Article
Gastroenterology & Hepatology
Koichiro Haruki, Kenei Furukawa, Yuki Fujiwara, Tomohiko Taniai, Ryoga Hamura, Yoshihiro Shirai, Jungo Yasuda, Hironori Shiozaki, Shinji Onda, Takeshi Gocho, Hiroaki Shiba, Teruyuki Usuba, Yukio Nakabayashi, Shuichi Fujioka, Tomoyoshi Okamoto, Toru Ikegami
Summary: The study evaluates the significance of anatomical resection (AR) on therapeutic outcomes of patients with small hepatocellular carcinoma (HCC) using propensity score-matched (PSM) analysis. Results show that AR may improve disease-free survival in HCC patients with tumors of <= 5 cm diameter, with significantly lower liver remnant recurrence in the AR group.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Xiu-Ping Zhang, Shuai Xu, Zhao-Yi Lin, Qing-Lun Gao, Kang Wang, Zi-Li Chen, Mao-Lin Yan, Fan Zhang, Yu-Fu Tang, Zhi-Ming Zhao, Cheng-Gang Li, Wan Yee Lau, Shu-Qun Cheng, Ming-Gen Hu, Rong Liu
Summary: This study aimed to evaluate the impact of anatomical resection (AR) versus nonanatomical resection (NAR) combined with resection margin (RM) on long-term prognosis in HCC patients with MVI. The results showed that AR combined with wide RM can significantly improve overall and recurrence-free survival rates for these patients.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Jae Hyun Kwon, Jung-Woo Lee, Jong Woo Lee, Young Joo Lee
Summary: This study compared the survival outcomes and recurrence rates of anatomical resection (AR) versus non-anatomical resection (NAR) in hepatocellular carcinoma (HCC) according to tumor size. The results showed that AR reduced the risk of tumor recurrence and improved overall survival in patients with HCCs smaller than 5 cm, while AR and NAR showed comparable survival outcomes in HCCs larger than 5 cm.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jaejun Lee, Ji-Won Han, Pil-Soo Sung, Soon-Kyu Lee, Hyun Yang, Hee-Chul Nam, Sun-Hong Yoo, Hae-Lim Lee, Hee-Yeon Kim, Sung-Won Lee, Jung-Hyun Kwon, Jeong-Won Jang, Chang-Wook Kim, Soon-Woo Nam, Jung-Suk Oh, Ho-Jong Chun, Si-Hyun Bae, Jong-Young Choi, Seung-Kew Yoon
Summary: The study revealed that in unresectable hepatocellular carcinoma patients, lenvatinib and hepatic artery infusion chemotherapy showed similar objective response rates and overall survival. However, for patients with a high tumor burden, hepatic artery infusion chemotherapy resulted in longer overall survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Kai Li, Yinglin Long, Xuqi He, Yuxuan Wu, Jianliang Xu, Huolin Ye, Erjiao Xu, Qingjing Zeng, Jianning Chen, Lianxiong Yuan, Rongqin Zheng
Summary: The study suggests that anatomical thermal ablation is a favorable strategy with improved therapeutic effect for hepatocellular carcinoma with visible feeding vessels and reserved liver function. It leads to a larger ablation zone volume and lower recurrence and progression-free survival rates.
