Article
Nanoscience & Nanotechnology
Marta Pacheco, Carmen C. Mayorga-Martinez, Alberto Escarpa, Martin Pumera
Summary: Magnetic microrobots have been developed to efficiently remove nerve agents from contaminated water, offering a promising approach for large-scale water treatment and environmental remediation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Analytical
Conghui Liu, Juejiao Huang, Tailin Xu, Xueji Zhang
Summary: This article reviews the characteristics and progress of light-responsive Janus micro-/nanomotors in biomedicine and focuses on their applications in biosensing, bioimaging, and theranostic. The remaining challenges in practical application are summarized, and potential solutions are proposed.
Article
Chemistry, Multidisciplinary
Juan C. Fraire, Maria Guix, Ana C. Hortelao, Noelia Ruiz-Gonzalez, Anna C. Bakenecker, Pouria Ramezani, Charlotte Hinnekens, Felix Sauvage, Stefaan C. De Smedt, Kevin Braeckmans, Samuel Sanchez
Summary: Nanomotors, powered by enzymes and triggered by laser irradiation, can improve drug delivery efficiency and overcome biological barriers. These nanomotors can collectively displace and disrupt protein fibers in a blocked microchannel. This active motion and mechanical disruption provide a clear advantage for improving therapy.
Article
Chemistry, Multidisciplinary
Ning Zhang, Mengkang Fan, Yongchao Zhao, Xiaolong Hu, Qiongjun Zhu, Xiaolu Jiao, Qingbo Duanbin Li, Zheyong Huang, Guosheng Fu, Junbo Ge, Hongjun Li, Wenbin Zhang
Summary: A hybrid cell-derived extracellular vesicle (N@MEV) composed of mesenchymal stem cells and macrophage membranes with a ROS scavenger, MitoN, was constructed to promote heart healing. Through multiple mechanisms, N@MEV increased heart function 1.3-fold in a mouse myocardial injury model. Further mechanistic studies showed that N@MEV could modulate M2 macrophages, promote angiogenesis, reduce DNA damage and response, and restart cardiomyocyte proliferation.
Article
Chemistry, Physical
Qilin He, Shao-Xiong Lennon Luo, Tianyi Jin, Mingyu Liu, Sohyun Park, Alfredo Alexander-Katz, Benjamin R. McDonald, Francesco Fornasiero, Timothy M. Swager
Summary: Surface-tethered polymers have important applications in functional polymer coatings, and we have developed a new surface grafting strategy, termed grafting-to and from, using surface-initiated ring-opening metathesis polymerization (SI-ROMP). This method allows for the growth of thick and environmentally stable polymer brushes, which can be functionalized to enhance response capabilities. Our results demonstrate the effectiveness of this method in developing polymer-grafted breathable membranes that autonomously react to chemical warfare agents.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Xiaojun Xu, Maorui Tian, Zhengguo Lin, Xinning Zhang, Bo Wang, Xiaojie Ma
Summary: This study demonstrates the potential of Ln-based luminescent metal-organic framework (MOF) for nerve agent sensing, and develops a cooperation with glycerol as a method for sensitivity and selectivity enhancement. The sensing film based on a layer structural pyrazole-functionalized Eu MOF shows high sensitivity and selectivity for nerve agent detection, as well as low detection limit.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Chunchun Liang, Mengwei Li, Yulan Chen
Summary: This study reports a series of amphiphilic diazapyrenes that exhibit switchable fluorescence under mechanical force or water vapor stimulation. Through comprehensive studies of their photophysical properties, a stimuli-induced excimer-based sensing mechanism was revealed, and the relationship between molecular structures and optical responsive properties was illustrated. The unique fluorescent, stimuli-responsive behaviors of these compounds in the solid state were used to create sensory films for sensing mechanical force and water vapor, showing potential applications in biocompatible force sensors, data storage, and humidity sensors.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Wei Wang, Thomas E. Mallouk
Summary: The recent invention of nanoswimmers, synthetic, powered objects with characteristic lengths in the range of 10-500 nm, has generated widespread interest. However, studying nanoswimmers poses new opportunities and challenges, particularly in accurately characterizing and visualizing them.
