期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 85, 期 11, 页码 7181-7191出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c00561
关键词
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资金
- IISER Tirupati
- SERB, India [CRG/2018/002480/OC]
- UGC, India
Direct synthesis of N-heterocycles via the acceptorless dehydrogenative coupling is very challenging and scarcely reported under 3d transition-metal catalysis. Here, we have developed an efficient Mn(I)-catalyzed sustainable synthesis of various quinoxalines from 1,2-diaminobenzenes and 1,2-diols via the acceptorless dehydrogenative coupling reaction. Further, this strategy was successfully applied for the unprecedented synthesis of quinazolines by the reaction of 2-aminobenzyl alcohol with primary amides. The present protocol provides an atom-economical and sustainable route for the synthesis of various quinoxaline and quinazoline derivatives by employing an earth-abundant manganese salt and simple phosphine-free NNN-tridentate ligand.
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