Article
Chemistry, Multidisciplinary
Shuyan Zhang, Qing Yang Steve Wu, Yi Fan Chen, Melissa Hum, Dave Chi Lok Wong, Ern Yu Tan, Ann Siew Gek Lee, Jinghua Teng, U. S. Dinish, Malini Olivo
Summary: In this study, a label-free detection method based on broadband multi-resonant infrared metasurface for surface-enhanced infrared absorption (SEIRA) spectroscopy was used to detect miRNAs as biomarkers for breast cancer. The SEIRA resonances were optimized and showed a simulated resonance enhancement of up to 10(3) times. Testing on nine patient samples demonstrated good linear correlation with industry standards and introduced a novel analysis method. The findings pave the way for routine cancer diagnosis and have the potential for application in other biosensing activities.
Review
Oncology
Barbara Cardinali, Roberta Tasso, Patrizia Piccioli, Maria Chiara Ciferri, Rodolfo Quarto, Lucia Del Mastro
Summary: This review discusses the potential application of circulating microRNAs (miRNAs) as diagnostic and monitoring biomarkers in breast cancer. It highlights the advantages and challenges that need to be addressed. Although further studies are needed to support their clinical utility, miRNAs could represent novel tools for breast cancer management.
Review
Biochemistry & Molecular Biology
Alejandro Garrido-Palacios, Ana Maria Rojas Carvajal, Ana Maria Nunez-Negrillo, Jonathan Cortes-Martin, Juan Carlos Sanchez-Garcia, Maria Jose Aguilar-Cordero
Summary: This systematic review and meta-analysis investigated dysregulated miRNA biomarkers and their diagnostic accuracy in breast cancer. The study found that 34 microRNAs were significantly dysregulated and could be considered as biomarkers for breast cancer. Individually, miR-155 showed better diagnostic results compared to mammography. However, using a panel of multiple miRNAs improved sensitivity and specificity rates, and they can be associated with classic biomarkers such as CA-125 or CEA. Based on the results, miR-155 holds promise as a diagnostic biomarker for breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu
Summary: This study found that inhibiting miR-122-5p can activate p53 and hinder the progression of the MVA pathway in non-small cell lung cancer (NSCLC). This leads to a decrease in cell proliferation and migration, and an increase in apoptosis. miR-122-5p interacts with p53 and is negatively correlated with its expression. Thus, miR-122-5p regulates NSCLC by targeting p53, offering potential molecular targets for targeted drug development.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Caterina Gianni, Michela Palleschi, Filippo Merloni, Giandomenico Di Menna, Marianna Sirico, Samanta Sarti, Alessandra Virga, Paola Ulivi, Lorenzo Cecconetto, Marita Mariotti, Ugo De Giorgi
Summary: This review focuses on the available research on circulating cell-free DNA integrity as a biomarker for diagnosis, prognosis, and treatment response in breast cancer, highlighting new perspectives and critical issues for future applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Da Qin, Qingdong Guo, Rui Wei, Si Liu, Shengtao Zhu, Shutian Zhang, Li Min
Summary: This study proposed a new algorithm to quantitate plasma miRNA for colon cancer diagnosis. By establishing a miRNA-pair matrix and using various algorithms, a 4-miRNA pair model was successfully developed that showed good performance in differentiating CC from normal controls.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Domenico Tierno, Gabriele Grassi, Fabrizio Zanconati, Marina Bortul, Bruna Scaggiante
Summary: This review summarizes the potential of circulating tumor nucleic acids (ctNAs) analysis in aiding the diagnosis and prognosis of triple-negative breast cancer (TNBC). Mutations and copy number variations of TP53 and PIK3CA/AKT genes in plasma may serve as important markers for TNBC onset, progression, metastasis, and clinical follow-up. The expression profile of circulating tumor non-coding RNAs (ctncRNAs) can predict molecular subtypes of breast cancer and aid in the identification of TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Huaiwu Lu, Yunyun Liu, Jingyu Wang, Shaliu Fu, Lingping Wang, Chunxian Huang, Jing Li, Lingling Xie, Dongyan Wang, Dan Li, Hui Zhou, Qunxian Rao
Summary: This study demonstrates that cfDNA methylomes generated with cfMeDIP-seq could be used to identify OC-specific biomarkers for OC, especially early OC detection.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Michela Saviana, Giulia Romano, Joseph McElroy, Giovanni Nigita, Rosario Distefano, Robin Toft, Federica Calore, Patricia Le, Daniel Del Valle Morales, Sarah Atmajoana, Stephen Deppen, Kai Wang, L. James Lee, Mario Acunzo, Patrick Nana-Sinkam
Summary: This study proposes a miRNA-based biomarker classifier for SCLC that considers clinical demographics with specific cut offs to inform SCLC diagnosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Zhihao Chen, Liubing Li, Ziyuan Li, Xi Wang, Mingxiao Han, Zongshuai Gao, Min Wang, Gangfeng Hu, Xiaolu Xie, Hong Du, Zonggang Xie, Haifang Zhang
Summary: Novel key serum biomarkers for the diagnosis and metastatic prediction of osteosarcoma were identified based on an analysis of immune cell infiltration and associated RNA molecules.
