Gut stem cell necroptosis by genome instability triggers bowel inflammation

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

(2019) Yong-Jie Zhang et al.   SCIENCE

Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination

(2019) Zhixiong Liu et al.   NEURON

Female-biased embryonic death from inflammation induced by genomic instability

(2019) Adrian J. McNairn et al.   NATURE

Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell

(2019) Arshad Ayyaz et al.   NATURE

OUP accepted manuscript

(2018)   BIOINFORMATICS

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

(2018) Wanqiang Sheng et al.   CELL

Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease

(2018) Kelli L. VanDussen et al.   GASTROENTEROLOGY

In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity

(2018) Kun Zhang et al.   Cell Stem Cell

­­­Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia­­

(2017) Trinna L. Cuellar et al.   JOURNAL OF CELL BIOLOGY

Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis

(2017) Huairui Yuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Environmental triggers in IBD: a review of progress and evidence

(2017) Ashwin N. Ananthakrishnan et al.   Nature Reviews Gastroenterology & Hepatology

Clonal evolution of colorectal cancer in IBD

(2017) Chang-Ho R. Choi et al.   Nature Reviews Gastroenterology & Hepatology

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy

(2017) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis

(2017) Yongfeng Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Pediatric Inflammatory Bowel Disease

(2016) Joanna M. Peloquin et al.   Annual Review of Immunology

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells

(2016) Alessandra Pasquarella et al.   DEVELOPMENT

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

(2016) Silvia Alvarez-Diaz et al.   IMMUNITY

RIPK1 inhibits ZBP1-driven necroptosis during development

(2016) Kim Newton et al.   NATURE

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

(2016) Juan Lin et al.   NATURE

Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II

(2016) Xiaodong Lu et al.   NUCLEIC ACIDS RESEARCH

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes

(2015) Patrick L. Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

(2014) Q Remijsen et al.   Cell Death & Disease

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

(2013) Wei Mo et al.   CELL

DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs

(2011) Mohammad M. Karimi et al.   Cell Stem Cell

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Nuclear β-Arrestin1 Functions as a Scaffold for the Dephosphorylation of STAT1 and Moderates the Antiviral Activity of IFN-γ

(2008) Wei Mo et al.   MOLECULAR CELL