Article
Chemistry, Multidisciplinary
Yinghao Li, Zhonglei He, Jing Lyu, Xianqing Wang, Bei Qiu, Irene Lara-Saez, Jing Zhang, Ming Zeng, Qian Xu, A. Sigen, James F. Curtin, Wenxin Wang
Summary: Polymeric gene delivery nano-vectors with hyperbranched structures have been shown to be more effective than their linear counterparts due to the abundant terminal groups, which play crucial roles in cargo entrapment, material-cell interaction, and endosome escape. However, the effect of the non-ideal termination has not been optimized in previous studies. In this work, the effect of the non-ideal termination was carefully evaluated and a series of hyperbranched structures with only ideal terminations were synthesized. The resulting hyperbranched poly(beta-amino ester)s exhibited significantly enhanced transfection performance, surpassing leading commercial benchmarks for DNA delivery.
Article
Polymer Science
Jiajun Zhou, Mao Li, Jiadong Wu, Chongyin Zhang, Zidong He, Yan Xiao, Gangsheng Tong, Xinyuan Zhu
Summary: A new kind of hyperbranched semi-aromatic poly(ester-imide)s with hydroxyl terminated groups has been successfully synthesized by a simple one-pot melting polymerization method, possessing low glass transition temperature and high thermostability, as well as abundant terminal hydroxyl functional groups.
Article
Materials Science, Multidisciplinary
Yingnan Zhang, Changhao Fang, Wildemar S. P. Carvalho, Yongfeng Gao, Michael J. Serpe
Summary: The light- and temperature-responsive poly(N-isopropylacrylamide-co-nitrobenzyl methacrylate) microgels demonstrated efficient release of fluorescein through UV irradiation-induced cleavage and heating-induced deswelling, showing potential applications in triggered cargo release systems.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Analytical
Jing Chen, Dan Li, Tingting Zhao, Junhao Wang, Jiaheng Shi, Shuwei Chen, Yue Yin, Shenghao Xu, Xiliang Luo
Summary: This study designed Au NBP dimer-based plasmonic nanogap antennas, which can significantly enhance fluorescence intensity through improvement of the electromagnetic fields and strand displacement amplification. These antennas were used for imaging of intracellular correlated dual disease biomarkers, and the AND-gate sensing mechanism was confirmed.
ANALYTICAL CHEMISTRY
(2022)
Article
Polymer Science
Jiaxin Zhao, Mingjuan Zhou, Yan Zhou, Danming Chao
Summary: This study reports a multi-stimuli-responsive color/fluorescence dual-switching polymer material, which can undergo conformation change, reversible aggregation/de-aggregation, and molecular structure transition under various environmental stimuli. This material has potential applications in the field of sensors, controlled drug release, and intelligent devices.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Yong-Fu Li, Wen-Li Guan, Chun-Yu Wang, Yan Wang, Qi Lin, Ying-Wei Yang
Summary: A metallosupramolecular polymer network (DSPy subset of SHP5@Zn) was constructed by hierarchical self-assembly of a double-armed pillar[5]arene host (SHP5), a ditopic guest (DSPy), and Zn2+ ions, with host-guest recognition and metal-ligand coordination interactions playing a crucial role. The DSPy subset of SHP5@Zn assembly exhibits reversible sol-gel transition properties in response to various external stimuli, making it an excellent candidate for constructing smart gels. In addition, it can be used as a highly selective dual-channel sensor for OH anions, facilitating the development of a convenient test kit for OH sensing.
Article
Pharmacology & Pharmacy
Sajid Iqbal, Alessandro F. Martins, Muhammad Sohail, Jingjing Zhao, Qi Deng, Muhan Li, Zhongxi Zhao
Summary: This study synthesized and characterized poly (beta-amino ester) (P beta AE-447) and evaluated its properties and transfection efficiency as a nanocarrier. The results showed that P beta AE-447 performed better than the commonly used PEI in terms of cell transfection, suggesting its potential for gene delivery.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Polymer Science
Xianshuo Zhang, Peipei Wang, Yaoyu Xu, Jun Wang, Yunfeng Shi, Wenxu Niu, Wenjing Song, Ruru Liu, Cui-Yun Yu, Hua Wei
Summary: A robust yet facile strategy for the synthesis of biodegradable hyperbranched amphiphilic copolymers is reported in this study. The block-statistical structure is identified as a better polymer architecture for controlled release applications.