CANCER CELL INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Alina Ioana Scarlatescu, Miruna Mihaela Micheu, Nicoleta-Monica Popa-Fotea, Maria Dorobantu
Summary: MicroRNAs have emerged as promising tools in the field of cardiovascular diseases, with potential in diagnostic, prognostic, and therapeutic applications for patients with ST elevation myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Claudia Piombino, Ilenia Mastrolia, Claudia Omarini, Olivia Candini, Massimo Dominici, Federico Piacentini, Angela Toss
Summary: Liquid biopsies, as an alternative to molecular re-characterization, have been widely studied for monitoring tumor evolution and applied in early cancer diagnosis, tumor burden monitoring, tumor heterogeneity, molecular resistance, and minimal residual disease detection. Among extracellular vesicles, exosomes are considered one of the most promising predictors of early cancer diagnosis and treatment response due to their ability to reflect the biological fingerprints of parental cells and their crucial role in cell communication.
Article
Oncology
Anna Adam-Artigues, Iris Garrido-Cano, Juan Antonio Carbonell-Asins, Ana Lameirinhas, Soraya Simon, Belen Ortega-Morillo, Maria Teresa Martinez, Cristina Hernando, Vera Constancio, Octavio Burgues, Begona Bermejo, Rui Henrique, Ana Lluch, Carmen Jeronimo, Pilar Eroles, Juan Miguel Cejalvo
Summary: The study developed and validated a plasma microRNA signature as a non-invasive biomarker for early-stage breast cancer diagnosis. Results confirmed the value of the signature based on miR-30b and miR-99a levels in plasma samples, demonstrating its potential for very early detection. The proposed microRNA signature presents a high value as a fast, cost-effective, and non-invasive biomarker for early-stage breast cancer detection.
Article
Biochemistry & Molecular Biology
Shuang Yu, Changan Liu, Yingtong Hou, Jie Li, Zhuming Guo, Xinwen Chen, Luyao Zhang, Sui Peng, Shubin Hong, Lixia Xu, Xiaoxing Li, Rengyun Liu, Shuwei Chen, Bin Li, Zongpeng Weng, Yanbing Li, Weiming Lv, Jun Yu, Haipeng Xiao
Summary: Discriminating papillary thyroid cancer (PTC) from benign thyroid nodule (BTN) is challenging, but this study identified a panel of 17 differential metabolites that can effectively differentiate between the two. The panel showed high sensitivity and specificity in both discovery and validation cohorts, and it also improved the accuracy and specificity for diagnosing papillary thyroid microcarcinoma compared to ultrasound.
Review
Genetics & Heredity
Yafei Xiao, Mengyuan Qiu, Cong Tan, Wanting Huang, Shaowen Hu, Xiaowei Jiang, Mingjie Guo, Congcong Wang, Jingyu Liang, Yimei Wu, Mengmeng Li, Quanying Li, Changjiang Qin
Summary: This study provides a comprehensive analysis of the expression patterns, biological functions, and clinical significance of circRNAs in colorectal cancer (CRC). Through the construction of circRNA-miRNA-mRNA interaction networks, the study identifies circRNAs that play important roles in the diagnosis, treatment, and prognosis of CRC. The study also highlights the significance of exosomal circRNAs as unique biomarkers in CRC.
