Review
Biochemistry & Molecular Biology
Feng-Wei Guo, Qun Zhang, Yu-Cheng Gu, Chang-Lun Shao
Summary: In this paper, we reviewed 95 new sulfur-containing marine natural products isolated between 2021 and March 2023. We also discussed the strategies and emerging technologies, such as natural product-based antibody drug conjugates (ADCs), small-molecule-based proteolysis targeting chimeras (PROTACs), nanotechnology-based drug carriers, and artificial intelligence-driven drug discovery, that have been used to improve the efficiency and success rate of NP-based drug development. Additionally, we provided perspectives on the challenges, opportunities, and future research directions in sulfur-containing marine natural product-based drug discovery and development.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kazuhiro Kajiyama, Chieko Ishiguro, Takashi Ando, Yuki Kubota, Natsumi Kinoshita, Yukio Oniyama, Toyotaka Iguchi, Yoshiaki Uyama
Summary: A case-control study investigated the association between G-CSF preparations and thrombocytopenia in patients treated with antineoplastic agents. The results showed an increased risk of thrombocytopenia with the use of any G-CSF preparations, particularly with pegfilgrastim. This led to regulatory safety actions and revisions in precautions for pegfilgrastim use.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Cong-Min Peng, Shih-Wei Wang, Yi-Lin Hwang, Wen-Chun Sun, Li-Pin Chiu, Yi-Ting Liu, Yu-Wei Lai, Hsueh-Yun Lee
Summary: The in situ CuI-mediated cyclization methodology was used to synthesize benzimidazoles with different substitution manner. Structure-activity relationship (SAR) study confirmed the significance of the 5,6,7-trimethoxybenzimidazole moiety. Representative derivatives exhibited potent antiproliferative activity against A549, HCT-116, and PC-3 cells, as well as inhibition of tubulin polymerization. Compound 10 showed the most promising activity with an IC50 value of 0.07 μM against cancer cell growth and 0.26 μM against tubulin polymerization.
Article
Oncology
Aleksandr Yurkovetskiy, Natalya D. Bodyak, Mao Yin, Joshua D. Thomas, Susan M. Clardy, Patrick R. Conlon, Cheri A. Stevenson, Alex Uttard, LiuLiang Qin, Dmitry R. Gumerov, Elena Ter-Ovanesyan, Charlie Bu, Alex J. Johnson, Venu R. Gurijala, Dennis McGillicuddy, Michael J. DeVit, Laura L. Poling, Marina Protopopova, Ling Xu, Qingxiu Zhang, Peter U. Park, Donald A. Bergstrom, Timothy B. Lowinger
Summary: After years of effort, ADCs have gained momentum as a therapeutic modality, with dolaflexin being a novel ADC technology that overcomes key limitations of common ADC platforms. Preclinical studies have shown that the HER2-targeted dolaflexin ADC has a lower threshold for cell killing in tumors with low HER2 expression and induces tumor regressions in xenograft models resistant to T-DM1, highlighting its potential as a promising therapeutic option.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Mateusz Maszczyk, Klaudia Banach, Marta Karkoszka, Zuzanna Rzepka, Jakub Rok, Artur Beberok, Dorota Wrzesniok
Summary: Glioblastoma is a type of glioma with high mortality rates and resistance to treatment. Research suggests that neobavaisoflavone may enhance the pro-apoptotic activity of chemotherapeutic drugs like etoposide and doxorubicin in glioblastoma cells, indicating potential chemosensitizing properties of this isoflavone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
James McNulty, Chanti Babu-Dokuburra, Jon Scattolon, Carlos Zepeda-Velazquez, Maribeth A. Wesesky, Jill K. Caldwell, Wenxiao Zheng, Jadranka Milosevic, Paul R. Kinchington, David C. Bloom, Vishwajit L. Nimgaonkar, Leonardo D'Aiuto
Summary: The total synthesis of four novel mono-methoxy and hydroxyl substituted ring-A dihydronarciclasine derivatives identified the 7-hydroxyl derivative as a potent and selective antiviral agent against SARSCoV-2 and HSV-1. The IC50 for inhibiting HSV-1 infection, determined using induced pluripotent stem cells-derived brain organ organoids, was estimated to be 0.504 μM and 0.209 μM. No significant reduction in organoid viability was observed up to concentrations of 50 mM. Genomic expression analyses revealed activation of host-cell innate immunity, including the integrated stress response and type I IFN, as factors enhancing host-defense mechanisms against viral infection. In vivo experiments showed that the compound significantly reduced HSV-1 shedding in mouse eyes.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Romeika Lorena Mendes da Silva, Tamara Taynah Medeiros da Silva, Renata Lima Pessoa, Ayane Cristine Alves Sarmento, Kleyton Santos Medeiros, Daniele Vieira Dantas, Rodrigo Assis Neves Dantas
Summary: This study aims to evaluate the effects of ginger on chemotherapy-induced nausea and vomiting in patients with cervical cancer undergoing treatment with cisplatin and radiotherapy. A randomized intervention clinical and controlled trial with a triple-blind design is described to compare the effects of institutional antiemetic therapy alone and in combination with 2 different ginger concentrations. Ethical approval has been obtained and the results will be disseminated through publication in peer-reviewed journals and public data repositories.