Article
Chemistry, Analytical
Cheng Li, Qian-Qi Yang, Tian-Jiao Zhang, Zhao-Zi Lv, Yong Wang, Yu Chen
Summary: The study introduces a hybrid ratiometric fluorescence sensor for efficient and accurate detection of dissolved CO2, which was proven effective for determining the CO2 concentration in real samples. This is the first report of a water-soluble, quantitatively CO2-responsive, ratiometric fluorescence sensor synergizing TPE and Au NCs in the amino-rich hyperbranched skeleton without the participation of any free organic compounds.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Elena Yu. Kozhunova, Anna V. Plutalova, Andrey V. Sybachin, Alexander V. Chertovich, Elena V. Chernikova
Summary: This study investigated the double stimuli-responsive properties of PNIPA and PVIM block copolymers in aqueous solutions for the first time. The synthesis of two different block copolymers was performed using RAFT polymerization. The conformational behavior and self-assembly ability of the polymers were found to depend on the location of hydrophobic groups derived from the RAFT agent within the chain, as well as the length and charge of the PVIM block.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Jiahao Shi, Yuhe Zhang, Bin Ma, Haiyang Yong, Delu Che, Chaolan Pan, Wei He, Dezhong Zhou, Ming Li
Summary: A modular strategy was developed to manipulate the amphiphilicity of PAE/DNA polyplexes by synthesizing hydrophobic and hydrophilic modules and changing their ratio. Using this strategy, the polyplexes with the highest gene transfection efficiency and safety profile were identified.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Shengjie Du, Shengyi Chen, Zekai Zhang, Zhicheng Ye, Huanv Mao, Huiting Yang, Cheng Lian, Chunyan Bao
Summary: In this study, a hydroxyl-terminated poly(amine-ester) hyperbranched polymer (HPAE-OHs) was used as a green, effective and economic corrosion inhibitor for mild steel. The results showed that HPAE-OHs can efficiently inhibit the corrosion of mild steel with a corrosion inhibition efficiency of 94.9% at a dosage of 100 mg/L.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Physical
Yanli Wang, Wangchong Ji, Yongjing Xu, Liming Zou, Hongwei Lu, Chenkai Sun
Summary: Highly branched poly(phenylalanine-lysine) (HBP(P-L)) was synthesized and used to modify multiwalled carbon nanotubes (MWCNTs), resulting in improved dispersibility and excellent linear relationship between fluorescence intensity and mass ratio of MWCNT-HBP(P-L). The modified MWCNT-HBP(P-L) shows potential for applications in optical materials due to its unique dispersion properties and fluorescence characteristics.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Pharmacology & Pharmacy
Nuria Puigmal, Victor Ramos, Natalie Artzi, Salvador Borros
Summary: Nucleic acid vaccines are important in combating emerging infectious diseases and cancer. Delivery of these vaccines via the transdermal route has the potential to enhance their efficacy due to the presence of immune cells in the skin. Researchers have developed a new library of transfection vectors that can specifically target antigen presenting cells in the skin. These vectors have demonstrated high transfection efficiency and the ability to mediate gene transfer when applied to transdermal devices. The use of these efficient vectors derived from PBAEs has the potential to advance nucleic acid vaccination in clinical settings.
Article
Cell & Tissue Engineering
Andrew Dunn, Yuqi Cai, Kentaro Iwasawa, Masaki Kimura, Takanori Takebe
Summary: This study developed a novel poly(beta-amino) ester labeling system, named POLYseq, which efficiently delivers fluorescent molecules or DNA barcodes through non-covalent binding for rapid creation of custom sample pools. The system successfully identified human and mouse cultured cell lines by single-cell RNA sequencing, showcasing its multifunctional applications in live cell imaging and NGS in a scalable and cost-effective manner.
Review
Statistics & Probability
Linlin Tian, Lihua Bai
Summary: This paper considers the problem of minimizing the ruin probability of an insurance company using the Sparre Andersen model in a Markovian framework. The regularity properties of the value function and dynamic programming principle are investigated. Unique constrained viscosity solution to the associated Hamilton-Jacobi-Bellman equation is proven through the construction of strict viscosity supersolution.
