Article
Nutrition & Dietetics
Jyrki K. Virtanen, Tarja Nurmi, Antti Aro, Elizabeth R. Bertone-Johnson, Elina Hypponen, Heikki Kroger, Christel Lamberg-Allardt, JoAnn E. Manson, Jaakko Mursu, Pekka Mantyselka, Sakari Suominen, Matti Uusitupa, Ari Voutilainen, Tomi-Pekka Tuomainen, Sari Hantunen
Summary: A 5-year randomized trial found that vitamin D-3 supplementation did not reduce the incidences of major cardiovascular events or invasive cancer among older adults.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Verena Theiler-Schwetz, Christian Trummer, Martin R. Grubler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Spyridon N. Karras, Winfried Marz, Stefan Pilz, Stephanie Gangler
Summary: This post hoc analysis investigated the effects of vitamin D on blood pressure and found that vitamin D supplementation did not have an antihypertensive effect in individuals with vitamin D deficiency. However, there was a significant association between achieved 25(OH)D concentrations and blood pressure.
Review
Cardiac & Cardiovascular Systems
Shari S. Bassuk, JoAnn E. Manson
Summary: VITAL trial is the only large-scale randomized trial to investigate the preventive effects of marine omega-3 fatty acid supplementation on cardiovascular disease in a general population. The findings suggest that the intervention did not significantly reduce the primary endpoint of major CVD events, but did reduce the risk of total myocardial infarction, percutaneous coronary intervention, fatal myocardial infarction, and recurrent hospitalization for heart failure. Further research is needed to identify individuals who may benefit the most from this intervention.
CARDIOVASCULAR RESEARCH
(2023)
Article
Nutrition & Dietetics
Alicja Kolodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka
Summary: A study was conducted to assess the effectiveness of monitored vitamin D supplementation in preterm infants. Results showed that a higher percentage of infants in the monitored group had safe vitamin D levels, while potential vitamin D toxicity was observed in the standard treatment group. Therefore, vitamin D intake should be between 800-1000 IU and monitored to avoid overdose.
Article
Geriatrics & Gerontology
Mary Waterhouse, Emma Sanguineti, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Dallas R. English, Bruce K. Armstrong, Peter R. Ebeling, Gunter Hartel, Michael G. Kimlin, Rachel L. O'Connell, Hai Pham, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: This study found that monthly high-dose vitamin D supplementation did not reduce the risk of falls, and may potentially increase the risk of falling in individuals with normal BMI. Further investigation is needed to better understand the impact of vitamin D supplementation on falls risk in different populations.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Orthopedics
Matthew T. Weintraub, Jonathan Guntin, JaeWon Yang, Anne DeBenedetti, Vasili Karas, Craig J. Della Valle, Denis Nam
Summary: This randomized controlled trial aimed to investigate the effects of a one-time dose of vitamin D3 prior to total knee arthroplasty. The results showed no significant improvements in functional scores, walking test times, or complications in the early postoperative period when compared to the placebo group.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Medicine, General & Internal
Daphne M. Stol, Eelco A. B. Over, Ilse F. Badenbroek, Monika Hollander, Mark M. J. Nielen, Roderik A. Kraaijenhagen, Francois G. Schellevis, Niek J. de Wit, G. Ardine de Wit
Summary: The study investigated the long-term cost-effectiveness of stepwise CMD risk assessment and individualized treatment compared to care as usual, showing that although the intervention group had higher costs and some health benefits after 60 years, the intervention was not considered cost-effective in the long term.
Article
Nutrition & Dietetics
Josipa Domazet Bugarin, Svjetlana Dosenovic, Darko Ilic, Nikola Delic, Ivana Saric, Ivo Ugrina, Sanda Stojanovic Stipic, Bozidar Duplancic, Lenko Saric
Summary: COVID-19 symptoms range from asymptomatic cases to severe illness requiring hospitalization and intensive care. Low vitamin D levels have been associated with increased severity and mortality of COVID-19. However, this study found no significant benefit of vitamin D supplementation in patients with severe COVID-19 disease admitted to the ICU and in need of respiratory support.
