Article
Microbiology
Guiying Yang, Farhan Ahmad, Qihuan Zhou, Meixia Guo, Shiyou Liang, Hassan Ahmed Gaal, Jianchu Mo
Summary: Termitomyces species are wild edible mushrooms that are difficult to cultivate due to their symbiotic association with termites. This study examined the differences in physicochemical indices and microbial communities between combs with and without Termitomyces basidiomes. Fatty acid contents were similar in both comb categories, while bacterial genera Alistipes, Burkholderia, Sediminibacterium, and Thermus were dominant in all combs, with other genera more abundant in combs with Termitomyces basidiomes. Basidiomycota and Ascomycota were also identified in combs, with various Termitomyces species present but not abundantly in individual combs.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Yu Wang, Zhan-nan Yang, Shi-qiong Luo
Summary: The interaction between microorganisms and plants plays a significant role in plant growth and disease resistance. This study investigated the impact of assembled bacterial communities on promoting the growth of Artemisia annua L. and suppressing a pathogenic fungus. The results showed that the constructed bacterial community could inhibit the growth of the fungus and enhance the plant's resistance, leading to better growth and disease suppression in the seedlings inoculated with the bacterial community.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Andres Mauricio Caraballo-Rodriguez, Sara P. Puckett, Kathleen E. Kyle, Daniel Petras, Ricardo da Silva, Louis-Felix Nothias, Madeleine Ernst, Justin J. J. van der Hooft, Anupriya Tripathi, Mingxun Wang, Marcy J. Balunas, Jonathan L. Klassen, Pieter C. Dorrestein
Summary: Many ant species cultivate fungus gardens to pre-digest food, and a 3D molecular map of an Atta texana fungus garden was generated using mass spectrometry to reveal chemical modifications as plant substrates pass through. The metabolomics approach presented in this study can be applied to study similar processes in natural environments.
Article
Biology
Pritam Kundu, Amit Ghosh
Summary: Research finds that specialized microbial communities in the fungus-farming termite gut and fungal comb microbiome contribute to host nutrition through interactive biochemical activities. High-throughput sequencing and mathematical modeling techniques have been used to construct genome-scale community metabolic models that reveal inter-microbial interaction patterns. These findings enhance our understanding of microbial activities and offer potential for developing efficient microcosms for complex plant polymer utilization.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Entomology
Siqi Chen, Daifeng Cheng, Zhen Liu, Babar Hassan, Yijuan Xu
Summary: This study investigated the actinobacterial communities in Odontotermes formosanus individuals and their fungal combs. The results showed the diversity of actinobacteria and their asymmetric antifungal activities. The study also revealed variations in the relative abundance of Coriobacteriia among different termite groups.
ECOLOGICAL ENTOMOLOGY
(2023)
Article
Environmental Sciences
Qianqian Lu, Junbo Mao, Haijun Xia, Siyuan Song, Wenjuan Chen, Dehua Zhao
Summary: The effluent of wastewater treatment plants can significantly alter the bacterial composition in rivers, especially in sediment. The bacterial species composition of the effluent discharge point differs significantly from upstream sites, while the impact in the water column is relatively small.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biotechnology & Applied Microbiology
Liangliang Liu, Yuanyuan Yan, Huanxin Ding, Jun Zhao, Zucong Cai, Chuanchao Dai, Xinqi Huang
Summary: The study reveals a direct relationship between soil properties and plant health status, with the fungal community composition being most important for predicting plant health. Microbiome disease-suppressive activity in soils with low disease incidences (LDS) could be transferred to soils with high disease incidences (HDS). Certain fungal genera like Acremonium, Mycothermus, and Chryseolinea are identified as potential disease-suppressive agents.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Robert W. Buchkowski, Klara Benedek, Janos Balint, Attila Molnar, Tamas Felfoldi, Csaba Fazakas, Oswald J. Schmitz, Adalbert Balog
Summary: This study demonstrates that soil and its associated microbial community, in conjunction with the chemical content of plant leaves, determine the composition of the soil microbial community. Although there are sporadic effects of different combinations of leaf types and soil sources, the source of soil has a more significant impact on the microbial communities decomposing the leaf litter.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Fangying Lei, Xueduan Liu, Haonan Huang, Shaodong Fu, Kai Zou, Shuangfei Zhang, Li Zhou, Jianguo Zeng, Hongwei Liu, Luhua Jiang, Bo Miao, Yili Liang
Summary: This study investigated the bacterial community composition and abundance in different parts of Macleaya cordata using high-throughput gene sequencing. The results showed significant variations in bacterial community structure among compartments, with a strong correlation observed between endophytic bacteria and alkaloids.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Agricultural Engineering
Sha Long, Yongkui Yang, Spyros G. Pavlostathis, Lin Zhao
Summary: The study investigated the individual and combined effects of sulfamethoxazole (SMX) and oxytetracycline (OTC) on an enhanced biological phosphorus removal (EBPR) system. OTC at 5 mg/L led to filamentous bulking and collapse of the EBPR system, while the inhibition effects of SMX and SMX + OTC on P removal, COD removal, glycogen transformation, and extracellular polymeric substances content were reversible with prolonged operation. Factors like the presence of nitrification inhibitor, high pH, and low tetX abundance limited the removal of SMX and OTC in the system.
