melinda R. Grosser et al.   PLoS Pathogens

Isotopically nonstationary 13 C flux analysis of cyanobacterial isobutyraldehyde production

(2017) Lara J. Jazmin et al.   METABOLIC ENGINEERING

Amino Acid Catabolism in Staphylococcus aureus and the Function of Carbon Catabolite Repression

(2017) Cortney R. Halsey et al.   mBio

Lysine and Threonine Biosynthesis from Aspartate Contributes to Staphylococcus aureus Growth in Calf Serum

(2016) Yuichi Oogai et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

De NovoGuanine Biosynthesis but Not the Riboswitch-Regulated Purine Salvage Pathway Is Required for Staphylococcus aureus InfectionIn Vivo

(2016) Eric M. Kofoed et al.   JOURNAL OF BACTERIOLOGY

Comparative genome-scale modelling ofStaphylococcus aureusstrains identifies strain-specific metabolic capabilities linked to pathogenicity

(2016) Emanuele Bosi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanded Glucose Import Capability Affords Staphylococcus aureus Optimized Glycolytic Flux during Infection

(2016) Nicholas P. Vitko et al.   mBio

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Glycolytic Dependency of High-Level Nitric Oxide Resistance and Virulence in Staphylococcus aureus

(2015) Nicholas P. Vitko et al.   mBio

Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection

(2015) Aimee D. Wilde et al.   PLoS Pathogens

Preferential Use of Central Metabolism In Vivo Reveals a Nutritional Basis for Polymicrobial Infection

(2015) Christopher J. Alteri et al.   PLoS Pathogens

Inter- and Intraspecies Metabolite Exchange Promotes Virulence of Antibiotic-Resistant Staphylococcus aureus

(2014) Neal D. Hammer et al.   Cell Host & Microbe

Brain infection withStaphylococcus aureusleads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc

(2014) Bjørnar Hassel et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Single-copy vectors for integration at the SaPI1 attachment site for Staphylococcus aureus

(2014) John Chen et al.   PLASMID

Genes Contributing to Staphylococcus aureus Fitness in Abscess- and Infection-Related Ecologies

(2014) M. D. Valentino et al.   mBio

High-Resolution Transcriptomic Analysis of the Adaptive Response of Staphylococcus aureus during Acute and Chronic Phases of Osteomyelitis

(2014) Anna K. Szafranska et al.   mBio

Aerobic Glycolysis in Osteoblasts

(2014) Emel Esen et al.   Current Osteoporosis Reports

A Secreted Bacterial Protease Tailors the Staphylococcus aureus Virulence Repertoire to Modulate Bone Remodeling during Osteomyelitis

(2013) James E. Cassat et al.   Cell Host & Microbe

Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus

(2013) L. A. Mike et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential Staphylococcus aureus Genes

(2013) P. D. Fey et al.   mBio

Identification of Genes Involved in Polysaccharide-Independent Staphylococcus aureus Biofilm Formation

(2010) Blaise R. Boles et al.   PLoS One

Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus

(2009) Kati Seidl et al.   BMC MICROBIOLOGY

Trends in the Incidence of Methicillin‐ResistantStaphylococcus aureusInfection in Children’s Hospitals in the United States

(2009) Jeffrey S. Gerber et al.   CLINICAL INFECTIOUS DISEASES

Staphylococcus aureussynthesizes adenosine to escape host immune responses

(2009) Vilasack Thammavongsa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

At the Crossroads of Bacterial Metabolism and Virulence Factor Synthesis in Staphylococci

(2009) G. A. Somerville et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Staphylococcus aureus CcpA Affects Biofilm Formation

(2008) K. Seidl et al.   INFECTION AND IMMUNITY

Nucleotide Biosynthesis Is Critical for Growth of Bacteria in Human Blood

(2008) Shalaka Samant et al.   PLoS Pathogens