Article
Biochemistry & Molecular Biology
Liu-Yun Wu, Cheuk Ni Kan, Irwin K. Cheah, Joyce Ruifen Chong, Xin Xu, Henri Vrooman, Saima Hilal, Narayanaswamy Venketasubramanian, Christopher P. Chen, Barry Halliwell, Mitchell K. P. Lai
Summary: Low blood concentrations of ergothioneine (ET), a compound derived from diet, have been associated with cognitive impairment and cerebrovascular disease (CeVD). This study found that lower plasma ET levels were associated with poorer cognitive performance and faster rates of decline in function, memory, executive function, attention, visuomotor speed, and language. These associations were found in non-demented individuals and seemed to be explained by severity of concomitant CeVD and brain atrophy. Further assessment of plasma ET as a prognostic biomarker for cognitive decline is warranted.
Article
Clinical Neurology
Wai-Ying Wendy Yau, Zahra Shirzadi, Hyun-Sik Yang, Akpevweoghene P. Ikoba, Jennifer S. Rabin, Michael J. Properzi, Dylan R. Kirn, Aaron P. Schultz, Dorene M. Rentz, Keith A. Johnson, Reisa A. Sperling, Jasmeer P. Chhatwal
Summary: Elevated vascular risk and Aβ burden interact to promote cognitive decline, with tau accumulation playing a mediating role.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Pauline H. Croll, Elisabeth J. Vinke, Nicole M. Armstrong, Silvan Licher, Meike W. Vernooij, Robert J. Baatenburg de Jong, Andre Goedegebure, M. Arfan Ikram
Summary: The study found that hearing loss was associated with lower cognitive function at baseline and accelerated cognitive decline on a memory test. However, after additional adjustment for non-linear age effects, the association between hearing loss and accelerated cognitive decline was non-significant.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Emer R. McGrath, Alexa S. Beiser, Adrienne O'Donnell, Jayandra J. Himali, Matthew P. Pase, Claudia L. Satizabal, Sudha Seshadri
Summary: The association between vascular risk factors and dementia varies with age. Age-specific dementia risk scores should prioritize including different vascular risk factors at different ages.
Article
Health Care Sciences & Services
Sazzli Shahlan Kasim, Nurulain Ibrahim, Sorayya Malek, Khairul Shafiq Ibrahim, Muhammad Firdaus Aziz, Cheen Song, Yook Chin Chia, Anis Safura Ramli, Kazuaki Negishi, Nafiza Mat Nasir
Summary: This study validated and compared the performance of four cardiovascular disease risk prediction models in an Asian population. The FRS and RPCE models showed good discrimination but poor calibration in predicting CVD risk. SCORE2 and RPCE outperformed their previous versions, SCORE and PCE, respectively.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Geriatrics & Gerontology
Hui Shi, Mei-Ling Ge, Birong Dong, Qian-Li Xue
Summary: Higher Framingham CVD risk score was associated with a greater risk of incident frailty among Chinese older adults in this study. However, this association was no longer significant after adjusting for chronological age.
Article
Medicine, General & Internal
Zhangyu Wang, Kaiwang Cui, Ruixue Song, Xuerui Li, Xiuying Qi, Aron S. Buchman, David A. Bennett, Weili Xu
Summary: The study showed that a higher cardiovascular risk burden is associated with a faster decline in motor function, specifically in dexterity, gait, and hand strength. Cardiovascular diseases accumulation and cognitive decline may partially mediate the relationship between cardiovascular risk burden and decline in global motor function.
FRONTIERS IN MEDICINE
(2022)
Correction
Clinical Neurology
Jarith L. Ebenau, Wiesje Pelkmans, Inge M. W. Verberk, Sander C. J. Verfaillie, Karlijn A. van den Bosch, Mardou van Leeuwenstijn, Lyduine E. Collij, Philip Scheltens, Niels D. Prins, Frederik Barkhof, Bart N. M. van Berckel, Charlotte E. Teunissen, Wiesje M. van der Flier
Summary: In this study, we found that neurodegeneration biomarkers are moderately correlated, indicating they reflect different aspects of neurodegeneration and should not be used interchangeably. CSF total tau (t-tau), serum neurofilament light (NfL), and serum glial fibrillary acidic protein (GFAP) added predictive value beyond A beta and p-tau in predicting clinical progression.
