Editorial Material
Cell Biology
Magali Devriese, Sephora Da Silva, Maryvonnick Carmagnat, Jean-Luc Taupin
Summary: HLA-DRB1*07:143N and HLA-DRB1*07:144 differ from DRB1*07:01:01:01 by single mismatches in exons 3 and 2 respectively.
Article
Immunology
Korbinian N. Kropp, Martina Fatho, Enes Huduti, Marilena Faust, Silke Luebcke, Volker Lennerz, Annette Paschen, Matthias Theobald, Thomas Woelfel, Catherine Woelfel
Summary: This study isolated two CSPG4-reactive T-cell clones and confirmed their specific and efficient recognition of CSPG4+HLA-C*07:01+ cancer cells. Cross-over TCR constructs also showed some level of activity, suggesting potential for further preclinical and clinical evaluation.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Cell Biology
Maria Loginova, Daria Smirnova, Svetlana Kutyavina, Konstantin Kashin, Igor Paramonov
Summary: A single nucleotide replacement in codon 177 of HLA-DRB1*07:01:01:01 leads to the emergence of a novel allele, HLA-DRB1*07:130.
Article
Cell Biology
Maria Loginova, Svetlana Druzhinina, Igor Paramonov
Summary: Three novel HLA-DRB1 alleles, HLA-DRB1*07:150, HLA-DRB1*13:345 and HLA-DRB1*14:256, were identified.
Article
Pharmacology & Pharmacy
Nora Kutszegi, Andras Gezsi, Agnes F. Semsei, Judit Muller, Reka Simon, Erika Rozalia Kovacs, Katalin Hegedus, Gabor T. Kovacs, Csaba Szalai, Daniel J. Erdelyi
Summary: Rs28383172 and rs7775228 are suitable markers for identifying carriers of the HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype, with sensitivity and specificity values exceeding 95%. Patients with a genotype prone to hypersensitivity would benefit more from receiving less immunogenic PEGylated ASP treatment before hypersensitivity develops, incurring minimal additional cost.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Editorial Material
Cell Biology
Maria Loginova, Kristina Repnicyna, Igor Paramonov
Summary: Two novel HLA-DRB1 alleles, HLA-DRB1*04:362 and HLA-DRB1*07:148, were identified using NGS.
Letter
Genetics & Heredity
Christian Schwarm, Damian Gola, Maike M. Holtsche, Anabelle Dieterich, Anita Bhandari, Miriam Freitag, Peter Nuernberg, Mohammad Toliat, Wolfgang Lieb, Michael Wittig, Andre Franke, Margitta Worm, Michael Sticherling, Jan Ehrchen, Claudia Guenther, Regine Glaeser, Wiebke K. Peitsch, Miklos Sardy, Ruediger Eming, Michael Hertl, Sandrine Benoit, Matthias Goebeler, Claudia Pfoehler, Manfred Kunz, Alexander Kreuter, Nina van Beek, Jeanette Erdmann, Hauke Busch, Detlef Zillikens, Christian D. Sadik, Misa Hirose, Inke R. Koenig, Enno Schmidt, Saleh M. Ibrahim
Summary: Bullous pemphigoid (BP) is characterized by autoimmunity against certain proteins, and the strongest association in Germans was found in the HLA loci HLA-DQA1*05:05 and HLA-DRB1*07:01. Further research with larger sample sizes and integrating multiple pathogenic factors is planned.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Editorial Material
Cell Biology
Kuo-Liang Yang, Chi-Cheng Li, Py-Yu Lin
Summary: A nucleotide mutation in codon 34 of HLA-DRB1*07:01:01:01 leads to the creation of a novel allele HLA-DRB1*07:129N.
