Review
Biochemistry & Molecular Biology
Mojgan Morvaridzadeh, Ehsan Sadeghi, Shahram Agah, Siavash Fazelian, Mehran Rahimlou, Ferdinand Georg Kern, Shilan Heshmati, Amirhosein Omidi, Emma Persad, Javad Heshmati
Summary: The study provides convincing evidence supporting the efficacy of ginger supplementation in improving oxidative stress levels, including an increase in antioxidant enzyme activity and total antioxidant capacity, as well as a decrease in malondialdehyde levels.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Review
Food Science & Technology
Helya Rostamkhani, Amir Hossein Faghfouri, Parisa Veisi, Alireza Rahmani, Nooshin Noshadi, Zohreh Ghoreishi
Summary: This study conducted a meta-analysis of previously conducted animal studies to investigate the protective antioxidant effect of ginger extracts on acute kidney injury. The results showed that ginger extract supplementation significantly increased the levels of SOD, CAT, GSH, and TAC, while reducing MDA levels. However, no significant effect was observed for GPx and GST. These findings provide strong evidence for the protective antioxidant activity of ginger extracts in animals with acute kidney injury.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Chao Li, Jie Li, Feng Jiang, Nikolay T. Tzvetkov, Jaroslaw O. Horbanczuk, Yunlun Li, Atanas G. Atanasov, Dongdong Wang
Summary: Ginger is rich in various chemical constituents that have positive effects on the vascular system, including alleviating oxidative stress and inflammation, promoting nitric oxide synthesis, and suppressing vascular smooth muscle cell proliferation.
Article
Plant Sciences
Pan Zhang, Yanhong Wang, Jie Wang, Gang Li, Siyun Li, Jiawei Ma, Xiangyan Peng, Junliang Yin, Yiqing Liu, Yongxing Zhu
Summary: Storing ginger at low temperatures can extend its shelf life but may also cause negative effects such as chilling injury, loss of flavor, and excessive water loss. This study investigated the effects of chilling stress on ginger quality and found that storage at 2 degrees C led to increased concentrations of lignin, soluble sugar, flavonoids, and phenolics, as well as accumulation of reactive substances. Chilling stress also affected hormone levels and activated protein kinase pathways, potentially impacting ginger quality and increasing the risk of pathogenesis.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Chemistry, Medicinal
Alaa Kassar Salih, Ala Hadi Alwan, Murad Khadim, Zahraa Haleem Al-qaim, Bobosher Mardanov, Amr A. El-Sehrwy, Yousief Irshad Ahmed, Atefeh Amerizadeh
Summary: The effect of ginger supplementation on lipid profile in humans, especially in diabetic patients, remains controversial. This study found that ginger intake significantly reduced total cholesterol and triglyceride levels, but had no significant effect on high-density lipoprotein cholesterol and low-density lipoprotein cholesterol.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Chunyang Zhao, Weiyuan Chen, Daqiu Wang, Xiufeng Cong, Min Zhu, Chengrui Zhu, Jiayao Xu, Jiayi Cai
Summary: This study conducted a network meta-analysis to compare the efficacy of different ginger preparations in controlling postoperative nausea and vomiting (PONV). It found that ginger oil had the highest probability of being ranked best in reducing the incidence of postoperative vomiting. However, there were no obvious advantages of ginger preparations in reducing postoperative nausea compared to placebo.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Immunology
Arduino A. Mangoni, Angelo Zinellu
Summary: This study evaluated the pathophysiological role of neopterin in patients with rheumatic diseases through systematic review and meta-analysis. The results showed that neopterin concentrations were significantly higher in patients with RD compared to healthy controls. However, there were no significant associations found between neopterin concentrations and factors such as age and gender ratio, but associations were observed with geographical area and type of RD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Elisabetta Zinellu, Alessandro G. Fois, Elisabetta Sotgiu, Sabrina Mellino, Arduino A. Mangoni, Ciriaco Carru, Angelo Zinellu, Pietro Pirina
Summary: This systematic review and meta-analysis revealed that serum albumin concentrations are significantly lower in patients with stable COPD compared to non-COPD controls, indicating a deficiency in systemic anti-inflammatory and antioxidant defense mechanisms in COPD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Alaaeldin Ahmed Hamza, Gehan Hussein Heeba, Salsabil Hamza, Ali Abdalla, Amr Amin
Summary: The study demonstrates that ginger has chemo-preventive effects against liver cancer by reducing carcinogenic changes, inducing apoptosis, and protecting the liver from oxidative and inflammatory damage. Ginger also inhibits cell proliferation and promotes cell death, showcasing its potential as a natural preventive agent for liver cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Elham Moslemi, Vali Musazadeh, Zeynab Kavyani, Navid Naghsh, Seyyed Morteza Seyyed Shoura, Parvin Dehghan
