Article
Medicine, General & Internal
Hao Jiang, Wen Xu, Wenjing Chen, Lingling Pan, Xueshu Yu, Yincai Ye, Zhendong Fang, Xianwei Zhang, Zhiqiang Chen, Jie Shu, Jingye Pan
Summary: Early application of critical care transthoracic echocardiography (TTE) during mechanical ventilation (MV) was found to be beneficial for improving in-hospital mortality and other outcomes, based on a retrospective cohort study using data from the MIMIC-III and eICU databases. The adjusted odds ratio showed a favourable effect of early TTE on in-hospital mortality, 30-day mortality, and ventilation-free and vasopressor-free days. Further investigation with prospectively collected data is needed to confirm these findings.
Article
Pediatrics
Yogen Singh, Shazia Bhombal, Anup Katheria, Cecile Tissot, Maria Fraga
Summary: Cardiac point of care ultrasound (POCUS) is increasingly utilized in neonatal intensive care units to provide real-time information for clinical decision making. However, there is a lack of defined training programs and scope of practice for neonatal cardiac POCUS, despite the publication of expert consensus guidelines. Differentiating between cardiac POCUS and advanced hemodynamic evaluation remains unclear.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Medicine, General & Internal
Kamlin Ekambaram, Karim Hassan
Summary: Acute severe cardiac valve emergencies, such as AMR and AAR, pose challenges for diagnosis and management. Handheld point-of-care ultrasound devices are emerging as crucial tools for emergency physicians to promptly and accurately diagnose these emergencies, especially in resource-limited settings. However, current diagnostic protocols lack quantitative assessments of left-sided cardiac valves. This review evaluates the diagnostic utility of HoPE in AMR and AAR by reviewing literature and clinical case examples, and proposes a novel diagnostic framework integrating HoPE for patients with acute cardiorespiratory failure and suspected severe left-sided valve lesions.
Article
Veterinary Sciences
Christinax Eberhardt, Colin C. Schwarzwald
Summary: This study aimed to assess the training necessary to become proficient in performing focused cardiac ultrasound (FoCUS) using a hand-carried ultrasound (HCU) device. After a 1-day training course, both veterinarians and veterinary students showed significant improvement in knowledge and proficiency in echocardiography.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Review
Anesthesiology
Jose R. Navas-Blanco, Jack Louro, John Reynolds, Richard H. Epstein, Roman Dudaryk
Summary: Focused cardiac ultrasound (FoCUS) has been shown to be a potentially useful, noninvasive method for differentiating causes of intraoperative hypotension and guiding corrective interventions in patients undergoing noncardiac surgery, although the quality of evidence supporting its utility is very low. Further high-quality studies are needed to determine if intraoperative FoCUS is associated with improved outcomes.
ANESTHESIA AND ANALGESIA
(2021)
Editorial Material
Critical Care Medicine
Thomas W. Conlon, David B. Kantor, Eliotte L. Hirshberg, Maria Fraga, Christie L. Glau, Russ Horowitz, Jeffrey H. Burzynski, Aaron J. Godshall, Akira Nishisaki
Summary: Healthcare regulatory bodies have raised concerns about non-radiologists and non-cardiologists using point-of-care ultrasound, but recent data do not support these concerns. The global point-of-care ultrasound community, particularly in pediatric critical care, can lead the way in demonstrating safe and effective translation of new skills and technologies to the bedside. There is an opportunity to continue the conversation and propose next steps for integrating point-of-care ultrasound into pediatric critical care practice.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Letter
Medicine, General & Internal
Dermot M. Phelan, Susan A. Mayer, Raymond F. Stainback
Summary: Cardiac POCUS is a versatile tool for rapid bedside diagnosis, but must be operated by qualified professionals to avoid potential harm.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Critical Care Medicine
Laila Hussein, Mohammad Anzal Rehman, Tomislav Jelic, Alexei Berdnikov, Felipe Teran, Simon Richards, Nicole Askin, Robert Jarman
Summary: This systematic review found that while TEE can help identify reversible causes during cardiac arrest resuscitation, the evidence is of low certainty due to study heterogeneity and bias risk. Further research is needed to clarify TEE's diagnostic accuracy in identifying reversible causes and cardiac contractility during cardiac arrest.
Article
Anesthesiology
Nibras Bughrara, J. Ross Renew, Kenneth Alabre, Josh Schulman-Marcus, Krishnaveni Sirigaddi, Aliaksei Pustavoitau, Elizabeth R. Lesser, Jose L. Diaz-Gomez
Summary: The study compared the ability of subcostal-only window echocardiography and focused transthoracic echocardiography using three windows to provide critical information for novice sonographers. Results showed substantial agreement in evaluating RV size, LV size, LV contractility, pericardial effusion, RV contractility, and interventricular septal motion between the two methods. The EASy examination was found to be sufficiently accurate and can serve as an entry-point technique for novice clinicians.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Review
Medicine, General & Internal
Amer M. Johri, Casey Glass, Braeden Hill, Trevor Jensen, Wilfredo Puentes, Olusegun Olusanya, Juana Nicoll Capizzano, Ria Dancel, Kreegan Reierson, Nathaniel Reisinger, Kiera Liblik, Benjamin T. Galen
Summary: The use of cardiac point-of-care ultrasound (POCUS) is widespread in various medical fields. Users include medical trainees, advanced practice practitioners, and attending physicians in different specialties. This review provides a brief history of cardiac POCUS and discusses its current state of the art in different medical fields.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Anesthesiology
Cesar R. Padilla, Amir Shamshirsaz
Summary: The leading causes of ICU admission in pregnancy are hemorrhage, hypertensive disorders of pregnancy, and sepsis. Although the incidence of ICU admission during pregnancy may be low, critical illness in the postpartum period is relatively high. Early recognition of high-risk obstetric patients plays a crucial role in preventing maternal deaths.
BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Iria Lopez-Dequidt, Amparo Martinez-Monzonis, Carlos Pena-Gil, Adrian Gonzalez-Maestro, Violeta Gonzalez-Salvado, Emilio Rodriguez-Castro, Maria Santamaria-Cadavid, Susana Arias-Rivas, Manuel Rodriguez-Yanez, Jose Maria Prieto Gonzalez, JoseRamon Gonzalez-Juanatey
Summary: In this study, focused cardiac ultrasound was performed on 706 patients with ischemic stroke or transient ischemic attack. The incidence of structural heart disease was found to be 52.1%, and the presence of cardioembolic source was found in 31.9% of patients. Adverse cardiovascular events occurred in 5.49% of patients during the first year of follow-up. The presence of de novo structural heart disease was independently associated with a higher probability of adverse cardiovascular events.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Urology & Nephrology
Oscar J. L. Mitchell, Felipe Teran, Sharad Patel, Cameron Baston
Summary: Critical care echocardiography (CCE) is a common application of critical care ultrasound that involves the goal-directed use of transthoracic or transesophageal echocardiography. Nephrologists working in the ICU will regularly encounter CCE as part of patient care. The four primary indications for CCE include shock characterization, preload evaluation, volume responsiveness evaluation, and hemodynamic assessment.
ADVANCES IN CHRONIC KIDNEY DISEASE
(2021)
Article
Medicine, General & Internal
Irene Casado-Lopez, Yale Tung-Chen, Marta Torres-Arrese, Davide Luordo-Tedesco, Arantzazu Mata-Martinez, Jose Manuel Casas-Rojo, Esther Montero-Hernandez, Gonzalo Garcia de Casasola-Sanchez
Summary: This study assessed the utility of diagnostic multi-organ point-of-care ultrasound (PoCUS) in patients admitted to an internal medicine ward. Relevant ultrasound findings were detected in 27.7% of the 310 patients, with 19.3% triggering a therapeutic change. Older age and higher degree of dependency were associated with these findings. Multi-organ PoCUS provides relevant diagnostic information and facilitates therapy adjustment in internal medicine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Atsuko Furukawa, Yukio Abe, Atsushi Morizane, Tsuyoshi Miyaji, Shingo Hosogi, Hiroshi Ito
Summary: The study evaluated the diagnostic accuracy of a visual AS score developed by emergency physicians for screening AS. The results showed that a visual AS score >3 had high sensitivity, specificity, and predictive value for diagnosing moderate or severe AS, and patients with a score >3 had a higher prevalence of AS-related events during hospitalization.
JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yu Wu, Cheng Deng, Jia Xu, Wei Wang, Yihan Chen, Xiaojuan Qin, Qing Lv, Mingxing Xie
Summary: Abnormal proliferation and migration of VSMCs are crucial in the formation and rupture of atherosclerotic plaques. The use of UTMD for miR-145 delivery significantly improved gene transfection efficiency and promoted the contraction phenotype of VSMCs in vitro. In vivo, this approach reduced the atherosclerotic plaque area compared to free miR-145 treatment.
