Editorial Material
Immunology
Kenneth McIntosh, Stanley Perlman, Arnold Monto, Janet A. Englund
Summary: The term "common cold coronaviruses" (ccCoV) is proposed to describe four human coronaviruses commonly associated with upper respiratory tract disease, differentiating them from the viruses causing more severe disease in humans.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Federico Giovannoni, Zhaorong Li, Federico Remes-Lenicov, Maria E. Davola, Mercedes Elizalde, Ana Paletta, Ali A. Ashkar, Karen L. Mossman, Andrea Dugour, Juan M. Figueroa, Andrea A. Barquero, Ana Ceballos, Cybele C. Garcia, Francisco J. Quintana
Summary: It has been found that coronaviruses activate AHR signaling, potentially impacting antiviral immunity and lung epithelial cells. The activation of AHR by coronaviruses is a common strategy to evade antiviral immunity and promote viral replication. This suggests that AHR could be a target for host-directed antiviral therapy.
NATURE COMMUNICATIONS
(2021)
Article
Infectious Diseases
Sook-Young Lee, Chul-Un Chung, Jun Soo Park, Yoon Ji Kim, Young-Sik Kim, Eun-Jee Na, YongKwan Kim, Jae-Ku Oem
Summary: A molecular epidemiological investigation of South Korean bat viruses revealed bats as natural reservoirs of various potentially zoonotic viruses. Coronaviruses were detected in samples collected across provinces, showing genetic diversity within different subgenera. The analysis indicates that Korean bat MERS-related coronaviruses are unlikely to bind with the human DPP4 receptor.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Soan Park, Jeong Wook Lee
Summary: The study introduces a new nucleic acid detection method that allows fast, sensitive, specific, and colorimetric detection of coronavirus. This method combines reverse transcription loop-mediated amplification with a toehold reaction, enhancing the sensitivity and speed of RNA virus detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Gang Wang, Ze Xiang, Wei Wang, Zhi Chen
Summary: The ongoing COVID-19 epidemic has seen a slow increase in vaccination rates and the development of treatments and drugs. Additionally, there is growing evidence of preexisting immunity against the SARS-CoV-2 virus in humans, mainly consisting of antibodies and immune cells. Preexisting immunity can help protect against infection, reduce disease severity, and enhance immune response.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Veterinary Sciences
Pei-Hua Wang, Amina Nawal Bahoussi, Pir Tariq Shah, Yan-Yan Guo, Changxin Wu, Li Xing
Summary: Transmissible gastroenteritis virus (TGEV) is a porcine coronavirus that remains elusive despite years of research efforts. A systematic analysis of TGEV genomes showed two distinct evolutionary clades, GI and GII, with Chinese strains clustering with traditional or attenuated vaccine strains within clade GI and recent US strains falling into clade GII. There were significant differences in genomic similarity between Chinese and US strains, and several potential genomic recombination events were identified. Genomic recombination appears to contribute to the expansion of TGEV genomic diversity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Immunology
Yuan Peng, Yongcheng Liu, Yabin Hu, Fangfang Chang, Qian Wu, Jing Yang, Jun Chen, Shishan Teng, Jian Zhang, Rongzhang He, Youchuan Wei, Mihnea Bostina, Tingrong Luo, Wenpei Liu, Xiaowang Qu, Yi-Ping Li
Summary: This study identified antibodies with broad-spectrum reactivity against all seven human coronaviruses, including MERS-CoV and SARS-CoV-2. By screening convalescent sera from COVID-19 patients, the researchers found that a significant proportion of antibodies showed cross-reactivity with MERS-CoV. They also generated monoclonal antibodies that exhibited binding activity to MERS-CoV spike protein and other coronaviruses. These findings have important implications for the development of diagnostic methods and vaccines for multiple coronaviruses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
M. Khalid Ijaz, Raymond W. Nims, Julie McKinney, Charles P. Gerba
Summary: The laundering process can spread infectious viruses to appliance surfaces and other household surfaces, as well as the hands of the laundry worker. This study explores the effectiveness of laundry sanitizers in inactivating coronaviruses and influenza viruses. The results show that laundry sanitizers containing specific active ingredients can effectively inactivate these viruses, reducing the risk of contamination.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Gustavo R. Perez-Lemus, Cintia A. Menendez, Walter Alvarado, Fabian Bylehn, Juan J. de Pablo
Summary: This study investigates the structural coordination and dynamics of the SARS-CoV-2 Nsp13 helicase and its complexes with natural ligands using atomistic molecular dynamics simulations. The results reveal a complex communication network and activation mechanism among the five domains of Nsp13, which are modulated by the presence of ligands. The study also presents the binding free energy and mechanism of action for three small molecules that efficiently inhibit the previous SARS-CoV Nsp13 enzyme. These findings provide important insights for the rational design of broad-spectrum antivirals against coronaviruses.