Summary: This umbrella meta-analysis summarized existing systematic reviews and meta-analyses of clinical trials on vitamin D supplementation. The findings revealed that vitamin D supplementation significantly reduced serum levels of CRP, TNF-alpha, and MDA, but did not show significant changes in IL-6, TAC, and GSH. Vitamin D could be considered as an adjuvant therapy for relieving inflammation and oxidative stress.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biology
Ni Li, Yan Xing, Afrah Hameed Sultan, Mahdieh Raeeszadeh, Abolfazl Akbari, Haining Liu
Summary: The study demonstrates that while ethanol decreases testosterone levels and induces oxidative stress and inflammation, ginger can effectively improve these impacts and prevent ethanol-induced reproductive dysfunction.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Zhimin Song, Hongbin Fang, Xiaojuan Zhang, Yong-Ming Yan, Yufei Liu, Jingjing Miao, Huiying Niu, Weisheng Feng, Yong-Xian Cheng, Yanzhi Wang
Summary: This article investigates new natural compounds from ginger and determines their chemical structures and stereo configurations. The study also evaluates the activities of these compounds in treating renal fibrosis, finding that some of them show potential for renal fibrosis treatment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Miaohong Liu, Yao Lv, Bili Cao, Zijing Chen, Kun Xu
Summary: We simulated higher salt concentration in ginger using 'Shannong No.1' experimental material and investigated the physiological responses of different parts of ginger seedlings under salt stress. The results showed that salt stress led to decreased fresh and dry weight, lipid membrane peroxidation, increased sodium ion content, and enhanced activity of antioxidant enzymes in ginger. The roots and leaves of ginger showed the most significant changes, jointly initiating MAPK signaling pathways in response to salt stress. Through the combination of physiological and molecular indicators, we elucidated the response of different tissues and parts of ginger to salt stress during the seedling stage.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Nutrition & Dietetics
Dongli Xie, Jianchen Hu, Zhenhua Yang, Tong Wu, Wei Xu, Qingyang Meng, Kangli Cao, Xiaogang Luo
Summary: Supplementation of vitamin E can effectively reduce oxidative stress and inflammatory responses induced by nanomaterials, providing a cost-effective option for prevention.
Review
Medicine, Research & Experimental
Stefania Bassu, Arduino A. Mangoni, Dario Argiolas, Ciriaco Carru, Pietro Pirina, Alessandro G. Fois, Angelo Zinellu
Summary: Our meta-analysis has shown that serum PON-1 concentrations are significantly lower in patients with asthma, suggesting the presence of an impaired antioxidant defense in this group.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Omid Asbaghi, Sajjad Moradi, Shokufeh Nezamoleslami, Seyedeh Parisa Moosavian, Mohammad Ali Hojjati Kermani, Anastasia Viktoria Lazaridi, Maryam Miraghajani
Summary: Magnesium supplementation significantly reduces serum LDL levels in type 2 diabetes patients, with no effect on TG, TC, and HDL levels. Supplementing with magnesium for more than 12 weeks leads to a significant decrease in TC levels, while a dose of less than 300 mg decreases LDL concentrations and over 300 mg increases HDL levels significantly. Inorganic magnesium supplementation reduces LDL and TC levels, while organic magnesium supplementation shows no difference.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Mohammad Jalali, Navid Jamali, Shahla Rezaei, Kamran Hessami, Pedram Keshavarz, Saeed Shahabi, Ali Asghar Kolahi, Kristin Carson-Chahhoud, Amirhossein Sahebkar, Saeid Safiri
Summary: Intake of diacerein may lead to significant reductions in hemoglobin A1c and body mass index in patients with type 2 diabetes mellitus, but has no significant effects on other cardiometabolic parameters.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Razieh Hassannejad, Seyedeh Parisa Moosavian, Noushin Mohammadifard, Marjan Mansourian, Hamidreza Roohafza, Masoumeh Sadeghi, Nizal Sarrafzadegan
Summary: This longitudinal study indicates a significant association between red meat consumption and lipid profile in healthy Iranian adults, with an increase in red meat and organ meat intake being linked to higher levels of triacylglycerol, total cholesterol, low-density lipoprotein, high-density lipoprotein, low-density to high-density lipoprotein ratio, and non-high-density lipoprotein. However, processed meat consumption showed no significant association with lipid profile.
Review
Integrative & Complementary Medicine
Zahra Mosallanezhad, Marzieh Mahmoodi, Sara Ranjbar, Razieh Hosseini, Cain C. T. Clark, Kristin Carson-Chahhoud, Zahra Norouzi, Ali Abbasian, Zahra Sohrabi, Mohammad Jalali
Summary: The results of the study indicate that soy intake is associated with improvements in systolic and diastolic blood pressure in adults. The effects were more pronounced in younger participants with lower baseline diastolic blood pressure and shorter intervention durations.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Razieh Hosseini, Gordon A. Ferns, Amirhossein Sahebkar, Mohammad Ali Mirshekar, Mohammad Jalali
Summary: This study found that zinc supplements can significantly reduce serum concentrations of inflammation and oxidation markers, including CRP, TNF-alpha, and MDA. The duration of treatment was identified as the source of inter-study heterogeneity.
