Article
Pharmacology & Pharmacy
Jose Javier Lopez-Cano, Miriam Ana Gonzalez-Cela-Casamayor, Vanessa Andres-Guerrero, Rocio Herrero-Vanrell, Irene Teresa Molina-Martinez
Summary: The development of ophthalmic formulations using liposomes has been a popular topic in recent years. Understanding the physiological and anatomical structures of the eye is crucial for the design of effective liposomal formulations. Liposomes offer an effective, safe, and versatile strategy for the treatment of ocular diseases, with the potential for using specific biomaterials to enhance therapeutic properties.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Pharmacology & Pharmacy
Sofia M. Saraiva, Lucia Martin-Banderas, Matilde Duran-Lobato
Summary: The interest in using cannabinoids for medical applications, especially in treating eye conditions, has been growing. However, due to the unfavorable properties of cannabinoids and barriers for local administration in the eye, drug delivery systems are needed. This review focuses on identifying eye diseases that could be treated with cannabinoids, reviewing formulation properties, evaluating cannabinoid-based formulations for ocular administration, and exploring potential alternative formulations for eye administration.
Review
Pharmacology & Pharmacy
Ayah Mohammad Burhan, Butsabarat Klahan, Wayne Cummins, Vanessa Andres-Guerrero, Mark E. Byrne, Niall J. O'Reilly, Anuj Chauhan, Laurence Fitzhenry, Helen Hughes
Summary: This study presents an overview of posterior segment eye diseases, barriers to topical drug delivery, and the application of chitosan in ophthalmic drug delivery. It discusses how mucoadhesive formulations can help enhance drug delivery to the posterior eye segment.
Article
Pharmacology & Pharmacy
Chau-Minh Phan, Manish Shukla, Hendrik Walther, Miriam Heynen, David Suh, Lyndon Jones
Summary: The purpose of this study was to develop an advanced in vitro blink model to examine the release of various components from soft contact lenses. The model successfully simulated tear fluid flow, eyewear materials, and contact lens absorption, providing results that were more accurate than traditional static vial incubation models. Additionally, the study found that different types of contact lenses released dye at varying rates, with one type exhibiting sustained release both in a vial and in the eye model.
Article
Multidisciplinary Sciences
Sean Swetledge, Renee Carter, Rhett Stout, Carlos E. Astete, Jangwook P. Jung, Cristina M. Sabliov
Summary: Polymeric nanoparticles loaded with lutein showed higher stability at low temperature with minimal lutein release and no significant morphological changes, but had decreased stability and increased lutein release at room temperature and high temperature. Additionally, these lutein-loaded nanoparticles demonstrated higher resistance to photodegradation compared to free lutein when exposed to ultraviolet light.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Christopher D. Conrady, Steven Yeh
Summary: Uveitis is a group of inflammatory disorders of the eye that require medical and surgical management, with challenges in drug delivery due to absorption barriers. New drugs and drug delivery platforms are being developed to reduce intraocular inflammation and its complications.
Review
Pharmacology & Pharmacy
Bastien Leclercq, Dan Mejlachowicz, Francine Behar-Cohen
Summary: The eye is composed of tissues and cavities that are regulated to maintain their optical properties and functions. Specialized junctions between cells control the passage of drugs, while specific transporters regulate the movement of water, ions, and macromolecules. Ocular barriers limit the bioavailability of gene therapy products, but also allow for local treatment with minimal systemic side-effects. Understanding these barriers is essential for the development of efficient gene delivery systems.
Article
Materials Science, Multidisciplinary
Qiaoyun Gong, Yue Zhao, Tianwei Qian, Haiyan Wang, Zuhao Li
Summary: Functionalized hydrogels show great potential in ophthalmic applications. This review summarizes the various functionalized hydrogels for different eye diseases and introduces advanced research progress in ophthalmic applications. Engineered hydrogels are expected to become powerful tools for the treatment of ocular diseases in the future.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Jing-jie Wang, Xin-xin Liu, Chen-chen Zhu, Tian-zuo Wang, Si-yu Wang, Yan Liu, Xin-yang Pan, Min-hua Liu, Ding Chen, Ling-li Li, Zhi-min Zhou, Kai-hui Nan
Summary: Researchers developed an affinity hydrogel for diquafosol tetrasodium (DQS) to achieve sustained release. The hydrogel demonstrated sustained release, low corneal permeation, and extended ocular retention, which are desirable attributes for ocular surface drug delivery. The superior therapeutic effects of the hydrogel over other vehicles were demonstrated in a mouse dry eye model.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Mingyue Cui, Mengjia Zheng, Christian Wiraja, Sharon Wan Ting Chew, Arti Mishra, Venkatesh Mayandi, Rajamani Lakshminarayanan, Chenjie Xu
Summary: The study introduced cryomicroneedles (cryoMN) for the ocular delivery of predatory Bdellovibrio bacteriovorus (B. bacteriovorus) bacteria, demonstrating their effectiveness in treating ocular bacterial infections and opening new avenues for the treatment of ocular surface disorders.
