Article
Chemistry, Applied
Man Hyung Koo, Hae-Jung Chae, Jun Hyuck Lee, Sung-Suk Suh, Ui Joung Youn
Summary: Phytochemical and biological studies of methanolic extracts from Ganoderma lucidum led to the discovery of a new lanostane triterpenoid, ganosidone A, and eight known derivatives. The compounds showed potential for cancer chemoprevention by inhibiting nitric oxide production in vitro, with compounds 4 and 7 exhibiting significant inhibition rates at a concentration of 50 μM.
NATURAL PRODUCT RESEARCH
(2021)
Article
Microbiology
Liyun Ye, Xiaofang He, Congbao Su, Haiying Feng, Guoliang Meng, Bingzhi Chen, Xiaoping Wu
Summary: This study analyzed the effect of mitochondria on Ganoderma lucidum morphology, yield, and main primary bioactive components using isonuclear alloplasmic strains, revealing differences in mycelial growth rate, basidiospore yield, and polysaccharide and triterpenoid content. Transcriptome data indicated involvement of differentially expressed genes in specific biological pathways.
Article
Biotechnology & Applied Microbiology
Wen-Fang Wang, Han Xiao, Jian-Jiang Zhong
Summary: In this study, a new GA, DHLDOA, was successfully synthesized in engineered yeast by oxidation of HLDOA using CYP5139G1 from Ganoderma lucidum. Enzymatic experiments confirmed the activity of CYP5139G1, and strategies to increase DHLDOA production were also explored.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Microbiology
Xiaolan Xu, Fengli Zhu, Yuxuan Zhu, Yujie Li, Hao Zhou, Shilin Chen, Junshan Ruan
Summary: Ganoderma lucidum is a traditional Chinese medicine containing ganoderma triterpenoids. This study analyzed the chemical composition and transcriptomes of mycelia, primordia, and fruiting bodies of G. lucidum. Correlation analysis revealed that certain transcription factors showed positive or negative correlation with the content of total triterpenoids. Furthermore, overexpression of a specific gene in Pichia pastoris decreased the production of lanosterol, suggesting its role as a negative regulator in ganoderma triterpenoid biosynthesis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Physical
Tran Do Dat, Nguyen Duc Viet, Nguyen Minh Dat, Phan Le Thao My, Doan Ba Thinh, Lu Thi Mong Thy, Le Minh Huong, Pham Tan Khang, Nguyen Duy Hai, Hoang Minh Nam, Mai Thanh Phong, Nguyen Huu Hieu
Summary: This study successfully synthesized silver nanoparticles using Vietnamese Ganoderma lucidum extract, showing good crystallinity and nanoparticle stability. The synthesized silver nanoparticles exhibited excellent antimicrobial and antioxidant activities against various bacteria and fungi, and showed potential in anticancer applications as well.
SURFACES AND INTERFACES
(2021)
Article
Food Science & Technology
Ruobing Liu, Jing Gan, Mengdi Du, Xiao Kong, Chunxia Xu, Yue Lue, Shengliang Cao, Ting Meng, Bo Wang, Tianying Yu
Summary: In this study, chitosan, sodium alginate, and sodium tripolyphosphate were used to prepare hydrogels as a stable polypeptide delivery system. The prepared M-SCT hydrogels showed excellent pH sensitivity and loading capacity for Ganoderma lucidum peptides (GLP). The characterization and evaluation of the hydrogels were performed, confirming their internal network structure, electrostatic interactions among the components, and improved stability. The hydrogels also demonstrated efficient peptide release and retained the antioxidant activity of GLP, suggesting their potential as a carrier for oral delivery.
Article
Multidisciplinary Sciences
He Li, Yawei Du, Hanrui Ji, Yanan Yang, Changchang Xu, Qiaodan Li, Longkai Ran, Chongming Wu, Qile Zhou, Shengxian Wu
Summary: The adenosine extract from Ganoderma lucidum (AEGL) was found to have lipid-lowering effects on hyperlipidemic mice, significantly reducing serum cholesterol and triglyceride levels, improving hepatic steatosis without causing liver or kidney damage. Regulating the expression and acetylation/crotonylation of proteins involved in the PPAR signaling pathway may be one of the potential mechanisms behind the lipid-lowering effects of AEGL.