BIORESOURCE TECHNOLOGY
(2021)
Article
Agronomy
Siji Wang, Shilong Duan, Timothy S. George, Gu Feng, Lin Zhang
Summary: Plant-derived metabolites, such as flavonoids and fatty acids, play a crucial role in plant-microbe interactions. Flavonoids were found to directly regulate rhizosphere bacterial community structure, leading to increased alkaline phosphatase activity and promoting organic P mineralization. These findings suggest that manipulating plant-microbial communities by adding flavonoids can enhance plant P nutrition and fertilizer efficiency.
Article
Mycology
Wilma J. Nel, Z. Wilhelm de Beer, Michael J. Wingfield, Michael Poulsen, Duur K. Aanen, Brenda D. Wingfield, Tuan A. Duong
Summary: The Ophiostomatales includes over 300 species with morphological adaptations for arthropod dispersal, mainly wood-inhabiting fungi associated with bark or ambrosia beetles. Recent surveys of fungus-growing termites led to the discovery of ophiostomatalean-like fruiting structures, which were identified using morphological characteristics, molecular markers, and whole genome sequencing. Two new genera and three new species were introduced based on phylogenomic analyses, revealing that these fungi do not depend on the Termitomyces comb material for growth.
Article
Environmental Sciences
Li Zhao, Sonia Brugel, Kesava Priyan Ramasamy, Agneta Andersson
Summary: Bacteria are important consumers of dissolved organic matter in aquatic systems. The response of bacterial communities to changing DOM types and inputs from climate change is not well understood.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Alvaro Daniel Fernandez-Fernandez, Simon Stael, Frank Van Breusegem
Summary: Proteolysis in plants is a significant field of study because proteases play crucial roles in plant cell death, disease, and development. Proteolytic activities are tightly regulated to ensure precise activity and minimize unwanted effects. Only a few plant proteases and their activation mechanisms have been extensively studied.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Agronomy
Jun He, Xiaoying Li, Ying Tian, Xinru He, Ken Qin, Lizhen Zhu, Youlong Cao
Summary: Root-restriction cultivation can improve the growth and fruit quality of L. barbarum, but it can also reduce soil bacteria abundance and diversity. The results showed that the X60 treatment resulted in the best plant growth.
Article
Plant Sciences
Farhan Ahmad, Aisha Kamal, Ananya Singh, Farha Ashfaque, Saud Alamri, Manzer H. Siddiqui
Summary: This study evaluated the effect of seed priming with salicylic acid (SA) on reducing the adverse effects of salt stress in pea seedlings. The results showed that seed priming with SA alleviated the negative impact of salinity on overall plant performance, including growth and photosynthetic attributes. SA achieved this by inducing enzymatic and non-enzymatic antioxidant systems, promoting soluble sugar and proline accumulation, and regulating ion homeostasis. Seed priming with SA could be a promising approach for cultivating salt-tolerant plants.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Review
Environmental Sciences
Sima Singh, Arshid Numan, Dinesh Sharma, Rahul Shukla, Amit Alexander, Gaurav Kumar Jain, Farhan Jalees Ahmad, Prashant Kesharwani
Summary: The outbreak of the COVID-19 pandemic in 2019 and 2020 has led to a new era of communicable infectious diseases, with the emergence of Hantavirus infection posing a new public health emergency. Hantavirus, a zoonotic pathogen, causes two major clinical manifestations - HFRS and HCPS. Despite the lack of effective treatments or vaccines, public awareness and precautionary measures can help reduce the spread of the virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Biochemical Research Methods
S. M. Kawish, Abdul Qadir, Suma Saad, Sarwar Beg, Gaurav K. Jain, Mohd Aqil, Amer M. Alanazi, Azmat Ali Khan, Md Abdur Rashid, Rehan A. Rab, Waleed H. Almalki, Farhan J. Ahmad
Summary: A cost-effective, reliable, and rapid HPTLC method was developed for estimating GLA in borage oil, utilizing aluminum plates precoated with silica gel as the stationary phase and a hexane:toulene:glacial acetic acid mixture as the mobile phase. The method showed well-resolved spots for GLA and was validated for parameters like linearity, accuracy, specificity, and precision. The method demonstrated high sensitivity for GLA estimation in herbal oil samples and formulations.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Mansi Budhiraja, Sobiya Zafar, Sohail Akhter, Majed Alrobaian, Md Abdur Rashid, Md. Abul Barkat, Sarwar Beg, Farhan J. Ahmad
Summary: This study developed a combinational drug delivery system by embedding mupirocin-loaded chitosan microspheres in a collagen scaffold containing Piper betle extract, aiming to improve wound healing. The results showed that this method effectively promoted wound healing and exhibited good antibacterial effects.