Article
Biotechnology & Applied Microbiology
Kunal S. Parikh, Revaz Omiadze, Aditya Josyula, Richard Shi, Nicole M. Anders, Ping He, Youseph Yazdi, Peter J. McDonnell, Laura M. Ensign, Justin Hanes
Summary: Sutures are commonly used to modulate local, postoperative biological responses and prevent bacterial infections. Loading drugs directly into nanofiber-based sutures allows sustained drug delivery while meeting size and strength requirements for microsurgical ocular procedures.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, General & Internal
Lina Mikalauskiene, Andrzej Grzybowski, Reda Zemaitiene
Summary: Dry eye disease can cause ocular discomfort and visual disturbances, with older adults being at higher risk when needing ophthalmic surgery. Factors such as preoperative dry eye disease, surgical procedures, and postoperative treatment can contribute to ocular surface dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Malihe Sadat Razavi, Pedram Ebrahimnejad, Yousef Fatahi, Antony D'Emanuele, Rassoul Dinarvand
Summary: Ocular disorders are major causes of blindness, and natural products show potential in treating these diseases. However, most beneficial compounds have low solubility, resulting in low bioavailability. Nanotechnology-based strategies can improve drug bioavailability and overcome limitations in ocular drug delivery.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
L. L. Tundisi, G. B. Mostaco, P. C. Carricondo, D. F. S. Petri
Summary: HPMC, a cellulose ether widely used in drug formulations, is commonly employed in ocular formulations as a viscosity enhancer, gelling agent, and polymeric matrix. Its physicochemical properties facilitate local drug delivery for challenging eye anatomy barriers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Chemistry, Physical
Bhavin R. Choradiya, Sanjay B. Patil
Summary: Nanoemulsions formulated for ocular drug delivery have advantages in terms of transparency, advanced bioavailability, and improved shelf life. They are part of a multiphase colloidal dispersion system with droplets in the size range of 20-600 nm. This review provides detailed information on their preparation, characteristics, evaluation, and applications for sustained release and prolonged therapeutic effect in ophthalmic drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Materials Science, Biomaterials
Ece Ozcan Bulbul, Neslihan Ustundag Okur, Duygu Misirli, Erdal Cevher, Vasilios Tsanaktsis, Ozlem Bingol Ozakpinar, Panoraia I. Siafaka
Summary: In this study, a quality by design approach was used to blend poly(lactic acid) (PLA) with poly(ethylene succinate) (PESu) or poly(ethylene glycol) (PEG) to produce sustained-release matrices for Paclitaxel delivery. The physicochemical properties of the matrices were comprehensively characterized, and in vitro cancer toxicity was evaluated in lung and breast adenocarcinoma cell lines. The developed Paclitaxel-loaded films show promise as alternative topical matrices for breast and lung cancer treatment.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Seda Rencber, Ece O. Bulbul, Zeynep A. Senyigit, Neslihan U. Okur, Panoraia I. Siafaka
Summary: This review article discusses the applications of bioadhesive nanoparticles in biomedical field, including the categorization and basic characteristics of nanoparticles, as well as the biomedical applications of bioadhesive drug nanocarriers and various administration routes.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Panoraia Siafaka, Emre Sefik Caglar, Evren Atlihan Gundogdu, Neslihan Ustundag Okur
Summary: It is well documented that cancer is a leading cause of death worldwide, and the suspension of cancer screening during the pandemic has led to an increase in deaths related to various cancer types. The early diagnosis of cancer is crucial, and the introduction of nanotechnology-based carriers has shown promise in combining imaging and therapeutic modalities. Nanotheranostics can potentially improve survival rates and overall quality of life for cancer patients.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Panoraia I. Siafaka, Evren Atlihan Guendogdu, Emre Sefik Caglar, Emre oezgenc, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Neslihan uestuendag Okur
Summary: There is ongoing research to develop innovative drug delivery systems with improved therapeutic efficacy in the pharmaceutical technology field. Scientists focus on the advancement of novel pharmaceutical formulations to address the limitations of current excipients. The development of drug formulations that can target specific organs and tissues is also a focus.
