Article
Oncology
Wanxia Li, Chao Yang, Feipeng Zhao, Junzheng Li, Zonghua Li, Ping Ouyang, Xiaofei Yuan, Shuting Wu, Yue Yuan, Linchong Cui, Huiru Feng, Danfan Lin, Zilu Chen, Juan Lu, Xiaohong Peng, Jing Chen
Summary: The study found that smoking has a negative impact on the prognosis of patients with nasopharyngeal carcinoma (NPC), with a dose-dependent effect on survival outcomes. Furthermore, the combination of cumulative smoking consumption and pre-treatment EBV DNA levels was identified as an independent predictor of poor prognosis in male NPC.
Article
Cell Biology
Sieglinde Zelzer, Edith Hofer, Andreas Meinitzer, Eva Fritz-Petrin, Sebastian Simstich, Walter Goessler, Reinhold Schmidt, Markus Herrmann
Summary: The study found that vitamin D metabolites were associated with memory function in elderly individuals, with deficient individuals showing poorer memory performance without structural brain atrophy. Future research should further investigate whether vitamin D supplementation can improve cognitive function.
Article
Endocrinology & Metabolism
Johanna Oberg, Rolf Jorde, Bjorg Almas, Christopher Sivert Nielsen, Thomas Alexander Gerds, Kevin D. Cashman, Guri Grimnes
Summary: This study presents population-based data from an Arctic adolescent population, investigating the changes in vitamin D status during adolescence and the potential impact of lifestyle changes on vitamin D levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
F. Alhussain, M. Alomar, A. Alenazi, M. Aldraihem, L. Alshiha, S. Bashir
Summary: The study aimed to investigate the relationship between vitamin D levels and cognitive function in MS patients. Results showed impaired cognitive performance in MS patients, with vitamin D deficiency potentially predicting cognitive impairment independently.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marie Bicikova, Ludmila Macova, Martin Hill
Summary: Vitamin D plays an important role in immunomodulation, brain development, and functioning. Its potential immunoprotective role in COVID-19 has been discussed. This study found that individuals who took vitamin D had a significantly lower risk of COVID-19 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Carl Jenkinson, Reena Desai, Malcolm D. McLeod, Jonathan Wolf Mueller, Martin Hewison, David J. Handelsman
Summary: This study analyzed the contribution of sulfate and glucuronide vitamin D metabolites relative to unconjugated levels in human serum. The results showed that sulfate conjugates formed a higher proportion of circulating vitamin D metabolites compared to glucuronide conjugates. The findings suggest that a combination of both conjugated and unconjugated measurements may provide a more accurate assessment of vitamin D status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Anne Gaml-Sorensen, Nis Brix, Lea Lykke Harrits Lunddorf, Andreas Ernst, Birgit Bjerre Hoyer, Gunnar Toft, Tine Brink Henriksen, Cecilia Host Ramlau-Hansen
Summary: Maternal intake of vitamin D supplements may affect the timing of puberty in children, with a more significant impact observed in boys.
Article
Nutrition & Dietetics
Naoko Tsugawa, Mayu Nishino, Akiko Kuwabara, Honami Ogasawara, Maya Kamao, Shunjiro Kobayashi, Junichi Yamamura, Satoshi Higurashi
Summary: The study found that the low vitamin D status in recent lactating mothers may have decreased the concentrations of vitamin D and 25OHD in breast milk, compared to the 1980s. This has important implications for improving the vitamin D status of lactating mothers and infants.
Article
Nutrition & Dietetics
Francois Parant, Justin Bouloy, Julie Haesebaert, Lamia Bendim'red, Karine Goldet, Philippe Vanhems, Laetitia Henaff, Thomas Gilbert, Charlotte Cuerq, Emilie Blond, Muriel Bost, Marc Bonnefoy
Summary: This study aimed to assess the relationships between vitamin D status and supplementation and the severity of COVID-19 in older adults. The study found that vitamin D supplementation taken during the 3 months preceding the infection onset may have a protective effect on the development of severe forms of COVID-19. Age, gender, and BMI were also found to be associated with the severity of COVID-19.