Article
Geriatrics & Gerontology
Xiaoli Ji, Hui Gao, Daoyuan Sun, Wensui Zhao, Jianlin Zhuang, Kan Wang, Fariba Ahmadizar
Summary: This study found a positive association between baseline cardiovascular risk burden and subsequent cognitive decline in middle-aged and older Chinese. However, there was no consistent relationship between changes in cardiovascular risk burden and cognitive decline. The external validation using the English Longitudinal Study of Ageing confirmed the results.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Yi-Cheng Lin, Chih-Ping Chung, Pei-Lin Lee, Kun-Hsien Chou, Li-Hung Chang, Szu-Ying Lin, Yi-Jung Lee, Ching-Po Lin, Pei-Ning Wang
Summary: The coexistence of physical and cognitive impairments in older adults can predict incident disability, dementia, and mortality. This study investigated the natural course and prevalence of these impairments and found that skeletal muscle mass/function and memory function are crucial factors associated with the progression or reversal of functional impairments.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Lidan Zheng, Fiona E. Matthews, Kaarin J. Anstey
Summary: This study found that cardiovascular diseases are associated with a decrease in lifespan and cognitive impairment-free life expectancy, with stroke patients having the shortest lifespan and cognitive impairment-free life expectancy. Analysis of multiple cardiovascular risk factors revealed that each additional cardiovascular condition was exponentially linked to a decrease in lifespan and cognitive impairment-free life expectancy.
Article
Geriatrics & Gerontology
Christopher L. Schaich, Joseph Yeboah, Mark A. Espeland, Laura D. Baker, Jingzhong Ding, Kathleen M. Hayden, Bonnie C. Sachs, Suzanne Craft, Stephen R. Rapp, Jose A. Luchsinger, Annette L. Fitzpatrick, Susan R. Heckbert, Wendy S. Post, Gregory L. Burke, Norrina B. Allen, Timothy M. Hughes
Summary: Background vascular risk scores are associated with cognitive performance and decline, with differences in associations observed among different risk scores and racial/ethnic groups.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Clint L. Miller, Amy R. Kontorovich, Ke Hao, Lijiang Ma, Conrad Iyegbe, Johan L. M. Bjorkegren, Jason C. Kovacic
Summary: Atherosclerosis is the most common vascular disease worldwide, while Mendelian vascular diseases are caused by single genetic changes. These two types of diseases have very different genetic bases, thus requiring different precision medicine approaches for treatment.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cell Biology
Jiachen Chen, Margaret F. Doyle, Yuan Fang, Jesse Mez, Paul K. Crane, Phoebe Scollard, Claudia L. Satizabal, Michael L. Alosco, Wei Qiao Qiu, Joanne M. Murabito, Kathryn L. Lunetta
Summary: This study investigates the associations between inflammatory protein biomarkers and cognitive function as well as incident dementia outcomes. Higher levels of certain proteins are associated with worse executive function and language domain scores. Stratified analyses suggest differential effects between APOE e2 and e4 carriers, with e4 carriers showing associations with executive function and memory domains, and e2 carriers showing associations with the visuospatial domain. Higher levels of TNFB and CDCP1 are associated with increased risks of incident all-cause and AD dementia.