Review
Microbiology
Manuel Ruiz-Aravena, Clifton McKee, Amandine Gamble, Tamika Lunn, Aaron Morris, Celine E. Snedden, Claude Kwe Yinda, Julia R. Port, David W. Buchholz, Yao Yu Yeo, Christina Faust, Elinor Jax, Lauren Dee, Devin N. Jones, Maureen K. Kessler, Caylee Falvo, Daniel Crowley, Nita Bharti, Cara E. Brook, Hector C. Aguilar, Alison J. Peel, Olivier Restif, Tony Schountz, Colin R. Parrish, Emily S. Gurley, James O. Lloyd-Smith, Peter J. Hudson, Vincent J. Munster, Raina K. Plowright
Summary: Bats are known to carry a variety of coronaviruses and have been identified as prime reservoir hosts for emerging viruses. Since the first SARS epidemic in 2002, the understanding of bats as key hosts of coronaviruses has rapidly advanced. There are critical knowledge gaps regarding bat coronaviruses, and filling these gaps may help prevent the next pandemic.
NATURE REVIEWS MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Muhammad Imran Sajid, Muhammad Moazzam, Yeseom Cho, Shun Kato, Ava Xu, J. J. Way, Sandeep Lohan, Rakesh K. Tiwari
Summary: The ongoing global pandemic has caused millions of deaths and affected around 151 million people worldwide. Despite the hope brought by vaccines for COVID-19, researchers are still seeking new ways to combat the viral pandemic. RNA interference (RNAi) has emerged as a promising antiviral agent, with the potential for significant impact in treating coronaviruses.
MOLECULAR PHARMACEUTICS
(2021)
Review
Medicine, General & Internal
George D. Liatsos
Summary: The study investigates confounding factors in ribavirin treatment studies and proposes a therapeutic scheme for COVID-19.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Public, Environmental & Occupational Health
Suncanica Ljubin-Sternak, Tomislav Mestrovic, Ivana Luksic, Maja Mijac, Jasmina Vranes
Summary: Respiratory viral infections are a major global health burden, requiring timely and targeted diagnostic approaches. Seasonal coronaviruses, rhinoviruses, adenoviruses, and bocaviruses play a persistent role in respiratory infections, emphasizing the need for continuous virological diagnosis and global monitoring of disease burden associated with these viruses.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biology
Qingxing Wang, Sabrina Noettger, Qinya Xie, Chiara Pastorio, Alina Seidel, Janis A. Mueller, Christoph Jung, Timo Jacob, Konstantin M. J. Sparrer, Fabian Zech, Frank Kirchhoff
Summary: By analyzing the ability of Spike proteins from 26 human or animal coronaviruses to use ACE2 receptors, this study identifies determinants of ACE2 receptor usage for diverse coronaviruses and suggests that COVID-19 vaccination may protect against future zoonotic diseases caused by bat coronaviruses.
COMMUNICATIONS BIOLOGY
(2023)
Review
Psychiatry
Mounica Reddy-Thootkur, Nina Vanessa Kraguljac, Adrienne Carol Lahti
Summary: There is considerable overlap between schizophrenia and mood disorders, both of which are associated with cognitive deficits and altered glutamatergic and GABAergic neurometabolism. However, the relationship between these neurotransmitters and cognitive dysfunction in mental illness is still not well understood.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Neurosciences
Eric A. Nelson, Nina Kraguljac, Jose O. Maximo, Frederic Briend, William Armstrong, Lawrence W. Ver Hoef, Victoria Johnson, Adrienne C. Lahti
Summary: The study identified specific patterns of hippocampal functional connectivity in patients with psychosis spectrum disorder, characterized by hypoconnectivity to the default mode network and hyperconnectivity to the lateral occipital cortex. It also showed a predictive relationship between hippocampal glutamate + glutamine levels and functional connectivity in healthy individuals, which was reversed in patients with first-episode psychosis. These findings suggest that alterations in the glutamate-functional connectivity relationship may disrupt key neural networks.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Psychiatry
James Edward Bryant, Adrienne Carol Lahti, Frederic Briend, Nina Vanessa Kraguljac
Summary: The deficit syndrome of schizophrenia is characterized by enduring negative symptoms, while the nondeficit form of the illness is associated with different pathophysiological processes. Patients with deficit features have lower glutamate levels compared to those without, indicating potential neurobiological differences between the two subtypes.
