Article
Immunology
Julius Nueckel, Elisa Planatscher, Anne Wiebe Mohr, Karolin Deichl, Hrvoje Mijocevic, Martin Feuerherd, Lisa Wolff, Johanna Erber, Jochen Schneider, Michael Quante, Christoph Winter, Juergen Ruland, Alexander Hapfelmeier, Wolfgang Hammerschmidt, Andreas Moosmann, Ulrike Protzer, Uta Behrends, Josef Mautner
Summary: Understanding immune responses to SARS-CoV-2 is crucial for controlling the COVID-19 pandemic. Studies have shown a strong correlation between the severity of COVID-19 and immune responses against the nucleocapsid protein of SARS-CoV-2, as well as the number of viral antigens targeted. Additionally, there is a correlation between COVID-19 severity and immune responses against the nucleocapsid protein of endemic alpha-coronaviruses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Julien De Greef, Anais Scohy, Francis Zech, Frank Aboubakar, Charles Pilette, Ludovic Gerard, Lucie Pothen, Halil Yildiz, Leila Belkhir, Jean Cyr Yombi
Summary: The kinetics of IgG antibodies after COVID-19 remain poorly understood, with levels decreasing significantly over time. Age, BMI, and immunosuppression appear to influence IgG kinetics, while short-term corticotherapy does not have a significant effect. Further research is needed to determine the determinants of long-term seroprotection against SARS-CoV-2.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Xiquan Yan, Guoqiang Chen, Zhaoxia Jin, Zhongwei Zhang, Bing Zhang, Jiangming He, Siqing Yin, Juanshu Huang, Maiying Fan, Zhenyuan Li, Fang Chen, Yong Zeng, Xiaotong Han, Yimin Zhu
Summary: The level of virus-specific IgG antibodies is positively correlated with the severity of COVID-19, with the highest titers observed in severe cases. Asymptomatic carriers tended to have lower or even negative anti-SARS-CoV-2 IgG test results.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Immunology
Mohadeseh Haji Abdolvahab, Shima Moradi-kalbolandi, Mohammad Zarei, Deepanwita Bose, Keivan Majidzadeh-A, Leila Farahmand
Summary: COVID-19, caused by SARS-CoV-2, is a public health crisis originating from bats and transmitted to humans. The disease is mainly spread through respiratory means with an incubation period of 2-14 days, with symptoms including fever, sore throat, and cough. Treatment focuses on supportive care and interferons, with combination therapy potentially being more effective.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Microbiology
Justyna Adamczuk, Piotr Czupryna, Justyna Dunaj-Malyszko, Ewelina Kruszewska, Slawomir Pancewicz, Karol Kaminski, Karol Borawski, Sambor Grygorczuk, Anna Moniuszko-Malinowska
Summary: The study aimed to assess the presence of anti-SARS-CoV-2 antibodies in COVID-19 convalescents and investigate their production in relation to disease severity, sex, vaccination, and correlation with inflammatory parameters. The results showed that immunological response could last over 6 months, with significantly higher antibody titers in severe cases and vaccinated patients. The immunological response was not dependent on sex. There was also a significant correlation between antibody production and the degree of inflammation.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
William B. Stubblefield, H. Keipp Talbot, Leora R. Feldstein, Mark W. Tenforde, Mohammed Ata Ur Rasheed, Lisa Mills, Sandra N. Lester, Brandi Freeman, Natalie J. Thornburg, Ian D. Jones, Michael J. Ward, Christopher J. Lindsell, Adrienne Baughman, Natasha Halasa, Carlos G. Grijalva, Todd W. Rice, Manish M. Patel, Wesley H. Self
Summary: Out of 249 healthcare personnel who worked in hospital units with COVID-19 patients for 1 month, 7.6% tested positive for SARS-CoV-2 antibodies. Among the 19 personnel with positive serology, only 57.9% reported prior illness symptoms, indicating asymptomatic healthcare personnel could be a significant source of SARS-CoV-2 transmission.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Biophysics
Nastaran Taleghani, Fariborz Taghipour