Article
Neurosciences
Bibek Gyanwali, Celestine Xue Ting Cai, Christopher Chen, Henri Vrooman, Chuen Seng Tan, Saima Hilal
Summary: Hypertension is associated with the progression of cerebrovascular disease, highlighting the importance of careful monitoring and management of blood pressure to reduce the incidence and progression.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Christina S. Dintica, Debora Rizzuto, Anna Marseglia, Gregoria Kalpouzos, Anna-Karin Welmer, Inger Wardh, Lars Backman, Weili Xu
NEUROBIOLOGY OF AGING
(2018)
Article
Clinical Neurology
Christina S. Dintica, Anna Marseglia, Debora Rizzuto, Rui Wang, Janina Seubert, Konstantinos Arfanakis, David A. Bennett, Weili Xu
Article
Clinical Neurology
Hui Xu, Rongrong Yang, Xiuying Qi, Christina Dintica, Ruixue Song, David A. Bennett, Weili Xu
Article
Clinical Neurology
Zhida Wang, Anna Marseglia, Ying Shang, Christina Dintica, Cesare Patrone, Weili Xu
ALZHEIMERS & DEMENTIA
(2020)
Article
Cell Biology
Christina S. Dintica, Anna Marseglia, Inger Wardh, Per Stjernfeldt Elgestad, Debora Rizzuto, Ying Shang, Weili Xu, Nancy L. Pedersen
Article
Clinical Neurology
Hui Xu, Rongrong Yang, Christina Dintica, Xiuying Qi, Ruixue Song, David A. Bennett, Weili Xu
ALZHEIMERS & DEMENTIA
(2020)
Article
Geriatrics & Gerontology
Zhi Cao, Christina Dintica, Ying Shang, Yangyang Cheng, Shu Li, Hongxi Yang, Li Sun, Weili Xu, Yaogang Wang
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2020)
Article
Clinical Neurology
Rui Wang, Chengxuan Qiu, Christina S. Dintica, Ying Shang, Amaia Calderon Larranaga, Hui-Xin Wang, Weili Xu
Summary: The study found that Alzheimer's disease (AD) and ischemic stroke (IS) share certain risk and protective factors, such as education level, lifestyle, and psychological well-being. Having protective factors can significantly reduce the risk of developing AD and IS, with up to 57.8% of cases prevented if individuals have no risk factors.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Rosanne Freak-Poli, Nina Wagemaker, Rui Wang, Thom S. Lysen, M. Arfan Ikram, Meike W. Vernooij, Christina S. Dintica, Myrra Vernooij-Dassen, Rene J. F. Melis, Erika J. Laukka, Laura Fratiglioni, Weili Xu, Henning Tiemeier
Summary: Loneliness is independently associated with cognitive decline and an increased risk of developing dementia. However, perceived and structural social support do not have a significant impact on cognitive function or dementia risk.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Christina S. Dintica, Mohamad Habes, Guray Erus, Eric Vittinghoff, Christos Davatzikos, Ilya M. Nasrallah, Lenore J. Launer, Stephen Sidney, Kristine Yaffe
Summary: We found that elevated blood pressure from early to mid-adulthood is associated with advanced brain aging in mid-life, even if the blood pressure is below the clinical cutoffs.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Christina S. Dintica, Tina Hoang, Norrina Allen, Stephen Sidney, Kristine Yaffe
Summary: Metabolic syndrome (MetS) is associated with lower cognition and microstructural brain alterations in midlife.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychiatry
Christina S. Dintica, Kristine Yaffe
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2022)
Article
Clinical Neurology
Christina S. Dintica, Mohamad Habes, Guray Erus, Tamar Simone, Pamela Schreiner, Kristine Yaffe
Summary: Long-term depressive symptoms in early adulthood are associated with accelerated brain aging and may have implications for brain health in midlife.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cell Biology
Christina S. Dintica, Miriam L. Haaksma, Jonas K. Olofsson, David A. Bennett, Weili Xu
Summary: Emerging evidence suggests that olfactory function is closely linked to memory function. This study aimed to assess whether olfactory and episodic memory functions follow similar age-related decline trajectories, and identified three different patterns of decline. Factors such as age, sex, genetic status, cognitive activity level, and BMI were predictors of these patterns, with participants in the declining in both functions class most likely to develop dementia. Such classification can contribute to a better understanding of the factors related to cognitive decline and dementia.