SCHIZOPHRENIA BULLETIN
(2021)
Review
Psychiatry
Nina Vanessa Kraguljac, Adrienne Carol Lahti
Summary: Schizophrenia is a complex neuropsychiatric disorder with diverse brain abnormalities that can be captured through neuroimaging studies. Alterations in brain circuitry have been linked to the pathophysiology of schizophrenia, and non-specific factors such as antipsychotic drug exposure should be considered when interpreting disease signatures. Mechanistically oriented neuroimaging studies are crucial for rational drug development and relieving the burden of schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Psychiatry
Kevin P. Hill, Mark S. Gold, Charles B. Nemeroff, William McDonald, Adrienne Grzenda, Alik S. Widge, Carolyn Rodriguez, Nina Kraguljac, John H. Krystal, Linda L. Carpenter
Summary: This review aims to outline the evidence for the therapeutic use of cannabinoids for specific medical conditions and the potential side effects associated with acute and chronic cannabis use. The results show that there are currently no approved psychiatric indications for cannabinoids, and the evidence supporting their use in the treatment of psychiatric disorders is limited. The strongest evidence for cannabinoid prescription is for the management of pain and spasticity.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Review
Psychiatry
Genelle D. Samson, Adrienne C. Lahti, Nina V. Kraguljac
Summary: Neurological soft signs (NSS) are common in patients with schizophrenia, with the basal ganglia and cerebellum implicated as structural substrates. Somatomotor and somatosensory regions, as well as areas involved in visual processing and spatial orientation, are suggested to underlie NSS in psychosis spectrum disorders. Dysfunction of frontoparietal and cerebellar networks has also been implicated. However, it remains unclear if white matter integrity deficits or neurometabolic alterations contribute to NSS in schizophrenia. Knowledge about the temporal evolution of NSS and associated brain signatures is limited. Future studies addressing these gaps will be important.
Article
Psychiatry
Victoria L. King, Adrienne C. Lahti, Jose O. Maximo, Lawrence W. Ver Hoef, Sooraj John, Nina Kraguljac
Summary: This study used resting-state functional magnetic resonance imaging to investigate the connectivity of the frontoparietal control network (FPCN) and its subnetworks in patients with deficit syndrome of schizophrenia. The results showed that there were differences in connectivity patterns between patients who displayed deficit syndrome features and those who did not. Further analysis revealed a significant reduction in within-FPCN(A) connectivity in patients displaying deficit features.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Natalie Remiszewski, James Edward Bryant, Saige E. Rutherford, Andre F. Marquand, Eric Nelson, Ibrahim Askar, Adrienne Carol Lahti, Nina Vanessa Kraguljac
Summary: This study aimed to evaluate whether baseline deviations from a normative reference range in subcortical volumes are better predictors of antipsychotic treatment response than raw volumes in patients with first-episode psychosis.
Article
Behavioral Sciences
Eric A. Nelson, Nina Kraguljac, Jose O. Maximo, William Armstrong, Adrienne C. Lahti
Summary: This study found that the caudate may play a more important role than the putamen in driving early cortico-striatal dysconnectivity. These dysconnectivity patterns were also predictive of treatment response.
BRAIN AND BEHAVIOR
(2022)
Review
Psychiatry
Mara Parellada, Alvaro Andreu-Bernabeu, Monica Burdeus, Antonia San Jose Caceres, Elena Urbiola, Linda L. Carpenter, Nina V. Kraguljac, William M. McDonald, Charles B. Nemeroff, Carolyn I. Rodriguez, Alik S. Widge, Matthew W. State, Stephan J. Sanders
Summary: The aim of this study was to evaluate response biomarkers correlated with autism spectrum disorder (ASD) symptoms. A systematic review was conducted and 280 articles were included, reporting on 940 biomarkers. However, the studies showed high heterogeneity and there is currently no sufficient evidence for response biomarkers in ASD clinical trials.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Review
Nursing
Debra Pettit Bruns, Nina V. Kraguljac
Summary: The objective of this review is to provide a clinical overview of epidemiology, diagnosis, and treatment of co-occurring opioid use disorder (OUD) and serious mental illness (SMI), and to discuss the public health impact and implications for healthcare delivery and research. The findings suggest that contemporary diagnostics and treatment approaches for co-occurring OUD and SMI are underutilized, and comprehensive clinical guidelines are lacking at this time.
JOURNAL OF NURSING SCHOLARSHIP
(2023)
Article
Psychiatry
Eric A. Nelson, Nina Kraguljac, Jose O. Maximo, William Armstrong, Adrienne C. Lahti
Summary: The aim of this study was to predict the response to antipsychotic treatment in two cohorts of patients with psychosis spectrum disorders by identifying patterns of hippocampal connectivity. The results showed that stronger connectivity between the hippocampus and occipital cortex was predictive of better treatment response. Additionally, a greater reduction in hippocampal connectivity to the visual cortex during treatment was associated with better clinical response.
SCHIZOPHRENIA BULLETIN
(2023)
Meeting Abstract
Neurosciences
Natalie Remiszewski, James Edward Bryant, Saige Rutherford, Andre Marquand, Eric Nelson, Ibrahim Askar, Adrienne Lahti, Nina Kraguljac
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Nina Kraguljac
NEUROPSYCHOPHARMACOLOGY
(2021)