Article
Biochemistry & Molecular Biology
Roya Ghaffarnia, Zahra Saffarian, Majid Shahbazi, Mahdi Zamani
Summary: The study evaluated the association and role of HLA-DRB4*01:01, -DRB1*07:01, and -DQB1*03:03:2 genes in different clinical subtypes of Vitiligo in the Iranian population. Results showed positive associations of DRB4*01:01 and DRB1*07:01 allelic genes with early-onset Vitiligo, as well as strong protection against late-onset Vitiligo with DRB4*01:01. Additionally, DRB1*07:01 was found to increase susceptibility to Sporadic Vitiligo.
MOLECULAR BIOLOGY REPORTS
(2022)
Editorial Material
Cell Biology
Yanmin He, Xuan You, Sudan Tao, Ji He, Faming Zhu
Summary: Compared to HLA-DRB1*15:01:01:01, the alleles HLA-DRB1*15:01:43 and HLA-DRB1*15:01:44 each exhibit a single nucleotide substitution.
Editorial Material
Cell Biology
Fang Wang, Ying Li, Nanying Chen, Wei Zhang, Faming Zhu
Summary: Compared to HLA-DRB1*09:01:02:01, HLA-DRB1*09:01:12 and HLA-DRB1*09:49 each have one nucleotide substitution, respectively.
Editorial Material
Cell Biology
Evgeny A. Leonov, Ekaterina G. Khamaganova, Elena P. Kuzminova, Alena R. Abdrakhimova, Tatiana V. Gaponova
Summary: Two new gene variants HLA-A*26:01:01:53 and DRB1*01:141 have been identified in Russian individuals.
Editorial Material
Cell Biology
Murielle Verboom, Lina Vergin, Hannah Streich, Michael Hallensleben
Summary: HLA-C*07:1044N differs from HLA-C*07:01:01:01 due to a single nucleotide deletion at codon 124, nt. 442, in exon 3.
Editorial Material
Cell Biology
Maria Rosa Moya-Quiles, Manuel Muro
Summary: Two novel HLA-DPB1 alleles, HLA-DPB1*1443:01 and -DPB1*11:01:07, were detected using next generation sequencing.
Article
Immunology
C. K. Thomsen, R. Steffensen, H. S. Nielsen, A. M. Kolte, M. C. Krog, P. Egerup, E. C. Larsen, T. V. Hviid, O. B. Christiansen
Summary: This study did not confirm an association between HLA-DRB1*03 and RPL, but detected an association with HLA-DRB1*07 for the first time. Typing for HLA-DRB1*07 in RPL patients may help in understanding the pathogenesis of the disease, but further research is needed to confirm this finding.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Allergy
Dean J. Naisbitt, Anna Olsson-Brown, Andrew Gibson, Xiaoli Meng, Monday O. Ogese, Arun Tailor, Paul Thomson
Article
Allergy
Adriana Ariza, Ruben Fernandez-Santamaria, Xiaoli Meng, Maria Salas, Monday O. Ogese, Arun Tailor, Gador Bogas, Maria Jose Torres, Dean J. Naisbitt
Article
Toxicology
Monday O. Ogese, Joel Watkinson, Adam Lister, Lee Faulkner, Andrew Gibson, Aimee Hillegas, Melanie Z. Sakatis, Brian Kevin Park, Dean J. Naisbitt
TOXICOLOGICAL SCIENCES
(2020)
Editorial Material
Gastroenterology & Hepatology
Sandra De Jonghe, Daniel Weinstock, Jason Aligo, Kay Washington, Dean Naisbitt
Article
Allergy
Jobst F. Roehmel, Monday O. Ogese, Alexander Rohrbach, Marcus A. Mall, Dean J. Naisbitt
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Toxicology
James C. Waddington, Xiaoli Meng, Patricia T. Illing, Arun Tailor, Kareena Adair, Paul Whitaker, Jane Hamlett, Rosalind E. Jenkins, John Farrell, Neil Berry, Anthony W. Purcell, Dean J. Naisbitt, Brian Kevin Park
TOXICOLOGICAL SCIENCES
(2020)
Article
Toxicology
Arun Tailor, Xiaoli Meng, Kareena Adair, John Farrell, James C. Waddington, Ann Daly, Munir Pirmohamed, Gordon Dear, B. Kevin Park, Dean J. Naisbitt
TOXICOLOGICAL SCIENCES
(2020)
Article
Chemistry, Medicinal
Andrew Gibson, Sean Hammond, Kanoot Jaruthamsophon, Sharin Roth, Merrie Mosedale, Dean J. Naisbitt
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Article
Immunology
Monday O. Ogese, Adam Lister, Rosalind E. Jenkins, Xiaoli Meng, Ana Alfirevic, Lisa Douglas, Rachel Mcloughlin, Edward Silva, B. Kevin Park, Munir Pirmohamed, Dean J. Naisbitt
JOURNAL OF IMMUNOLOGY
(2020)
Article
Toxicology
Sean Hammond, Andrew Gibson, Kanoot Jaruthamsophon, Sharin Roth, Merrie Mosedale, Dean J. Naisbitt
Summary: Exposure to tolvaptan is associated with a significant risk of liver injury, potentially due to an adaptive immune attack. The study suggests that tolvaptan and metabolite-specific T cells may be candidate effector cells in such injury.
