Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis

The role of orphan G protein-coupled receptors in the pathophysiology of multiple sclerosis: A review

(2019) Mohaddeseh Sadat Alavi et al.   LIFE SCIENCES

Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination

(2018) Giusy T. Coppolino et al.   GLIA

Identification of novel GPR17-agonists by structural bioinformatics and signaling activation

(2018) Konda Mani Saravanan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Differentiation in Response to Lysolecithin-Induced Demyelination

(2018) Changqing Lu et al.   Scientific Reports

3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17

(2018) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Probing and Molecular Modeling of the A3 Adenosine Receptor: A Focus on Agonist Binding

(2017) Antonella Ciancetta et al.   MOLECULES

Achievements and obstacles of remyelinating therapies in multiple sclerosis

(2017) Martin Stangel et al.   Nature Reviews Neurology

A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights

(2016) Chiara Parravicini et al.   CELLULAR SIGNALLING

Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracy

(2016) Stefano Costanzi et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

(2016) Marta Fumagalli et al.   NEUROPHARMACOLOGY

Epidemiology of multiple sclerosis

(2016) E. Leray et al.   REVUE NEUROLOGIQUE

Open challenges in structure-based virtual screening: Receptor modeling, target flexibility consideration and active site water molecules description

(2015) Francesca Spyrakis et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structure versus function—The impact of computational methods on the discovery of specific GPCR–ligands

(2015) Marcel Bermudez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization

(2015) Marta Fumagalli et al.   GLIA

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

(2015) Julia Marschallinger et al.   Nature Communications

Advancements in therapeutically targeting orphan GPCRs

(2015) Jennifer A. Stockert et al.   Frontiers in Pharmacology

Oxysterols act as promiscuous ligands of class-A GPCRs: In silico molecular modeling and in vitro validation

(2014) Cristina Sensi et al.   CELLULAR SIGNALLING

The Regulated Expression, Intracellular Trafficking, and Membrane Recycling of the P2Y-like Receptor GPR17 in Oli-neu Oligodendroglial Cells

(2013) Alessandra Fratangeli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury

(2013) Heike Franke et al.   Purinergic Signalling

Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist

(2013) S. Hennen et al.   Science Signaling

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

(2012) Christopher A. Lipinski et al.   ADVANCED DRUG DELIVERY REVIEWS

Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee

(2012) Jia-Ming Chang et al.   BMC BIOINFORMATICS

The innate immune system in demyelinating disease

(2012) Lior Mayo et al.   IMMUNOLOGICAL REVIEWS

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

(2012) Robert J Fox et al.   Multiple Sclerosis Journal

Central nervous system remyelination in culture — A tool for multiple sclerosis research

(2011) Hui Zhang et al.   EXPERIMENTAL NEUROLOGY

The GPR17 receptor in NG2 expressing cells: Focus on in vivocell maturation and participation in acute trauma and chronic damage

(2011) Enrica Boda et al.   GLIA

Phenotypic Changes, Signaling Pathway, and Functional Correlates of GPR17-expressing Neural Precursor Cells during Oligodendrocyte Differentiation

(2011) Marta Fumagalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases

(2011) Ivano Eberini et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands

(2011) S. Daniele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Axonal Damage in Multiple Sclerosis

(2011) Jeffery D. Haines et al.   MOUNT SINAI JOURNAL OF MEDICINE

Use of the GTPγS ([35S]GTPγS and Eu-GTPγS) binding assay for analysis of ligand potency and efficacy at G protein-coupled receptors

(2010) Philip G. Strange   BRITISH JOURNAL OF PHARMACOLOGY

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic Progressive Multiple Sclerosis – Pathogenesis of Neurodegeneration and Therapeutic Strategies

(2010) Dirk Fitzner et al.   Current Neuropharmacology

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach

(2010) Chiara Parravicini et al.   BMC STRUCTURAL BIOLOGY

The diagnosis of multiple sclerosis and the clinical subtypes

(2009) BarrieJ Hurwitz   Annals of Indian Academy of Neurology

The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury

(2009) Stefania Ceruti et al.   BRAIN

The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination

(2009) Ying Chen et al.   NATURE NEUROSCIENCE

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

GPR17: Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors

(2008) Chiara Parravicini et al.   BMC BIOINFORMATICS

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

(2008) Davide Lecca et al.   PLoS One