Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

(2019) Paul RHJ Timmers et al.   eLife

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

(2019) Tom G Richardson et al.   eLife

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

(2019) Mashaal Sohail et al.   eLife

Analysis of polygenic risk score usage and performance in diverse human populations

(2019) L. Duncan et al.   Nature Communications

The “All of Us” Research Program

(2019)   NEW ENGLAND JOURNAL OF MEDICINE

Characterizing rare and low-frequency height-associated variants in the Japanese population

(2019) Masato Akiyama et al.   Nature Communications

Left ventricular hypertrophy offsets the sex difference in cardiovascular risk (the Campania Salute Network)

(2018) Eva Gerdts et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

(2018) Fredrick R. Schumacher et al.   NATURE GENETICS

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Adult height and all-cause and cause-specific mortality in the Japan Public Health Center-based Prospective Study (JPHC)

(2018) Hikaru Ihira et al.   PLoS One

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Risk Factors, Mortality, and Cardiovascular Outcomes in Patients with Type 2 Diabetes

(2018) Aidin Rawshani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

(2018) Symen Ligthart et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Behavioral impact of return of genetic test results for complex disease: Systematic review and meta-analysis.

(2018) Maia J. Frieser et al.   HEALTH PSYCHOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Overview of the BioBank Japan Project: Study design and profile

(2017) Akiko Nagai et al.   JOURNAL OF EPIDEMIOLOGY

Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases

(2017) Makoto Hirata et al.   JOURNAL OF EPIDEMIOLOGY

Overview of BioBank Japan follow-up data in 32 diseases

(2017) Makoto Hirata et al.   JOURNAL OF EPIDEMIOLOGY

Association of Changes in Diet Quality with Total and Cause-Specific Mortality

(2017) Mercedes Sotos-Prieto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

(2017) Peter K. Joshi et al.   Nature Communications

Genotype Imputation with Millions of Reference Samples

(2016) Brian L. Browning et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Age-sex-specific ranges of platelet count and all-cause mortality: prospective findings from the MOLI-SANI study

(2016) M. Bonaccio et al.   BLOOD

Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review

(2016) Uffe Ravnskov et al.   BMJ Open

Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials

(2015) Jessica L Mega et al.   LANCET

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Liver enzymes and risk of all-cause mortality in general populations: a systematic review and meta-analysis

(2014) Setor K Kunutsor et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons

(2014) Krista Fischer et al.   PLOS MEDICINE

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Use of allele scores as instrumental variables for Mendelian randomization

(2013) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

50-Year Trends in Smoking-Related Mortality in the United States

(2013) Michael J. Thun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

(2012) et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Cardiovascular Outcomes in Framingham Participants With Diabetes

(2011) Guanmin Chen et al.   HYPERTENSION

Relation Between Blood Pressure and Vascular Events and Mortality in Patients With Manifest Vascular Disease

(2011) Johannes A.N. Dorresteijn et al.   HYPERTENSION

Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians

(2011) Wei Zheng et al.   NEW ENGLAND JOURNAL OF MEDICINE

Premature deaths attributable to blood pressure in China: a prospective cohort study

(2009) Jiang He et al.   LANCET