COMMUNICATIONS IN STATISTICS-THEORY AND METHODS
(2022)
Article
Biochemistry & Molecular Biology
Lihua Bai, Pengfei Yang, Liulong Guo, Susu Liu, Hongxia Yan
Summary: In this study, a truly multicolor emissive hyperbranched polysiloxane material was successfully synthesized by adjusting the distribution of electron-rich atoms and grafting s-cyclodextrin. The material exhibited high quantum yields and could be used as a multisensitivity sensor and cellular imaging material. It also showed high drug loading capacity and pH-controlled drug release in drug delivery systems.
Article
Urology & Nephrology
Jia Chen, Lihua Bai, Yani He
Summary: This case report describes a 33-year-old male patient who had been intermittently taking carbamazepine for 10 years and exhibited renal phospholipidosis symptoms resembling Fabry disease. After further investigation, Fabry disease was ruled out and the patient's proteinuria improved after discontinuing the medication.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Engineering, Multidisciplinary
Pengxu Xie, Lihua Bai, Huayue Zhang
Summary: This paper investigates the optimal proportional reinsurance and investment strategy for an insurer who invests one paired assets with price spread described by Ornstein-Uhlenbeck (O-U) processes. The insurer aims to maximize the expected exponential utility of the terminal wealth in a finite time horizon under two risk models: a classical risk model and a diffusion model. By employing the classical stochastic control approach based on the Hamilton-Jacobi-Bellman equation, the optimal strategies are characterized and a verification result for the value function is provided through the exponential integrability of the square of an O-U process. Numerical examples are presented for sensitivity analysis.
JOURNAL OF INDUSTRIAL AND MANAGEMENT OPTIMIZATION
(2023)
Article
Engineering, Electrical & Electronic
Ting-Ting Wang, Xiao Wang, Zhen-Hai Cui, Wen Hong, Yang Li, Liu-An Li, Yue He, Mao Jia, Chen Guo, Li-Hua Bai, Ying-Zhao Geng, Yue Hao, Jin-Ping Ao
Summary: This study investigates AlGaN/GaN heterostructure lateral Schottky barrier diodes (SBDs) with TiN and NiN dual anode on sapphire substrates. The results show that the turn-on voltage and leakage current of the DA SBDs can be adjusted by varying the radius of the TiN anode. Additionally, it is found that the NiN anode with its high work-function leads to low leakage current and high breakdown voltage, while the TiN anode with its low work-function determines the low turn-on voltage of the DA SBDs.
SEMICONDUCTOR SCIENCE AND TECHNOLOGY
(2022)
Article
Urology & Nephrology
Wenjun Zhao, Shi Feng, Cuili Wang, Pingping Ren, Junjun Zhang, Lei Yu, Chunjiang Zhang, Lihua Bai, Ying Chen, Qin Zhou, Lihui Qu, Jianghua Chen, Hong Jiang
Summary: In this study, urinary IL-6 and TGF-01 levels were found to be potential prognostic markers for IgAN. Elevated urinary IL-6 level was independently associated with the progression of IgAN, making it a promising noninvasive predictor.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Optics
Changjie Cheng, Qing Cao, Lihua Bai, Chaoyue LI, Jirui Zhu, Wenxuan Chen, Yaxing Mao
Summary: To overcome the low diffraction efficiency and scattering caused by dispersion from different waveguide modes, a new kind of photon sieve working in the terahertz band is proposed. The effective index of a metal square-hole waveguide is determined by the side length of the pinhole, allowing for adjustment of the optical path difference. Simulation results demonstrate a significant increase in intensity compared to the traditional single-mode waveguide photon sieve.
