Chevalierinol A and B, two new neolignan sesquiterpenoids from Magnolia chevalieri

Two new neolignan sesquiterpenoids, chevalierinol A (1) and chevalierinol B (2), were isolated from the ethyl acetate extract of Magnolia chevalieri leaves, together with twelve known compounds (3-14). Their structures were elucidated by analysis of spectroscopic data including 1D, 2D and mass spectra and compared with the reported data. Compounds 1, 3, 4, 6, 7, 10 were evaluated for their inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophage cells.

Automated summary

Two new neolignan sesquiterpenoids, chevalierinol A and chevalierinol B, were isolated from Magnolia chevalieri leaves, along with twelve known compounds. The structures of these compounds were determined by spectroscopic data analysis and compared with reported data. Compound 1, 3, 4, 6, 7, and 10 showed inhibitory effects on nitric oxide production in RAW264.7 macrophage cells induced by lipopolysaccharide.