Long-term clinically relevant rodent model of methotrexate-induced cognitive impairment

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Chemotherapy and cognition: International cognition and cancer task force recommendations for harmonising preclinical research

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Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model

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Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

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Long-term brain structural magnetic resonance imaging and cognitive functioning in children treated for acute lymphoblastic leukemia with high-dose methotrexate chemotherapy alone or combined with CNS radiotherapy at reduced total dose to 12 Gy

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Neurobiological changes by cytotoxic agents in mice

(2016) R. Seigers et al.   BEHAVIOURAL BRAIN RESEARCH

Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitors Remyelinate the Brain and Rescue Behavioral Deficits following Radiation

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Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat

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Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia

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Chemotherapy-related cognitive dysfunction: current animal studies and future directions

(2013) R. Seigers et al.   Brain Imaging and Behavior

Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: a review

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Diffusion tensor imaging of hippocampal network plasticity

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Effects of chemotherapy on the brain in childhood: diffusion tensor imaging of subtle white matter damage

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Chemotherapy-Related Cognitive Dysfunction

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Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy

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Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats

(2009) Riejanne Seigers et al.   BEHAVIOURAL BRAIN RESEARCH

Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release

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Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor

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Recurrent intrathecal methotrexate induced neurotoxicity in an adolescent with acute lymphoblastic leukemia: Serial clinical and radiologic findings

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Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat

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