期刊
NATURE REVIEWS NEUROSCIENCE
卷 21, 期 5, 页码 264-276出版社
NATURE RESEARCH
DOI: 10.1038/s41583-020-0287-1
关键词
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资金
- Wellcome Trust [091593/Z/10/Z, 098362/A/12/Z] Funding Source: Medline
The very earliest stages of sensory processing have the potential to alter how we perceive and respond to our environment. These initial processing circuits can incorporate subcortical regions, such as the thalamus and brainstem nuclei, which mediate complex interactions with the brain's cortical processing hierarchy. These subcortical pathways, many of which we share with other animals, are not merely vestigial but appear to function as 'shortcuts' that ensure processing efficiency and preservation of vital life-preserving functions, such as harm avoidance, adaptive social interactions and efficient decision-making. Here, we propose that functional interactions between these higher-order and lower-order brain areas contribute to atypical sensory and cognitive processing that characterizes numerous neuropsychiatric disorders. Early processing in subcortical areas has been underemphasized in models of how perception and cognition are altered in psychiatric disorders. Here, McFadyen and colleagues review recent discoveries in how subcortical-cortical dynamics contribute to perception and higher-order cognition.
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