Summary: Health organizations and countries globally are struggling to control the spread of COVID-19, with scientists working on rapid testing and vaccine development. Fast and accurate diagnosis is crucial for disease prevention and control, and ongoing research and technology advancements are key in this effort.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Virology
Helene Haguet, Jonathan Douxfils, Christine Eucher, Marc Elsen, Julie Cadrobbi, Marie Tre-Hardy, Jean-Michel Dogne, Julien Favresse
Summary: The study evaluated the clinical performance of the Panbio COVID-19 IgG/IgM rapid test, showing high sensitivity for IgG, particularly suitable for testing more than 14 days after symptom onset. However, the sensitivity for IgM was lower, while both IgG and IgM exhibited excellent specificity in the assay.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Rachid Laajaj, Camilo De los Rios, Ignacio Sarmiento-Barbieri, Danilo Aristizabal, Eduardo Behrentz, Raquel Bernal, Giancarlo Buitrago, Zulma Cucunuba, Fernando de la Hoz, Alejandro Gaviria, Luis Jorge Hernandez, Leonardo Leon, Diane Moyano, Elkin Osorio, Andrea Ramirez Varela, Silvia Restrepo, Rodrigo Rodriguez, Norbert Schady, Martha Vives, Duncan Webb
Summary: Latin America has been severely affected by the COVID-19 pandemic, with limited estimations of infection rates available. A sentinel surveillance study in Bogota found that by March 2021, over half of the population had been infected, despite only a small fraction of cases being detected. This highlights the importance of detailed data in understanding the dynamics and impact of the pandemic.
NATURE COMMUNICATIONS
(2021)
Article
Infectious Diseases
Cristina Mussini, Marco Falcone, Silvia Nozza, Caterina Sagnelli, Roberto Parrella, Marianna Meschiari, Nicola Petrosillo, Claudio Mastroianni, Antonio Cascio, Chiara Iaria, Massimo Galli, Antonio Chirianni, Evangelista Sagnelli, Carmelo Iacobello, Giovanni Di Perri, Francesco Mazzotta, Giampiero Carosi, Marco Tinelli, Paolo Grossi, Orlando Armignacco, Vincenzo Portelli, Massimo Andreoni, Marcello Tavio
Summary: This study summarized the literature on the management of COVID-19 to assist frontline healthcare workers in better understanding the current evidence for disease treatment and guidelines. The research team conducted a detailed review of literature and clinical trial results to develop treatment indications for different COVID-19 patients.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Raquel Jimenez-Garcia, Javier Nogueira, Azucena Retuerta-Oliva, Talia Sainz, Julia Cano-Fernandez, Patricia Flores-Perez, Ana Mendez-Echevarria, Enrique Villalobos-Pinto, Lourdes Calleja-Gero, Fancisco J. Sanz-Santaeufemia, Maria P. Romero, Teresa del Rosal, Fernando Baquero-Artigao, Carlos Grasa, Cristina Calvo
Summary: The study found that during the lockdown period of the first pandemic wave, only a small percentage of children hospitalized with pneumonia were attributable to SARS-CoV-2, with other common etiologies. Older age, presence of headache, vomiting, lymphopenia, and thrombopenia were associated with COVID-19 pneumonia.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Review
Microbiology
Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, Vineet D. Menachery
Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.
CELL HOST & MICROBE
(2021)
Article
Public, Environmental & Occupational Health
E. Dickson, N. E. Palmateer, J. Murray, C. Robertson, C. Waugh, L. A. Wallace, L. Mathie, K. Heatlie, S. Mavin, P. Gousias, B. Von Wissman, D. J. Goldberg, A. McAuley
Summary: The study estimated the seroprevalence of SARS-CoV-2 antibodies in the general population of Scotland, finding a rate of 4.3% over the study period. The proportion varied between 1.9% and 6.8% each week with no significant differences by age, sex, or geographical area.
Review
Medicine, Research & Experimental
Farnaz Farshidfar, Navid Koleini, Hossein Ardehali
Summary: The emergence of SARS-CoV-2 has led to a global pandemic with a high impact on public health. Apart from lung involvement, COVID-19 also affects the cardiovascular system, with preexisting cardiovascular disease increasing mortality in patients with the virus. Potential mechanisms for cardiovascular complications include direct viral infection and cytokine storm-induced myocarditis.