HEPATOLOGY RESEARCH
(2022)
Article
Surgery
Rosalinda Filippo, Maria Conticchio, Francesca Ratti, Riccardo Inchingolo, Maximiliano Gelli, Ferdinando Massimiliano Anelli, Alexis Laurent, Giulio Cesare Vitali, Paolo Magistri, Giacomo Assirati, Emanuele Felli, Taiga Wakabayashi, Patrick Pessaux, Tullio Piardi, Fabrizio Di Benedetto, Nicola de'Angelis, Delgado Francisco Javier Briceno, Antonio Gaetano Rampoldi, Rene Adam, Daniel Cherqui, Luca Aldrighetti, Riccardo Memeo
Summary: This study compared the outcomes of liver resection (LR) and radiofrequency ablation (RFA) in octogenarian patients with hepatocellular carcinoma (HCC). The results showed that LR had a higher rate of complications, longer operative time, and hospital stays, but had better long-term outcomes in terms of survival rate.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Dan-Jun Song, Kai Zhu, Jin-Peng Tan, Jia-Bin Cai, Min-Zhi Lv, Jie Hu, Zhen-Bin Ding, Guo-Ming Shi, Ning Ren, Xiao-Wu Huang, Ying-Hong Shi, Shuang-Jian Qiu, Qing-Hai Ye, Hui-Chuan Sun, Qiang Gao, Jian Zhou, Jia Fan, Xiao-Ying Wang
Summary: LLR can result in less liver function damage, better attenuation of inflammatory response, faster recovery, and parallel oncologic outcomes compared to OLR.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Tatsuya Orimo, Toshiya Kamiyama, Tatsuhiko Kakisaka, Shingo Shimada, Akihisa Nagatsu, Yoh Asahi, Yuzuru Sakamoto, Hirofumi Kamachi, Akinobu Taketomi
Summary: In terms of anatomical liver sectionectomy approaches, central hepatectomy (CH) and major hepatectomy (MH) are feasible options for a centrally located hepatocellular carcinoma (HCC). After propensity score matching, the short- and long-term surgical outcomes of CH and MH for centrally located HCC are similar, with CH having the advantage of not requiring preoperative portal vein embolization and increased chances of repeat hepatectomy for recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Kejie Zheng, Anque Liao, Lunan Yan, Jiayin Yang, Tianfu Wen, Wentao Wang, Bo Li, Hong Wu, Li Jiang
Summary: This study aimed to compare the efficacy of hepatic resection (HR) combined with radiofrequency ablation (RFA) versus HR alone in patients with multifocal hepatocellular carcinomas (HCCs). The study found that for selected patients with moderately advanced multifocal HCCs, HR+RFA may offer similar overall survival (OS) and recurrence-free survival (RFS) as HR alone. However, HR may be more suitable for patients with two tumors, or with all lesions in the same lobe or without microvascular invasion (MVI). In addition, en bloc resection may be recommended for patients with all lesions in the same lobe.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shi-Ye Yang, Jin-Kai Feng, Mao-Lin Yan, Lei Guo, Yun-Fei Duan, Jia-Zhou Ye, Zong-Han Liu, Yan-Jun Xiang, Li Xu, Jie Xue, Jie Shi, Wan Yee Lau, Shu-Qun Cheng, Wei-Xing Guo
Summary: This study aimed to compare the perioperative results and long-term oncological outcomes of HCC patients with T2DM treated with LLR versus OLR. The LLR group had less blood loss, shorter hospitalization, and fewer postoperative complications compared to the OLR group. LLR showed significantly better overall survival and recurrence-free survival for HCC patients with T2DM regardless of the course of T2DM.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Plant Sciences
Shaoju Luo, Hao Hu
Summary: The effectiveness of huaier granules in prolonging overall survival and reducing recurrence risk after curative resection of HCC has been demonstrated. Specifically, for solitary HCC with a diameter <= 30 mm, huaier granules can improve overall survival, while for solitary HCC with a diameter >30 mm, huaier granules can improve both overall survival and recurrence-free survival.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Wen-qiang Wang, Jian Li, Bin-yong Liang, Xing Lv, Rong-hua Zhu, Jin-lin Wang, Zhi-yong Huang, Shu-hong Yang, Er-lei Zhang
Summary: This study compared the prognostic outcomes of anatomical resection (AR) and non-anatomical resection (NAR) for patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA). The results showed that AR had better 5-year overall survival and recurrence-free survival rates compared to NAR, especially for patients with tumors smaller or equal to 5 cm in diameter.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
He Linye, Xia Zijing, Peng Wei, He Chao, Li Chuan, Wen Tianfu
Summary: Thymosin alpha-1 (T alpha 1) as an adjuvant therapy improves the prognosis of solitary HBV-related HCC patients after curative liver resection, showing better recurrence-free survival (RFS) and overall survival (OS) rates.