Article
Dentistry, Oral Surgery & Medicine
F. R. M. Leite, R. Lopez, J. B. Pajaniaye, G. G. Nascimento
Summary: This study investigated the influence of different levels of smoking on periodontal healing and found that heavy smokers had worse periodontal parameters compared to light smokers/quitters and moderate smokers after nonsurgical periodontal therapy. Therefore, smoking cessation should be included in periodontal therapy to achieve optimal treatment outcomes.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Oncology
Ikuko Kato, Jun Sun, Theresa A. Hastert, Judy Abrams, Joseph C. Larson, Wei Bao, Aladdin H. Shadyab, Charles Mouton, Lihong Qi, Lisa Warsinger Martin, JoAnn E. Manson
Summary: Low circulating vitamin D levels are more prevalent in Black than White individuals. Calcium plus vitamin D supplementation does not reduce risks of cancer, CVD, or other major causes of death in Black women overall. Other medical, behavioral, or social interventions should be considered to narrow health disparities related to these outcomes. However, further investigation is needed for colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Mioara Desdemona Stepan, Stefanita Bianca Vintilescu, Ioana Streata, Mihaela Andreea Podeanu, Dan Nicolae Florescu
Summary: Non-alcoholic fatty liver disease (NAFLD) is a complex chronic condition that is one of the most important issues in pediatric pathology due to the lack of screening-monitoring markers and effective standardized treatment. This study analyzed the role of vitamin D supplementation in obese children with or without NAFLD and its impact on the components of metabolic syndrome (MS). The results showed that there was a statistical association between NAFLD and MS components, which were present in both simple obesity and the 6-9 years age group. Vitamin D deficiency was associated with obesity, NAFLD, and MS components, and correcting the deficiency tended to normalize the associated parameters. Treatment based solely on the regimen led to decreases in vitamin D values and additional alterations of certain parameters. Supplementation with vitamin D enhanced the effects of the specific regimen, and its effects seemed to be dependent on the MS components.
Article
Obstetrics & Gynecology
Pelle G. Lindqvist, Mika Gissler, Birgitta Essen
Summary: Sweden and Finland have a high proportion of low plasma vitamin D levels. National vitamin D fortification was associated with a 15% drop in stillbirths. This finding could be a milestone in preventing stillbirths and reducing health inequalities.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Aysun Erdem Yaman, Ufuk Sadik Ceylan
Summary: Vitamin D levels are associated with long-term cardiac events in patients with coronary artery disease, and vitamin D deficiency is linked to an increased risk of non-ST-elevated myocardial infarction and unstable angina.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Kunchit Judprasong, Sochannet Chheng, Chanika Chimkerd, Sitima Jittinandana, Nattapol Tangsuphoom, Piyanut Sridonpai
Summary: This study examined the effect and stability of UV-B irradiation and subsequent cooking on the vitamin D content in commonly consumed mushrooms in Thailand. The results showed that UV-B irradiation significantly increased the vitamin D2 content in all mushroom varieties, with the highest increase observed in enokitake mushrooms. UV-B irradiation also increased the levels of 25-OH D2 and vitamin D4 in enokitake mushrooms. The true retention of vitamin D2 after cooking ranged from 53% to 89%, with stir-fried mushrooms having the highest retention. The two-sided UV-B cabinet has the potential to increase the vitamin D content in commercial mushroom production with economic investment.
Article
Clinical Neurology
Jens Kuhle, Tanuja Chitnis, Brenda Banwell, Marc Tardieu, Douglas L. Arnold, Andreea M. Rawlings, Svend S. Geertsen, Alex L. Lublin, Stephane Saubadu, Philippe Truffinet, Ludwig Kappos
Summary: The TERIKIDS study demonstrated that teriflunomide is effective and safe in children with relapsing multiple sclerosis (RMS). Teriflunomide treatment is associated with significantly reduced pNfL levels in children with RMS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Tim Spelman, Serkan Ozakbas, Raed Alroughani, Murat Terzi, Suzanne Hodgkinson, Guy Laureys, Tomas Kalincik, Anneke Van der Walt, Bassem Yamout, Jeannette Lechner-Scott, Aysun Soysal, Jens Kuhle, Jose Luis Sanchez-Menoyo, Yolanda Blanco Morgado, Daniele La Spitaleri, Vincent van Pesch, Dana Horakova, Radek Ampapa, Francesco Patti, Richard Macdonell, Abdullah Al-Asmi, Oliver Gerlach, Jiwon Oh, Ayse Altintas, Namita Tundia, Schiffon L. Wong, Helmut Butzkueven