Article
Oncology
Cassia Emanuella Nobrega Malta, Joyce Ohana de Lima Martins, Anna Clara Aragao Matos Carlos, Milena Oliveira Freitas, Iana Aragao Magalhaes, Herica Cristina Alves de Vasconcelos, Isabelly Joyce De Lima Silva-Fernandes, Paulo Goberlanio de Barros Silva
Summary: This study found that factors such as chemotherapy cycles, sex, location of primary tumor, and specific chemotherapy drugs increase the risk of dysgeusia after chemotherapy treatment.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Public, Environmental & Occupational Health
Cristina Villanueva-Bueno, Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Jose Luis Revuelta-Herrero, Maria Belen Marzal-Alfaro, Eva Gonzalez-Haba, Jose Angel Arranz-Arija, Santiago Osorio, Ana Herranz-Alonso, Maria Sanjurjo-Saez
Summary: This study analyzed the impact of the eOncosalud app on the management and follow-up of adverse effects in patients receiving oral antineoplastic agents. The app enabled real-time monitoring of patients and provided automatic recommendations, optimizing healthcare resources and improving treatment safety.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Engineering, Chemical
Fredrik Lehmann, Johan Wennerberg
Summary: Despite significant advancements in anticancer drug development, there is a critical need for novel agents with unique but effective mechanisms to combat highly aggressive and drug-resistant tumors. Alkylating agents, particularly nitrogen-based ones, are commonly used for hematological and solid malignancies, exerting their antineoplastic effects throughout the cell cycle. Certain alkylating agents have been designed to enhance penetration into cells and increase their activity against tumors.
Review
Oncology
Ataollah Shahbandi, Darsh S. Shah, Caroline C. Hadley, Akash J. Patel
Summary: In the past 35 years, various systemic therapies for recurrent or refractory meningiomas have been studied. This review collected and analyzed the current evidence on the safety and efficacy of these treatments, as well as assessing the ongoing clinical trials for medical therapy of meningiomas. The findings of this study will contribute to future research by providing insights into the investigated therapeutic regimens, promising intervention targets, and the current design of clinical trials.
Article
Oncology
Maxime Frelaut, Elena Paillaud, Guillaume Beinse, Anne-Laure Scain, Stephane Culine, Christophe Tournigand, Johanne Poisson, Sylvie Bastuji-Garin, Florence Canoui-Poitrine, Philippe Caillet
Summary: This study evaluated the predictive performance of the CRASH and CARG scores in older patients for chemotherapy-related toxicities. The results showed that these scores were poor predictors of severe chemotherapy toxicities. The study also identified factors associated with severe chemotherapy-related toxicities.
Article
Oncology
Maxime Frelaut, Elena Paillaud, Guillaume Beinse, Anne-Laure Scain, Stephane Culine, Christophe Tournigand, Johanne Poisson, Sylvie Bastuji-Garin, Florence Canoui-Poitrine, Philippe Caillet
Summary: The CARG and CRASH scores showed poor predictive performance in predicting the risk of severe chemotherapy toxicities in an external cohort of older patients referred for a pretherapeutic geriatric assessment.
Article
Dentistry, Oral Surgery & Medicine
Luciana Prado Maia, Yara Loyanne de Almeida Silva Levi, Pedro Henrique Felix Silva, Luana Carla Wons, Livia Pizzo Pitelli, Jessica Goulart de Castro, Eder da Silva Dolens, Danielle Gregorio, Fabiana Gouveia Straioto, Carolina dos Santos Santinoni, Renato Casarin, Edilson Ervolino, Flavia Aparecida Chaves Furlaneto, Michel Reis Messora
Summary: This study evaluated the effects of the probiotic Bifidobacterium animalis subsp. lactis HN019 (HN019) on the development of experimental periodontitis in rats submitted to chemotherapy. The results showed that the EP-5FU-HN019 group had less bone and connective tissue loss compared to the EP-5FU group, while the EP-HN019 and EP-5FU-HN019 groups had greater bone volume than the EP and EP-5FU groups, respectively. Probiotic therapy also led to an increase in the proportions of B. lactis in the feces and reduced the expression of periodontopathogens in the biofilm of rats submitted to chemotherapy.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Oncology
Aasha Hoogland, Heather S. L. Jim, Brian D. Gonzalez, Brent J. Small, Danielle Gilvary, Elizabeth C. Breen, Julienne E. Bower, Mayer Fishman, Babu Zachariah, Paul B. Jacobsen
Summary: Increases in fatigue, depressive symptomatology, and cognitive impairment are common in prostate cancer patients after receiving androgen deprivation therapy (ADT). Circulating interleukin-6 (IL-6) may play a role in fatigue related to ADT, suggesting a need for further research on interventions to reduce inflammation and improve fatigue in this population.
