Article
Chemistry, Multidisciplinary
Chao Ye, Ying Tong, Nan Wu, Guo-wei Wan, Fen Zheng, Jing-yu Chen, Jian-zhen Lei, Hong Zhou, Ai-dong Chen, Jue-jin Wang, Qi Chen, Yue-hua Li, Yu-ming Kang, Guo-qing Zhu
Summary: The study demonstrated that miR-135a-5p promotes vascular smooth muscle cell (VSMC) proliferation in spontaneously hypertensive rats (SHRs), while FNDC5 inhibits it. Silencing miR-135a-5p or upregulating FNDC5 could attenuate VSMC proliferation and vascular remodeling in SHRs. These findings suggest that manipulating miR-135a-5p or FNDC5 levels may be a therapeutic strategy for reducing vascular remodeling and hypertension.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Miaomiao Zhang, Yanxiang Li, Yujie Guo, Jiashuo Xu
Summary: The semi-essential amino acid L-arginine (Arg) has been shown to attenuate inflammatory response during cardiovascular disease by suppressing NLRP3 inflammasome activation and increasing SIRT1 expression, partially through inhibition of ROS production. This suggests a potential mechanism for Arg's inhibitory effect on NLRP3 inflammasome activation in vascular endothelial cells.
Article
Immunology
Reham A. Ammar, Ahmed F. Mohamed, Mohamed M. Kamal, Marwa M. Safar, Noha F. Abdelkader
Summary: Liraglutide exerts neuroprotection in multiple sclerosis through its anti-inflammatory, autophagic flux activation, NLRP3 inflammasome suppression, and anti-apoptotic mechanisms.
INFLAMMOPHARMACOLOGY
(2022)
Article
Cell Biology
Qi Pang, Peiwen Wang, Yajing Pan, Xingtong Dong, Ting Zhou, Xinyu Song, Aihua Zhang
Summary: This study demonstrates for the first time that Irisin protects the cardiovascular system against vascular calcification in CKD by inducing autophagy and inhibiting VSMC pyroptosis.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Ling Li, Kelei Qian, Yuli Sun, Yong Zhao, Yun Zhou, Ying Xue, Xinyu Hong
Summary: Omarigliptin shows significant anti-inflammatory effects in diabetic nephropathy by suppressing NLRP3 inflammasome activation and improving inflammation in renal glomerular endothelial cells induced by high glucose.
Article
Biochemistry & Molecular Biology
Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Karim J. Brandt, Kapka Miteva
Summary: The study demonstrated that oxLDL-activated monocytes can directly affect VSMCs in a co-culture system, leading to reduced expression of certain markers and upregulation of others, as well as activation of caspase 1, secretion of IL-1 beta, and pyroptosis in VSMCs. The activation of VSMC NLRP3 inflammasome by monocytes may play a detrimental role in atherosclerotic plaque stability in human atherosclerosis, as evidenced by findings in both mice and human atherosclerotic plaques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Kemal Ugur Tufekci, Bedir Irem Eltutan, Kamer Burak Isci, Sermin Genc
Summary: Our study demonstrates that resveratrol suppresses NLRP3 inflammasome and miR-155 expression in microglia by modulating AMPK and Sirt1 pathways, revealing its anti-inflammatory properties.
NEUROTOXICITY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chao Zhong, Jing Yang, Keke Deng, Xiaoya Lang, Jiangtao Zhang, Min Li, Liang Qiu, Guoyue Zhong, Jun Yu
Summary: Tiliroside was found to inhibit the activation of NLRP3 inflammasome by promoting AMPK activation, reducing mitochondrial damage, and attenuating inflammation, suggesting its potential therapeutic application for NLRP3-related diseases.
Article
Cell Biology
Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu, Chengjiang Gao
Summary: USP5 acts as a key scaffold protein in recruiting the E3 ligase MARCHF7 for autophagic degradation of NLRP3 independently of its deubiquitinating enzyme activity. Knockdown of USP5 promotes inflammatory signaling release, while overexpression has inhibitory effects.
