Phenethyl isothiocyanate synergistically induces apoptosis with Gefitinib in non–small cell lung cancer cells via endoplasmic reticulum stress‐mediated degradation of Mcl‐1

Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AML

(2019) Larissa Ewald et al.   Cell Death & Disease

The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells

(2018) Zhaodong Li et al.   LEUKEMIA

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

(2017) Delphine Merino et al.   Science Translational Medicine

The resistance mechanisms and treatment strategies for EGFR-mutant advanced non-small-cell lung cancer

(2017) Wen-Zhao Zhong et al.   Oncotarget

c-FLIP and the NOXA/Mcl-1 axis participate in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells

(2017) Xiaofei Zhao et al.   PLoS One

Sulforaphene–Carboplatin Combination Synergistically Enhances Apoptosis by Disruption of Mitochondrial Membrane Potential and Cell Cycle Arrest in Human Non-Small Cell Lung Carcinoma

(2016) Saswata Chatterjee et al.   JOURNAL OF MEDICINAL FOOD

Evodiamine induces apoptosis and enhances apoptotic effects of erlotinib in wild-type EGFR NSCLC cells via S6K1-mediated Mcl-1 inhibition

(2016) Yang-ling Li et al.   MEDICAL ONCOLOGY

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

Phenylethyl isothiocyanate reverses cisplatin resistance in biliary tract cancer cells via glutathionylation-dependent degradation of Mcl-1

(2016) Qiwei Li et al.   Oncotarget

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

(2015) Souvik Dey et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoptotic Effect of Galbanic Acid via Activation of Caspases and Inhibition of Mcl-1 in H460 Non-Small Lung Carcinoma Cells

(2015) Bum-Seok Oh et al.   PHYTOTHERAPY RESEARCH

Mcl-1 is an important therapeutic target for oral squamous cell carcinomas

(2015) Santanu Maji et al.   Oncotarget

Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma

(2015) Iza Denis et al.   Oncotarget

Sulforaphane Inhibits Growth of Human Breast Cancer Cells and Augments the Therapeutic Index of the Chemotherapeutic Drug, Gemcitabine

(2014) Arif Hussain et al.   Asian Pacific Journal of Cancer Prevention

Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanisms

(2014) Parul Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Molecular targets of isothiocyanates in cancer: Recent advances

(2014) Parul Gupta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Benzyl Isothiocyanate Inhibits HNSCC Cell Migration and Invasion, and Sensitizes HNSCC Cells to Cisplatin

(2014) M. Allison Wolf et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Endogenous Noxa Determines the Strong Proapoptotic Synergism of the BH3-Mimetic ABT-737 with Chemotherapeutic Agents in Human Melanoma Cells

(2014) Arnim Weber et al.   Translational Oncology

The effect of benzyl isothiocyanate and its computer-aided design derivants targeting alkylglycerone phosphate synthase on the inhibition of human glioma U87MG cell line

(2014) Yu Zhu et al.   TUMOR BIOLOGY

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells

(2013) Katherine Liu et al.   Cancer Cell International

Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells

(2013) A. Sehrawat et al.   CARCINOGENESIS

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers

(2013) H. A. Yu et al.   CLINICAL CANCER RESEARCH

Exploring the effects of isothiocyanates on chemotherapeutic drugs

(2013) Anna Minarini et al.   Expert Opinion on Drug Metabolism & Toxicology

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

Mcl-1 Phosphorylation Defines ABT-737 Resistance That Can Be Overcome by Increased NOXA Expression in Leukemic B cells

(2012) S. Mazumder et al.   CANCER RESEARCH

Benzyl isothiocyanate induces protective autophagy in human prostate cancer cells via inhibition of mTOR signaling

(2012) Ji-Fan Lin et al.   CARCINOGENESIS

Apoptosis Induced by Benzyl Isothiocyanate in Gefitinib-Resistant Lung Cancer Cells is Associated with Akt/MAPK Pathways and Generation of Reactive Oxygen Species

(2012) Bo-Ning Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Enhancement of cisplatin cytotoxicity by benzyl isothiocyanate in HL-60 cells

(2012) Younghyun Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

(2012) King Pan Ng et al.   NATURE MEDICINE

Targeting Mcl-1 for the therapy of cancer

(2011) Bridget A Quinn et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Treatment of Non–Small-Cell Lung Cancer with Erlotinib or Gefitinib

(2011) Vince D. Cataldo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells

(2010) Xiang Wu et al.   BMC CANCER

Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death

(2010) Bettina M. Kaminski et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells

(2010) Chhavi Sharma et al.   Cancer Epidemiology

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Sensitization of Non-small Cell Lung Cancer Cells to Cisplatin by Naturally Occurring Isothiocyanates

(2010) Anthony J. Di Pasqua et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells

(2010) Dong Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and Prostate

(2010) Georgios Kallifatidis et al.   MOLECULAR THERAPY

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

(2010) Deric L. Wheeler et al.   Nature Reviews Clinical Oncology

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines

(2010) H Zhang et al.   ONCOGENE

Phenethyl Isothiocyanate Sensitizes Androgen-Independent Human Prostate Cancer Cells to Docetaxel-Induced Apoptosis In Vitro and In Vivo

(2010) Dong Xiao et al.   PHARMACEUTICAL RESEARCH

Are isothiocyanates potential anti-cancer drugs?

(2009) Xiang Wu et al.   ACTA PHARMACOLOGICA SINICA

Cruciferous Vegetable Consumption and Lung Cancer Risk: A Systematic Review

(2009) T. K. Lam et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells

(2009) Sutapa Mukherjee et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

(2008) C.-H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA