Article
Clinical Neurology
Audrey Low, Maria A. Prats-Sedano, James D. Stefaniak, Elizabeth Frances McKiernan, Stephen F. Carter, Maria-Eleni Douvani, Elijah Mak, Li Su, Olivia Stupart, Graciela Muniz, Karen Ritchie, Craig W. Ritchie, Hugh S. Markus, John Tiernan O'Brien
Summary: Markers of cerebrovascular disease are common in midlife adults, but their clinical relevance in predicting future dementia remains unclear. This study found that the Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) risk score is associated with markers of cerebral small vessel disease (SVD) and predicts the progression of SVD in midlife adults. The study also highlighted the potential of the CAIDE score as a prognostic and predictive marker for managing modifiable risk factors in cerebrovascular disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Fanny M. Elahi, Michael M. Wang, James F. Meschia
Summary: Cerebral small vessel disease (CSVD) is a common factor driving age-dependent diseases, such as stroke and dementia. This review discusses evolving criteria and imaging biomarkers for diagnosing CSVD-related dementia, as well as diagnostic challenges and the lack of effective biomarkers. The review also explores the relationship between CSVD and neurodegenerative diseases, and summarizes recent studies on cardiovascular medicines and CSVD-related cognitive impairment. Despite remaining questions, the increased attention to CSVD has provided a clearer understanding of the upcoming challenges imposed by this disease.
Article
Clinical Neurology
Ellen Backhouse, Susan D. Shenkin, Andrew M. McIntosh, Mark E. Bastin, Heather C. Whalley, Maria Valdez Hernandez, Susana Munoz Maniega, Mathew A. Harris, Aleks Stolicyn, Archie Campbell, Douglas Steele, Gordon D. Waiter, Anca-Larisa Sandu, Jennifer M. J. Waymont, Alison D. Murray, Simon R. Cox, Susanne R. de Rooij, Tessa J. Roseboom, Joanna M. Wardlaw
Summary: This study found that early life factors such as birth weight, childhood IQ, and education level are associated with small vessel disease in later life, independent of each other, vascular risk factors, and adult socio-economic status. These findings suggest that risk for small vessel disease may originate in early life and highlight the importance of investing in early child development to improve brain health and prevent dementia and stroke in older age.
Article
Clinical Neurology
Xian Fu, Weijin Zhang, Xianliang Li, Hongying Liu, Yin Zhang, Qingchun Gao
Summary: The purpose of this study was to investigate the cerebrovascular hemodynamics, including critical closing pressure (CrCP) and pulsatility index (PI), and their independent relationship with cerebral small vessel disease (CSVD) burden. The results showed that CrCP was an independent determinant and predictor of CSVD burden, and it was significantly correlated with age, BMI, and systolic blood pressure. These findings provide new insights into the development of CSVD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Sanne S. Mooldijk, M. Arfan Ikram
Summary: Cerebral small vessel disease (CSVD) is a major cause of cognitive decline and dementia, but the pathogenesis and mechanisms are still unclear. The current challenge lies in the difficulty of accurately quantifying CSVD, which hampers the understanding of its pathogenesis and pathophysiology. The markers currently used for CSVD mainly reflect brain abnormalities, but fail to capture morphological and functional changes of the microvasculature.
Article
Clinical Neurology
Masahiro Uemura, Yuya Hatano, Hiroaki Nozaki, Shoichiro Ando, Hajime Kondo, Akira Hanazono, Akira Iwanaga, Hiroyuki Murota, Yosuke Osakada, Masato Osaki, Masato Kanazawa, Mitsuyasu Kanai, Yoko Shibata, Reiko Saika, Tadashi Miyatake, Hitoshi Aizawa, Takeshi Ikeuchi, Hidekazu Tomimoto, Ikuko Mizuta, Toshiki Mizuno, Tomohiko Ishihara, Osamu Onodera
Summary: This study aimed to clarify the frequency and clinical features of monogenic cerebral small vessel disease (mgCSVD) among patients with adult-onset severe CSVD in Japan. The study found that over 90% of mgCSVD can be diagnosed by screening for NOTCH3, HTRA1, and ABCC6 mutations.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Chih-Ping Chung, Wei-Ju Lee, Kun-Hsien Chou, Pei-Lin Lee, Li-Ning Peng, Pei-Ning Wang, Ching-Po Lin, Liang-Kung Chen
Summary: This study evaluates the impact of frailty on the risk of dementia in individuals with subclinical CSVD. The results demonstrate that mobility frailty is associated with an increased risk of dementia and may serve as a marker for identifying individuals at risk of cognitive impairment in the early stages of CSVD.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Clinical Neurology
Thijs R. J. Landman, Dick H. J. Thijssen, Anil M. Tuladhar, Frank-Erik de Leeuw
Summary: Regular physical activity was found to be associated with lower all-cause mortality and reduced incidence of cerebrovascular events in patients with cerebral small vessel disease, but showed no relationship with the progression of MRI markers of the disease over a nine-year follow-up period.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Hilde van den Brink, Fergus N. Doubal, Marco Duering
Summary: This review summarizes recent advancements in advanced neuroimaging techniques for cerebral small vessel disease (cSVD), including structural imaging, functional and dynamic abnormality imaging, and the application of ultrahigh field MRI at 7 T. These advanced techniques provide novel pathophysiological insights into cSVD, allow improved quantification of disease burden and progression, and have important applications in clinical trials.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Geriatrics & Gerontology
Mana Shams, Sara Shams, Juha Martola, Lena Cavallin, Tobias Granberg, Magnus Kaijser, Max Wintermark, Eric Westman, Peter Aspelin, Maria Kristoffersen Wiberg, Lars-Olof Wahlund
Summary: The study found that APOE epsilon 4 is associated with MRI markers of SVD related to amyloid pathology, specifically CMBs and A beta 42 plaque formation in the brain, as reflected by decreased CSF A beta 42 levels. On the other hand, APOE epsilon 3 and epsilon 2 are associated with markers of hypertensive arteriopathy, such as the association with CMBs in deep and infratentorial brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
O. K. L. Hamilton, S. R. Cox, L. Ballerini, M. E. Bastin, J. Corley, A. J. Gow, S. Munoz Maniega, P. Redmond, M. del C. Valdes Hernandez, J. M. Wardlaw, I. J. Deary
Summary: Cerebral small vessel disease (SVD) burden is negatively associated with cognitive ability, processing speed, verbal memory, and visuospatial ability. The association between SVD burden and processing speed remains even after controlling for general cognitive ability, suggesting an independent impact. Testing processing speed may be particularly sensitive to the cognitive effects of SVD.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
Emilia Salvadori, Michela Brambilla, Giorgia Maestri, Alessia Nicotra, Ilaria Cova, Simone Pomati, Leonardo Pantoni
Summary: There is no consensus on which test is more suitable for assessing cognitive deficits in cerebral small vessel disease (cSVD) patients. A meta-analysis of 86 studies was conducted to explore the ability of eight cognitive tests commonly used in this population to differentiate cSVD patients, controls, and other dementing conditions. The results showed that cSVD patients performed worse than healthy controls in all tests, but data on the comparison to neurodegenerative diseases were limited. There is currently incomplete evidence that a single test could differentiate cSVD patients with cognitive decline from other dementing diseases. Preliminary proposals were made to gain information about the clinical definition of cSVD, which currently remains based on neuroimaging.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Mozhu Ding, Rui Wang, Gregoria Kalpouzos, Erika J. Laukka, Yuanjing Li, Kristina Johnell, Laura Fratiglioni, Chengxuan Qiu
Summary: The study revealed that atrial fibrillation is associated with accelerated progression of white matter lesions and ventricular enlargement among older adults, independent of cerebral infarcts. However, there was no significant association between atrial fibrillation and changes in perivascular spaces or lacune number.
Article
Geriatrics & Gerontology
Elisabeth J. Vinke, Pinar Yilmaz, Janine E. van der Toorn, Rahman Fakhry, Kate Frenzen, Florian Dubost, Silvan Licher, Marleen de Bruijne, Maryam Kavousi, M. Arfan Ikram, Meike W. Vernooij, Daniel Bos
Summary: Intracranial arteriosclerosis is increasingly recognized as a risk factor for cognitive impairment and dementia, with possible mechanisms involving structural brain changes and cerebral small vessel disease. The burden of intracranial carotid artery and vertebrobasilar artery calcification is related to accelerating structural brain changes over time, but not significantly associated with accelerated brain atrophy.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
Joyce van Arendonk, Julia Neitzel, Rebecca M. E. Steketee, Danielle M. E. van Assema, Henri A. Vrooman, Marcel Segbers, M. Arfan Ikram, Meike W. Vernooij
Summary: In a large cohort of dementia-free participants, diabetes is associated with increased risk of amyloid-positive status and higher amyloid-beta burden after 7 years, independent of genetic dementia risk, while hypertension is associated with subsequent amyloid-beta pathology in APOE4 carriers only.
Article
Dermatology
Selma Mekic, Luba M. Pardo, David A. Gunn, Leonie C. Jacobs, Merel A. Hamer, M. Arfan Ikram, Eline J. Vinke, Meike W. Vernooij, Annet E. G. Haarman, Eric F. Thee, Joelle E. Vergroesen, Caroline C. W. Klaver, Pauline H. Croll, Andre Goedegebure, Katerina Trajanoska, Fernando Rivadeneira, Joyce B. J. van Meurs, Banafsheh Arshi, Maryam Kavousi, Emmely W. de Roos, Guy G. O. Brusselle, Manfred Kayser, Tamar Nijsten
Summary: In this study from the Netherlands, looking younger than one's chronological age was associated with less osteoporosis, age-related hearing loss, cataracts, chronic lung obstructive disease, and higher cognitive function. This suggests that the appearance of a person's face reflects systemic aging and cognitive function.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Clinical Neurology
Cevdet Acarsoy, Lana Fani, Linda Al-Hassany, Brian Berghout, Peter J. Koudstaal, Antoinette Maassen Van Den Brink, M. Kamran Ikram, Daniel Bos
Summary: This study found an association between migraine and the risk of stroke in middle-aged and elderly individuals, but it was not statistically significant.
Article
Cardiac & Cardiovascular Systems
Banafsheh Arshi, Hamid A. Aliahmad, M. Arfan Ikram, Daniel Bos, Maryam Kavousi
Summary: A larger epicardial fat volume (EFV) is associated with increased risks of cardiovascular disease and atrial fibrillation. This study found that EFV is also associated with impaired cardiac function and an increased risk of heart failure (HF).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neuroimaging
Sven P. R. Luijten, Daniel Bos, Pieter-Jan van Doormaal, Mayank Goyal, Rick M. Dijkhuizen, Diederik W. J. Dippel, Bob Roozenbeek, Aad van der Lugt, Esther A. H. Warnert
Summary: Restoring blood flow is crucial for tissue survival and clinical outcome in ischemic stroke patients. Using ASL MRI, we found that hyperperfusion frequently occurs in infarcted and salvaged brain tissue following successful recanalization. Higher reperfusion levels are associated with better early neurological outcomes.
NEUROIMAGE-CLINICAL
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Judith van der Bie, Marcel van Straten, Ronald Booij, Daniel Bos, Marcel L. Dijkshoorn, Alexander Hirsch, Simran P. Sharma, Edwin H. G. Oei, Ricardo P. J. Budde
Summary: Photon-counting computed tomography (PCCT) is a new technology that offers higher spatial resolution, energy resolved imaging, and spectral post-processing compared to conventional CT techniques. This results in improved contrast-to-noise ratio, reduction in artifacts and potential dose, as well as elimination of electronic noise. The shift from pre-clinical studies to clinical research has been observed since the introduction of clinical PCCT in 2021. This review article focuses on the initial clinical results of PCCT, including the current PCCT systems, applications, and challenges.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Melody Chemaly, David Marlevi, Maria-Jesus Iglesias, Mariette Lengquist, Malin Kronqvist, Daniel Bos, Dianne H. K. van Dam-Nolen, Anja van der Kolk, Jeroen Hendrikse, Mohamed Kassem, Ljubica Matic, Jacob Odeberg, Margreet R. de Vries, M. Eline Kooi, Ulf Hedin
Summary: This study explored the biomarker potential of plasma BLVRB, finding that it is associated with intraplaque hemorrhage (IPH) in carotid plaques and the risk of recurrent ischemic stroke. Additionally, the study demonstrated that plasma BLVRB levels can be used to monitor the efficacy of pharmacotherapy targeting IPH. These findings suggest that plasma BLVRB may serve as a biomarker for atherosclerotic plaque instability.
Article
Geriatrics & Gerontology
Lisanne Tap, Meike W. Vernooij, Frank Wolters, Esther van den Berg, Francesco U. S. Mattace-Raso
Summary: Cerebral small vessel disease (cSVD) is commonly seen in brain imaging of older adults, especially those with cardiovascular disease risk factors. The link between cSVD and cognitive impairment is established, but how and when these vascular changes lead to cognitive decline is still uncertain. Technological advances allow for more accurate identification and quantification of cSVD, which can aid in diagnosing vascular cognitive impairment and identifying individuals at higher risk of cognitive and functional deterioration. This study explores how improved assessment of cSVD through neuropsychological testing, comprehensive geriatric assessment, and modern imaging techniques can enhance diagnosis and prognosis of cognitive impairment. The study also discusses new treatment approaches for cSVD and how these insights can optimize screening and treatment strategies for older adults with cognitive impairment and multiple morbidities.
Article
Clinical Neurology
Marjolein H. G. Dremmen, Dorottya Papp, Juan A. Hernandez-Tamames, Meike W. Vernooij, Tonya White
Summary: This study investigated the influence of lack of air in the paranasal sinuses on measurements of WM diffusion characteristics. The results showed that the amount of air in the paranasal sinuses can influence fractional anisotropy and mean diffusivity values of WM tracts in pediatric populations.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Neurosciences
Kursat Gurel, Farid Khasiyev, Antonio Spagnolo-Allende, Salwa Rahman, Minghua Liu, Erin R. Kulick, Amelia Boehme, Tatjana Rundek, Mitchell S. Elkind, Randolph S. Marshall, Daniel Bos, Jose Gutierrez
Summary: This study aimed to test the association between intracranial arterial calcification (IAC) and intracranial large artery stenosis (ILAS) as well as the risk of vascular events and mortality. Through data from two cohorts, cross-sectional and longitudinal analyses revealed that IAC was associated with ILAS and higher mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.
Article
Transplantation
Nynke Wijbenga, Nadine L. A. de Jong, Rogier A. S. Hoek, Bas J. Mathot, Leonard Seghers, Joachim G. J. V. Aerts, Daniel Bos, Olivier C. Manintveld, Merel E. Hellemons
Summary: This study aimed to evaluate the diagnostic accuracy of electronic nose (eNose) technology for noninvasive detection of bacterial colonization in lung transplant recipients. The results showed that eNose-based breath analysis has the potential to detect bacterial colonization in an accurate and noninvasive manner. Through supervised machine learning and data analysis, the diagnostic accuracy of eNose technology for bacterial colonization was assessed.
TRANSPLANTATION DIRECT
(2023)
Article
Health Care Sciences & Services
Bernhard P. Berghout (Brian), Daniel Bos, Peter J. Koudstaal, M. Arfan Ikram, M. Kamran Ikram
Summary: This population-based cohort study provides estimates on the risk of recurrent stroke, showing that almost one in five people with a first-ever stroke suffer a recurrence within ten years. The risk of recurrence has declined over time.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Computer Science, Information Systems
Elizaveta Lavrova, Zohaib Salahuddin, Henry C. Woodruff, Mohamed Kassem, Robin Camarasa, Anja G. Der Van Kolk, Paul J. Nederkoorn, Daniel Bos, Jeroen Hendrikse, M. Eline Kooi, Philippe Lambin
Summary: We propose a fully automated method for carotid artery outer wall segmentation in black blood MRI using partially annotated data and compare it to state-of-the-art reference model. Our method achieves state-of-the-art results, outperforming top-ranked methods, with a Dice similarity coefficient of 91.7% and volumetric intraclass correlation of 0.90 on development data and 91.1% and 0.83 on external data. The uncertainty-based approach increases interpretability of the proposed method by providing an uncertainty map together with the segmentation.