Summary: This study compared treatment patterns and clinical outcomes of multiple sclerosis (MS) patients treated with cladribine tablets versus other oral disease-modifying treatment (DMT) using real-world data. The results demonstrated that cladribine tablets were associated with longer treatment persistence, delayed time to first relapse, and lower relapse rate compared to other oral DMTs.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Christian Barro, Brian C. Healy, Yanqing Liu, Shrishti Saxena, Anu Paul, Mariann Polgar-Turcsanyi, Charles R. G. Guttmann, Rohit Bakshi, Harald Kropshofer, Howard L. Weiner, Tanuja Chitnis
Summary: Neurodegeneration and astrocytic activation are characteristic pathological features of progressive MS. sNfL and sGFAP can be used as tools to stratify patients based on progression and disease activity status.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Editorial Material
Clinical Neurology
Felix Hess, Paula Uibel, Achim Berthele, Bernhard Hemmer
Article
Clinical Neurology
Rene Carvajal, Carmen Tur, Xavier Martinez-Gomez, Luca Bollo, Juliana Esperalba, Marta Rodriguez, Agustin Pappolla, Alvaro Cobo-Calvo, Pere Carbonell, Blanca Borras-Bemejo, Jordi Rio, Joaquin Castillo, Nathane Braga, Neus Mongay-Ochoa, Jose Angel Rodrigo-Pendas, Angela Vidal-Jordana, Georgina Arrambide, Breogan Rodriguez-Acevedo, Ana Zabalza, Luciana Midaglia, Ingrid Galan, Manuel Comabella, Jaume Sastre-Garriga, Xavier Montalban, Mar Tintore, Susana Otero-Romero
Summary: A single-dose attempt of VAR and/or MMR vaccines could effectively protect almost two-thirds of patients with multiple sclerosis and reduce delays in immunosuppressive treatment initiation.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Alan J. Thompson, Marcello Moccia, Maria Pia Amato, Peter A. Calabresi, Marcia Finlayson, Annie Hawton, Fred D. Lublin, Ruth Ann Marrie, Xavier Montalban, Michael Panzara, Maria Pia Sormani, Jon Strum, Barbara G. Vickrey, Timothy Coetzee
Summary: The survey results show that stakeholders of multiple sclerosis (MS) believe that the current clinical course descriptors need to change and support a mechanism-driven framework for describing MS. Clinical validation and ease of communication with patients are the most important considerations when developing a new framework.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Immunology
Maria Inmaculada Dominguez-Mozo, Ines Gonzalez-Suarez, Luisa Maria Villar, Lucienne Costa-Frossard, Noelia Villarrubia, Yolanda Aladro, Belen Pilo, Xavier Montalban, Manuel Comabella, Ignacio Casanova-Peno, Maria Luisa Martinez-Gines, Jose Manuel Garcia-Dominguez, Maria Angel Garcia-Martinez, Rafael Arroyo, Roberto Alvarez-Lafuente
Summary: Treatment with teriflunomide reduced IgG antibody titers against EBV and HHV-6. Higher levels of EBNA-1 IgG prior to teriflunomide initiation were associated with a better clinical response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Nicolas Fissolo, Laura Calvo-Barreiro, Herena Eixarch, Ursula Boschert, Luisa M. Villar, Lucienne Costa-Frossard, Mireia Ferrer, Alex Sanchez, Eva Borras, Eduard Sabido, Carmen Espejo, Xavier Montalban, Manuel Comabella
Summary: This study characterized the transcriptomic and proteomic profiles induced by cladribine in blood cells, and identified potential treatment response biomarkers to cladribine in patients with multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Ilaria Callegari, Mika Schneider, Vera Aebischer, Margarete M. M. Voortman, Undine Proschmann, Tjalf Ziemssen, Raija Lindberg, Bettina Fischer-Barnicol, Michael Khalil, Ludwig Kappos, Jens Kuhle, Nicholas S. R. Sanderson, Tobias Derfuss
Summary: This study found that natalizumab can diffuse in different anatomical compartments, including cerebrospinal fluid and milk. By developing a flow-cytometry-based assay and applying it to quantify natalizumab in body fluids, including cerebrospinal fluid, breastmilk, and serum, a better understanding of the safety of therapeutic antibody administration during pregnancy and lactation can be achieved.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
Rozhin Ashgari, Jutta Gaertner, Stephen Hauser, Amit Bar-Or, Xavier Montalban, Jeffrey Cohen, Derrick Robertson, Anne Cross, Carrie Hersh, Kumaran Deiva, Karlsson Goeri, Ayan Das Gupta, Ronald Zielman, Soudeh Ansari, Bernd Kieseier, Ludwig Kappos
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
Michael Barnett, Andrew Chan, Huiyu Feng, Kazuo Fujihara, Gavin Giovannoni, Ralf Gold, Xavier Montalban, Fu-Dong Shi, Maria Tintore, Qun Xue, Chunsheng Yang, Hongyu Zhou
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
Xavier Montalban, Jens Kuhle, Robert Fox, Timothy Vartanian, Dana Horakova, Massimo Filippi, Ernest Roos, Erik Wallstroem, Nazem Atassi
Meeting Abstract
Clinical Neurology
Xavier Montalban, Jerry S. Wolinsky, Douglas L. Arnold, Martin S. Weber, Karolina Piasecka-Stryczynska, Davorka Tomic, Andrea Seitzinger, Hans Guehring
Meeting Abstract
Clinical Neurology
X. Montalban, J. Kuhle, R. Fox, T. Vartanian, D. Horakova, M. Filippi, E. Roos, V. Nicolas, E. Wallstroem, N. Atassi
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
X. Montalban, J. S. Wolinsky, D. L. Arnold, M. S. Weber, K. Piasecka-Stryczynska, D. Tomic, A. Seitzinger, H. Guehring
MULTIPLE SCLEROSIS JOURNAL
(2023)