Article
Clinical Neurology
Erik H. Middlebrooks, Ayushi Jain, Lela Okromelidze, Chen Lin, Erin M. Westerhold, Chad A. O'Steen, Anthony L. Ritaccio, Alfredo Quinones-Hinojosa, William O. Tatum, Sanjeet S. Grewal
Summary: The study showed that high-frequency stimulation (HFS) and low-frequency stimulation (LFS) in deep brain stimulation (DBS) for epilepsy treatment produce significant differences in local and downstream network effects, particularly displaying opposing effects within the limbic network and default mode network (DMN).
Article
Clinical Neurology
Robert E. Gross, Robert S. Fisher, Michael R. Sperling, Jonathon E. Giftakis, Paul H. Stypulkowski
Summary: This study analyzed the relationship between DBS lead locations and clinical outcomes, finding that subjects with good bilateral lead placements based on defined targets were more likely to be clinical responders. Specific sites within the ANT may be associated with superior clinical outcomes, highlighting the importance of continuing to evaluate these relationships to optimize DBS therapy.
Article
Clinical Neurology
Giovanna Aiello, Debora Ledergerber, Tena Dubcek, Lennart Stieglitz, Christian Baumann, Rafael Polania, Lukas Imbach
Summary: This study provides a detailed neurofunctional characterization of the interaction between the anterior nucleus of the thalamus (ANT) and the cortex, revealing the mechanisms of ANT deep brain stimulation (DBS) therapy and proposing electrophysiological biomarkers as predictors of treatment efficacy. It delivers crucial information for optimizing clinical DBS responses in patients with drug-resistant epilepsy.
Article
Clinical Neurology
Cuiping Xu, Lei Qi, Xueyuan Wang, Frederic L. W. V. J. Schaper, Di Wu, Tao Yu, Xiaoming Yan, Guangyuan Jin, Qiao Wang, Xiaopeng Wang, Xinqi Huang, Yuke Wang, Yuanhong Chen, Jinghui Liu, Yuping Wang, Andreas Horn, Robert S. Fisher, Liankun Ren
Summary: This study aimed to investigate whether the functional connectivity between the ANT-DBS sites and the seizure foci is associated with effective seizure control in refractory epilepsy.
Article
Neurosciences
Kaijia Yu, Zhiwei Ren, Tao Yu, Xueyuan Wang, Yongsheng Hu, Song Guo, Jianyu Li, Yongjie Li
Summary: The study investigated the potential of using 3T QSM to delineate the ANT in the human brain, finding that QSM can clearly visualize the ANT and may be suitable for DBS surgery targeting. The morphology and location of the ANT were found to be highly variable among patients in the AC-PC system.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Elisabeth Kaufmann, Kai Boetzel, Christian Vollmar, Jan-Hinnerk Mehrkens, Soheyl Noachtar
Summary: The study retrospectively analyzed the long-term outcomes of 23 patients with anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), showing that most patients experienced a reduction in seizure frequency of over 50% and had positive treatment effects. Bilateral implantation and successful stimulation of the ANT appeared to be more effective in controlling seizures.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Adeel Ilyas, Kathryn M. Snyder, Tessy M. Thomas, Nitin Tandon
Summary: This study reviewed seven studies on ANT DBS and found that 56% of patients were considered responders at an average follow-up of 2.3 years post-DBS. The active contacts of responders were found to be 1.6 mm anterior compared to nonresponders and were adjacent to the MTT.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Jana C. Buenzli, Esther Werth, Christian R. Baumann, Anina Belvedere, Roland Renzel, Lennart H. Stieglitz, Lukas L. Imbach
Summary: In this study, the impact of continuous deep brain stimulation (DBS) on sleep in epilepsy patients was investigated. The findings showed that continuous high-frequency DBS leads to more consolidated and deeper slow wave sleep (SWS). The location of the stimulation contact within the anterior nucleus of the thalamus (ANT) was also found to be related to the changes in SWS.
