期刊
OBESITY
卷 28, 期 -, 页码 S104-S113出版社
WILEY
DOI: 10.1002/oby.22816
关键词
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资金
- NIH/NIDDK Colorado Nutrition Obesity Research Center [P30 DK048520]
- NIH/National Center for Research Resources Colorado Clinical and Translational Sciences Institute [UL1 RR025780, K01 DK113063, K24 DK02935, RO1 DK62874, K01 DK110138]
- University of Colorado Innovative Seed Grant Award
Objective The circadian system provides an organism with the ability to anticipate daily food availability and appropriately coordinate metabolic responses. Simultaneous assessment of factors involved in both the anticipation of energy availability (i.e., hormones involved in appetite regulation) and subsequent metabolic responses (such as energy expenditure and substrate oxidation) have been assessed under conditions designed to reveal circadian rhythmicity in few studies. Methods Eight healthy adults (four females; age: 28.0 +/- 2.3 years; BMI: 24.3 +/- 2.9 kg/m(2)) participated in a 26-hour constant routine protocol involving continuous wakefulness with constant posture, temperature, dim light, and hourly isocaloric snacks. Indirect calorimetry was performed every 3 hours for measurement of energy expenditure and substrate oxidation. Subjective hunger was obtained hourly using questionnaires. Saliva and plasma were obtained hourly to assess melatonin (circadian phase marker) and hormones (leptin, ghrelin, and peptide YY). Results Fat and carbohydrate oxidation were highest in the biological evening and morning, respectively. Subjective hunger ratings peaked during the middle of the biological day. Significant circadian rhythms were identified for ghrelin and peptide YY with peaks in the biological evening and morning, respectively. Conclusions These findings support a role for the circadian system in the modulation of nutrient oxidation, subjective measures of appetite, and appetitive hormones.
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