Article
Pharmacology & Pharmacy
Guang-Jie Tai, Qing-Qing Yu, Jia-Peng Li, Wei Wei, Xiao-Man Ji, Rui-Fang Zheng, Xiao-Xue Li, Li Wei, Ming Xu
Summary: The research found abnormal activation of NLRP3 inflammasome in aortas of both T2DM and old mice, and the deletion or inhibition of NLRP3 gene improved vascular aging and dysfunction, partially by regulating the growth and migration of aortic endothelial cells and vascular smooth muscle cells.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Dongsheng Bai, Jiaying Du, Xiumin Bu, Wangjia Cao, Tifan Sun, Jiawei Zhao, Yue Zhao, Na Lu
Summary: ALDOA acts as a glycolytic sensor to regulate NLRP3 inflammasome activity, maintaining mitochondrial damage and controlling autophagy, thus influencing the occurrence and progression of inflammation.
Article
Agriculture, Multidisciplinary
Min-Min Hu, Wen-Ya Zheng, Ming-Hui Cheng, Zi-Yu Song, Horia Shaukat, Mahnoor Atta, Hong Qin
Summary: Sesamol can reverse the muscle fiber-type conversion in obesity by stimulating the muscular SIRT1/AMPK signal pathway, providing a potential therapeutic strategy for obesity and obesity-related metabolic disorders.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Environmental Sciences
Xiaoying Zhu, Wudi Hao, Ziyue Liu, Yushuai Song, Chenyu Hao, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
Summary: Aluminum exposure activates microglia and induces neuroinflammation through P2X7-NLRP3 pathway. P2X7 and HIF-1 alpha have a mutual regulatory relationship in the progression of neuroinflammation. BBG and YC-1 intervention can relieve the injuries caused by aluminum-induced neuroinflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Fangyuan Jia, Rui Ji, Gang Qiao, Zhigang Sun, Xiaosan Chen, Zhidong Zhang
Summary: Recent studies have shown that bitter taste receptors play a role in regulating various cellular processes. This study found that the bitter taste receptor activator amarogentin (AMA) can inhibit the proliferation and migration of vascular smooth muscle cells (VSMCs) by activating the AMPK signaling pathway, thereby attenuating neointimal hyperplasia. This highlights the potential of AMA as a new drug candidate for the treatment of neointimal hyperplasia.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Dan Li, Ziwei Xing, Tingting Yu, Wei Dong, Zhiwei Wang, Cheng Peng, Chao Yang
Summary: Pogostone (PO) ameliorates adipose tissue inflammation by activating SIRT1 and inhibiting the phosphorylation of MAPK and NF-κB pathways. PO also reduces the migratory ability of macrophages to inflammatory adipocytes and suppresses the expression of inflammatory cytokines and chemokines. Additionally, PO exhibits anti-inflammatory effects in mouse experiments.
Review
Cardiac & Cardiovascular Systems
Feng Zhang, Aidong Chen, Yan Pan, Xingxing Wang, Yu Xu, Ankit A. Desai, Haiyang Tang, Ying Han
Summary: PAH is a progressive disease with high mortality and complex etiology, leading to right heart failure. The renin-angiotensin system plays a critical role in maintaining cardiovascular homeostasis, with the ACE2-Ang-(1-7)-Mas axis potentially representing a novel target for PAH treatment.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Yuan Xue, Sihan Hu, Chichi Chen, Jiachen He, Jie Sun, Yesheng Jin, Yuanshu Zhang, Guoqing Zhu, Qin Shi, Yongjun Rui
Summary: Irisin plays a regulatory role in bone homeostasis and promotes MSC-derived osteogenesis. Lack of Irisin leads to bone loss and enhanced bone resorption, while the presence of Irisin can promote osteogenesis by activating signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lu-Lu Wu, Yue Zhang, Xiu-Zhen Li, Xin-Li Du, Ying Gao, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
Summary: Selective renal afferent denervation attenuated sympathetic activity, oxidative stress, vascular remodeling, and hypertension in spontaneously hypertensive rats (SHR).