Review
Plant Sciences
Sze Wa Chan, Brian Tomlinson, Paul Chan, Christopher Wai Kei Lam
Summary: This review examines the effects of Ganoderma lucidum on major risk factors for cardiometabolic disease, showing potential benefits such as antioxidative, antihypertensive, hypoglycaemic, lipid-lowering, and anti-inflammatory properties in in vitro and in vivo studies. However, clinical trials have shown inconsistent results, indicating the need for further large controlled studies to clarify the potential health benefits of G. lucidum preparations standardized by known active components in the prevention and treatment of cardiometabolic disease.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pan Zou, Yongze Guo, Shu Ding, Zhaowei Song, Hanyuan Cui, Yue Zhang, Zhijun Zhang, Xiaoming Chen
Summary: This study revealed the significant role of organic acids in the cropping obstacles of Ganoderma lucidum through nontargeted metabonomic technology. The findings contribute to promoting the sustainable utilization of fungus substrate.
Article
Biochemistry & Molecular Biology
Meilin Cui, Yuchang Ma, Youwei Yu
Summary: This study demonstrated that Ganoderic triterpenoids (GTs) accumulation in Ganoderma lucidum mycelia can be enhanced by heme oxygenase-1 (HO-1)/carbon monoxide (CO) signaling. The findings suggest that HO-1/CO signaling may play a direct regulatory role in promoting GT accumulation by modulating gene expression in the mevalonate pathway and reactive oxygen species (ROS) and Ca2+ pathways. This research contributes to the understanding of GT metabolic networks and signaling pathways for potential large-scale production.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Chemistry, Applied
Min Wu, Cui-e Shen, Qiao-fa Lin, Jin-yi Zhong, Yan-fei Zhou, Ben-chen Liu, Jian-hua Xu, Zhi-qiang Zhang, Peng Li
Summary: Various compounds were isolated and identified from Ganoderma lucidum, with ganoderiol F showing potent activity in reversing P-glycoprotein mediated tumor multidrug resistance.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Shuai Zhou, Xiaoyu Zhang, Fuying Ma, Shangxian Xie, Chuanhong Tang, Qingjiu Tang, Jingsong Zhang
Summary: The study focused on understanding the relationship between substrate degradation and carbohydrate/triterpenoid metabolism in Ganoderma lucidum. It was found that carbohydrate degradation products contribute to the synthesis of polysaccharides, trehalose, and polyols during initial fruiting body formation, providing precursors for triterpenoid synthesis. The findings suggest that enhancing triterpenoid synthesis can be achieved through regulating carbohydrate metabolism and substrate degradation in addition to enzyme expression in the triterpenoid pathway.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Chemistry, Applied
Ivan Milovanovic, Gokhan Zengin, Svetolik Maksimovic, Vanja Tadic
Summary: This study investigated the effects of supercritical carbon-oxide (scCO(2)) extraction on the antioxidant capacity, enzyme inhibitory potential, and levels of ergosterol and ganoderic acid in cultivated and wild-grown G. lucidum. The study found that wild samples had slightly higher extraction yields and lower levels of ganoderic acid and ergosterol compared to cultivated samples. Cultivated samples had higher total phenolic content and exhibited stronger antioxidant potential. However, wild samples showed greater lipase activity. Cultivated G. lucidum may be a valuable source of natural bioactive agents for health-promoting products.
NATURAL PRODUCT RESEARCH
(2023)
Review
Food Science & Technology
Elif Ekiz, Emel Oz, A. M. Abd El-Aty, Charalampos Proestos, Charles Brennan, Maomao Zeng, Igor Tomasevic, Tahra Elobeid, Kenan Cadirci, Muharrem Bayrak, Fatih Oz
Summary: Ganoderma lucidum, a medicinal mushroom used in Chinese medicine for centuries, has various medicinal properties such as antioxidant, anti-inflammatory, and immune-boosting effects. Recent research has explored its potential benefits in treating metabolic disorders and infections caused by the coronavirus. However, further clinical trials are needed to confirm its effectiveness in preventing or treating coronavirus infections.
Article
Thermodynamics
Kompet Inla, Sungwan Bunchan, Bundit Krittacom, Ratinun Luampon
Summary: This study investigated a hybrid drying technique of convection-assisted microwave drying for lingzhi mushrooms to increase their shelf life and maintain quality. The results showed that increasing drying temperature and microwave power increased drying rate and color differences, while reducing drying time and rehydration percentage.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Plant Sciences
Biljana M. Nikolic, Iris Dordevic, Marina Todosijevic, Zorica Mitic, Milena A. Stefanovic, Jovana M. Stankovic, Srdjan Bojovic, Vele Tesevic, Petar D. Marin
Summary: This study examined the content of nonacosan-10-ol and n-alkanes in needle waxes of 12 different Pinus taxa and investigated the carbon preference index and average chain length values in selected taxa. The results showed significant chemical composition differences among different Pinus taxa.
