Sunscreen active ingredients in loggerhead turtles (Caretta caretta) and their relation to molecular markers of inflammation, oxidative stress and hormonal activity in wild populations

The present study sought to determine bioaccumulation and potential molecular effects of four of the most environmentally significant sunscreen agents in juvenile loggerhead sea turtles (Caretta caretta) from the Italian coasts of the central Adriatic Sea. Each of these sunscreen agents were found in most of the plasma samples analyzed, with benzophenone-3 as the dominant species. Total concentrations of the sunscreen agents ranged from not detected (< LOD) to 28.43 mu g mL(-1). Almost all of the gene biomarkers of inflammation, oxidative stress and hormonal activity assessed by RT-qPCR in blood tissue showed significant positive correlations with total sunscreen agent concentrations. The present study is the first to provide data on contamination by sunscreen agents in loggerheads, and indicates that these chemicals tend to bioaccumulate and exert potential adverse effects in sea turtles.