Article
Food Science & Technology
Sarushi Rastogi, Vinita Kumari, Vasudha Sharma, F. J. Ahmad
Summary: The use of gold nanoparticles (AuNP) in food safety is crucial due to their unique properties. Nanosensors are emerging as key technologies to detect various contaminants in food industries. Research is ongoing in the food industry to explore the applications of AuNP-based nanosensors and nanobiosensors.
FOOD ANALYTICAL METHODS
(2022)
Review
Biochemistry & Molecular Biology
Syed M. Kawish, Shwetakshi Sharma, Waleed H. Almalki, Saad Alghamdi, Obaid Afzal, Imran Kazmi, Abdulmalik S. A. Altamimi, Fahad A. Al-Abbasi, Sarwar Beg, Farhan J. Ahmad
Summary: The pharmaceutical industry is advancing towards personalized medicine through innovation in drug development. Three-dimensional printing technology has enabled the manufacturing of personalized dosage forms, opening up new possibilities for discovering compounds and technologies.
CURRENT DRUG METABOLISM
(2022)
Article
Food Science & Technology
Sarushi Rastogi, Vinita Kumari, Vasudha Sharma, Farhan Jalees Ahmad
Summary: A colorimetric method was developed for visual detection of oxytocin in bottle gourd. The method showed high sensitivity and a quick reaction time, allowing for accurate screening of oxytocin.
FOOD ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Rehan A. Rub, Sagar Suman Panda, Sunil K. Panda, Waleed H. Almalki, Majed Alrobaian, Abdul Hafeez, Mahfoozur Rahman, Sarwar Beg, Asgar Ali, Farhan J. Ahmed
Summary: The research focuses on developing an analytical method for estimating aripiprazole in rat plasma using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Propranolol was chosen as the internal standard for maximum recovery of the drug from rat plasma during pharmacokinetic evaluation.
SEPARATION SCIENCE PLUS
(2022)
Article
Engineering, Biomedical
Saman Fatima, Mubashshir Ali, Syed Naved Quadri, Sarwar Beg, M. Samim, Suhel Parvez, Malik Zainul Abdin, Prashant Mishra, Farhan Jalees Ahmad
Summary: The study reported the use of nanoparticles to enhance the targeting and bioavailability of ropinirole hydrochloride for the treatment of ischemic stroke. The nanoparticles showed improved therapeutic effects and reduced unwanted toxicities. Additionally, they were able to attenuate ischemic injury and restore neurological and behavioral deficits.
Editorial Material
Biochemistry & Molecular Biology
Md. Abul Barkat, Sarwar Beg, Farhan J. Ahmad
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
S. M. Kawish, Nazeer Hasan, Sarwar Beg, Abdul Qadir, Gaurav K. Jain, Mohd Aqil, Farhan J. Ahmad
Summary: In this study, a novel docetaxel-nanoemulsion was developed to improve therapeutic effectiveness and reduce side effects through targeted delivery. The optimized nanoemulsion demonstrated excellent characteristics in terms of drug encapsulation, drug release kinetics, and in vivo pharmacokinetics.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Pavitra Solanki, Mohd Danish Ansari, Mohd Iqbal Alam, Mohd Aqil, Farhan J. Ahmad, Yasmin Sultana
Summary: This study developed an orally effective nanoformulation of disodium pamidronate for the treatment of osteoporosis. Through rational design and optimization, a commercially potential self nano-emulsifying drug delivery system (SNEDDS) was developed, which showed improved oral bioavailability and enhanced anti-osteoporotic activity. The study provided significant achievements in the treatment of postmenopausal osteoporosis and may lead to the use of nanotherapeutic-driven emerging biodegradable carriers-based drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Farhan Ahmad, Shalini Singh, Niraj Kumari
Summary: Spontaneous regression (SR) is relatively rare in non-small-cell lung cancer, especially with adenocarcinoma histology. Various mechanisms have been postulated, but the exact underlying mechanism is still uncertain.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Arif Nadaf, Akash Gupta, Nazeer Hasan, Fauziya, Shadaan Ahmad, Prashant Kesharwani, Farhan J. Ahmad
Summary: Electrospinning is a versatile technique for generating ultrathin fibers, and this review provides a comprehensive overview of electrospinning and non-electrospinning processes, their setup, fabrication process, components, and applications. The review covers the characteristics of nanofibers, materials required for their production, and the diverse applications they have in various fields. It also discusses the challenges and future prospects of nanofiber development.
Article
Polymer Science
Mohammad Zubair Ahmed, Anshul Gupta, Musarrat Husain Warsi, Ahmed M. Abdelhaleem Ali, Nazeer Hasan, Farhan J. Ahmad, Ameeduzzafar Zafar, Gaurav K. Jain
Summary: Vitamin D deficiency is prevalent among nearly 50% of the global population, and this study developed a vitamin D oil-in-water nanoemulsion incorporated in edible gummies to enhance bioavailability and stability. The nanoemulsion prevented degradation of vitamin D and retained its activity over 15 days. The vitamin D gummies formulated with the nanoemulsion had optimal hardness and maintained taste and acceptance over 45 days of storage. This study highlights the potential of nanoemulsions to improve the delivery and effectiveness of vitamin D.