Article
Chemistry, Physical
Joanna Skopinska-Wisniewska, Marta Tuszynska, Ewa Olewnik-Kruszkowska
Summary: This study investigated the cross-linking of gelatin using different cross-linking agents, and found that dialdehyde starch is a better cross-linking agent for gelatin compared to EDC-NHS. Meanwhile, the use of squaric acid did not result in beneficial changes to the properties of the hydrogel.
Article
Engineering, Environmental
Liang Chen, Taotao Qiang, Xuejun Chen, Wenqi Ren, Hui Jie Zhang
Summary: This study utilized gelatin extracted from waste skin scrap in the leather industry to fabricate a waste gelatin-based film with high gelatin content, excellent mechanical performance, and autonomous biodegradability, by introducing covalent bonds and metal-ligand bonds to the gelatin matrix, improving its properties significantly.
Article
Engineering, Environmental
Estefania Alvarez-Castillo, Maria Jesus Pelagio, Carlos Bengoechea, Antonio Guerrero
Summary: This study aims to improve the mechanical properties of superabsorbent bioplastics based on porcine plasma protein by adding different amounts of glutaraldehyde as a cross-linking agent. The results showed that adding glutaraldehyde through immersion can significantly reduce soluble material loss.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Polymer Science
Luca Vaghi, Mauro Monti, Marcello Marelli, Elisa Motto, Antonio Papagni, Laura Cipolla
Summary: Gelatin is a costless polypeptide material capable of forming potentially useful hydrogels in biomaterial scaffold design, although it is unstable at physiological conditions. This study introduces the use of bi- and trifunctional tetrazoles for photoinduced gelatin cross-linking to produce physiologically stable hydrogels. The efficacy of the treatment depends on the structure of the cross-linking agent used, with substantial improvement observed by switching from bifunctional to trifunctional cross-linkers.
Article
Materials Science, Multidisciplinary
Giulia Mugnaini, Rita Gelli, Leonardo Mori, Massimo Bonini
Summary: Gelatin-based hydrogels are widely used in various fields due to their biocompatibility and versatility. However, their poor thermal stability limits their applications. In this study, we investigated the use of glutaraldehyde and glyceraldehyde as cross-linking agents in gelatin hydrogels. We found that by adjusting the type and amount of the cross-linker, we can tune the properties of the hydrogels, including their dissolution behavior, micro- and nanostructure, and mechanical properties. These findings are important for finding alternative cross-linking agents without toxicity concerns.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Biomaterials
Adam Mirek, Habib Belaid, Fanny Barranger, Marcin Grzeczkowicz, Yasmine Bouden, Vincent Cavailles, Dorota Lewinska, Mikhael Bechelany
Summary: This study aimed to develop a new stable and biodegradable gelatin-alginate hydrogel matrix for drug delivery applications by combining 3D bioprinting with different cross-linking techniques. The results confirmed that the 3D bioprinted cross-linked drug-loaded alginate-gelatin hydrogel is a good and satisfying material with potential use as a drug delivery system.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Kaidong Song, Bing Ren, Yingnan Zhai, Wenxuan Chai, Yong Huang
Summary: Three-dimensional bioprinting is a powerful engineering method for developing cellular structures with unique mechanical and biological properties. This study establishes a direct mapping between the printability of a gelatin microgel-gelatin solution composite bioink and the concentration and cross-linking time of the transglutaminase (TG) enzyme. The results show that by optimizing the TG concentration and cross-linking time, the bioink exhibits good injectability, feature formability, and cell viability.
Review
Biochemistry & Molecular Biology
Dong-Jin Lim
Summary: This article introduces the application of cross-linking agents to improve the performance of electrospun nanofibrous bone scaffolds in bone tissue engineering. Glutaraldehyde and genipin are two commonly used cross-linking agents, with genipin gaining attention due to its superior biocompatibility. In addition, citric acid is an emerging natural cross-linking agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Ting Zhang, Zhe Yu, Yun Ma, Bor-Sen Chiou, Fei Liu, Fang Zhong
Summary: Collagen films cross-linked with glutaraldehyde at different pH values demonstrated varying physicochemical properties, with optimal cross-linking degree achieved under neutral and alkaline conditions. pH influenced the reaction position and degree, resulting in improved mechanical properties and thermal stability in the cross-linked films compared to non-cross-linked films. Control of reaction pH can be utilized to modulate the collagen films' properties for specific applications.
