期刊
CHEMICAL RESEARCH IN TOXICOLOGY
卷 29, 期 3, 页码 430-435出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrestox.6b00038
关键词
-
资金
- faculty development funding from Texas A&M Health Science Center
Phthalates, an endocrine disruptor group, cause oxidative stress (OS) in the placenta. However, no studies have reported OS-related miRNAs induced by phthalates. In the present study, we demonstrate that mono-(2-ethylhexyl) phthalate (MEHP) induces OS responsive miR-17-5p, miR-155-5p, and miR-126-3p in HTR8/SVneo in a dose- and time-dependent manner. Furthermore, MEHP altered the expression of phosphoinositide-3-kinase regulatory subunit 1 alpha phosphatase and tensin homolog, CDKN2A interacting protein, superoxide dismutase 2, and 3 beta-hydroxysterol-D24 reductase, which are involved in OS and predicted to be regulated by these miRNAs. Our results suggest that placental exposure to MEHP may result in aberrant miRNA expression leading to pregnancy complications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据