Article
Oncology
Qingqing Xie, Yongwen Yang, Bin Qu, Ping Xiao, Faqing Tang, Haoming Shen
Summary: This study aimed to explore treatment choices for hepatocellular carcinoma (HCC) patients, especially elderly patients aged 65 and above. The results showed that surgical resection can provide survival benefits for elderly patients with single lesions less than 5 cm in size.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tao Wang, Yan Zhao, Ming Wang, Peng Zhang, Guole Lin, Qian Liu, Fan Feng, Zhiguo Xiong, Junbo Hu, Bo Zhang, Yingjiang Ye, Lijian Xia, Kaixiong Tao
Summary: This study compared local excision (LE) and radical resection (RR) for low rectal gastrointestinal stromal tumors (GISTs) in a multicenter retrospective cohort study. The results showed that LE had better postoperative outcomes and comparable oncological safety for patients with tumors <= 2 cm. However, for tumors >2 cm, RR might be a more appropriate option with better recurrence-free survival (RFS).
Article
Oncology
Wen-Jun Jia, Shi-Quan Sun, Luo-Shun Huang, Qiao-Li Tang, Yu-Dong Qiu, Liang Mao
MOLECULAR MEDICINE REPORTS
(2018)
Article
Oncology
Chuang Chen, Hui Zhao, Xu Fu, LuoShun Huang, Min Tang, XiaoPeng Yan, ShiQuan Sun, WenJun Jia, Liang Mao, Jiong Shi, Jun Chen, Jian He, Jin Zhu, YuDong Qiu
Article
Infectious Diseases
Xiaoyuan Chen, Shiquan Sun, Xiaopeng Yan, Xu Fu, Yinyin Fan, Dayu Chen, Yudong Qiu, Liang Mao
SURGICAL INFECTIONS
(2020)
Article
Biochemistry & Molecular Biology
Wen-Jun Jia, Qiao-Li Tang, Shan Jiang, Shi-Quan Sun, Bin Xue, Yu-Dong Qiu, Chao-Jun Li, Liang Mao
Article
Biochemistry & Molecular Biology
Min Deng, Shiquan Sun, Rongce Zhao, Renguo Guan, Zhen Zhang, Shaohua Li, Wei Wei, Rongping Guo
Summary: This study investigates the expression levels of pyroptosis-related genes in hepatocellular carcinoma (HCC) and their relationship with prognosis. A 10-gene signature was constructed to classify HCC patients into low-risk and high-risk groups, and the results showed that the low-risk group had significantly better survival rates. PRGs play a significant role in tumor immunity and have the potential to predict the prognosis of HCC patients.
MOLECULAR MEDICINE
(2022)
Article
Oncology
Xiaoyuan Chen, Shiquan Sun, Yiwei Lu, Xiaoli Shi, Ziyi Wang, Xuejiao Chen, Guoyong Han, Jie Zhao, Yun Gao, Xuehao Wang
Summary: This study aimed to investigate the role of liver transplantation (LT) in combined hepatocellular- cholangiocarcinoma (CHC) and develop a novel risk scoring model (RSM) for evaluating transplantation benefits. The results showed that LT was an independent protective factor for CHC patients and those who received LT had better outcomes compared to other treatment methods. The RSM performed better than existing criteria in predicting patient prognosis.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Shiquan Sun, Min Deng, Juan Wen, Xiaoyuan Chen, Jiaqi Xu, Yu Liu, Huanhuan Wan, Jin Wang, Leping Yan, Yong He, Yunsheng Xu
Summary: This study found that the expression of ASPHD1 gene is closely related to the survival time of skin cutaneous melanoma (SKCM) patients and may participate in the regulation of tumor immune microenvironment. In addition, ASPHD1 may serve as a prognostic biomarker for SKCM, and future in-depth studies are necessary to explore its value.