Review
Chemistry, Analytical
Pablo Labra-Vazquez, Marie Gressier, Guillaume Rioland, Marie-Jolle Menu
Summary: This manuscript presents a literature survey on solution- and vapor-responsive sensors and analytical assays for the detection of phthalates. It provides a detailed analysis of the analytical performance and advantages of each class of sensor covered in this review, as well as fundamental information on the physicochemical responses exploited by these sensors and assays.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biotechnology & Applied Microbiology
Yingshuai Wang, Tao Yu, Feihu Hu
Summary: This study explores the application of miRNAs and exosomes in peripheral nerve regeneration and finds that a hypocapnia environment can enhance exosome function. By delivering miR-218 through engineered exosomes, sciatic nerve regeneration can be facilitated, and hypocapnia stimuli-responsive exosomes show better results.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Computer Science, Theory & Methods
Aleksandr Saprykin, Ndaona Chokani, Reza S. Abhari
Summary: This study presents a novel GPU-accelerated simulation model for large-scale fleet deployment that can run countrywide, multi-modal scenarios with millions of agents and fleets of tens of thousands of vehicles within a couple of minutes. Assessments of various scenarios of automated vehicle deployment in Zurich, Switzerland's largest city, were conducted, indicating that one automated vehicle could replace 7-8 private cars.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Andrea Bernardos, Matej Bozik, Ana Montero, Edgar Perez-Esteve, Esther Garcia-Casado, Miloslav Lhotka, Adela Frankova, Maria Dolores Marcos, Jose Manuel Barat, Ramon Martinez-Manez, Pavel Kloucek
Summary: This study prepared biomimetic systems for the controlled release of eugenol inspired by natural plant defense mechanisms, and described their antifungal activity. Compared to systems capped with saccharides, maltodextrin- and maltose-capped systems release less eugenol in the absence of Aspergillus niger fungus but deliver more in its presence.
Article
Nanoscience & Nanotechnology
Ting Wu, Feng Qiu, Ran Xu, Qi Zhao, Longfei Guo, Dairong Chen, Cheng Li, Xiuling Jiao
Summary: The development of functional materials that can detoxify multiple chemical warfare agents at the same time is of great significance. In this study, PAN@Zr(OH)4@MOF-808 nanofiber membranes were prepared for detoxification of both nerve agent and blistering agent simulants. The nanofiber membranes showed excellent detoxification performance and recycling stability, with great application potential.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Editorial Material
Clinical Neurology
Simon Thebault, Hailey Bergman, Harold L. Atkins, Mark S. Freedman, John Brooks
Summary: This study reports a case of CLIPPERS that achieved durable and steroid-free remission after IV cladribine. The patient responded dramatically to steroids with no identifiable cause, and attempts to wean prednisone resulted in relapses. IV cladribine was selected as a steroid-sparing agent, and the patient achieved complete remission without steroids.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Chemistry, Multidisciplinary
Jing Qian, Srikanth Kolagatla, Aleksejus Pacalovas, Xia Zhang, Larisa Florea, A. Louise Bradley, Colm Delaney
Summary: Two photon polymerization using direct laser writing is a growing field of research that focuses on incorporating soft, responsive polymers to microstructures for added value. By moving to the micron-scale, the speed of actuation for stimuli-responsive materials can be significantly increased. This study demonstrates the fabrication of submicron 2D photonic structures using a vapor-responsive photoresist and evaluates their feasibility as vapor sensors. The structures show reproducible and reversible spectral and structural color changes when exposed to different vapors.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Virendra V. Singh, Vinod Kumar, Utpal Biswas, Mannan Boopathi, Kumaran Ganesan, Arvind K. Gupta