MOLECULAR PHARMACEUTICS
(2023)
Letter
Genetics & Heredity
Yichan Zhang, Wenqian Wu, Yali Yang, Mingxing Xie, Jing Wang
PRENATAL DIAGNOSIS
(2023)
Review
Medicine, General & Internal
Lang Gao, Li Zhang, Zisang Zhang, Yixia Lin, Mengmeng Ji, Qing He, Mingxing Xie, Yuman Li
Summary: Myocardial fibrosis (MF), a non-reversible process, is a crucial pathological manifestation in patients with end-stage cardiovascular diseases and closely related to cardiac adverse events. Early quantitative analysis of MF, using strain imaging techniques, plays an important role in risk stratification, clinical decision, and improvement in prognosis, by detecting MF early in cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Surgery
Lingli Peng, Wenqian Wu, Lingyun Fang, Mingxing Xie
ASIAN JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Qing He, Yixia Lin, Ye Zhu, Lang Gao, Mengmeng Ji, Li Zhang, Mingxing Xie, Yuman Li
Summary: Right ventricular-pulmonary artery coupling refers to the relationship between RV contractility and RV afterload. RV-PA uncoupling leads to RV dysfunction and right heart failure. Accurate evaluation of RV-PA coupling is important for patient assessment, clinical decision making, risk stratification, and prognosis judgment in cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Sushan Xiao, Junmin Zhang, Ye Zhu, Zisang Zhang, Haiyan Cao, Mingxing Xie, Li Zhang
Summary: Prenatal ultrasonography is a crucial tool in pregnancy, but limitations such as fetal mobility, maternal abdominal thickness, and inter-observer variability hinder traditional ultrasound's clinical application. The combination of artificial intelligence (AI) and obstetric ultrasound can optimize fetal ultrasound examination by reducing time, workload, and improving diagnostic accuracy. AI has been successfully used for automatic fetal ultrasound detection, biometric measurements, and disease diagnosis, enhancing traditional imaging approaches. This review comprehensively examines the applications and advantages of AI in prenatal fetal ultrasound, and discusses the challenges and potential of this emerging field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Qiaofeng Jin, Dandan Chen, Yishu Song, Tianshu Liu, Wenqu Li, Yihan Chen, Xiaojuan Qin, Li Zhang, Jing Wang, Mingxing Xie
Summary: In this study, ultrasound-responsive biomimetic superhydrophobic mesoporous silica nanoparticles, modified with red blood cell membrane and loaded with doxorubicin, were used for RM-1 tumor sonodynamic therapy. The use of these nanoparticles resulted in significantly higher accumulation in the tumor and reduced uptake in the spleen compared to the control group. The combination of the nanoparticles and multiple ultrasounds provided continuous sonodynamic therapy, resulting in a significantly better tumor inhibition rate in the experimental group.
Article
Pharmacology & Pharmacy
Wenqu Li, Qiaofeng Jin, Li Zhang, Shukun He, Yishu Song, Lingling Xu, Cheng Deng, Lufang Wang, Xiaojuan Qin, Mingxing Xie
Summary: This study explored the value and mechanism of ultrasound-targeted microbubble destruction (UTMD)-mediated Galectin-3 (Gal-3) short hairpin RNA (shRNA) transfection in anti-myocardial fibrosis. The results showed that Gal-3 shRNA/CMBs + US improved left ventricular ejection fraction (LVEF) and reduced myocardial fibrosis area, collagen expression, and production. In conclusion, UTMD-mediated Gal-3 shRNA transfection effectively silenced Gal-3 expression, alleviated myocardial fibrosis, and protected cardiac ejection function.
Editorial Material
Cardiac & Cardiovascular Systems
Chun Wu, Ruohan Zhao, Mingxing Xie, Qing Lv
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Tan Liu, Yongxing Zhang, Manwei Liu, Yuman Li, Mingxing Xie
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Medicine, General & Internal
Yixia Lin, Li Zhang, Xiaoqing Hu, Lang Gao, Mengmeng Ji, Qing He, Mingxing Xie, Yuman Li
Summary: Heart failure with preserved ejection fraction (HFpEF) is a condition where the left ventricular ejection fraction (LVEF) is not less than 50%. It accounts for more than 50% of all heart failure cases and its prevalence is increasing due to the aging population. However, assessing cardiac function and prognosis in HFpEF patients is challenging due to the normal range of LVEF and nonspecific symptoms and signs. Speckle-tracking echocardiography (STE) has emerged as a sensitive and accurate method for comprehensive assessment of cardiac function and prognosis in HFpEF patients.
