期刊
POLYMER REVIEWS
卷 61, 期 2, 页码 319-356出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15583724.2020.1758718
关键词
Poly(caprolactone fumarate) (PCLF); oligo[poly(ethylene glycol) fumarate] (OPF); synthesis; nerve regeneration; cartilage regeneration; bone regeneration; 3-D printing; hydrogels; biodegradable scaffolds
资金
- National Institutes of Health [R01 AR075037]
Fumarate-based polymers like PCLF and OPF have gained significant interest in biomedical applications for their tunable mechanical properties and biodegradability. PCLF is used for scaffolds while OPF is mostly explored as a hydrogel system, showing important applications in nerve, cartilage, and bone tissue engineering as well as drug delivery. Innovations in synthesis methods and the development of nano- and micro-composites using these polymers are key areas of research in enhancing cartilage and bone tissue regeneration.
The past few decades have seen a significant interest in the fumarate-based polymers for biomedical applications. Poly(caprolactone fumarate) (PCLF) and oligo[poly(ethylene glycol) fumarate] (OPF) are derivatives of polycaprolactone and polyethylene glycol respectively, which are rendered cross-linkable, biodegradable, and possess tunable mechanical properties by the introduction of unsaturated fumarate groups. PCLF is a hydrophobic polymer, mostly applied as pre-formed or 3-D printed scaffolds while OPF is an aqueous-solvent based polymer mostly explored as a hydrogel system in tissue regeneration and drug delivery applications. This review summarizes the synthesis methods of these two polymers and the improvements on these methods over the years. The influence of precursor monomers on the physical properties of the synthesized polymer is comprehensively described, along with the cross-linking strategies. The major focus of this review is to highlight the applications of PCLF and OPF over the years in nerve, cartilage, and bone tissue engineering, as well as drug delivery applications. The nano- and micro- composites developed using these polymers to better accommodate the required application especially in cartilage and bone tissue regeneration are explained in detail. Finally, we provide our perspective on future directions for these polymers in regenerative medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据