Summary: A novel turn-on fluorescence detection method for sulfur mustard gas at room temperature was explored, utilizing luminol and an ionic liquid combination in water. The method showed rapid detection of sulfur mustard gas within seconds and excellent sensitivity and selectivity, making it suitable for field-deployable applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Ceramics
William M. Mellor, Kevin Kaufmann, Olivia F. Dippo, Samuel D. Figueroa, Grant D. Schrader, Kenneth S. Vecchio
Summary: In the last decade, single-phase high-entropy materials have been of interest due to their unique properties. The recent development of 5-cation high-entropy carbides has demonstrated promising properties, and there is now a proposed development of ultrahigh-entropy carbides containing 6+ principal elements with greater combinatorial possibilities. The use of 6+ multi-cation compositions allows for ceramics with tunable properties and potentially higher orders of entropic stabilization.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Multidisciplinary Sciences
Kevin Kaufmann, Hobson Lane, Xiao Liu, Kenneth S. Vecchio
Summary: Transfer learning can accelerate the training of deep learning models and improve performance with limited data. In this study, a few-shot transfer learning approach is used to classify electron backscatter diffraction pattern images, demonstrating its applicability for real-world phase identification and differentiation.
SCIENTIFIC REPORTS
(2021)
Article
Entomology
Aytul Ucak Koc, Mete Karacaoglu, Murat Uygun, Zehra Burcu Bakir, Burcu Keser
Summary: The composition of royal jelly is affected by harvest time and the number of grafted larvae, influencing substances such as 10-HDA, total protein, furosine, superoxide dismutase activity, and phenolic compounds.
JOURNAL OF APICULTURAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Baha Ondes, Murat Uygun, Sinem Evli, Deniz Aktas Uygun
Summary: In this study, a new micromotor was developed for immobilizing urokinase. The micromotors were functionalized through covalent bonding between urokinase and carboxyl groups on the graphene oxide surface. The micromotors exhibited magnetic properties due to the inner nickel layer, allowing easy separation with a magnet. The immobilized urokinase showed higher activity, stability, and storage stability compared to free urokinase.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Kevser Kusat, Selami Baglamis, Cansu Ilke Kuru, Fulden Ulucan, Murat Uygun, Sinan Akgol
Summary: Serum proteins are valuable resources for detecting various diseases, but the majority of them are composed of only a few proteins. A new material, dye ligand affinity-based hydrogel membranes, was proposed in this study to enhance the affinity towards Immunoglobulin (IgG). The synthesized micron mesh p(HEMA)-RR241 hydrogel membranes showed good water absorption properties and a micron network structure. The optimized conditions for IgG adsorption were also determined. The proposed material demonstrated the potential for repeated use.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Chemistry, Physical
Murat Uygun, Sinem Evli, Baha Ondes, Mustafa Sami Ozaydin, Deniz Aktas Uygun
Summary: In this study, a uricase immobilized Au/Ni/PANI microrocket was developed for potential hyperuricemia therapy. The microrocket was designed to be magnetically guided and controlled, with the outermost Au layer for enzyme immobilization and the innermost PANI layer to prevent leakage of Ni. The immobilized uricase demonstrated improved stability, resistance to protease enzymes, and enhanced substrate affinity compared to the free uricase.
Article
Environmental Sciences
S. Evli, B. Ondes, M. Uygun, D. A. Uygun
Summary: This paper introduces the first lipase loaded reduced graphene oxide/nickel/platin nanowires for tributyrin degradation. Covalent bonds were formed between the reduced graphene segment of the nanowire and lipase, and the nanowires demonstrated good catalytic activity and reusability in tributyrin degradation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Baha Ondes, Sinem Evli, Yuksel Sahin, Murat Uygun, Deniz Aktas Uygun
Summary: Gold nanoparticles and TiS2 nanosheets were prepared and characterized in this study, and their composite showed excellent performance as a modification for uric acid biosensor. The nanocomposite exhibited high sensitivity and selectivity.
