期刊
MONATSHEFTE FUR CHEMIE
卷 151, 期 8, 页码 1235-1240出版社
SPRINGER WIEN
DOI: 10.1007/s00706-020-02622-5
关键词
Reversed-phase liquid chromatography; Liquid crystals; Chirality; Polysaccharide-based column; Enantiomeric resolution; Polar organic mode
Fast baseline enantioseparation of twenty racemic liquid crystalline compounds was carried out via ultra-performance liquid chromatography through direct enantioseparation in polar organic and reversed-phase modes. Tris(3-chloro-5-methyl-phenylcarbamate) derivative of amylose was used as chiral stationary phase; the chiral selector was covalently immobilized on sub-2 mu m silica particles. Experiments were done using either pure acetonitrile as mobile phase or simple binary mobile phases consisting of acetonitrile/water mixtures in different volume ratios. No buffers or additives were used. Studied materials are a set of structurally similar compounds comprising two different structures of chiral center, various length of alkoxy spacer and four patterns of lateral substitution of aromatic core by fluorine. The compounds do not contain any ionizable group. The effect of the enantiomer structure on the retention and enantioseparation was evaluated. Flow rate and column temperature were optimized as part of method development. Graphic abstract
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