期刊
MARINE DRUGS
卷 18, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/md18050232
关键词
fucoidan; cancer; metastasis; epithelial mesenchymal transition; nanoparticles
资金
- National Commission for Scientific and Technological Research (CONICYT) [21201835]
- National Funding for Scientific and Technologic Development of Chile (FONDECYT) [11150802, 3170826]
Fucoidans are sulphated polysaccharides that can be obtained from brown seaweed and marine invertebrates. They have anti-cancer properties, through their targeting of several signaling pathways and molecular mechanisms within malignant cells. This review describes the chemical structure diversity of fucoidans and their similarity with other molecules such as glycosaminoglycan, which enable them to participation in diverse biological processes. Furthermore, this review summarizes their influence on the development of metastasis and drug resistance, which are the main obstacles to cure cancer. Finally, this article discusses how fucoidans have been used in clinical trials to evaluate their potential synergy with other anti-cancer therapies.
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