Review
Virology
Sana Shabbir, Muhammad Hassan Raza, Muhammad Arshad, Muhammad Jawad Khan
Summary: The global population has been significantly impacted by COVID-19, caused by SARS-CoV-2 with no effective treatment options available. Research has shown that patients exhibit active immune responses, potentially leading to issues like cytokine storm syndrome.
ARCHIVES OF VIROLOGY
(2021)
Article
Medicine, General & Internal
Yuan-Pin Hung, Po-Lin Chen, Ching-Yu Ho, Chih-Chia Hsieh, Chung-Hsun Lee, Ching-Chi Lee, Wen-Chien Ko
Summary: The study found that delayed administration of antimicrobial therapy has a significant impact on the short-term survival of middle-aged, old, and very old patients with bloodstream infections. After propensity-score matching, significant differences were observed in survival curves between patients with delayed AAT > 24 or >48 h and those without delayed administration in each age group.
FRONTIERS IN MEDICINE
(2022)
Letter
Infectious Diseases
Jia-Arng Lee, Shin-Hei Du, Tai-fen Lee, Yu-Shan Huang, Chun-Hsing Liao, Yu-Tsung Huang, Po-Ren Hsueh
JOURNAL OF INFECTION
(2023)
Letter
Infectious Diseases
Yuag-Meng Liu, Wen-Chien Ko, Mao-Wang Ho, Yu-Lin Lee, Po-Ren Hsueh
JOURNAL OF INFECTION
(2023)
Letter
Infectious Diseases
Jiaxin Yu, Hsiu-Hsien Lin, Kun-Hao Tseng, Ni Tien, Po-Ren Hsueh, Der-Yang Cho
JOURNAL OF INFECTION
(2023)
Review
Virology
Chih-Cheng Lai, Chi-Kuei Hsu, Shun-Chung Hsueh, Muh-Yong Yen, Wen-Chien Ko, Po-Ren Hsueh
Summary: Following the emergence of multisystem inflammatory syndrome in children (MIS-C), a similar clinical scenario called multisystem inflammatory syndrome in adults (MIS-A) has been observed. Although the prevalence of MIS-A is low and likely underdiagnosed, it can be associated with high mortality. MIS-A is a multisystem disease that affects the cardiovascular, respiratory, gastrointestinal, dermatologic, hematologic, and neurologic systems. The diagnosis of MIS-A requires clinical manifestations, laboratory evidence of inflammation, and SARS-CoV-2 infection. The appropriate treatment for MIS-A is still uncertain, but anti-inflammatory agents like intravenous immunoglobulin and corticosteroids are commonly used. Further research is needed to determine the true prevalence, pathogenesis, and effective treatment for MIS-A.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Virology
Chih-Cheng Lai, Po-Ren Hsueh
Summary: Nirmatrelvir/ritonavir (NMV-r) is an effective antiviral agent for treating nonhospitalized COVID-19 patients. However, there have been rare cases of virologic and symptomatic rebound after NMV-r treatment, which is a cause for concern. This review provides comprehensive information on the frequency, mechanism, outcomes, and management of COVID-19 rebound after NMV-r. The incidence of rebound was less than 2% and most cases had mild symptoms, with favorable clinical outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Immunology
Huan-Yi Wu, Peng-Hao Chang, Yu-Shan Huang, Chin-Shiang Tsai, Kuan-Yu Chen, I-Fan Lin, Wen-Hsin Hsih, Wan-Lin Tsai, Jiun-An Chen, Te-Liang Yang, Chun-Yuan Lee, Tzong-Shiann Ho, Hsiao-Wei Wang, Shiang-Fen Huang, Alice Ying-Jung Wu, Hung-Jui Chen, Yi-Ching Chen, Wan-Chen Chen, Chien-Hao Tseng, Pei-Chin Lin, Ching-Hsiang Yang, Pi-Lien Hong, Susan Shin-Jung Lee, Yao-Shen Chen, Yung-Ching Liu, Fu-Der Wang