TOXICOLOGICAL SCIENCES
(2021)
Article
Allergy
Paul J. Thomson, Laila Kafu, Xiaoli Meng, Jan Snoeys, An De Bondt, Dries De Maeyer, Hans Wils, Laurent Leclercq, Petra Vinken, Dean J. Naisbitt
Summary: The study aimed to generate and characterize atabecestat(metabolite)-responsive T-cell clones from patients with liver injury. CD4(+) T-cell clones activated via a pharmacological interactions pathway in patients with liver injury suggest an immune-based mechanism for the observed hepatic enzyme elevations.
Article
Multidisciplinary Sciences
Kangsa Amporndanai, Xiaoli Meng, Weijuan Shang, Zhenmig Jin, Yao Zhao, Zihe Rao, Zhi-Jie Liu, Haitao Yang, Leike Zhang, Paul M. O'Neill, S. Samar Hasnain, Michael Rogers
Summary: The study demonstrates that ebselen and its derivatives can effectively inhibit the SARS-CoV-2 main protease with potent antiviral activity. Further analysis reveals that the derivatives show stronger inhibition and ability to rescue infected cells compared to ebselen. The crystallographic structures also confirm the formation of enzyme-bound organoselenium covalent adducts through hydrolysis mechanism, suggesting broader therapeutic applications against SARS-CoV-2 and other zoonotic beta-corona viruses.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Adriana Ariza, Kanoot Jaruthamsophon, Xiaoli Meng, Marina Labella, Kareena Adair, Arun Tailor, Chonlaphat Sukasem, Paul Whitaker, Daniel Peckham, Munir Pirmohamed, Maria Jose Torres, Dean John Naisbitt
Summary: This study reveals that there is cross-reactivity between clavulanic acid and tazobactam due to overlapping antigenic determinants.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Chemistry, Medicinal
Serat-E Ali, Xiaoli Meng, Laila Kafu, Sean Hammond, Qing Zhao, Monday Ogese, Rowena Sison-Young, Robert Jones, Benjamin Chan, Lucia Livoti, Yonghu Sun, Lele Sun, Hong Liu, Anthony Topping, Christopher Goldring, Furen Zhang, Dean John Naisbitt
Summary: This study utilized metabolite-responsive T-cells and primary human hepatocytes to establish a hepatocyte immune cell coculture system for detecting metabolite formation and metabolite-specific T-cell responses. The results showed that metabolites could be transferred between hepatocytes and immune cells and stimulate T-cell proliferation. This study demonstrates the use of hepatocyte immune cell coculture systems for detecting in situ metabolite formation and metabolite-specific T-cell responses.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
James C. Waddington, Serat-E Ali, Sophie L. Penman, Paul Whitaker, Jane Hamlett, Amy Chadwick, Dean J. Naisbitt, B. Kevin Park, Xiaoli Meng
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
