Article
Oncology
Qiqi Shi, Bo Yu, Yingwen Zhang, Yi Yang, Chenxin Xu, Mingda Zhang, Guoyu Chen, Fei Luo, Bowen Sun, Ru Yang, Yanxin Li, Haizhong Feng
Summary: TRIM24 is overexpressed in neuroblastoma and is associated with poor prognosis. Knockout of TRIM24 promotes cell differentiation, reduces stemness, and inhibits tumor growth. In addition, TRIM24 knockout activates the retinoic acid pathway. Therefore, TRIM24 may be a critical target in neuroblastoma differentiation therapy.
Article
Multidisciplinary Sciences
Cheng Zeng, Jiwei Chen, Emmalee W. Cooke, Arijita Subuddhi, Eliana T. Roodman, Fei Xavier Chen, Kaixiang Cao
Summary: This study reveals the catalytic-independent role of LSD1 in regulating gene expression and cellular differentiation, demonstrating that the loss of LSD1 protein globally de-represses enhancers and impairs cell fate transition. The researchers found that the increase of H3K27ac catalyzed by P300/CBP, rather than the loss of CoREST complex components from chromatin, contributes to the transcription de-repression of LSD1 targets and differentiation defects caused by LSD1 loss.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
James M. Gahan, Ian U. Kouzel, Kamilla Ormevik Jansen, Pawel Burkhardt, Fabian Rentzsch
Summary: This study reveals the role of chromatin modifier Lsd1 in developmental regulation in cnidarians. The findings suggest that the integration of chromatin modifying proteins into developmental regulation predates the divergence of cnidarians and bilaterians, and is an ancient feature of animal development.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Tzu-Ling Shao, Ruei-Teng Ting, Ming -Chia Lee
Summary: This study investigates the interaction between Lsd1 and lncRNAs and its role in ovarian development and cell differentiation using fly ovaries as a model.
Article
Biochemistry & Molecular Biology
Alba Maiques-Diaz, Luciano Nicosia, Naseer J. Basma, Isabel Romero-Camarero, Francesco Camera, Gary J. Spencer, Fabio M. R. Amaral, Fabrizio Simeoni, Bettina Wingelhofer, Andrew J. K. Williamson, Andrew Pierce, Anthony D. Whetton, Tim C. P. Somervaille
Summary: Inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in AML patients with MLL gene translocations. The interaction of HMG20B with LSD1 is disrupted by LSD1 inhibition, and HMG20B is a critical component of the GFI1:LSD1 transcription repressor complex contributing to leukemia cell differentiation block.
Article
Hematology
Lei Yu, Greggory Myers, Chia-Jui Ku, Emily Schneider, Yu Wang, Sharon A. Singh, Natee Jearawiriyapaisarn, Andrew White, Takashi Moriguchi, Rami Khoriaty, Masayuki Yamamoto, Michael G. Rosenfeld, Julien Pedron, John H. Bushweller, Kim-Chew Lim, James Douglas Engel
Summary: Studies have shown that LSD1 promotes erythropoiesis by repressing myeloid cell fate in adult erythroid progenitors, and inhibiting the myeloid-differentiation pathway can reverse the lineage switch induced by LSD1 inactivation.
Article
Biochemistry & Molecular Biology
Lipeng Gan, Qilin Shangguan, Fang Zhang, Xiaomei Tong, Dandan Qi, Yan Zhao, Xin Ye
Summary: HBV infection downregulates LINC01010 expression, resulting in inhibition of cell proliferation and migration. The mechanism of action of LINC01010 primarily involves interfering with the formation of vimentin filaments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yagnesh Ladumor, Bo Kyung Alex Seong, Robin Hallett, Ivette Valencia-Sama, Teresa Adderley, Yingying Wang, Lynn Kee, Alexander Gont, David R. Kaplan, Meredith S. Irwin
Summary: The study found that calcipotriol, a vitamin D3 analog, selectively targets cell lines with enhanced metastatic potential in neuroblastoma, leading to reduced proliferation and survival via vitamin D receptor (VDR) signaling. This compound also reduces the levels of YAP and TAZ, the effectors of the Hippo pathway, by increasing the expression of RASSF2, a negative regulator of the pathway.
MOLECULAR CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yi Liu, Brian Debo, Mingfeng Li, Zhennan Shi, Wanqiang Sheng, Yang Shi
Summary: Targeting the histone demethylase LSD1 can increase the persistence of exhausted CD8(+) T cells in chronic infections and cancer, improving response to immune checkpoint blockade therapy. This strategy may alleviate T cell exhaustion and enhance the effectiveness of immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
William M. Yashar, Brittany M. Curtiss, Daniel J. Coleman, Jake VanCampen, Garth Kong, Jommel Macaraeg, Joseph Estabrook, Emek Demir, Nicola Long, Daniel Bottomly, Shannon K. McWeeney, Jeffrey W. Tyner, Brian J. Druker, Julia E. Maxson, Theodore P. Braun
Summary: This study found that combined use of LSD1 and FLT3 inhibitors can induce synergistic cell death in FLT3-mutant AML. Multi-omic profiling revealed that the drug combination disrupts binding of STAT5, LSD1, and GFI1 at the MYC blood superenhancer, suppressing superenhancer accessibility as well as MYC expression and activity. The drug combination also leads to the accumulation of repressive H3K9me1 methylation, an LSD1 substrate, at MYC target genes. These findings were validated in 72 primary AML samples, with almost every sample showing synergistic responses to the drug combination.
