Article
Environmental Sciences
Wonhyoung Park, Sunwoo Park, Whasun Lim, Gwonhwa Song
Summary: Research results indicate that bifenthrin inhibits cell proliferation and viability, induces cell cycle arrest and apoptosis in both porcine trophectoderm and uterine luminal epithelial cells. Bifenthrin also damages mitochondria, induces reactive oxygen species production, leading to endoplasmic reticulum stress and calcium dysregulation in the cells. Finally, bifenthrin alters MAPK/PI3K signaling pathway and expression of pregnancy-related genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Agronomy
Yasir Majeed, Xi Zhu, Ning Zhang, Adnan Rasheed, Majid Mahmood Tahir, Huaijun Si
Summary: This article discusses the role of specific MAPK gene families in potato in response to various biotic and abiotic stresses, providing new insights into the functional analysis of these gene families under stress conditions.
MOLECULAR BREEDING
(2022)
Article
Biochemistry & Molecular Biology
Feifei Zhao, Sara Whiting, Sarah Lambourne, R. John Aitken, Ying-pu Sun
Summary: The study demonstrates that melatonin can protect human sperm from heat-induced oxidative stress by suppressing sperm mitochondrial ROS generation, increasing mitochondrial membrane potential, reducing lipid peroxidation product 4-HNE formation, and decreasing sperm DNA damage and apoptosis. This suggests melatonin as a potential treatment option for male infertility caused by heat-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Chaojun Kong, Longfei Jia, Jianping Jia
Summary: This study demonstrated that gamma-mangostin can attenuate oxidative stress and inflammation caused by Aβ42 oligomers, while protecting neurons from toxic medium-induced injury, suggesting its potential protective effect in Alzheimer's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chung-Yi Chen, Yan-Ning Chen, Jun-Ping Shiau, Jen-Yang Tang, Ming-Feng Hou, Hsueh-Wei Chang
Summary: This study found that 3HDT has an antiproliferative effect on triple-negative breast cancer cells, while having less impact on normal cells. Through various tests, it was found that 3HDT mainly acts on TNBC cells through oxidative stress and causes DNA damage. Therefore, 3HDT is an effective drug with selective antiproliferative and therapeutic effects on TNBC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Olakkaran Shilpa, Kizhakke Purayil Anupama, Anet Antony, Hunasanahally Puttaswamygowda Gurushankara
Summary: The study suggests that Pb accumulation in Drosophila brains induces oxidative stress, leading to DNA damage, apoptosis, and vacuolation.
Article
Biochemistry & Molecular Biology
Tzu-Jung Yu, Yuan-Bin Cheng, Li-Ching Lin, Yi-Hong Tsai, Bo-Yi Yao, Jen-Yang Tang, Fang-Rong Chang, Chia-Hung Yen, Fu Ou-Yang, Hsueh-Wei Chang
Summary: PHA is a potential natural product for anti-breast-cancer, which modulates oxidative-stress response, cell-cycle disturbance, apoptosis, and gamma H2AX-detected DNA damage.
Article
Biochemistry & Molecular Biology
Jun Bai, Jun Li, Ning Liu, Hai Jia, Xuemeng Si, Yusong Zhou, Zhian Zhai, Ying Yang, Fazheng Ren, Zhenlong Wu
Summary: This study found that glucosamine can protect porcine trophectoderm (pTr) cells from apoptosis and oxidative damage induced by zearalenone. Further research suggests that glucosamine exerts its protective effect by activating the PI3K/AKT signaling pathway. These findings provide a theoretical basis for the application of glucosamine in alleviating impaired early embryo development.