Article
Clinical Neurology
Juan Luis Alcala-Zermeno, Nicholas M. Gregg, Elaine C. Wirrell, Matt Stead, Gregory A. Worrell, Jamie J. Van Gompel, Brian Nils Lundstrom
Summary: The study reported on 16 children and adults with drug resistant epilepsy who underwent deep brain stimulation targeting the centromedian and anterior nucleus of the thalamus. Results showed a significant reduction in seizure frequency, improved life satisfaction, and relative safety of the DBS treatment.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Clinical Neurology
Hao Yan, Xueyuan Wang, Xiaohua Zhang, Liang Qiao, Runshi Gao, Duanyu Ni, Wei Shu, Cuiping Xu, Liankun Ren, Tao Yu
Summary: By studying the surgical outcome of deep brain stimulation (DBS) of different target nuclei for patients with refractory epilepsy, we aimed to explore a clinically feasible target nucleus selection strategy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Tingting Du, Yingchuan Chen, Lin Shi, Defeng Liu, Yuye Liu, Tianshuo Yuan, Xin Zhang, Guanyu Zhu, Jianguo Zhang
Summary: The study showed that ANT-DBS can decrease seizure frequency, reduce neuronal loss and apoptosis in the basal ganglia, increase D1 and D2 receptor expression, and downregulate overactivation of the GPi, enhancing the antiepileptic function of the basal ganglia.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Abhijeet Gummadavelli, Dario J. Englot, Jason M. Schwalb, Chengyuan Wu, Jorge Gonzalez-Martinez, Joseph Niemat, Jason L. Gerrard
Summary: Neuromodulation has provided additional surgical treatment options for patients with medically refractory epilepsy, especially for those who are not candidates for resective surgery. DBS of the bilateral anterior nucleus of the thalamus has been proven to be a safe and effective treatment option for refractory focal epilepsy.
Article
Neurosciences
Sungjun Bae, Hyun-Kyoung Lim, Yoonyi Jeong, Seong-Gi Kim, Sung-Min Park, Young-Min Shon, Minah Suh
Summary: This study examined the mechanism of ANT-DBS in treating refractory temporal lobe epilepsy. The results showed that ANT-DBS not only reduced the number of seizures, but also induced cellular changes in the hippocampus, specifically in inhibitory neurons.
Review
Neurosciences
Dayton P. Grogan, Henry M. Skelton, Alejandra M. Fernandez, Claire-Anne N. E. Gutekunst, Robert E. Gross
Summary: Electrical deep brain stimulation (DBS) is a common treatment for medically refractory epilepsy. The mechanism underlying DBS remains largely unknown. This paper explores the role of cholinergic projections from the laterodorsal tegmentum (LDT) in seizure mitigation and encourages further research in this area.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Clinical Neurology
Manuel L. Herrera, Ana Suller-Marti, Andrew Parrent, Keith MacDougall, Jorge G. Burneo
Summary: ANT-DBS is an effective and safe treatment for focal therapy-resistant epilepsy, especially beneficial for patients with multifocal epilepsy due to regional lesion. Further research is needed to determine the optimal stimulation parameters.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Agnes Langer, Lara Lucke-Paulig, Lucia Gassner, Rejko Krueger, Daniel Weiss, Alireza Gharabaghi, Heidemarie Zach, Walter Maetzler, Markus A. Hobert
Summary: This study compared the effects of deep brain stimulation and dopaminergic medication on gait parameters in patients with advanced Parkinson disease. The results showed that dopaminergic medication had larger additional effects on gait parameters under both single-tasking and dual-tasking conditions, while deep brain stimulation only improved specific gait parameters.
Article
Neurosciences
Kathrin Machetanz, Florian Grimm, Ruth Schaefer, Leonidas Trakolis, Helene Hurth, Patrick Haas, Alireza Gharabaghi, Marcos Tatagiba, Georgios Naros
Summary: This study introduces a cost-effective custom-made EMG biofeedback system for facial rehabilitation, demonstrating its good application potential in both healthy subjects and patients with facial palsy. There is a correlation between electrophysiological measurements and clinical outcomes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jonas M. Getzmann, Hamidreza Ashouri, Jakob M. Burgstaller, Fabio Valeri, Sebastian Winklhofer, Nils H. Ulrich, Roman Guggenberger
Summary: This study found that paraspinal fatty muscle infiltration (FMI) and cumulative lumbar spine degeneration have an influence on long-term clinical outcomes in patients with lumbar spinal canal stenosis (LSCS). Total lumbar spine degeneration is not associated with clinical symptoms, while FMI is associated with lower function and quality of life in LSCS patients.
Article
Neurosciences
Maximilian Scherer, Tianlu Wang, Robert Guggenberger, Luka Milosevic, Alireza Gharabaghi
Summary: Neural communication across different spatial and temporal scales is of great interest in clinical and basic science. The direct modulation index (dMI), a novel measure, provides an accurate and reliable estimate of phase-amplitude coupling (PAC), resistant to noise and suitable for small amounts of data. Comparisons with existing methods show that dMI outperforms them in estimating PAC and is robust to varying noise levels and signal lengths. Therefore, dMI allows for a reliable investigation of PAC, offering crucial insights into functional brain architecture in key contexts such as behavior and cognition.
HUMAN BRAIN MAPPING
(2023)
Article
Neuroimaging
Kevin Kern, Mathias Vukelic, Robert Guggenberger, Alireza Gharabaghi
Summary: Motor restoration after severe stroke is often limited. However, some severely impaired stroke patients still have rehabilitative potential. A study found that biomarkers can identify these patients and promote improvement in wrist movement through rehabilitation training using a brain-machine interface.