Review
Pharmacology & Pharmacy
Peyman Nowrouzi-Sohrabi, Shahla Rezaei, Mohammad Jalali, Mahkameh Ashourpour, Ahmad Ahmadipour, Pedram Keshavarz, Hamed Akbari
Summary: This study found that GLP-1 receptor agonists have certain therapeutic effects on patients with T2DM and NAFLD, significantly reducing body mass index, waist circumference, and body weight, while decreasing postprandial glucose levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Seyedeh Parisa Moosavian, Mehran Rahimlou, Omid Asbaghi, Sajjad Moradi, Wolfgang Marx, Zamzam Paknahad
Summary: A systematic review and meta-analysis on the effect of soy product consumption on adiponectin and leptin levels in adults found no significant impact. Future larger and well-designed trials are needed to further explore this research area due to the heterogeneous study design used in existing literature.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Nutrition & Dietetics
Omid Asbaghi, Damoon Ashtary-Larky, Reza Bagheri, Seyedeh Parisa Moosavian, Hadi Pourmirzaei Olyaei, Behzad Nazarian, Mahnaz Rezaei Kelishadi, Alexei Wong, Darren G. Candow, Frederic Dutheil, Katsuhiko Suzuki, Amirmansour Alavi Naeini
Summary: Folic acid supplementation significantly reduces some markers of glycemic control in adults, but the effects are relatively small, which may limit clinical applications for adults with type II diabetes. Further research is needed to confirm these findings.
Review
Nutrition & Dietetics
Omid Asbaghi, Damoon Ashtary-Larky, Reza Bagheri, Seyedeh Parisa Moosavian, Behzad Nazarian, Reza Afrisham, Mahnaz Rezaei Kelishadi, Alexei Wong, Frederic Dutheil, Katsuhiko Suzuki, Amirmansour Alavi Naeini
Summary: This study found that folic acid supplementation may improve inflammation by reducing serum concentrations of CRP, but had no significant effects on IL-6 and TNF-alpha. Dose-response analysis showed a significant relationship between higher doses of folic acid supplementation and lower CRP concentrations. Future RCTs with larger sample sizes and more diverse populations are needed to confirm and expand these findings.
Review
Biochemistry & Molecular Biology
Damoon Ashtary-Larky, Mahnaz Rezaei Kelishadi, Reza Bagheri, Seyedeh Parisa Moosavian, Alexei Wong, Sayed Hossein Davoodi, Pardis Khalili, Frederic Dutheil, Katsuhiko Suzuki, Omid Asbaghi
Summary: Nano-curcumin supplementation shows beneficial effects on cardiovascular disease risk factors, including improvements in glycemic and lipid profiles, reduction in inflammatory markers, and lowering of systolic blood pressure. Additional large-scale studies with longer durations are needed for further exploration.
Review
Nutrition & Dietetics
Omid Asbaghi, Damoon Ashtary-Larky, Aya Mousa, Mahnaz Rezaei Kelishadi, Seyedeh Parisa Moosavian
Summary: The consumption of soy products can have a positive impact on cardiovascular risk factors in patients with type 2 diabetes, leading to reductions in triglycerides, total cholesterol, LDL cholesterol, and C-reactive protein levels. Additionally, soy intake may lower fasting blood sugar and systolic blood pressure in certain subgroups.
ADVANCES IN NUTRITION
(2022)
Review
Chemistry, Medicinal
Seyedeh Parisa Moosavian, Mehran Rahimlou, Mahnaz Rezaei Kelishadi, Sajjad Moradi, Cyrus Jalili
Summary: Almond consumption was found to decrease LDL-cholesterol levels in patients with type 2 diabetes in this systematic review and meta-analysis of available RCTs. However, it had no favorable effect on other cardiometabolic outcomes. Further high-quality studies are needed to confirm the clinical efficacy of almonds.
PHYTOTHERAPY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Fateme Moradi, Seyedeh Parisa Moosavian, Farhang Djafari, Azam Teimori, Zahra Faghih Imani, Amirmansour Alavi Naeini
Summary: This study found a significant relationship between dietary patterns and non-alcoholic fatty liver disease. Adherence to a western dietary pattern is associated with an increase in the odds of non-alcoholic fatty liver disease, while adherence to a healthy dietary pattern is associated with a lower odds of non-alcoholic fatty liver disease.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2022)
Article
Food Science & Technology
Seyedeh Parisa Moosavian, Awat Feizi, Ahmad Esmaillzadeh, Leila Azadbakht
Summary: This study found that food-secure households had higher adherence to AHEI-2010 and better micronutrient adequacy ratios compared to food-insecure households.
NUTRITION & FOOD SCIENCE
(2021)
Review
Nutrition & Dietetics
Arman Arab, Seyedeh Parisa Moosavian, Amir Hadi, Elham Karimi, Maryam Nasirian
CLINICAL NUTRITION ESPEN
(2020)