Article
Food Science & Technology
Archana Molangiri, Saikanth Varma, M. Satyavani, Saikrishna Kambham, Asim K. Duttaroy, Sanjay Basak
Summary: Early exposure to bisphenol may result in adverse reproductive health issues in later life. This study investigated the effects of orally administered bisphenol S (BPS) and bisphenol A (BPA) on testicular development in rats. The results showed that prenatal exposure to BPS can lead to changes in plasma testosterone levels, testis histology, inflammation, oxidative stress, and sperm DNA damage, potentially affecting male reproductive functions.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tuy An Trinh, Young Hye Seo, Sungyoul Choi, Jun Lee, Ki Sung Kang
Summary: Oxidative stress is a main cause of brain cell death in neurological disorders, while natural antioxidants can alleviate neurodegeneration. The study shows that osmundacetone from Elsholtzia ciliata has a neuroprotective effect against glutamate-induced oxidative toxicity and may be a potential agent for treating neurodegenerative diseases.
Article
Multidisciplinary Sciences
Sana Ullah, Shahid Ahmad, Yasir Altaf, Farman Ullah Dawar, Syed Ishtiaq Anjum, Mirza Muhammad Faran Ashraf Baig, Shah Fahad, F. Al-Misned, Usman Atique, Xinle Guo, Ghulam Nabi, Kunyuan Wanghe
Summary: This study assessed the toxicological effects of bifenthrin on grass carp, including changes in physiological, biochemical, and behavioral characteristics. The research found that acute exposure to bifenthrin resulted in stress responses and subtle biological alterations in grass carp.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tsu-Ming Chien, Kuang-Han Wu, Ya-Ting Chuang, Yun-Chiao Yeh, Hui-Ru Wang, Bi-Wen Yeh, Chia-Hung Yen, Tzu-Jung Yu, Wen-Jeng Wu, Hsueh-Wei Chang
Summary: Withaferin A exhibits anti-bladder cancer effects by inhibiting proliferation, inducing apoptosis, and causing DNA damage in a manner dependent on oxidative stress.
Article
Biochemistry & Molecular Biology
Wangta Liu, Li-Ching Lin, Pei-Ju Wang, Yan-Ning Chen, Sheng-Chieh Wang, Ya-Ting Chuang, I-Hsuan Tsai, Szu-Yin Yu, Fang-Rong Chang, Yuan-Bin Cheng, Li-Chen Huang, Ming-Yii Huang, Hsueh-Wei Chang
Summary: The study evaluated the antioxidant properties and antiproliferative impact of Nepenthes ethyl acetate extract (EANT) on leukemia cells. EANT demonstrated oxidative stress-dependent anti-leukemia ability associated with apoptosis and DNA damage in HL-60 cells. This suggests the potential of EANT as a therapeutic agent for leukemia treatment.
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Environmental Sciences
Anwesha Das, Sarbashri Bank, Srilagna Chatterjee, Nirvika Paul, Kunal Sarkar, Arindam Chatterjee, Santanu Chakraborty, Chaitali Banerjee, Anasuya Majumdar, Madhusudan Das, Sudakshina Ghosh
Summary: This study aimed to investigate the effect of the synthetic pyrethroid bifenthrin (BF) on mitochondrial DNA copy number variation in the edible fish Punitus sophore. Results showed that BF reduced the expression level of mitochondria COI gene, inhibited complex IV activity, and led to oxidative stress and mitochondrial dysfunction. BF also induced neurotoxicity by inhibiting AchE activity and caused an imbalance in antioxidant enzyme activity. Molecular docking and simulation analysis predicted that BF binds to the active sites of the enzyme. These findings suggest that the reduction of mtDNAcn could be a potential biomarker to assess BF-induced toxicity in aquatic ecosystems.
Article
Environmental Sciences
Amal Salah, Chayma Bouaziz, Alexandre Prola, Julie Pires Da Silva, Hassen Bacha, Salwa Abid-Essefi, Christophe Lemaire
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2017)
Article
Environmental Sciences
Amal Salah, Chayma Bouaziz, Ines Amara, Salwa Abid-Essefi, Hassen Bacha
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2019)
Article
Cell Biology
Ines Amara, Amal Salah, Rim Timoumi, Emna Annabi, Maria Scuto, Angela Trovato, Fadwa Neffati, Vittorio Calabrese, Salwa Abid-Essefi
CELL STRESS & CHAPERONES
(2020)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)