CURRENT DRUG DELIVERY
(2023)
Article
Chemistry, Medicinal
Rawan Ranna, Burcu Uner, Neslihan Ustundag Okur, Cetin Tas
Summary: This study aimed to increase the solubility of eplerenone by using liquid and solid self-emulsifying drug delivery systems as an alternative to the marketed tablet product. The results showed that solid self-emulsifying drug delivery systems prepared with Aerosil and Neusilin significantly improved the dissolution of eplerenone, releasing the entire dose within 5 and 30 minutes, respectively, compared to the marketed product and pure eplerenone (p < 0.05).
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Chemistry, Physical
Emre Sefik Caglar, Mehmet Evren Okur, Buket Aksu, Neslihan Ustundag Okur
Summary: The aim of this study was to investigate the potential use of microemulsions as a transdermal drug delivery system for ACM. Pseudo-ternary phase diagrams were created using microemulsions containing isopropyl myristate, Tween 80, Transcutol HP, Labrafil M1944 CS, ethanol, and distilled water. The microemulsions were characterized using various parameters, and in vitro permeability investigations were conducted. The results showed that the ideal formulation had superior characteristics and achieved greater penetration of ACM, demonstrating its potential as a transdermal delivery system for ACM.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dilara Sahin, Emre Sefik Caglar, Tugce Boran, Ayse Esra Karadag, Gul Ozhan, Neslihan Ustundag Okur
Summary: The aim of this study was to develop microemulsion formulations containing naringenin for anti-aging purposes. Different cosurfactants and surfactants were used to formulate topical microemulsions, and a triangle phase diagram was utilized to determine the optimal microemulsion system. The formulated microemulsions were characterized and tested for permeation, release, enzyme inhibition, antioxidant properties, cytotoxicity, gene expression, and cell culture. The results showed that the developed microemulsions had promising properties for anti-aging purposes.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Panoraia I. Siafaka, Ece Ozcan Bulbul, Androulla N. Miliotou, Ioannis D. Karantas, Mehmet Evren Okur, Neslihan Ustundag Okur
Summary: Ocular drug delivery is a challenging but fascinating route of administration that requires overcoming obstacles presented by the complex structure of the eye. Researchers have proposed using biomaterials, especially polymers, to create drug delivery systems that can effectively target eye diseases. Electrospun fibrous structures have shown promise in delivering therapeutic molecules to the ocular surface due to their biocompatibility, biodegradability, and ability to be molded into different shapes and textures. Despite advancements in the electrospinning process, the clinical translation of these fibrous matrices is still in the early stages. This review article focuses on recent therapeutic applications of ocular fibrous systems and categorizes them based on the target eye disease.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Vildan Yozgatli, Neslihan Ustundag Okur, Mehmet Evren Okur, Hande Sipahi, Mohammad Charehsaz, Ahmet Aydin, Timucin Ugurlu
Summary: The purpose of this study was to develop an alternative microemulsion of tetrahydrozoline hydrochloride (THZ) for the management of allergic conjunctivitis. Pseudo-ternary phase diagrams were used to produce the microemulsions, and various surfactants were tested for their suitability. The microemulsions showed promising characteristics and can be used as a carrier for topical eye application.
JOURNAL OF SURFACTANTS AND DETERGENTS
(2023)
Article
Pharmacology & Pharmacy
Saniye Ozcan, Emre Sefik Caglar, Mustafa Sinan Kaynak, Neslihan Ustundag Okur
Summary: One of the most popular methods for determining drug's intestinal permeability is the intestinal perfusion (SPIP) approach. The goal of our study was to develop and validate a reversed-phase liquid chromatographic method for simultaneous detection of Domperidone maleate, metoprolol, and phenol red in intestinal perfusion studies. The method involved using a C18 column with a specific mobile phase and was validated using FDA's standards. This newly developed and validated approach can facilitate standardized in situ intestinal permeability experiments.
JOURNAL OF RESEARCH IN PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Neslihan Ustundag Okur, Ecehan Onay, Beril Kadioglu Yaman, Hande Sipahi
Summary: Microemulsions containing etofenamate were prepared and evaluated as dermal delivery carriers. Among the developed formulations, M2(ETF) showed better permeation, lower penetration, and higher anti-inflammatory activity, making it the ideal formulation choice.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
