期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 505, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2020.110711
关键词
Endocrine disruptors; Sheep model; Fetal exposure; Thyroid; Mixture
资金
- SRF Academic Scholarship Award 2013
- Wellcome Trust [080388]
- European Community's Seventh Framework Programme [212885]
- French Region Midi-Pyrenees [31000642]
- French National Research Program for Environmental and Occupational Health of Anses [2015/1/112]
- French National Research Agency [ANR-13-CESA0007-1]
There are many challenges to overcome in order to properly understand both the exposure to, and effects of, endocrine disruptors (EDs). This is particularly true with respect to fetal life where ED exposures are a major issue requiring toxicokinetic studies of materno-fetal exchange and identification of pathophysiological consequences. The sheep, a large, monotocous, species, is very suitable for in utero fetal catheterization allowing a modelling approach predictive of human fetal exposure. Predicting adverse effects of EDs on human health is frequently impeded by the wide interspecies differences in the regulation of endocrine functions and their effects on biological processes. Because of its similarity to humans as regards gestational and thyroid physiologies and brain ontogeny, the sheep constitutes a highly appropriate model to move one step further on thyroid disruptor hazard assessment. As a grazing animal, the sheep has also proven to be useful in the evaluation of the consequences of chronic environmental exposure to real-life complex mixtures at different stages of the reproductive life cycle.
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