Article
Chemistry, Applied
Caroline Zanella Cagnini, Angelica Barbosa Dias, Mariana Rodrigues Vilas Boas, Fabiana Pacheco Reis Batista, Maria Graciela Iecher Faria, Jasmina Glamoclija, Marina Sokovic, Vele Tesevic, Ederlan de Souza Ferreira, Nelson Barros Colauto, Giani Andrea Linde, Zilda Cristiani Gazim
Summary: This study investigated the antimicrobial activity and chemical composition of Annona muricata leaf oleoresin extracted by supercritical CO2. The oleoresin showed high bactericidal activity against various bacteria, but low fungicidal activity. Promising applications in food, cosmetic, and pharmaceutical industries were suggested for the leaf oleoresin of A. muricata.
NATURAL PRODUCT RESEARCH
(2022)
Article
Medicine, General & Internal
Ljubica Tasic, Natasa Avramovic, Melissa Quintero, Danijela Stanisic, Lucas G. Martins, Tassia Brena Barroso Carneiro da Costa, Milka Jadranin, Maria Theresa de Souza Accioly, Paulo Faria, Beatriz de Camargo, Bruna M. de Sa Pereira, Mariana Maschietto
Summary: Pediatric cancer NMR-metabonomics offers a powerful tool for studying tumor development and improving cancer diagnosis and treatment. This study used HR-MAS NMR to analyze Wilms tumor and normal kidney samples, revealing significant differences in metabolites between the tumor and normal tissues. These findings provide insight into the altered metabolic pathways in Wilms tumor.
Article
Chemistry, Multidisciplinary
Valerija Madzgalj, Aleksandar Petrovic, Uros Cakar, Vesna Maras, Ivana Sofrenic, Vele Tesevic
Summary: This study aimed to demonstrate the aromatic profile of wines produced from two native grape cultivars Krstac (K) and Zizak (Z). The use of enzymatic preparations and different skin contact times resulted in increased content of aromatic compounds, particularly 2-phenylethyl and isoamyl alcohols. The wines from both varieties showed higher content of certain acids and esters, which contribute to the fruity aroma and pleasant taste of the wine. Sensory evaluation showed high grades for wines with longer skin contact time.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Green & Sustainable Science & Technology
Dragan Vukolic, Tamara Gajic, Marko D. Petrovic, Jovan Bugarcic, Ana Spasojevic, Sonja Veljovic, Nikola Vuksanovic, Marina Bugarcic, Milos Zrnic, Snezana Knezevic, Sandra R. Rakic, Bojana D. Draskovic, Tijana Petrovic
Summary: Specific gastronomy plays a vital role in the development of agro-tourism destinations. Understanding the motivations of tourists visiting these destinations is crucial for the sustainable development of such concepts. This research investigated a total of 607 respondents who stayed in agro-tourism destinations in the Republic of Serbia in 2022. The results revealed significant influences of cultural experience, excitement, interpersonal relations, and sensory appeal dimensions on the visitation of agro-tourism destinations by gastronomic tourists.
Article
Integrative & Complementary Medicine
Juliana Scanavacca, Wanessa de Campos Bortolucci, Ezilda Jacomassi, Irineia Paulina Baretta, Maria Graciela Iecher Faria, Carla Maria Mariano Fernandez, Vele Tesevic, Jasmina Glamoclija, Marina Sokovic, Nelson Barros Colauto, Giani Andrea Linde, Zilda Cristiani Gazim
Summary: This study evaluated the chemical composition and antimicrobial activity of Tetradenia riparia leaf essential oil. The essential oil showed broad antibacterial and antifungal activity, making it a potential alternative for microbial control.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Article
Food Science & Technology
Sonja Veljovic, Marija Petrovic, Marina Jovanovic, Dragana Mitic-Culafic, Tanja Zivkovic Semen, Marija Kostic, Maja Natic
Summary: This study aimed to characterize the chemical composition of industrial solid Ganoderma lucidum waste and evaluate its potential as a source of valuable bioactive compounds. The results showed that the extracts prepared with 70% ethanol had higher amino acid and phenolic compound contents, and exhibited cytotoxic, antioxidant, and photoprotective activities against human cancer cells.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Plant Sciences
Aleksandra Cvetanovic Kljakic, Milos Radosavljevic, Gokhan Zengin, Linlin Yan, Uros Gasic, Predrag Kojic, Aleksandra Torbica, Miona Belovic, Zoran Zekovic
Summary: Chamomile is widely used as a medicinal plant and its optimal extraction conditions were determined using an artificial neural network model. The optimized conditions included a solid-to-solvent ratio of 1:80, microwave power of 400 W, and extraction time of 30 min. The extract obtained under these conditions had a rich composition and high biological activity, and showed potential as a growth medium for probiotics. This study contributes to the improvement of extraction techniques using modern statistical designs and modeling.