NEUROIMAGE-CLINICAL
(2023)
Article
Medicine, Research & Experimental
Lara Planas-Paz, Alicia Pliego-Mendieta, Catherine Hagedorn, Domingo Aguilera-Garcia, Martina Haberecker, Fabian Arnold, Marius Herzog, Lorenz Bankel, Roman Guggenberger, Sabrina Steiner, Yanjiang Chen, Abdullah Kahraman, Martin Zoche, Mark A. Rubin, Holger Moch, Christian Britschgi, Chantal Pauli
Summary: Defects in homologous recombination repair (HRR) in tumors are associated with poor prognosis and metastases development. This study focuses on sarcoma and reveals high levels of genomic instability signatures and molecular alterations in HRR genes in specific sarcoma entities. Sarcomas with HRDness traits show a distinct transcriptional signature and lack RAD51 nuclear foci formation upon DNA damage. The study also identifies the therapeutic vulnerability of WEE1 kinase in sarcomas with HRDness.
EMBO MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Nevena Stajkovic, Yuanyuan Liu, Aleksandra Arsic, Ning Meng, Hang Lyu, Nan Zhang, Dirk Grimm, Holger Lerche, Ivana Nikic-Spiegel
Summary: We established a novel approach for live labeling of the axon initial segment (AIS) using unnatural amino acids (UAAs) and click chemistry. This method allowed us to label two large AIS components, neurofascin (NF186) and voltage-gated Na+ channel (NaV1.6), and study their localization using conventional and super-resolution microscopy.
JOURNAL OF CELL SCIENCE
(2023)
Article
Orthopedics
Esin Rothenfluh, Sambhav Jain, Roman Guggenberger, William R. Taylor, Seyyed Hamed Hosseini Nasab
Summary: The study investigated the extent of scaphoid waist fracture union required to withstand physiological loads using a finite element model based on a CT scan. The results showed that at least 60% union is needed for biomechanical stability, and a quantitative CT scan analysis can guide clinicians to determine if mid-waist scaphoid fractures are truly united.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2023)
Editorial Material
Clinical Neurology
Leon A. Steiner, Luka Milosevic
Summary: This scientific commentary discusses the research of Johnson et al. on how deep brain stimulation in the globus pallidus internus can induce resonant neural activity in Parkinson's disease patients.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Wolf-Julian Neumann, Leon A. Steiner, Luka Milosevic
Summary: Deep brain stimulation is a neuromodulatory treatment that uses electrodes to deliver pulsatile electrical stimulation to disease-relevant brain regions, aiming to restore neurocircuit function. However, the mechanisms of deep brain stimulation and its effects on brain activity are not fully understood.
Review
Biochemistry & Molecular Biology
Robert J. Lauerer, Holger Lerche
Summary: This review summarizes the importance of VGCC in the central nervous system and its association with epilepsy-related genes, providing guidance for disease-specific therapies when applicable.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Medicine, General & Internal
Malwina Kaniewska, Eva Deininger-Czermak, Maelene Lohezic, Falko Ensle, Roman Guggenberger
Summary: This study assessed the diagnostic performance of standard radial k-space (PROPELLER) MRI sequences and compared them with accelerated acquisitions combined with a deep learning-based convolutional neural network (DL-CNN) reconstruction for evaluation of the knee joint. The results showed that DL-CNN sequences had significantly higher image quality and diagnostic confidence compared to standard sequences. Both sequences performed similarly in the detection of knee-joint pathologies, but DL-CNN sequences were superior in evaluating retropatellar cartilage lesions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eva Deininger-Czermak, Dominic Gascho, Sabine Franckenberg, Pascal Kalin, Christian Bluthgen, Christina Villefort, Michael J. Thali, Roman Guggenberger
Summary: This study evaluated the added value of ultra-short echo time (UTE) and fast field echo resembling a CT using restricted echo-spacing (FRACTURE) MR sequences in the assessment of the osseous cervical spine. The results showed that compared to CT, the combination of UTE or FRACTURE sequences with standard MR sequences can provide comparable information on the cervical spine status, and can change the clinically significant stenosis grading.
Article
Radiology, Nuclear Medicine & Medical Imaging
Malwina Kaniewska, Eva Deininger-Czermak, Jonas M. Getzmann, Xinzeng Wang, Maelene Lohezic, Roman Guggenberger
Summary: Accelerated PROPELLER MRI sequences with DL post-processing showed superior image quality and higher diagnostic confidence compared to conventional sequences, particularly in assessing the pathologies of the subacromial bursa.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