FOOD HYDROCOLLOIDS
(2022)
Article
Materials Science, Multidisciplinary
Qiang Yang, Jing Guo, Yuanfa Liu, Fucheng Guan, Jingxing Song, Xueyong Gong
Summary: The novel C/AKP composite fibers with a multiple cross-linking network showed enhanced properties such as stronger crystallization ability and higher orientation degree, reaching optimal performance at a GA content of 0.2 wt%.
ADVANCED FIBER MATERIALS
(2022)
Article
Multidisciplinary Sciences
Lisa Rebers, Raffael Reichsollner, Sophia Regett, Guenter E. M. Tovar, Kirsten Borchers, Stefan Baudis, Alexander Southan
Summary: This study investigated the physical and chemical cross-linking of gelatin methacryloyl (GM) hydrogels and their impact on hydrogel strength. Results showed that regardless of the nature of the cross-links, the total cross-link density determined the stiffness of the hydrogels.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Inorganic & Nuclear
Amir Bahoor, Reza Ahmadi, Mojgan Heydari, Mozhgan Bagheri, Aliasghar Behnamghader
Summary: To control the rapid dissolution and high-speed drug release in oral drug delivery using gelatin, glutaraldehyde was used to cross-link gelatin. Gelatin nanoparticles (GNPs) carrying Gliclazide were prepared through a two-step dissolution method. Cross-linking of gelatin with glutaraldehyde was confirmed by the presence of an aldimine functional group in GNPs. The drug release from GNPs was controlled by the swelling degree, with the highest and lowest release percentages observed in cross-linked GNPs with 8%v/v and 25%v/v glutaraldehyde, respectively.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Junqing Qian, Aomei Huang, Hanxiao Zhu, Jing Ding, Wei Zhang, Yan Chen
Summary: In this study, cross-linked immobilized lipase (CLIL) was successfully prepared by physical adsorption and cross-linking with glutaraldehyde on silica nanoparticles. Microscopic analysis confirmed the immobilization of lipase on the surface of the nanoparticles. The cross-linking process altered the secondary structure of the lipase protein, resulting in significantly improved thermal and storage stability of the CLIL.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Article
Chemistry, Applied
Xiuying Han, Huiliang Wen, Yu Luo, Jun Yang, Wenhao Xiao, Jianhua Xie
Summary: The chemically modified porous starches showed higher thermal stability and adsorption performance compared to the original PS, while maintaining the crystal type unchanged. The solubility and swelling power of the modified porous starches were altered by the chemical modifications.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Yunshan Liu, Jianzhong Jiang
Summary: In this study, /9-ionone was encapsulated using complex coacervation of gelatin and pectin, followed by cross-linking with glutaraldehyde. The shape, size, and encapsulation efficiency of the microcapsule were significantly affected by the gelatin/pectin ratio and pH value. The microcapsules exhibited good thermal stability and slow release performance, making them a potential carrier for flavors like /9-ionone.
CARBOHYDRATE POLYMERS
(2023)
Article
Energy & Fuels
Taysnara Simioni, Caroline Borges Agustini, Aline Dettmer, Mariliz Gutterres
Summary: The combination of carbon and nitrogen-rich co-substrates improves the stability and balance of the anaerobic co-digestion process; the addition of untreated oat straw significantly increases biogas production in AcoD process. Different pretreatment techniques have varying effects on oat straw, with alkali treatment showing the most significant increase in cellulose content but also potential formation of toxic compounds.
BIOENERGY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Marieli Rosseto, Cesar Vinicius Toniciolli Rigueto, Daniela Dal Castel Krein, Lillian Avila Massuda, Naiana Pereira Balbe, Luciane Maria Colla, Aline Dettmer
Summary: This study aimed to enhance the properties of films produced from corn starch and gelatin recovered from CTLW by adding TGase and PESP. Significant improvements were achieved in water solubility and vapor permeability, as well as positive effects on soil covering.
BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR
(2021)
Article
Thermodynamics
Taysnara Simioni, Caroline Borges Agustini, Aline Dettmer, Mariliz Gutterres
Summary: This study investigated the impact of adding wheat straw on the anaerobic co-digestion of leather waste and its biogas production. The results showed that alkali treatment significantly increased the cellulose content of wheat straw, but inhibited methanogenesis, resulting in the lowest biogas production. However, the highest biogas yield was achieved when wheat straw was pretreated with acid, indicating its potential as an alternative for co-digestion.
Review
Agriculture, Multidisciplinary
Marieli Rosseto, Cesar Vinicius Toniciolli Rigueto, Ingridy Alessandretti, Rafaela de Oliveira, Daniela Alexia Raber Wohlmuth, Raquel Aparecida Loss, Aline Dettmer, Neila Silvia Pereira dos Santos Richards
Summary: The food industry is interested in extending the shelf life of food, and therefore, edible films and coatings have been explored as a solution. This study focuses on whey-based films for food packaging, which have unique characteristics such as antimicrobial and immunomodulatory properties. Various compounds can be incorporated into whey films to improve their solubility and mechanical properties. Meat and cheese are the most commonly studied food matrices for application. Edible and biodegradable films offer potential to replace synthetic polymers and have social, environmental, and economic benefits.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Environmental Sciences
Taysnara Simioni, Caroline Borges Agustini, Aline Dettmer, Mariliz Gutterres
Summary: This study evaluated the agronomic value and phytotoxic effect of liquid digestate obtained from the anaerobic co-digestion of tannery waste. The results showed that the liquid digestate had a bio-stimulating effect on plant development, similar to mineral fertilizers. The analysis of soil samples indicated that the liquid digestate provided the same nutrients as other fertilizers and did not negatively affect soil organic matter or cause metal accumulation.
WASTE AND BIOMASS VALORIZATION
(2023)
Article
Agronomy
Cesar Vinicius Toniciolli Rigueto, Marieli Rosseto, Raquel Aparecida Loss, Neila Silvia Pereira dos Santos Richards, Aline Dettmer, Ionara Regina Pizzutti
Summary: This study conducted a bibliometric analysis and literature review on gelatin-based films used for food packaging. It identified various compounds that can enhance the films' properties and discussed their application in different types of food. However, achieving large-scale application still poses challenges.
Review
Food Science & Technology
Cesar Vinicius Toniciolli Rigueto, Marieli Rosseto, Ingridy Alessandretti, Rafaela de Oliveira, Daniela Alexia Raber Wohlmuth, Juliana Ferreira Menezes, Raquel Aparecida Loss, Aline Dettmer, Ionara Regina Pizzutti
Summary: Gelatin, a potential polymer that can be extracted from waste sources, has good film-forming ability and compatibility with other compounds, making it suitable for the production of biodegradable films and coatings. It can contribute to reducing environmental pollution and positively impacting sustainable development goals.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Polymer Science
Leticia Mariane Deloss Gullich, Marieli Rosseto, Cesar Vinicius Toniciolli Rigueto, Barbara Biduski, Luiz Carlos Gutkoski, Aline Dettmer
Summary: This study examined the effects of annealing and oxidation on native wheat starch for use in biodegradable films. The modified starches were evaluated for various properties and then used to create films, which were compared to films made with native starch. Annealing led to a reorganization of starch molecules, resulting in more stable films with fewer changes in mechanical properties and solubility. On the other hand, oxidation caused more drastic changes, including a heterogeneous structure and decreased elongation. The annealing treatment showed promise for developing biodegradable packaging with superior properties to chemically modified starch films.