FRONTIERS IN GENETICS
(2022)
Letter
Medical Laboratory Technology
Vivek Kumar Garg, Neelam Goel, Dharambir Kashyap
CLINICAL BIOCHEMISTRY
(2018)
Review
Oncology
Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Katrin Sak, Tapan Mukherjee, Anupam Bishayee
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2018)
Review
Medicine, Research & Experimental
Dharambir Kashyap, Ajay Sharma, Katrin Sak, Hardeep Singh Tuli, Harpal Singh Buttar, Anupam Bishayee
Review
Genetics & Heredity
Dharambir Kashyap, Hardeep Singh Tuli, Vivek Kumar Garg, Neelam Goel, Anupam Bishayee
MOLECULAR DIAGNOSIS & THERAPY
(2018)
Review
Food Science & Technology
Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Katrin Sak, Vivek Kumar Garg, Harpal Singh Buttar, William N. Setzer, Gautam Sethi
JOURNAL OF FUNCTIONAL FOODS
(2018)
Review
Biochemistry & Molecular Biology
Vaishali Aggarwal, Dharambir Kashyap, Katrin Sak, Hardeep Singh Tuli, Aklank Jain, Ashun Chaudhary, Vivek Kumar Garg, Gautam Sethi, Mukerrem Betul Yerer
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Dharambir Kashyap, Vivek Kumar Garg, Hardeep Singh Tuli, Mukerrem Betul Yerer, Katrin Sak, Anil Kumar Sharma, Manoj Kumar, Vaishali Aggarwal, Sardul Singh Sandhu
Article
Oncology
Dharambir Kashyap, Hardeep Singh Tuli, Mukerrem Betul Yerer, Ajay Sharma, Katrin Sak, Saumya Srivastava, Anjana Pandey, Vivek Kumar Garg, Gautam Sethi, Anupam Bishayee
Summary: The application of natural product-based nanoformulations in the treatment of various human diseases, such as cancer, is a growing field. Nanotechnology in cancer therapeutics has overcome the limitations of conventional drug delivery systems, with promising results in targeting tumor cells and reducing side effects. The integration of phytotherapy and nanotechnology in clinical settings may lead to better pharmacological responses and improved clinical outcomes for patients.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Immunology
Suvradeep Mitra, Amanjit Bal, Dharambir Kashyap, Sandeep Kumar, Shreya Shrivastav, Ashim Das, Gurpreet Singh
Article
Hematology
Arambam Gautam, Sreejesh Sreedharanunni, Man Updesh Singh Sachdeva, Sonia Rana, Dharambir Kashyap, Parveen Bose, Amanjeet Bal, Gaurav Prakash, Pankaj Malhotra, Reena Das, Neelam Varma
Summary: The study demonstrates the potential of using CD148 and CD180 expression levels to differentiate various types of mature B cell neoplasms with high specificity and sensitivity.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Dharambir Kashyap, Vivek Kumar Garg, Elise N. Sandberg, Neelam Goel, Anupam Bishayee
Summary: Cancer, a disease of inappropriate cell proliferation, is closely linked to the cell cycle, with multiple genetic alterations leading to cancer development. Both oncogenes and tumor suppressor genes regulate the cell cycle and play key roles in breast cancer progression. These components are tightly controlled in normal breast epithelial cells, but following mitogenic stimuli, their deregulation promotes neoplastic transformation. Numerous clinical studies have revealed prognostic significance in screening for these components, impacting patient outcomes and treatment responses. The review aims to summarize the roles of oncogenic and tumor-suppressive components in breast cancer progression and prognosis.
Letter
Hematology
Arambam Gautam, Dharambir Kashyap, Deepesh Lad, Amanjit Bal, Reena Das, Sreejesh Sreedharanunni
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2021)
Article
Pharmacology & Pharmacy
Priya Yadav, Vishal Jaswal, Ajay Sharma, Dharambir Kashyap, Hardeep S. Tuli, Vivek K. Garg, Shonkor K. Das, R. Srinivas
PHARMACEUTICAL PATENT ANALYST
(2018)
Review
Pharmacology & Pharmacy
Ajay Sharma, Dharambir Kashyap, Katrin Sak, Hardeep Singh Tuli, Anil K. Sharma
PHARMACEUTICAL PATENT ANALYST
(2018)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.