MICROCHEMICAL JOURNAL
(2022)
Article
Engineering, Manufacturing
Xiao Liu, Haoren Wang, Kevin Kaufmann, Kenneth Vecchio
Summary: Additive manufacturing (AM) technology has evolved rapidly, enabling the rapid production of complex components using various materials. This study presents the first bulk copper parts with well-defined geometries produced using blown powder, directed energy deposition (DED) process with a blue laser. The results showed near full density (up to 99.6%) parts with a volume of 1000 mm3, which is the densest pure copper part reported so far in laser AM. The study also fabricated a larger part with a volume of 8000 mm3, the largest volume of pure copper reported in laser AM to date.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Chemistry, Multidisciplinary
Nurhan Gunay, Ulviye Kilimci, Gizem Ozturk, Deniz Aktas Uygun, Murat Uygun
Summary: This study describes the synthesis of poly(HEMA-EH) cryogel, immobilization of lysozyme, and the efficiency of the immobilized system in bacteria removal. Poly(HEMA-EH) cryogels were prepared using cryocopolymerization technique at sub-zero temperatures with HEMA monomer and EH functional epoxy-bearing monomer. The synthesized cryogel was characterized using FTIR, SEM, and an optical microscope. The maximum lysozyme loading was found to be 43.56 mg/g cryogel. The kinetics of free and immobilized lysozyme were also determined. Lastly, the bactericidal effect of immobilized lysozyme on Micrococcus lysodeikticus was studied, demonstrating efficient bacteria removal through staining.
Article
Nanoscience & Nanotechnology
Kevin Kaufmann, Emma Wenger, Kenneth Vecchio
Summary: The mechanical properties of rocksalt transition metal ceramics are strongly influenced by their valence electron concentration (VEC), with materials having VEC values between 9 and 10 generally exhibiting superior ductility and hardness. This study focuses on stabilizing Group-VIB carbides as room-temperature B1 structures through the addition of vanadium and correlating the VEC with nanoindentation measurements. The research thoroughly explores and verifies the minimum atom percent of vanadium required to form a single-phase B1 carbide using XRD, EDS, and EBSD techniques.
SCRIPTA MATERIALIA
(2023)
Article
Chemistry, Analytical
Baha Ondes, Cagdas Sunna, Ulviye Kilimci, Murat Uygun, Deniz Aktas Uygun
Summary: In this study, enzyme-modified boron nitride nanosheets were developed as a catalytic two-dimension material for sensor applications. The developed enzyme-based biosensor exhibited wide linear detection range, low limit of detection and quantitation values, good reproducibility, reusability, high selectivity, sensitivity, low Km value, and excellent shelf-life properties. It has also successfully identified uric acid in human serum with high recovery rate, promising rapid and high sensitivity applications in real serum.
MICROCHEMICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Davide G. Sangiovanni, Kevin Kaufmann, Kenneth Vecchio
Summary: High-entropy carbides (HECs) have attracted considerable interest due to their high hardness and tunable mechanical and physical properties. The resistance to fracture of refractory HECs is correlated with their valence electron concentration (VEC).
Article
Materials Science, Multidisciplinary
Baha Ondes, Sinem Evli, Murat Uygun, Deniz Aktas Uygun
Summary: This paper aims to synthesize and characterize lysozyme-modified microengines for bacterial degradation. Pt/reduced graphene oxide (rGO) microengines were synthesized and covalently modified with lysozyme enzyme. The activities of lysozyme-modified microengines were investigated and compared with free lysozyme. The high thermal and storage stability of the microengines were demonstrated, and they were able to degrade 100% of Micrococcus lysodeikticus within 5 minutes. The microengines functionalized with lysozyme could be used in environmental applications for bacterial destruction.
BULLETIN OF MATERIALS SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