Article
Nutrition & Dietetics
May M. Cheung, Rosemary D. Dall, Patricia A. Shewokis, Asma Altasan, Stella L. Volpe, Renee Amori, Harpreet Singh, Deeptha Sukumar
Summary: This study found that combined magnesium and vitamin D treatment may be more effective in increasing serum 25OHD concentrations compared to vitamin D supplementation alone in overweight and obese individuals, and it also has the potential to lower baseline systolic blood pressure.
Article
Clinical Neurology
P. N. Suresh Kumar, Vikas Menon, Chittaranjan Andrade
Summary: This study investigated the impact of vitamin D supplementation on depression treatment through a randomized controlled trial. The results showed that vitamin D supplementation did not improve the antidepressant effects of flexibly dosed escitalopram. Importantly, depressed patients with vitamin D deficiency may require higher antidepressant doses to experience similar benefits to those whose deficiency is corrected by vitamin D supplementation.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Geriatrics & Gerontology
Y. Zhang, Y. Li, J. Liu, X. Wei, N. Tan, J. Zhang, Wei Wang, Yong Wang
Summary: This meta-analysis found no significant effects of vitamin D or calcium supplementation on all-cause mortality, cardiovascular mortality, MACEs, and myocardial infarction among community-dwelling adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Cardiac & Cardiovascular Systems
Debasish Banerjee, Nihil Chitalia, Irina Chis Ster, Evan Appelbaum, Ravi Thadhani, Juan Carlos Kaski, David Goldsmith
Summary: A study on vitamin D supplementation in stable, non-diabetic CKD patients showed no beneficial effects on left ventricular mass.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Nutrition & Dietetics
Harriet Johansson, Giuseppe Spadola, Giulio Tosti, Mario Mandala, Alessandro M. Minisini, Paola Queirolo, Valentina Aristarco, Federica Baldini, Emilia Cocorocchio, Elena Albertazzi, Leonardo Zichichi, Saverio Cinieri, Costantino Jemos, Giovanni Mazzarol, Patrizia Gnagnarella, Debora Macis, Ines Tedeschi, Emanuela Omodeo Sale, Luigia Stefania Stucci, Bernardo Bonanni, Alessandro Testori, Elisabetta Pennacchioli, Pier Francesco Ferrucci, Sara Gandini
Summary: In a study involving newly resected stage II melanoma patients, adjuvant vitamin D3 significantly increased serum 25OHD levels, particularly in patients with a baseline Breslow score under 3 mm. Patients with low 25OHD levels and Breslow score >= 3 mm had shorter disease-free survival, suggesting a potential impact of vitamin D on melanoma prognosis. Larger trials with vitamin D supplementation in melanoma subjects are needed to further investigate these findings.
Article
Nutrition & Dietetics
Andrea Aparicio, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua, Kathleen Lee-Sarwar, Yang-Yu Liu
Summary: The maternal gut microbiome and vitamin D deficiency during pregnancy have been separately associated with health problems. This study analyzed data from pregnant women in the VDAART to investigate the association between vitamin D level and gut microbiome. The results suggest that increasing vitamin D level during pregnancy may protect against the growth of certain bacteria.
Article
Nutrition & Dietetics
Shuangshuang Ma, Wanjun Yin, Peng Wang, Haixia Wang, Lei Zhang, Ruixue Tao, Honglin Hu, Xiaomin Jiang, Ying Zhang, Fangbiao Tao, Peng Zhu
Summary: This study aimed to assess the effect of vitamin D supplementation during pregnancy on glucose levels and identify factors influencing the response to vitamin D intake. The results showed that vitamin D supplementation significantly protected glucose homeostasis, and the response to vitamin D may be influenced by basal vitamin D levels, VDR gene polymorphism, and metabolic profiles.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)