Article
Engineering, Environmental
Chao Wang, Sijia Liang, Lihua Bai, Xinyue Gu, Xin Jin, Yong Sik Ok, Cheng Gu
Summary: Recent studies have found that land serves as the most important sink for microplastics (MPs), but little is known about the photoaging processes of land surface MPs exposed to air. This study developed two spectroscopic methods to investigate the effect of air humidity on MP photoaging. The results showed that humidity significantly influenced the surface oxygen-containing moieties of MPs generated from photo-oxidation, especially for PVC-MPs. The study also revealed the RH dependence of coexisting contaminants' adsorption on photoaged MPs, which could be attributed to the varied hydrogen bonding between the contaminants and aged MP surfaces.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Yue He, Ke-Yue Chen, Ting-Ting Wang, Mao Jia, Li-Hua Bai, Xiao Wang, Yu-Yu Bu, Jin-Ping Ao
Summary: In this article, a biosensor based on AlGaN/GaN HFETs is developed to directly detect the tumor biomarker miRNA-155. By fixing the specific SH-RNA probe on the Au-gate surface of the AlGaN/GaN HFET, an RNA-Au-AlGaN/GaN HFET biosensor is fabricated, which can conveniently and rapidly detect miRNA155. The experimental results show that this biosensor has an excellent detection limit of 1.81 fM and a high sensitivity of 77 mu A/log concentration with a linear range (2 fM-2 nM). The biosensor exhibits a high specific recognition capacity but is weakly sensitive to mismatched miRNA.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Medicine, Research & Experimental
Fei Xiao, Shihui Hou, Kaizhen Kui, Xiaoyue Wang, Lihua Bai, Huanzi Dai
Summary: A 50-year-old Asian woman presented with unexplained fever and proteinuria. Lab tests showed cytopenia, elevated serum ferritin and IL-2 receptor concentrations, and evidence of hemophagocytosis in the bone marrow. Renal biopsy revealed macrophage infiltration and damage to podocytes and endothelial cells. This is the first documented case of HPS-related histiocytic glomerulopathy triggered by a malignant tumor.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Engineering, Environmental
Xiru Chen, Zeyu Xian, Song Gao, Lihua Bai, Sijia Liang, Haoting Tian, Chao Wang, Cheng Gu
Summary: This study investigated the transformation of fluoroquinolone antibiotics (FQs) in the presence of sediment mackinawite (FeS) under ambient conditions. The role of dissolved oxygen in the enhanced degradation of FQs induced by FeS was also evaluated. The results showed that typical FQs could be efficiently adsorbed and degraded by FeS under neutral pH conditions. Hydroxyl radical and superoxide radical anions were identified as the dominant reactive species responsible for FQs degradation.
Article
Emergency Medicine
Zhenyu Luo, Sihui Liu, Linhe Yang, Shuyan Zhong, Lihua Bai
Summary: This study aims to clarify the prevalence and characteristics of medical device-related pressure injuries (MDRPI) during ambulance transfer. A descriptive observational study was conducted with 101 participants, and the results showed a high prevalence of MDRPI during ambulance transfer, with different high-risk devices compared to inpatient settings. Therefore, more research is needed to prevent MDRPI during ambulance transfers.
BMC EMERGENCY MEDICINE
(2023)
Article
Optics
Guo Zhen, Bai Lihua, Liu Keying, Shen Yanwen
Summary: Nonsequential double ionization (NSDI) of N2 molecules in counter-rotating two-color circularly polarized few-cycle laser fields is investigated using the classical ensemble method. The results show that the yield of NSDI decreases significantly with the increasing laser wavelength, which is caused by the diffusion effects of electron wave packets. It is also found that the ionization mechanism of NSDI is affected by the laser wavelength. Collision excitation ionization becomes increasingly dominant with the rising laser wavelength, which is related to the return trajectory and return energy of the first electron. The electron momentum distribution of NSDI is also discussed in this study, revealing that the longer laser wavelength leads to clearer rotating three-lobed fan-like structures.
ACTA OPTICA SINICA
(2022)
Article
Optics
Kuang Qi, Shen Xiong, Xu Yilin, Bai Lihua, Liu Jun
Summary: This study proposes a deep learning method using a neural network called Dense-1D-U-Net for measuring spectral phases of femtosecond pulses with the SRSI method. The results show that the accuracy of spectral phase measurement using Dense-1D-U-Net is at least one order of magnitude higher than that of the traditional SRSI algorithm. Experimental data verifies that Dense-1D-U-Net trained on simulated data can calculate experimental data.
CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG
(2022)
Article
Quantum Science & Technology
X. S. Ma, L. H. Bai, Z. H. Guo, H. X. Cao
Summary: In this paper, the authors propose quantum magic square (QMS) models based on high-dimensional probability tensor to characterize various forms of nonlocal phenomena and derive a conditional majorization uncertainty relation for detecting quantum entanglement. They also introduce the concepts of probability and operator QMSs (P-QMSs and O-QMSs) to characterize Bell nonlocality of a bipartite correlation tensor (BCT) and EPR steerability of a bipartite state.
QUANTUM INFORMATION PROCESSING
(2022)