MOLECULAR CANCER RESEARCH
(2023)
Article
Immunology
Daniel B. Stamos, Lauren M. Clubb, Apratim Mitra, Laura B. Chopp, Jia Nie, Yi Ding, Arundhoti Das, Harini Venkataganesh, Jan Lee, Dalal El-Khoury, LiQi Li, Avinash Bhandoola, Remy Bosselut, Paul E. Love
Summary: The study demonstrates the critical role of the histone demethylase Lsd1 in regulating stem/progenitor transcriptional programs and repressive gene programs during T cell development, shedding light on epigenetic mechanisms underlying the acquisition of T cell gene signatures.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Anbarasu Kumaraswamy, Zhi Duan, Diana Flores, Chao Zhang, Archana Sehrawat, Ya-Mei Hu, Olivia A. Swaim, Eva Rodansky, William K. Storck, Joshua A. Kuleape, Karan Bedi, Rahul Mannan, Xiao-Ming Wang, Aaron Udager, Visweswaran Ravikumar, Armand Bankhead III, Ilsa Coleman, John K. Lee, Colm Morrissey, Peter S. Nelson, Arul M. Chinnaiyan, Arvin Rao, Zheng Xia, Joel A. Yates, Joshi J. Alumkal
Summary: LSD1 is highly upregulated in NEPC and its inhibition reduces NEPC cell survival and tumor growth, suggesting it may be a promising treatment strategy for NEPC.
Article
Cell Biology
Xinping Huang, Yan Zhao, Min Wei, Ruipeng Zhuge, Xiaofeng Zheng
Summary: Cellular senescence is a complex process regulated by multiple signals. Understanding the molecular mechanisms of cellular senescence and identifying novel regulators could lead to new treatment strategies for aging-related diseases.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aojie Cai, Zehong Lin, Nana Liu, Xiao Li, Jingmin Wang, Ye Wu, Kai Gao, Yuwu Jiang
Summary: Our study demonstrated the potential of AM580 to promote neuronal differentiation and treat neuroblastoma, neurodevelopmental, and neurodegenerative diseases.
NEUROCHEMICAL RESEARCH
(2022)
Article
Cell Biology
Mei Wu, Qi Chen, Jing Li, Yue Xu, Junwei Lian, Yongxiang Liu, Ping Meng, Yiyue Zhang
Summary: This study revealed the role of Gfi1aa in primitive erythrocyte generation and its ability to inhibit the expression of etv2 and sox7, promoting differentiation of hemangioblasts into primitive erythrocytes. These findings are of great importance for understanding the molecular basis of primitive hematopoiesis and the pathogenesis related to Gfi1aa.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Kai Chen, Fan Lv, Guofeng Xu, Min Zhang, Yeming Wu, Zhixiang Wu
Article
Oncology
Kai Chen, Yuanxia Cai, Min Zhang, Zhixiang Wu, Yeming Wu
PEDIATRIC BLOOD & CANCER
(2018)
Article
Oncology
Sheng Chen, Song Gu, Min Xu, Dongyu Mei, Yongtao Xiao, Kai Chen, Zhilong Yan
PEDIATRIC BLOOD & CANCER
(2020)
Letter
Oncology
Yaoyao Gu, Fan Lv, Yeming Wu, Zhixiang Wu
PEDIATRIC BLOOD & CANCER
(2021)
Article
Medicine, Research & Experimental
Lijia Pan, Litong Nie, Sheng Yao, Aiwei Bi, Yang Ye, Yeming Wu, Zhen Tan, Zhixiang Wu
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Oncology
Yaoyao Gu, Xiaoxiao Hu, Xiaowei Liu, Cheng Cheng, Kai Chen, Yeming Wu, Zhixiang Wu
Summary: High expression of MCM6 is associated with advanced tumor stage, high risk, and poor prognosis in neuroblastoma. Inhibition of MCM6 significantly impairs neuroblastoma cell proliferation, migration, and invasion. MCM6 is considered a driver of G1/S cell cycle progression and a potential therapeutic target in neuroblastoma.
Article
Oncology
Lijia Pan, Cheng Cheng, Peiwen Duan, Kai Chen, Yeming Wu, Zhixiang Wu
Summary: High expression of XPO1 in neuroblastoma is associated with poor prognosis. The specific inhibitor of XPO1, verdinexor, effectively suppresses cell proliferation, induces apoptosis, and causes cell cycle arrest in neuroblastoma cells both in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Xiaowei Liu, Yuanxia Cai, Cheng Cheng, Yaoyao Gu, Xiaoxiao Hu, Kai Chen, Yeming Wu, Zhixiang Wu
Summary: PCLAF is overexpressed in neuroblastoma and is associated with poor prognosis. Knocking down PCLAF restricts neuroblastoma cell proliferation and affects cell cycle-related pathways. PCLAF accelerates the G1/S transition of neuroblastoma cell cycle by activating the E2F1/PTTG1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Biochemical Research Methods
Cheng Cheng, Tian He, Kai Chen, Yuanxia Cai, Yaoyao Gu, Lijia Pan, Peiwen Duan, Yeming Wu, Zhixiang Wu
Summary: This study aimed to explore novel ways to indirectly target N-Myc by regulating its post-translational modifications (PTMs) and therefore protein stability. The researchers discovered that p300 can modulate the protein stability of N-Myc and is correlated with poor prognosis in NB patients.
MOLECULAR & CELLULAR PROTEOMICS
(2023)