Article
Food Science & Technology
Kristina Kukurova, Lenka Rerkova, Miona Belovic, Lidija Perovic, Aleksandra Torbica, Zuzana Ciesarova
Summary: This study shows that using wholegrain flour and sea buckthorn pomace can enhance the nutritional value of cereal biscuits, but the addition of sea buckthorn pomace also increases hardness and fracturability, as well as the formation of carcinogenic acrylamide. However, treating the sea buckthorn pomace with enzymes can reduce acrylamide formation and improve the texture and taste of the biscuits.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2023)
Article
Chemistry, Applied
Aleksandra Torbica, Ilinka Pecinar, Steva Levic, Miona Belovic, Mirjana Jovicic, Zora Dajic Stevanovic, Viktor Nedovic
Summary: Barley, rye, triticale, oat, sorghum and millet flours were analyzed after roasting or extrusion treatment to investigate the structural changes in starch and protein molecules. Extrusion treatment led to more extensive changes in both starch and protein structure compared to roasting treatment. The changes included alterations in protein secondary structure and disulfide bond conformation, as well as complete gelatinization and amylose-lipid complex formation in the starch structure. The rheological properties of the doughs were also affected by these structural changes, with extruded doughs exhibiting higher mechanical resistance.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Milica Lucic, Nebojsa Potkonjak, Ivana Sredovic Ignjatovic, Steva Levic, Zora Dajic-Stevanovic, Stefan Kolasinac, Miona Belovic, Aleksandra Torbica, Ivan Zlatanovic, Vladimir Pavlovic, Antonije Onjia
Summary: This study examines the effects of ultrasound and chemical pretreatments on the quality attributes of dried red pepper. The study finds that drying method, pretreatment time, and pH value have significant impacts on the phenolic content, color, rehydration ratio, antioxidant activity, and texture of the dried pepper. The use of ultrasound pretreatment and potassium metabisulfite as an additive show positive effects on the pepper's morphology and quality.
Article
Food Science & Technology
Zuzana Ciesarova, Kristina Kukurova, Viera Jelemenska, Jana Horvathova, Janka Kubincova, Miona Belovic, Aleksandra Torbica
Summary: Sea buckthorn pomace, a by-product of juice production, can be used as an effective addition to bakery products to enhance their nutritional value. However, the high content of asparagine in sea buckthorn leads to the formation of undesirable acrylamide. Treating sea buckthorn with asparaginase significantly reduces the asparagine content and subsequently decreases acrylamide formation in biscuits. This study confirms the effectiveness of asparaginase treatment in reducing health risks associated with acrylamide in fruit pomace-enriched biscuits.
Article
Biochemistry & Molecular Biology
Milka Jadranin, Natasa Avramovic, Zoran Miladinovic, Aleksandra Gavrilovic, Ljubica Tasic, Vele Tesevic, Boris Mandic
Summary: This study explored and compared the lipidomic profiles of serum samples from patients with bipolar disorder (BD) and healthy controls (C). The results revealed alterations in lipid metabolism in BD patients, highlighting the role of lipid pathways in BD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Valerija Madzgalj, Aleksandar Petrovic, Uros Cakar, Vesna Maras, Ivana Sofrenic, Vele Tesevic
Summary: This study aimed to show the aromatic profile of wines produced from two autochthonous grape cultivars Krstac and Zizak. Skin contact and the use of enzymatic preparations increased the content of aromatic compounds, particularly 2-phenylethyl and isoamyl alcohols. Furthermore, the wines showed increased content of esters responsible for fruity aroma and pleasant taste compared to the control.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Horticulture
Milica Acimovic, Biljana Loncar, Jovana Stankovic Jeremic, Mirjana Cvetkovic, Lato Pezo, Milada Pezo, Marina Todosijevic, Vele Tesevic
Summary: This study evaluated the quality of Lavandula sp. essential oil and hydrolate obtained from L. x intermedia cv. 'Budrovka' cultivated on Fruska Gora Mt. in Serbia. The composition and influence of weather conditions were assessed, and linear regression models and correlation analysis were used to predict and analyze the volatile compounds and composition of the products. The results indicated that Fruska Gora Mt. provides suitable conditions for cultivating Lavandula sp. and obtaining satisfactory essential oil and hydrolate.
