期刊
JOURNAL OF NATURAL PRODUCTS
卷 83, 期 4, 页码 1300-1304出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00144
关键词
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资金
- National Science and Technology Major Project for Significant New Drugs Development, China [2018ZX09735-004]
- National Natural Science Foundation of China [41830535]
- Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao, China) [2018SDKJ0406-5]
- High Performance Computer Center of Hebei University
- Taishan Scholars Program, China
Microketides A and B (1 and 2), a pair of new C-11 epimeric polyketides, were obtained from the gorgonian-derived fungus Microsphaeropsis sp. RA10-14 collected from the South China Sea. The absolute configurations of 1 and 2 were assigned by the modified Mosher's method, TDDFT-ECD, and NMR calculations. Compounds 1 and 2 were evaluated for antibacterial, antifungal, and growth inhibition of marine phytoplankton activities. Microketide A (1) exhibited promising inhibitory activity against Pseudomonas aeruginosa, Nocardia brasiliensis, Kocuria rhizophila, and Bacillus anthraci with the same MIC value as ciprofloxacin (0.19 mu g/mL).
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