Summary: COVID-19 is an emerging infectious disease caused by SARS-CoV-2, and has become a global pandemic with over 600 million infections and more than 6.6 million deaths as of November 25, 2022. The disease carries a high mortality rate, especially in severe cases. Co-infections and secondary infections with bacteria and fungi further complicate the diagnosis and management of COVID-19. This guideline provides recommendations for the management and treatment of COVID-19 associated bacterial and fungal infections, including CABI, CAPA, CAC, and CAM, based on the current evidence and using the GRADE methodology.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Immunology
Chin-Shiang Tsai, Po-Lin Chen, Nan-Yao Lee, Huey-Pin Tsai, Sung-Hsi Huang, Szu-Ying Chen, Yu-Wen Tang, Yen-Chun Lin, Pei-Fang Tsai, Lin-Wen Mao, Shu-Li Su, Jiun-Ling Wang, Wen-Chien Ko
Summary: The prevalence of rectal chlamydia among non-HIV men who have sex with men (MSM) in Taiwan is uncertain, and rectal lymphogranuloma venereum (LGV) has never been reported in the Far East. A study in southern Taiwan from 2020 to 2022 found that 6.2% of MSM had rectal chlamydia infection. Risk factors for rectal chlamydia included co-infection with rectal gonorrhea and multiple sexual partners. The study also identified different genotypes or genovariants of chlamydia, with L2b being the most prevalent in rectal LGV cases.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Immunology
Ahmad Rifai, Wan-Ching Wu, Yu-Wen Tang, Mei-Yun Lu, Pei-Jen Chiu, Carol Strong, Chung-Ying Lin, Po-Lin Chen, Wen-Chien Ko, Nai-Ying Ko
Summary: The COVID-19 pandemic has caused psychological distress among healthcare workers (HCWs), and this study investigated the association between psychological distress and adverse events (AEs), as well as the determinants of protective behaviors in Taiwanese HCWs. The results showed that depression, distress, and anger were significantly associated with physical AEs, while suicidal thoughts were related to systemic AEs after COVID-19 vaccination. Older age and female gender were associated with more engagement in preventive behaviors, and suicidal thoughts were related to the occurrence of systemic AEs among HCWs. Doctors performed better at preventive behaviors compared to nurses and other HCWs, and HCWs experiencing anxiety and nervousness tended to avoid crowds.
Letter
Infectious Diseases
Pin-Han Wu, Chih-Hao Chen, Wen-Hsin Hsih, Chia-Huei Chou, Chih-Yu Chi, Mao-Wang Ho, Yu-Tzu Lin, Hsiu-Hsien Lin, Kun-Hao Tseng, Po-Ren Hsueh
JOURNAL OF INFECTION
(2023)
Letter
Immunology
Chin-Shiang Tsai, Jiun-Ling Wang, Nan-Yao Lee, Po-Lin Chen, Ying-Jun Lin, Huey-Pin Tsai, Shu-Li Su, Hsin-Hui Huang, Lin-Wen Mao, Han Siong Toh, Wen-Chien Ko
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Ching-Chi Lee, Yuan-Pin Hung, Chih-Chia Hsieh, Ching-Yu Ho, Chiao-Ya Hsu, Cheng-Te Li, Wen-Chien Ko
Summary: This study aimed to develop scoring systems to predict short-term mortality and length of hospital stay in patients with bacteraemia. The study found that clinical variables that dynamically changed from day 0 to day 3 were crucial in predicting the outcomes.
BMC INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
Ming-Ta Chuang, Mei-Tsz Su, Chen-Hsi Chou, Yu-Ling Liang, Hsing-Fen Tsai, Pei-Hsiu Yu, Meng-Hsing Wu, Wen-Chien Ko, Pei-Yin Tsai
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Immunology
I-Ru Chen, Guei-Jane Wang, Po-Ren Hsueh, Chia-Hui Chou, Long-Bin Jeng, Hui-Ju Lin, Huang-Jiun Liao, Ping-Chin Lai, Jan-Gowth Chang, Chiu-Ching Huang
Summary: This study evaluated the immune responses and safety of COVID-19 vaccination in patients with atypical hemolytic uremic syndrome (aHUS) in Taiwan. The results showed that the vaccines effectively protected aHUS patients from severe COVID-19 complications without significant safety concerns. Transplant aHUS patients had lower immune response titers, indicating a need for additional vaccine doses.