Review
Environmental Sciences
Vera Analise Schommer, Ana Paula Vanin, Mateus Torres Nazari, Valdecir Ferrari, Aline Dettmer, Luciane Maria Colla, Jeferson Steffanello Piccin
Summary: Heavy metals contamination poses risks to ecosystems and human health. Bioremediation using biochar as a carrier for immobilized bacteria has emerged as an alternative to improve efficiency in environments with high concentrations of heavy metals. Bacillus spp. strains immobilized on biochar can reduce the toxicity and bioavailability of metals through biomineralization, biosorption, bioreduction, bioaccumulation, and adsorption mechanisms. This strategy promotes the reduction of toxicity and accumulation of metals in plants, enhances microbial and enzymatic activity in soil, but may also lead to competition and reduction of microbial diversity, as well as toxic characteristics of biochar. Further studies are needed to optimize this technology and understand its impacts, especially in field-scale applications.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Materials Science, Multidisciplinary
Cesar Vinicius Toniciolli Rigueto, Ingridy Alessandretti, Marieli Rosseto, Claudineia Aparecida Queli Geraldi, Raquel Aparecida Loss, Ionara Regina Pizzutti, Jeferson Steffanello Piccin, Aline Dettmer
Summary: This study investigated the adsorption performance of adsorbent composites based on commercial and chromium-tanned leather wastes (RCTLW) gelatin for tartrazine yellow dye. The RCTLW gelatin composite beads exhibited a higher adsorption capacity and better reusability.
MATERIA-RIO DE JANEIRO
(2022)
Article
Environmental Sciences
Ingridy Alessandretti, Cesar Vinicius Toniciolli Rigueto, Marieli Rosseto, Aline Dettmer
Summary: This study evaluated the potential of Chromium (III) tanned leather waste as an adsorbent for the removal of diclofenac sodium from aqueous media. The results showed that the waste leather had good adsorption performance and could efficiently remove diclofenac sodium.
ENVIRONMENTAL ENGINEERING AND MANAGEMENT JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Cesar Vinicius Toniciolli Rigueto, Samara Correia Harala, Marieli Rosseto, Bruna Elisangela Pessini Ostwald, Lillian Avila Massuda, Mateus Torres Nazari, Aline Dettmer, Raquel Aparecida Loss, Claudineia Aparecida Queli Geraldi
Summary: The study aimed to utilize soybean hull as a biosorbent to remove dye effluents, showing high adsorption efficiency with 88% dye removal achieved in about 120 minutes of equilibrium. Kinetic and equilibrium tests indicated that the pseudo-second order and Sips models were suitable for representing the experimental data.
MATERIA-RIO DE JANEIRO
(2021)
Article
Chemistry, Applied
E. Baggio, B. S. Scopel, D. D. C. Krein, C. V. T. Rigueto, F. C. Kovalski, C. Baldasso, A. Dettmer
Summary: The production of biodegradable polymers is a promising alternative to reduce residues and environmental pollution. Tannery wastes can be used for gelatin extraction and film production, with enzyme crosslinking improving properties such as water permeability and solubility. The enzyme transglutaminase can significantly affect the properties of gelatin films and their rate of soil degradation.
JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION
(2021)
Article
Engineering, Environmental
Cesar Vinicius Toniciolli Rigueto, Marieli Rosseto, Mateus Torres Nazari, Bruna Elisangela Pessini Ostwald, Ingridy Alessandretti, Christian Manera, Jeferson Steffanello Piccin, Aline Dettmer
Summary: This study aimed to produce composite beads for diclofenac removal using gelatin recovered from chromium tanned leather waste and carbon nanotubes, showing similar adsorption capacities and kinetic behaviors as commercial gelatin and carbon nanotubes, with potential applications in water treatment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Engineering, Environmental
Marieli Rosseto, Cesar Vinicius Toniciolli Rigueto, Daniela Dal Castel Krein, Lillian Avila Massuda, Bruna Elisangela Pessini Ostwald, Luciane Maria Colla, Aline Dettmer
Summary: Biodegradable films combining proteins and polysaccharides provide a sustainable alternative to fossil-based polymers; Starch and gelatin enhance the stability of the blend and improve film properties; Enzyme-treated films show better performance during accelerated aging, with increased tensile strength and elongation at break.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)