Article
Medicine, Research & Experimental
Yan Pan, Aidong Chen, Xingxing Wang, Changlei Bao, Shuxin Liang, Haiyang Tang, Ying Han
Summary: This study investigated the effects of salusin-beta on endothelium-dependent vascular relaxation and the progression of PAH. The results showed that elevated salusin-beta levels in PAH rats led to reduced endothelium-dependent vasodilatation and participated in PAH progression by stimulating NAD(P)H oxidase-ROS production and inhibiting eNOS-NO release.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Bing Zhou, Hong Song, Wuqin Xu, Yanbin Zhang, Yinhua Liu, Wei Qi
Summary: This study investigates the latent pathogenesis of prostate adenocarcinoma (PRAD) and identifies specific biomarkers for its treatment and prognosis. The hub gene ARRB2 is found to be highly expressed in PRAD and is associated with poor prognosis and immunotherapy. This research offers new directions for PRAD research.
Article
Oncology
Bing Zhou, Nan Wu, Yuan Yan, Lu-Lu Wu, Guo-Qing Zhu, Xiao-Qing Xiong
Summary: This study demonstrates that the upregulation of miR-31-5p and the downregulation of FNDC5 contribute to Ang II-induced VSMC proliferation and migration.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Li Wang, Jing-Xiao Wang, Jun-Liu Chen, Wen-Yuan Hao, Wen-Zhou Xu, Zhi-Qin Xu, Yu-Tong Jiang, Pei-Qi Luo, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiu-Zhen Li
Summary: This study discovered that high expression of asprosin in the PVN increased sympathetic outflow and blood pressure via the cAMP-PKA signaling-mediated NADPH oxidase activation and subsequent superoxide production. These findings highlight the important role of asprosin in regulating sympathetic and cardiovascular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xingxing Wang, Aidong Chen, Ruihua Hu, Feng Zhang, Shuxin Liang, Changlei Bao, Xuanxuan Liu, Haiyang Tang, Ying Han
Summary: This study investigates the effects of salusin-beta on the proliferation, migration, fibrosis, and calcification of pulmonary arterial smooth muscle cells (PASMCs). The results suggest that increased activity of salusin-beta contributes to vascular remodeling and the development of pulmonary arterial hypertension.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing-Xiao Wang, Xiao-Li Wang, Zhi-Qin Xu, Yue Zhang, Dong Xue, Rong Zhu, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
Summary: This study found that chemerin-9 in the PVN increases sympathetic activity and blood pressure through CMKLR1-dependent calcium influx, glutamate receptor-mediated NADPH oxidase activation, and subsequent superoxide production.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jin-Hua Bo, Jing-Xiao Wang, Xiao-Li Wang, Yang Jiao, Ming Jiang, Jun-Liu Chen, Wen-Yuan Hao, Qi Chen, Yue-Hua Li, Zheng-Liang Ma, Guo-Qing Zhu
Summary: Research shows that the use of dexmedetomidine can attenuate sympathetic activity and inflammation in sepsis. The drug reduces NADPH oxidase-dependent superoxide production by inhibiting the adenylate cyclase-cAMP-PKA signaling pathway and activating GABA(A) receptors, thus alleviating sympathetic overactivity.
Article
Physiology
Yu Xu, Xuejie Fei, Hangjiang Fu, Aidong Chen, Xinrui Zhu, Feng Zhang, Ying Han
Summary: This study aimed to determine the roles of salusin-beta in the paraventricular nucleus (PVN) in modulating enhanced cardiac sympathetic afferent reflex (CSAR) and sympathetic hyperactivation in rats with chronic heart failure (CHF). The results showed that salusin-beta expression in the PVN was upregulated in CHF rats, and the injection of salusin-beta into the PVN increased blood pressure, renal sympathetic nerve activity, and CSAR. In addition, the use of anti-salusin-beta IgG produced opposite effects.
Article
Medicine, Research & Experimental
Fen Zheng, Chao Ye, Rui Ge, Yu Wang, Xiao-Lei Tian, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Bing Zhou
Summary: This study demonstrates the important roles of EVs-mediated miR21-3p transfer in promoting VSMC proliferation and migration in SHR and identifies SORBS2 as a target of miR-21-3p in this process.
Article
Medicine, Research & Experimental
Chao Ye, Fen Zheng, Tao Xu, Nan Wu, Ying Tong, Xiao-Qing Xiong, Ye-Bo Zhou, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Ying Han
Summary: This study reveals that NE promotes the release of small EVs and ACE transfer from AFs, leading to VSMCs proliferation in hypertension. Intervention of AFs-derived EVs release may be a potential therapeutic approach for vascular remodeling in hypertension related to excessive sympathetic activation.